Publications by authors named "Eric Meffre"

90Publications

Interferon deficiency can lead to severe COVID.

Nature 2020 11;587(7834):374-376

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http://dx.doi.org/10.1038/d41586-020-03070-1DOI Listing
November 2020

Corrigendum: TACI Isoforms Regulate Ligand Binding and Receptor Function.

Front Immunol 2019;10:2772. Epub 2019 Dec 3.

Department of Clinical Immunology, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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http://dx.doi.org/10.3389/fimmu.2019.02772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901826PMC
December 2019

Impaired B-cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies.

Immunol Rev 2019 11 12;292(1):90-101. Epub 2019 Nov 12.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1111/imr.12821DOI Listing
November 2019

B cell depletion or absence does not impede anti-tumor activity of PD-1 inhibitors.

J Immunother Cancer 2019 06 14;7(1):153. Epub 2019 Jun 14.

Departments of Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06520, USA.

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http://dx.doi.org/10.1186/s40425-019-0613-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567557PMC
June 2019

Transitional B cells in quiescent SLE: An early checkpoint imprinted by IFN.

J Autoimmun 2019 08 10;102:150-158. Epub 2019 May 10.

CNRS UPR 3572 "Immunopathology and Therapeutic Chemistry"/Laboratory of Excellence Medalis, Institute of Molecular and Cellular Biology (IBMC), Strasbourg, France; Department of Clinical Immunology and Internal Medicine, National Reference Center for Autoimmune Diseases, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; UFR Médecine, Université de Strasbourg, Strasbourg, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2019.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642027PMC
August 2019

A novel ATM mutation associated with elevated atypical lymphocyte populations, hyper-IgM, and cutaneous granulomas.

Clin Immunol 2019 03 9;200:55-63. Epub 2019 Jan 9.

Immunodeficiency Diagnosis and Treatment Program, Department of Pediatrics, National Jewish Health, Denver, CO 80206, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15216616183062
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http://dx.doi.org/10.1016/j.clim.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027322PMC
March 2019

TACI Isoforms Regulate Ligand Binding and Receptor Function.

Front Immunol 2018 2;9:2125. Epub 2018 Oct 2.

Department of Clinical Immunology, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02125
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http://dx.doi.org/10.3389/fimmu.2018.02125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176016PMC
September 2019

The First B-Cell Tolerance Checkpoint in Mice and Humans: Control by AID.

Adv Immunol 2018 7;139:51-92. Epub 2018 May 7.

Department of Immunology, Duke University School of Medicine, Durham, NC, United States; Human Vaccine Institute, Duke University School of Medicine, Durham, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.ai.2018.04.001DOI Listing
September 2019

Defective Early B Cell Tolerance Checkpoints in Sjögren's Syndrome Patients.

Arthritis Rheumatol 2017 11 12;69(11):2203-2208. Epub 2017 Oct 12.

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1002/art.40215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062007PMC
November 2017

Smith-Magenis Syndrome Patients Often Display Antibody Deficiency but Not Other Immune Pathologies.

J Allergy Clin Immunol Pract 2017 Sep - Oct;5(5):1344-1350.e3. Epub 2017 Mar 9.

Division of Allergy Immunology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Penn. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2017.01.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591748PMC
May 2018

Progress and challenges for treating Type 1 diabetes.

J Autoimmun 2016 07 17;71:1-9. Epub 2016 May 17.

Department of Immunobiology, Yale University, New Haven, CT, USA; Department of Internal Medicine, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.jaut.2016.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903889PMC
July 2016

Big impact of microRNAs on central B cell tolerance.

Authors:
Eric Meffre

Nat Immunol 2016 Apr;17(4):353-4

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/ni.3414DOI Listing
April 2016

Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens.

Proc Natl Acad Sci U S A 2015 Nov 19;112(44):13447-54. Epub 2015 Oct 19.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1514944112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640740PMC
November 2015

CD19 controls Toll-like receptor 9 responses in human B cells.

J Allergy Clin Immunol 2016 Mar 21;137(3):889-98.e6. Epub 2015 Oct 21.

Department of Immunobiology, Yale University School of Medicine, New Haven, Conn. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.08.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783287PMC
March 2016

RAG Represents a Widespread Threat to the Lymphocyte Genome.

Cell 2015 Aug 30;162(4):751-65. Epub 2015 Jul 30.

Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, Box 208011, New Haven, CT 06520-8011, USA; Howard Hughes Medical Institute, 295 Congress Avenue, New Haven, CT 06511, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537821PMC
August 2015

Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation.

Immunity 2015 Jul 14;43(1):120-31. Epub 2015 Jul 14.

Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Laboratory Medicine and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523395PMC
July 2015

Circulating Human CD27-IgA+ Memory B Cells Recognize Bacteria with Polyreactive Igs.

J Immunol 2015 Aug 6;195(4):1417-26. Epub 2015 Jul 6.

Department of Immunology, Erasmus MC, University Medical Center, 3015 CN Rotterdam, the Netherlands;

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http://dx.doi.org/10.4049/jimmunol.1402708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595932PMC
August 2015

TNF receptor superfamily member 13b (TNFRSF13B) hemizygosity reveals transmembrane activator and CAML interactor haploinsufficiency at later stages of B-cell development.

J Allergy Clin Immunol 2015 Nov 19;136(5):1315-25. Epub 2015 Jun 19.

Department of Immunobiology, Yale University School of Medicine, New Haven, Conn; Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641026PMC
November 2015

Specific peripheral B cell tolerance defects in patients with multiple sclerosis.

J Clin Invest 2013 Jun 15;123(6):2737-41. Epub 2013 May 15.

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06511, USA.

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http://dx.doi.org/10.1172/JCI68775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668812PMC
June 2013

Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humans.

Autoimmunity 2013 Mar 10;46(2):148-56. Epub 2013 Jan 10.

INSERM, Unité U768, Hôpital Necker Enfants-Malades, Paris, France.

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http://dx.doi.org/10.3109/08916934.2012.750299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077434PMC
March 2013

B lymphocyte-induced maturation protein-1 contributes to intestinal mucosa homeostasis by limiting the number of IL-17-producing CD4+ T cells.

J Immunol 2012 Dec 16;189(12):5682-93. Epub 2012 Nov 16.

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.4049/jimmunol.1201966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529138PMC
December 2012

Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy.

J Clin Invest 2012 Jun 24;122(6):2141-52. Epub 2012 May 24.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Milan, Italy.

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http://dx.doi.org/10.1172/JCI61788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366410PMC
June 2012

The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases.

Authors:
Eric Meffre

Ann N Y Acad Sci 2011 Dec;1246:1-10

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06511, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2011.06347.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925509PMC
December 2011

B-cell tolerance checkpoints in health and autoimmunity.

Curr Opin Immunol 2008 Dec 25;20(6):632-8. Epub 2008 Oct 25.

Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S095279150800177
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http://dx.doi.org/10.1016/j.coi.2008.09.001DOI Listing
December 2008

CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance.

J Exp Med 2007 Jul 11;204(7):1583-93. Epub 2007 Jun 11.

Laboratory of Biochemistry and Molecular Immunology, Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.1084/jem.20062287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118633PMC
July 2007

Autoantibody selection and production in early human life.

J Clin Invest 2007 Mar;117(3):598-601

Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1172/JCI31578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1804337PMC
March 2007

Human B cell tolerance and its failure in rheumatoid arthritis.

Ann N Y Acad Sci 2005 Dec;1062:116-26

Laboratory of Biochemistry and Molecular Immunology, Hospital for Special Surgery, Research Department, 535 E. 70th St., New York, NY 10021, USA.

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http://dx.doi.org/10.1196/annals.1358.014DOI Listing
December 2005

Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity.

J Clin Invest 2005 Jun 2;115(6):1636-43. Epub 2005 May 2.

Laboratory of Biochemistry and Molecular Immunology, Hospital for Special Surgery, New York, New York 10021, USA.

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http://dx.doi.org/10.1172/JCI24387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088018PMC
June 2005

Impaired early B cell tolerance in patients with rheumatoid arthritis.

J Exp Med 2005 May;201(10):1659-67

Laboratory of Biochemistry and Molecular Immunology, Hospital for Special Surgery, Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1084/jem.20042321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212916PMC
May 2005

Defective B cell tolerance checkpoints in systemic lupus erythematosus.

J Exp Med 2005 Mar 28;201(5):703-11. Epub 2005 Feb 28.

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1084/jem.20042251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212839PMC
March 2005

Bruton's tyrosine kinase is essential for human B cell tolerance.

J Exp Med 2004 Oct;200(7):927-34

Laboratory of Biochemistry and Molecular Immunology, The Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.1084/jem.20040920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213290PMC
October 2004

Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies.

J Exp Med 2004 Jan 29;199(1):145-50. Epub 2003 Dec 29.

Laboratory of Molecular Immunology, The Rockefeller University, 1230 York Ave., New York, NY 10021, USA.

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http://dx.doi.org/10.1084/jem.20031550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887722PMC
January 2004

Predominant autoantibody production by early human B cell precursors.

Science 2003 Sep 14;301(5638):1374-7. Epub 2003 Aug 14.

Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10021, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1086907
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http://dx.doi.org/10.1126/science.1086907DOI Listing
September 2003

Deletion of immunoglobulin beta in developing B cells leads to cell death.

Proc Natl Acad Sci U S A 2002 Aug 6;99(17):11334-9. Epub 2002 Aug 6.

Laboratory of Molecular Immunology, The Rockefeller University and Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10021-6399, USA.

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http://dx.doi.org/10.1073/pnas.172369999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123257PMC
August 2002

Role of BCR affinity in T cell dependent antibody responses in vivo.

Nat Immunol 2002 Jun 20;3(6):570-5. Epub 2002 May 20.

Laboratory of Molecular Immunology, The Rockefeller University New York, NY 10021, USA.

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http://dx.doi.org/10.1038/ni803DOI Listing
June 2002