Eric Meffre

Eric Meffre

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Eric Meffre

Eric Meffre

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Impaired B-cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies.

Immunol Rev 2019 Nov 12. Epub 2019 Nov 12.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1111/imr.12821DOI Listing
November 2019

The First B-Cell Tolerance Checkpoint in Mice and Humans: Control by AID.

Adv Immunol 2018 7;139:51-92. Epub 2018 May 7.

Department of Immunology, Duke University School of Medicine, Durham, NC, United States; Human Vaccine Institute, Duke University School of Medicine, Durham, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.ai.2018.04.001DOI Listing
September 2019

TACI Isoforms Regulate Ligand Binding and Receptor Function.

Front Immunol 2018 2;9:2125. Epub 2018 Oct 2.

Department of Clinical Immunology, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02125
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http://dx.doi.org/10.3389/fimmu.2018.02125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176016PMC
September 2019

Transitional B cells in quiescent SLE: An early checkpoint imprinted by IFN.

J Autoimmun 2019 Aug 10;102:150-158. Epub 2019 May 10.

CNRS UPR 3572 "Immunopathology and Therapeutic Chemistry"/Laboratory of Excellence Medalis, Institute of Molecular and Cellular Biology (IBMC), Strasbourg, France; Department of Clinical Immunology and Internal Medicine, National Reference Center for Autoimmune Diseases, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; UFR Médecine, Université de Strasbourg, Strasbourg, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2019.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642027PMC
August 2019

B cell depletion or absence does not impede anti-tumor activity of PD-1 inhibitors.

J Immunother Cancer 2019 Jun 14;7(1):153. Epub 2019 Jun 14.

Departments of Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06520, USA.

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http://dx.doi.org/10.1186/s40425-019-0613-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567557PMC
June 2019

A novel ATM mutation associated with elevated atypical lymphocyte populations, hyper-IgM, and cutaneous granulomas.

Clin Immunol 2019 Mar 9;200:55-63. Epub 2019 Jan 9.

Immunodeficiency Diagnosis and Treatment Program, Department of Pediatrics, National Jewish Health, Denver, CO 80206, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15216616183062
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http://dx.doi.org/10.1016/j.clim.2019.01.002DOI Listing
March 2019

Smith-Magenis Syndrome Patients Often Display Antibody Deficiency but Not Other Immune Pathologies.

J Allergy Clin Immunol Pract 2017 Sep - Oct;5(5):1344-1350.e3. Epub 2017 Mar 9.

Division of Allergy Immunology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Penn. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2017.01.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591748PMC
May 2018

Defective Early B Cell Tolerance Checkpoints in Sjögren's Syndrome Patients.

Arthritis Rheumatol 2017 11 12;69(11):2203-2208. Epub 2017 Oct 12.

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1002/art.40215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062007PMC
November 2017

Progress and challenges for treating Type 1 diabetes.

J Autoimmun 2016 07 17;71:1-9. Epub 2016 May 17.

Department of Immunobiology, Yale University, New Haven, CT, USA; Department of Internal Medicine, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.jaut.2016.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903889PMC
July 2016

Big impact of microRNAs on central B cell tolerance.

Authors:
Eric Meffre

Nat Immunol 2016 Apr;17(4):353-4

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/ni.3414DOI Listing
April 2016

CD19 controls Toll-like receptor 9 responses in human B cells.

J Allergy Clin Immunol 2016 Mar 21;137(3):889-98.e6. Epub 2015 Oct 21.

Department of Immunobiology, Yale University School of Medicine, New Haven, Conn. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.08.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783287PMC
March 2016

TNF receptor superfamily member 13b (TNFRSF13B) hemizygosity reveals transmembrane activator and CAML interactor haploinsufficiency at later stages of B-cell development.

J Allergy Clin Immunol 2015 Nov 19;136(5):1315-25. Epub 2015 Jun 19.

Department of Immunobiology, Yale University School of Medicine, New Haven, Conn; Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641026PMC
November 2015

Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens.

Proc Natl Acad Sci U S A 2015 Nov 19;112(44):13447-54. Epub 2015 Oct 19.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1514944112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640740PMC
November 2015

Circulating Human CD27-IgA+ Memory B Cells Recognize Bacteria with Polyreactive Igs.

J Immunol 2015 Aug 6;195(4):1417-26. Epub 2015 Jul 6.

Department of Immunology, Erasmus MC, University Medical Center, 3015 CN Rotterdam, the Netherlands;

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http://dx.doi.org/10.4049/jimmunol.1402708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595932PMC
August 2015

RAG Represents a Widespread Threat to the Lymphocyte Genome.

Cell 2015 Aug 30;162(4):751-65. Epub 2015 Jul 30.

Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, Box 208011, New Haven, CT 06520-8011, USA; Howard Hughes Medical Institute, 295 Congress Avenue, New Haven, CT 06511, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537821PMC
August 2015

Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation.

Immunity 2015 Jul 14;43(1):120-31. Epub 2015 Jul 14.

Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Laboratory Medicine and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523395PMC
July 2015

Specific peripheral B cell tolerance defects in patients with multiple sclerosis.

J Clin Invest 2013 Jun 15;123(6):2737-41. Epub 2013 May 15.

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06511, USA.

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http://dx.doi.org/10.1172/JCI68775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668812PMC
June 2013

Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humans.

Autoimmunity 2013 Mar 10;46(2):148-56. Epub 2013 Jan 10.

INSERM, Unité U768, Hôpital Necker Enfants-Malades, Paris, France.

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http://dx.doi.org/10.3109/08916934.2012.750299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077434PMC
March 2013

B lymphocyte-induced maturation protein-1 contributes to intestinal mucosa homeostasis by limiting the number of IL-17-producing CD4+ T cells.

J Immunol 2012 Dec 16;189(12):5682-93. Epub 2012 Nov 16.

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.4049/jimmunol.1201966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529138PMC
December 2012

Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy.

J Clin Invest 2012 Jun 24;122(6):2141-52. Epub 2012 May 24.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Milan, Italy.

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http://dx.doi.org/10.1172/JCI61788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366410PMC
June 2012

The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases.

Authors:
Eric Meffre

Ann N Y Acad Sci 2011 Dec;1246:1-10

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06511, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2011.06347.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925509PMC
December 2011

B-cell tolerance checkpoints in health and autoimmunity.

Curr Opin Immunol 2008 Dec 25;20(6):632-8. Epub 2008 Oct 25.

Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S095279150800177
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http://dx.doi.org/10.1016/j.coi.2008.09.001DOI Listing
December 2008

CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance.

J Exp Med 2007 Jul 11;204(7):1583-93. Epub 2007 Jun 11.

Laboratory of Biochemistry and Molecular Immunology, Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.1084/jem.20062287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118633PMC
July 2007

Autoantibody selection and production in early human life.

J Clin Invest 2007 Mar;117(3):598-601

Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1172/JCI31578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1804337PMC
March 2007

Human B cell tolerance and its failure in rheumatoid arthritis.

Ann N Y Acad Sci 2005 Dec;1062:116-26

Laboratory of Biochemistry and Molecular Immunology, Hospital for Special Surgery, Research Department, 535 E. 70th St., New York, NY 10021, USA.

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http://dx.doi.org/10.1196/annals.1358.014DOI Listing
December 2005

Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity.

J Clin Invest 2005 Jun 2;115(6):1636-43. Epub 2005 May 2.

Laboratory of Biochemistry and Molecular Immunology, Hospital for Special Surgery, New York, New York 10021, USA.

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http://dx.doi.org/10.1172/JCI24387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088018PMC
June 2005

Impaired early B cell tolerance in patients with rheumatoid arthritis.

J Exp Med 2005 May;201(10):1659-67

Laboratory of Biochemistry and Molecular Immunology, Hospital for Special Surgery, Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1084/jem.20042321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212916PMC
May 2005

Defective B cell tolerance checkpoints in systemic lupus erythematosus.

J Exp Med 2005 Mar 28;201(5):703-11. Epub 2005 Feb 28.

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1084/jem.20042251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212839PMC
March 2005

Bruton's tyrosine kinase is essential for human B cell tolerance.

J Exp Med 2004 Oct;200(7):927-34

Laboratory of Biochemistry and Molecular Immunology, The Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.1084/jem.20040920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213290PMC
October 2004

Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies.

J Exp Med 2004 Jan 29;199(1):145-50. Epub 2003 Dec 29.

Laboratory of Molecular Immunology, The Rockefeller University, 1230 York Ave., New York, NY 10021, USA.

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http://dx.doi.org/10.1084/jem.20031550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887722PMC
January 2004

Predominant autoantibody production by early human B cell precursors.

Science 2003 Sep 14;301(5638):1374-7. Epub 2003 Aug 14.

Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10021, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1086907
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http://dx.doi.org/10.1126/science.1086907DOI Listing
September 2003

Deletion of immunoglobulin beta in developing B cells leads to cell death.

Proc Natl Acad Sci U S A 2002 Aug 6;99(17):11334-9. Epub 2002 Aug 6.

Laboratory of Molecular Immunology, The Rockefeller University and Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10021-6399, USA.

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http://dx.doi.org/10.1073/pnas.172369999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123257PMC
August 2002

Role of BCR affinity in T cell dependent antibody responses in vivo.

Nat Immunol 2002 Jun 20;3(6):570-5. Epub 2002 May 20.

Laboratory of Molecular Immunology, The Rockefeller University New York, NY 10021, USA.

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http://dx.doi.org/10.1038/ni803DOI Listing
June 2002