Eric Nuermberger

Eric Nuermberger

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Eric Nuermberger

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New β-Lactamase Inhibitors Nacubactam and Zidebactam Improve the Activity of β-Lactam Antibiotics against Mycobacterium abscessus Complex Clinical Isolates.

Antimicrob Agents Chemother 2019 Sep 23;63(9). Epub 2019 Aug 23.

Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.00733-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709484PMC
September 2019

Advancing the Therapeutic Potential of Indoleamides for Tuberculosis.

Antimicrob Agents Chemother 2019 Jul 24;63(7). Epub 2019 Jun 24.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.00343-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591635PMC
July 2019

Shortening Buruli Ulcer Treatment with Combination Therapy Targeting the Respiratory Chain and Exploiting Mycobacterium ulcerans Gene Decay.

Antimicrob Agents Chemother 2019 Jul 24;63(7). Epub 2019 Jun 24.

Department of Medicine, Johns Hopkins University Center for Tuberculosis Research, Baltimore, Maryland, USA

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http://aac.asm.org/lookup/doi/10.1128/AAC.00426-19
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http://dx.doi.org/10.1128/AAC.00426-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591589PMC
July 2019

Activity of New Tetracycline Analogs Omadacycline and Eravacycline against Drug-Resistant Clinical Isolates of .

Antimicrob Agents Chemother 2019 Jun 24;63(6). Epub 2019 May 24.

Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.00470-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535573PMC
June 2019

Contribution of Pretomanid to Novel Regimens Containing Bedaquiline with either Linezolid or Moxifloxacin and Pyrazinamide in Murine Models of Tuberculosis.

Antimicrob Agents Chemother 2019 May 25;63(5). Epub 2019 Apr 25.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.00021-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496099PMC
May 2019

Oxazolidinones Can Replace Clarithromycin in Combination with Rifampin in a Mouse Model of Buruli Ulcer.

Antimicrob Agents Chemother 2019 03 26;63(3). Epub 2019 Feb 26.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.02171-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395894PMC
March 2019

One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis.

N Engl J Med 2019 03;380(11):1001-1011

From the University of Nebraska Medical Center, Omaha (S.S., C.V.F.); Harvard T.H. Chan School of Public Health, Boston (R.R., J.L.-C., J.A.); Johns Hopkins University School of Medicine, Baltimore (A.G., E.N., R.E.C.), and Social and Scientific Systems, Silver Spring (L. Moran) - both in Maryland; University of California, San Diego, School of Medicine, La Jolla (C.A.B.); GHESKIO, Port-au-Prince, Haiti (M.A.J.J., P.S.); Asociación Civil Impacta Salud y Educación, Lima, Peru (J.R.L., J.V.); Botswana-Harvard AIDS Partnership, Gaborone, Botswana (A.O.-O., G.M.); Chiang Mai University, Chiang Mai, Thailand (K.S.); Helen Joseph Hospital, Johannesburg (N.M.), Perinatal HIV Research Unit, Soweto (L. Mohapi), and the University of Kwa-Zulu Natal, Durban (S.M.) - all in South Africa; Instituto de Pesquisa Clínica Evandro Chagas, Rio de Janeiro (R.O.S.E.); Johns Hopkins-Blantyre Clinical Trials Unit, Blantyre (P.B.), and the University of North Carolina-Lilongwe Clinical Research Site, Lilongwe (C.K.) - both in Malawi; the University of Zimbabwe, Harare (J.H.); and Kenya Medical Research Institute-Walter Reed Clinical Research Site, Nairobi (D.L.).

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http://dx.doi.org/10.1056/NEJMoa1806808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563914PMC
March 2019

High-Dose Rifamycins Enable Shorter Oral Treatment in a Murine Model of Mycobacterium ulcerans Disease.

Antimicrob Agents Chemother 2019 02 29;63(2). Epub 2019 Jan 29.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

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http://aac.asm.org/lookup/doi/10.1128/AAC.01478-18
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http://dx.doi.org/10.1128/AAC.01478-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355596PMC
February 2019

New drugs and regimens for tuberculosis.

Respirology 2018 11 19;23(11):978-990. Epub 2018 Jun 19.

Department of Health, Tuberculosis and Chest Service, Hong Kong, China.

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http://dx.doi.org/10.1111/resp.13345DOI Listing
November 2018

Multiparameter Responses to Tedizolid Monotherapy and Moxifloxacin Combination Therapy Models of Children With Intracellular Tuberculosis.

Clin Infect Dis 2018 11;67(suppl_3):S342-S348

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1093/cid/ciy612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260150PMC
November 2018

The Sterilizing Effect of Intermittent Tedizolid for Pulmonary Tuberculosis.

Clin Infect Dis 2018 11;67(suppl_3):S336-S341

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas.

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/cid/ciy626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260152PMC
November 2018

Shorter-course treatment for Mycobacterium ulcerans disease with high-dose rifamycins and clofazimine in a mouse model of Buruli ulcer.

PLoS Negl Trop Dis 2018 08 13;12(8):e0006728. Epub 2018 Aug 13.

Department of Medicine, Johns Hopkins University Center for Tuberculosis Research, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0006728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107292PMC
August 2018

Verapamil Increases the Bioavailability and Efficacy of Bedaquiline but Not Clofazimine in a Murine Model of Tuberculosis.

Antimicrob Agents Chemother 2018 01 21;62(1). Epub 2017 Dec 21.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.01692-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740328PMC
January 2018

Immunodeficiency and Intermittent Dosing Promote Acquired Rifamycin Monoresistance in Murine Tuberculosis.

Antimicrob Agents Chemother 2017 11 24;61(11). Epub 2017 Oct 24.

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.01502-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655103PMC
November 2017

In vitro and in vivo activity of biapenem against drug-susceptible and rifampicin-resistant Mycobacterium tuberculosis.

J Antimicrob Chemother 2017 08;72(8):2320-2325

Center for Tuberculosis Research, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1093/jac/dkx152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890701PMC
August 2017

Pyrazinoic Acid Inhibits a Bifunctional Enzyme in Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2017 07 27;61(7). Epub 2017 Jun 27.

State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

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http://dx.doi.org/10.1128/AAC.00070-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487608PMC
July 2017

Primary Clofazimine and Bedaquiline Resistance among Isolates from Patients with Multidrug-Resistant Tuberculosis.

Antimicrob Agents Chemother 2017 06 24;61(6). Epub 2017 May 24.

Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University, Beijing, China

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https://aac.asm.org/content/61/6/e00239-17.full.pdf
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http://erj.ersjournals.com/content/48/5/1526
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https://aac.asm.org/content/early/2017/03/14/AAC.00239-17.fu
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http://aac.asm.org/lookup/doi/10.1128/AAC.00239-17
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http://dx.doi.org/10.1128/AAC.00239-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444180PMC
June 2017

Preclinical Efficacy Testing of New Drug Candidates.

Microbiol Spectr 2017 06;5(3)

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, and Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231-1002.

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http://dx.doi.org/10.1128/microbiolspec.TBTB2-0034-2017DOI Listing
June 2017

Drug resistance mechanisms and novel drug targets for tuberculosis therapy.

J Genet Genomics 2017 01 11;44(1):21-37. Epub 2016 Oct 11.

State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2016.10.002DOI Listing
January 2017

Drug Concentration Thresholds Predictive of Therapy Failure and Death in Children With Tuberculosis: Bread Crumb Trails in Random Forests.

Clin Infect Dis 2016 Nov;63(suppl 3):S63-S74

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Dallas, Texas Department of Medicine, University of Cape Town, Observatory, South Africa.

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http://dx.doi.org/10.1093/cid/ciw471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064152PMC
November 2016

A Combination Regimen Design Program Based on Pharmacodynamic Target Setting for Childhood Tuberculosis: Design Rules for the Playground.

Clin Infect Dis 2016 Nov;63(suppl 3):S75-S79

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas Department of Medicine, University of Cape Town, Observatory, South Africa.

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http://dx.doi.org/10.1093/cid/ciw472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064153PMC
November 2016

Linezolid for Infants and Toddlers With Disseminated Tuberculosis: First Steps.

Clin Infect Dis 2016 Nov;63(suppl 3):S80-S87

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas Department of Medicine, University of Cape Town, Observatory, South Africa.

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http://dx.doi.org/10.1093/cid/ciw482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064157PMC
November 2016

Concentration-Dependent Synergy and Antagonism of Linezolid and Moxifloxacin in the Treatment of Childhood Tuberculosis: The Dynamic Duo.

Clin Infect Dis 2016 Nov;63(suppl 3):S88-S94

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas Department of Medicine, University of Cape Town, Observatory, South Africa.

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https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/
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http://dx.doi.org/10.1093/cid/ciw473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064154PMC
November 2016

A Faropenem, Linezolid, and Moxifloxacin Regimen for Both Drug-Susceptible and Multidrug-Resistant Tuberculosis in Children: FLAME Path on the Milky Way.

Clin Infect Dis 2016 Nov;63(suppl 3):S95-S101

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas Department of Medicine, University of Cape Town, Observatory, South Africa.

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http://dx.doi.org/10.1093/cid/ciw474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064155PMC
November 2016

Optimal Clinical Doses of Faropenem, Linezolid, and Moxifloxacin in Children With Disseminated Tuberculosis: Goldilocks.

Clin Infect Dis 2016 Nov;63(suppl 3):S102-S109

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas Department of Medicine, University of Cape Town, Observatory, South Africa.

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http://dx.doi.org/10.1093/cid/ciw483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064158PMC
November 2016

Mutations in pepQ Confer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2016 08 22;60(8):4590-9. Epub 2016 Jul 22.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.00753-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958187PMC
August 2016

High Systemic Exposure of Pyrazinoic Acid Has Limited Antituberculosis Activity in Murine and Rabbit Models of Tuberculosis.

Antimicrob Agents Chemother 2016 07 20;60(7):4197-205. Epub 2016 Jun 20.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.03085-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914615PMC
July 2016

Mouse model of pulmonary cavitary tuberculosis and expression of matrix metalloproteinase-9.

Dis Model Mech 2016 07 26;9(7):779-88. Epub 2016 May 26.

Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA

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http://dx.doi.org/10.1242/dmm.025643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958312PMC
July 2016

Efficacy of Rifampin Plus Clofazimine in a Murine Model of Mycobacterium ulcerans Disease.

PLoS Negl Trop Dis 2015 4;9(6):e0003823. Epub 2015 Jun 4.

Johns Hopkins University Center for Tuberculosis Research, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0003823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714850PMC
March 2016

Shortening Tuberculosis Treatment With Fluoroquinolones: Lost in Translation?

Clin Infect Dis 2016 Feb 1;62(4):484-90. Epub 2015 Nov 1.

Department of Medicine, Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1093/cid/civ911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006403PMC
February 2016

Selective Inactivity of Pyrazinamide against Tuberculosis in C3HeB/FeJ Mice Is Best Explained by Neutral pH of Caseum.

Antimicrob Agents Chemother 2016 Feb 16;60(2):735-43. Epub 2015 Nov 16.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.01370-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750710PMC
February 2016

Sterilizing Activity of Pyrazinamide in Combination with First-Line Drugs in a C3HeB/FeJ Mouse Model of Tuberculosis.

Antimicrob Agents Chemother 2016 Feb 7;60(2):1091-6. Epub 2015 Dec 7.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.02637-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750691PMC
February 2016

Contribution of Oxazolidinones to the Efficacy of Novel Regimens Containing Bedaquiline and Pretomanid in a Mouse Model of Tuberculosis.

Antimicrob Agents Chemother 2016 01 26;60(1):270-7. Epub 2015 Oct 26.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.01691-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704221PMC
January 2016

Extensively drug-resistant tuberculosis in a young child after travel to India.

Lancet Infect Dis 2015 Dec 16;15(12):1485-91. Epub 2015 Nov 16.

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(15)00356-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843989PMC
December 2015

Primary HIV infection presenting as limbic encephalitis and rhabdomyolysis.

Int J STD AIDS 2015 Oct 20;26(11):835-6. Epub 2014 Nov 20.

Division of Infectious Diseases, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1177/0956462414560777DOI Listing
October 2015

Systematic Analysis of Hollow Fiber Model of Tuberculosis Experiments.

Clin Infect Dis 2015 Aug;61 Suppl 1:S10-7

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas Department of Medicine, University of Cape Town, Observatory, South Africa.

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http://dx.doi.org/10.1093/cid/civ425DOI Listing
August 2015

Correlations Between the Hollow Fiber Model of Tuberculosis and Therapeutic Events in Tuberculosis Patients: Learn and Confirm.

Clin Infect Dis 2015 Aug;61 Suppl 1:S18-24

Critical Path to TB Drug Regimens, Critical Path Institute, Tucson, Arizona.

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http://dx.doi.org/10.1093/cid/civ426DOI Listing
August 2015

Forecasting Accuracy of the Hollow Fiber Model of Tuberculosis for Clinical Therapeutic Outcomes.

Clin Infect Dis 2015 Aug;61 Suppl 1:S25-31

Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1093/cid/civ427DOI Listing
August 2015

Evaluation of moxifloxacin-containing regimens in pathologically distinct murine tuberculosis models.

Antimicrob Agents Chemother 2015 Jul 27;59(7):4026-30. Epub 2015 Apr 27.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.00105-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468727PMC
July 2015

Assessing the landscape of tools and approaches for novel tuberculosis regimen development.

J Infect Dis 2015 Jun;211 Suppl 3:S81-2

Critical Path Institute, Tucson, Arizona.

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http://dx.doi.org/10.1093/infdis/jiv072DOI Listing
June 2015

Nonclinical models for antituberculosis drug development: a landscape analysis.

J Infect Dis 2015 Jun;211 Suppl 3:S83-95

Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland.

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http://jid.oxfordjournals.org/content/211/suppl_3/S83.full.p
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http://dx.doi.org/10.1093/infdis/jiv183DOI Listing
June 2015

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis.

Dis Model Mech 2015 Jun 30;8(6):591-602. Epub 2015 Mar 30.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA

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http://dx.doi.org/10.1242/dmm.019570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457037PMC
June 2015

Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis.

Dis Model Mech 2015 Jun 30;8(6):603-10. Epub 2015 Mar 30.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA

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http://dx.doi.org/10.1242/dmm.019513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457036PMC
June 2015

Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins.

Science 2015 Jun;348(6239):1106-12

Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research and Pharmaceutical Biotechnology, Saarland University, 66123 Saarbrücken, Germany. German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany.

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http://dx.doi.org/10.1126/science.aaa4690DOI Listing
June 2015

Expanding the evidence base supporting shorter treatment durations for multidrug-resistant tuberculosis.

Int J Tuberc Lung Dis 2015 May;19(5):497-8

Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, SAR China.

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http://dx.doi.org/10.5588/ijtld.15.0110DOI Listing
May 2015

Correction for lanoix et Al., novel regimens identified in mice for treatment of latent tuberculosis infection in contacts of patients with multidrug-resistant tuberculosis.

Antimicrob Agents Chemother 2015 Mar;59(3):1826

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1128/AAC.05096-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325801PMC
March 2015

Contribution of the nitroimidazoles PA-824 and TBA-354 to the activity of novel regimens in murine models of tuberculosis.

Antimicrob Agents Chemother 2015 Jan 20;59(1):129-35. Epub 2014 Oct 20.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/AAC.03822-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291340PMC
January 2015

Novel regimens identified in mice for treatment of latent tuberculosis infection in contacts of patients with multidrug-resistant tuberculosis.

Antimicrob Agents Chemother 2014 3;58(4):2316-21. Epub 2014 Feb 3.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1128/AAC.02658-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023781PMC
November 2014

Accelerated detection of mycolactone production and response to antibiotic treatment in a mouse model of Mycobacterium ulcerans disease.

PLoS Negl Trop Dis 2014 2;8(1):e2618. Epub 2014 Jan 2.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0002618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879254PMC
September 2014

Minding the gaps in tuberculosis research.

Drug Discov Today 2014 Sep 30;19(9):1279-82. Epub 2014 Jun 30.

Department of Pharmacology & Physiology, Rutgers University - New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA; Department of Medicine, Center for Emerging and Reemerging Pathogens, Rutgers University - New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2014.06.022DOI Listing
September 2014

Rapid, serial, non-invasive assessment of drug efficacy in mice with autoluminescent Mycobacterium ulcerans infection.

PLoS Negl Trop Dis 2013 19;7(12):e2598. Epub 2013 Dec 19.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America ; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0002598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868507PMC
July 2014

Principles for designing future regimens for multidrug-resistant tuberculosis.

Bull World Health Organ 2014 Jan 25;92(1):68-74. Epub 2013 Oct 25.

Access Campaign, Médecins Sans Frontières, 78 Rue de Lausanne, PO Box 116, Geneva, CH1211, Switzerland .

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http://dx.doi.org/10.2471/BLT.13.122028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865549PMC
January 2014

Pipeline of drugs for related diseases: tuberculosis.

Curr Opin HIV AIDS 2013 Nov;8(6):579-85

aJohns Hopkins University School of Medicine, Baltimore, Maryland, USA bStellenbosch University, Tygerberg, South Africa.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206795PMC
November 2013

Bactericidal activity does not predict sterilizing activity: the case of rifapentine in the murine model of Mycobacterium ulcerans disease.

PLoS Negl Trop Dis 2013 28;7(2):e2085. Epub 2013 Feb 28.

Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0002085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585034PMC
July 2013

Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis.

Tuberculosis (Edinb) 2012 Nov 30;92(6):453-88. Epub 2012 Aug 30.

Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60621-7231, USA.

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http://dx.doi.org/10.1016/j.tube.2012.07.003DOI Listing
November 2012

Activity of 5-chloro-pyrazinamide in mice infected with Mycobacterium tuberculosis or Mycobacterium bovis.

Indian J Med Res 2012 Nov;136(5):808-14

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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November 2012

Dose-ranging comparison of rifampin and rifapentine in two pathologically distinct murine models of tuberculosis.

Antimicrob Agents Chemother 2012 Aug 4;56(8):4331-40. Epub 2012 Jun 4.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1128/AAC.00912-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421552PMC
August 2012

Rifapentine is not more active than rifampin against chronic tuberculosis in guinea pigs.

Antimicrob Agents Chemother 2012 Jul 30;56(7):3726-31. Epub 2012 Apr 30.

Departments of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1128/AAC.00500-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393407PMC
July 2012

Sterilizing activities of novel combinations lacking first- and second-line drugs in a murine model of tuberculosis.

Antimicrob Agents Chemother 2012 Jun 2;56(6):3114-20. Epub 2012 Apr 2.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1128/AAC.00384-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370712PMC
June 2012

Autoluminescent Mycobacterium tuberculosis for rapid, real-time, non-invasive assessment of drug and vaccine efficacy.

PLoS One 2012 11;7(1):e29774. Epub 2012 Jan 11.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256174PMC
May 2012

Mouse model of necrotic tuberculosis granulomas develops hypoxic lesions.

J Infect Dis 2012 Feb 23;205(4):595-602. Epub 2011 Dec 23.

Department of Medicine, Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1093/infdis/jir786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266133PMC
February 2012

Sterilizing activity of novel TMC207- and PA-824-containing regimens in a murine model of tuberculosis.

Antimicrob Agents Chemother 2011 Dec 19;55(12):5485-92. Epub 2011 Sep 19.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://aac.asm.org/lookup/doi/10.1128/AAC.05293-11
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232786PMC
December 2011

Treating Mycobacterium ulcerans disease (Buruli ulcer): from surgery to antibiotics, is the pill mightier than the knife?

Future Microbiol 2011 Oct;6(10):1185-98

Johns Hopkins University Center for Tuberculosis Research, 1551 Jefferson Street, #154, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.2217/fmb.11.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243445PMC
October 2011

Short-course chemotherapy with TMC207 and rifapentine in a murine model of latent tuberculosis infection.

Am J Respir Crit Care Med 2011 Sep 9;184(6):732-7. Epub 2011 Jun 9.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1164/rccm.201103-0397OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208599PMC
September 2011

Effectiveness of tuberculosis chemotherapy correlates with resistance to Mycobacterium tuberculosis infection in animal models.

J Antimicrob Chemother 2011 Jul 20;66(7):1560-6. Epub 2011 May 20.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1093/jac/dkr188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112031PMC
July 2011

Treatment of tuberculosis with rifamycin-containing regimens in immune-deficient mice.

Am J Respir Crit Care Med 2011 May 17;183(9):1254-61. Epub 2011 Feb 17.

Division of Infectious Diseases, Johns Hopkins University School of Medicine, 1501 Orleans Street, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1164/rccm.201012-1949OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114054PMC
May 2011

Activity of the fluoroquinolone DC-159a in the initial and continuation phases of treatment of murine tuberculosis.

Antimicrob Agents Chemother 2011 Apr 31;55(4):1781-3. Epub 2011 Jan 31.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://aac.asm.org/lookup/doi/10.1128/AAC.01514-10
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http://dx.doi.org/10.1128/AAC.01514-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067133PMC
April 2011

Dose-dependent activity of pyrazinamide in animal models of intracellular and extracellular tuberculosis infections.

Antimicrob Agents Chemother 2011 Apr 31;55(4):1527-32. Epub 2011 Jan 31.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1128/AAC.01524-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067197PMC
April 2011

BCG-mediated protection against Mycobacterium ulcerans infection in the mouse.

PLoS Negl Trop Dis 2011 Mar 15;5(3):e985. Epub 2011 Mar 15.

Johns Hopkins University Center for Tuberculosis Research, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1371/journal.pntd.0000985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057947PMC
March 2011

Using bioluminescence to monitor treatment response in real time in mice with Mycobacterium ulcerans infection.

Antimicrob Agents Chemother 2011 Jan 15;55(1):56-61. Epub 2010 Nov 15.

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1128/AAC.01260-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019670PMC
January 2011

Activities of rifampin, Rifapentine and clarithromycin alone and in combination against mycobacterium ulcerans disease in mice.

PLoS Negl Trop Dis 2011 Jan 4;5(1):e933. Epub 2011 Jan 4.

Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0000933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014976PMC
January 2011