Eric M Reiman

Eric M Reiman

UNVERIFIED PROFILE

Are you Eric M Reiman?   Register this Author

Register author
Eric M Reiman

Eric M Reiman

Publications by authors named "Eric M Reiman"

Are you Eric M Reiman?   Register this Author

100Publications

2760Reads

15Profile Views

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Authors:
Cyril Pottier Yingxue Ren Ralph B Perkerson Matt Baker Gregory D Jenkins Marka van Blitterswijk Mariely DeJesus-Hernandez Jeroen G J van Rooij Melissa E Murray Elizabeth Christopher Shannon K McDonnell Zachary Fogarty Anthony Batzler Shulan Tian Cristina T Vicente Billie Matchett Anna M Karydas Ging-Yuek Robin Hsiung Harro Seelaar Merel O Mol Elizabeth C Finger Caroline Graff Linn Öijerstedt Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Johannes Prudlo Patrizia Rizzu Javier Simon-Sanchez Dieter Edbauer Sigrun Roeber Janine Diehl-Schmid Bret M Evers Andrew King M Marsel Mesulam Sandra Weintraub Changiz Geula Kevin F Bieniek Leonard Petrucelli Geoffrey L Ahern Eric M Reiman Bryan K Woodruff Richard J Caselli Edward D Huey Martin R Farlow Jordan Grafman Simon Mead Lea T Grinberg Salvatore Spina Murray Grossman David J Irwin Edward B Lee EunRan Suh Julie Snowden David Mann Nilufer Ertekin-Taner Ryan J Uitti Zbigniew K Wszolek Keith A Josephs Joseph E Parisi David S Knopman Ronald C Petersen John R Hodges Olivier Piguet Ethan G Geier Jennifer S Yokoyama Robert A Rissman Ekaterina Rogaeva Julia Keith Lorne Zinman Maria Carmela Tartaglia Nigel J Cairns Carlos Cruchaga Bernardino Ghetti Julia Kofler Oscar L Lopez Thomas G Beach Thomas Arzberger Jochen Herms Lawrence S Honig Jean Paul Vonsattel Glenda M Halliday John B Kwok Charles L White Marla Gearing Jonathan Glass Sara Rollinson Stuart Pickering-Brown Jonathan D Rohrer John Q Trojanowski Vivianna Van Deerlin Eileen H Bigio Claire Troakes Safa Al-Sarraj Yan Asmann Bruce L Miller Neill R Graff-Radford Bradley F Boeve William W Seeley Ian R A Mackenzie John C van Swieten Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Acta Neuropathol 2019 Jun 9;137(6):879-899. Epub 2019 Feb 9.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00401-019-01962-9
Publisher Site
http://dx.doi.org/10.1007/s00401-019-01962-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533145PMC
June 2019

Tau Positron-Emission Tomography in Former National Football League Players.

N Engl J Med 2019 05 10;380(18):1716-1725. Epub 2019 Apr 10.

From the Boston University School of Medicine (R.A.S., M.L.A., N.G.F., J.J.), Boston University School of Public Health (Y.T., B.M.), Brigham and Women's Hospital (M.E.S.), Harvard Medical School (M.E.S.), and the Veterans Affairs Boston Healthcare System (M.E.S.) - all in Boston; Mayo Clinic Arizona, Scottsdale (C.H.A., D.W.D.), Banner Alzheimer's Institute, Phoenix (K.C., J.L., D.D.G., E.M.R.), and Arizona State University, Tempe (D.M.) - all in Arizona; and Avid Radiopharmaceuticals, Philadelphia (M.N., M.D.D., M.A.M., M.J.P.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1900757DOI Listing
May 2019

A concise and persistent feature to study brain resting-state network dynamics: Findings from the Alzheimer's Disease Neuroimaging Initiative.

Hum Brain Mapp 2019 Mar 19;40(4):1062-1081. Epub 2018 Dec 19.

School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, Arizona.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hbm.24383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570412PMC
March 2019

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gena Roschupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 03 28;51(3):414-430. Epub 2019 Feb 28.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41588-019-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463297PMC
March 2019

Left lateralized cerebral glucose metabolism declines in amyloid-β positive persons with mild cognitive impairment.

Neuroimage Clin 2018 17;20:286-296. Epub 2018 Jul 17.

Banner Alzheimer's Institute, Phoenix, AZ, USA; School of Mathematics and Statistics (KC), Neurodegenerative Disease Research Center (EMR), Arizona State University, USA; Department of Neurology, College of Medicine - Phoenix (KC), Department of Psychiatry (EMR), University of Arizona, USA; Neurogenomics Division, Translational Genomics Research Institute, University of Arizona, Arizona State University, Phoenix, AZ, USA; Banner-Arizona State University, Neurodegenerative Disease Research Center, BioDesign Institute, Arizona State University, Tempe, AZ, USA; Arizona Alzheimer's Consortium, Phoenix, AZ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2018.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084012PMC
January 2019

Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus.

Neuron 2018 Jul 21;99(1):64-82.e7. Epub 2018 Jun 21.

Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Icahn Institute of Genomic Sciences and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Next Generation Healthcare, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ 85287-5001, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2018.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551233PMC
July 2018

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.

Authors:
Cyril Pottier Xiaolai Zhou Ralph B Perkerson Matt Baker Gregory D Jenkins Daniel J Serie Roberta Ghidoni Luisa Benussi Giuliano Binetti Adolfo López de Munain Miren Zulaica Fermin Moreno Isabelle Le Ber Florence Pasquier Didier Hannequin Raquel Sánchez-Valle Anna Antonell Albert Lladó Tammee M Parsons NiCole A Finch Elizabeth C Finger Carol F Lippa Edward D Huey Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Robert A Rissman Jaroslaw Slawek Emilia Sitek Peter Johannsen Jørgen E Nielsen Yingxue Ren Marka van Blitterswijk Mariely DeJesus-Hernandez Elizabeth Christopher Melissa E Murray Kevin F Bieniek Bret M Evers Camilla Ferrari Sara Rollinson Anna Richardson Elio Scarpini Giorgio G Fumagalli Alessandro Padovani John Hardy Parastoo Momeni Raffaele Ferrari Francesca Frangipane Raffaele Maletta Maria Anfossi Maura Gallo Leonard Petrucelli EunRan Suh Oscar L Lopez Tsz H Wong Jeroen G J van Rooij Harro Seelaar Simon Mead Richard J Caselli Eric M Reiman Marwan Noel Sabbagh Mads Kjolby Anders Nykjaer Anna M Karydas Adam L Boxer Lea T Grinberg Jordan Grafman Salvatore Spina Adrian Oblak M-Marsel Mesulam Sandra Weintraub Changiz Geula John R Hodges Olivier Piguet William S Brooks David J Irwin John Q Trojanowski Edward B Lee Keith A Josephs Joseph E Parisi Nilüfer Ertekin-Taner David S Knopman Benedetta Nacmias Irene Piaceri Silvia Bagnoli Sandro Sorbi Marla Gearing Jonathan Glass Thomas G Beach Sandra E Black Mario Masellis Ekaterina Rogaeva Jean-Paul Vonsattel Lawrence S Honig Julia Kofler Amalia C Bruni Julie Snowden David Mann Stuart Pickering-Brown Janine Diehl-Schmid Juliane Winkelmann Daniela Galimberti Caroline Graff Linn Öijerstedt Claire Troakes Safa Al-Sarraj Carlos Cruchaga Nigel J Cairns Jonathan D Rohrer Glenda M Halliday John B Kwok John C van Swieten Charles L White Bernardino Ghetti Jill R Murell Ian R A Mackenzie Ging-Yuek R Hsiung Barbara Borroni Giacomina Rossi Fabrizio Tagliavini Zbigniew K Wszolek Ronald C Petersen Eileen H Bigio Murray Grossman Vivianna M Van Deerlin William W Seeley Bruce L Miller Neill R Graff-Radford Bradley F Boeve Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Lancet Neurol 2018 06 30;17(6):548-558. Epub 2018 Apr 30.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(18)30126-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237181PMC
June 2018

HIPPOCAMPUS MORPHOMETRY STUDY ON PATHOLOGY-CONFIRMED ALZHEIMER'S DISEASE PATIENTS WITH SURFACE MULTIVARIATE MORPHOMETRY STATISTICS.

Proc IEEE Int Symp Biomed Imaging 2018 Apr 24;2018:1555-1559. Epub 2018 May 24.

School of Computing, Informatics, and Decision Systems Engineering, Arizona State Univ., Tempe, AZ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/ISBI.2018.8363870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097541PMC
April 2018

Long-term forgetting in preclinical Alzheimer's disease.

Authors:
Eric M Reiman

Lancet Neurol 2018 02;17(2):104-105

Banner Alzheimer's Institute, Phoenix, AZ 85006, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(17)30458-1DOI Listing
February 2018

A Cross-Sectional Analysis of Late-Life Cardiovascular Factors and Their Relation to Clinically Defined Neurodegenerative Diseases.

Alzheimer Dis Assoc Disord 2016 Jul-Sep;30(3):223-9

*Banner Sun Health Research Institute, Sun City ‡Mayo Clinic, Scottsdale §Banner Alzheimer's Institute, Phoenix ∥Arizona State University, Tempe, AZ †National Alzheimer's Coordinating Center, University of Washington, Seattle, WA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WAD.0000000000000138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940303PMC
November 2017

Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose.

PLoS One 2013 26;8(6):e67163. Epub 2013 Jun 26.

Departments of Radiology and Psychiatry, Saint Joseph's Hospital and Medical Center/The Barrow Neurologic Institute, Phoenix, Arizona, United States of America ; Department of Radiology, Creighton University School of Medicine, Omaha, Nebraska, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067163PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694066PMC
October 2017

Multivariate analyses of peripheral blood leukocyte transcripts distinguish Alzheimer's, Parkinson's, control, and those at risk for developing Alzheimer's.

Neurobiol Aging 2017 10 20;58:225-237. Epub 2017 Jun 20.

ASU-Banner Neurodegenerative Disease Research Center, Biodesign Institute, Arizona State University, Tempe, AZ, USA; Arizona Alzheimer Consortium, Phoenix, AZ, USA; Formerly at Banner Sun Health Research Institute, Sun City, AZ, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2017.05.012DOI Listing
October 2017

Subjective memory complaints in preclinical autosomal dominant Alzheimer disease.

Neurology 2017 Oct 6;89(14):1464-1470. Epub 2017 Sep 6.

From Massachusetts General Hospital (D.J.N., R.A., B.P., R.A.S., Y.T.Q.); Harvard Medical School (D.J.N., R.A., R.A.S., Y.T.Q.); Center for Alzheimer Research and Treatment, Brigham and Women's Hospital (R.A., R.A.S.), Boston, MA; Banner Alzheimer's Institute (H.P., K.C., P.T., J.B.L., E.M.R.), Phoenix, AZ; Grupo de Neurociencias (D.C.A.-A., V.T., C.M., F.L., Y.T.Q.), Universidad de Antioquia; Instituto de Alta Tecnologia Medica (G.C.), Medellin, Colombia; and Athinoula A Martinos Center for Biomedical Imaging (Y.T.Q.), Boston, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000004533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5631170PMC
October 2017

Deep Learning based Classification of FDG-PET Data for Alzheimers Disease Categories.

Proc SPIE Int Soc Opt Eng 2017 Oct 17;10572. Epub 2017 Nov 17.

School of Computing, Informatics and Decision Systems Engineering, Arizona State University, Tempe, AZ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1117/12.2294537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733797PMC
October 2017

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Authors:
Rebecca Sims Sven J van der Lee Adam C Naj Céline Bellenguez Nandini Badarinarayan Johanna Jakobsdottir Brian W Kunkle Anne Boland Rachel Raybould Joshua C Bis Eden R Martin Benjamin Grenier-Boley Stefanie Heilmann-Heimbach Vincent Chouraki Amanda B Kuzma Kristel Sleegers Maria Vronskaya Agustin Ruiz Robert R Graham Robert Olaso Per Hoffmann Megan L Grove Badri N Vardarajan Mikko Hiltunen Markus M Nöthen Charles C White Kara L Hamilton-Nelson Jacques Epelbaum Wolfgang Maier Seung-Hoan Choi Gary W Beecham Cécile Dulary Stefan Herms Albert V Smith Cory C Funk Céline Derbois Andreas J Forstner Shahzad Ahmad Hongdong Li Delphine Bacq Denise Harold Claudia L Satizabal Otto Valladares Alessio Squassina Rhodri Thomas Jennifer A Brody Liming Qu Pascual Sánchez-Juan Taniesha Morgan Frank J Wolters Yi Zhao Florentino Sanchez Garcia Nicola Denning Myriam Fornage John Malamon Maria Candida Deniz Naranjo Elisa Majounie Thomas H Mosley Beth Dombroski David Wallon Michelle K Lupton Josée Dupuis Patrice Whitehead Laura Fratiglioni Christopher Medway Xueqiu Jian Shubhabrata Mukherjee Lina Keller Kristelle Brown Honghuang Lin Laura B Cantwell Francesco Panza Bernadette McGuinness Sonia Moreno-Grau Jeremy D Burgess Vincenzo Solfrizzi Petra Proitsi Hieab H Adams Mariet Allen Davide Seripa Pau Pastor L Adrienne Cupples Nathan D Price Didier Hannequin Ana Frank-García Daniel Levy Paramita Chakrabarty Paolo Caffarra Ina Giegling Alexa S Beiser Vilmantas Giedraitis Harald Hampel Melissa E Garcia Xue Wang Lars Lannfelt Patrizia Mecocci Gudny Eiriksdottir Paul K Crane Florence Pasquier Virginia Boccardi Isabel Henández Robert C Barber Martin Scherer Lluis Tarraga Perrie M Adams Markus Leber Yuning Chen Marilyn S Albert Steffi Riedel-Heller Valur Emilsson Duane Beekly Anne Braae Reinhold Schmidt Deborah Blacker Carlo Masullo Helena Schmidt Rachelle S Doody Gianfranco Spalletta W T Longstreth Thomas J Fairchild Paola Bossù Oscar L Lopez Matthew P Frosch Eleonora Sacchinelli Bernardino Ghetti Qiong Yang Ryan M Huebinger Frank Jessen Shuo Li M Ilyas Kamboh John Morris Oscar Sotolongo-Grau Mindy J Katz Chris Corcoran Melanie Dunstan Amy Braddel Charlene Thomas Alun Meggy Rachel Marshall Amy Gerrish Jade Chapman Miquel Aguilar Sarah Taylor Matt Hill Mònica Díez Fairén Angela Hodges Bruno Vellas Hilkka Soininen Iwona Kloszewska Makrina Daniilidou James Uphill Yogen Patel Joseph T Hughes Jenny Lord James Turton Annette M Hartmann Roberta Cecchetti Chiara Fenoglio Maria Serpente Marina Arcaro Carlo Caltagirone Maria Donata Orfei Antonio Ciaramella Sabrina Pichler Manuel Mayhaus Wei Gu Alberto Lleó Juan Fortea Rafael Blesa Imelda S Barber Keeley Brookes Chiara Cupidi Raffaele Giovanni Maletta David Carrell Sandro Sorbi Susanne Moebus Maria Urbano Alberto Pilotto Johannes Kornhuber Paolo Bosco Stephen Todd David Craig Janet Johnston Michael Gill Brian Lawlor Aoibhinn Lynch Nick C Fox John Hardy Roger L Albin Liana G Apostolova Steven E Arnold Sanjay Asthana Craig S Atwood Clinton T Baldwin Lisa L Barnes Sandra Barral Thomas G Beach James T Becker Eileen H Bigio Thomas D Bird Bradley F Boeve James D Bowen Adam Boxer James R Burke Jeffrey M Burns Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Cynthia M Carlsson Regina M Carney Minerva M Carrasquillo Steven L Carroll Carolina Ceballos Diaz Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Malcolm Dick Ranjan Duara Denis A Evans Kelley M Faber Kenneth B Fallon David W Fardo Martin R Farlow Steven Ferris Tatiana M Foroud Douglas R Galasko Marla Gearing Daniel H Geschwind John R Gilbert Neill R Graff-Radford Robert C Green John H Growdon Ronald L Hamilton Lindy E Harrell Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Erin Abner Lee-Way Jin Gyungah Jun Anna Karydas Jeffrey A Kaye Ronald Kim Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Kathryn L Lunetta Constantine G Lyketsos Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller John C Morris Jill R Murrell Amanda J Myers Sid O'Bryant John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson William Perry Elaine Peskind Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Howard J Rosen Roger N Rosenberg Mark A Sager Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Fabienne Garzia Feroze Golamaully Gislain Septier Sebastien Engelborghs Rik Vandenberghe Peter P De Deyn Carmen Muñoz Fernadez Yoland Aladro Benito Hakan Thonberg Charlotte Forsell Lena Lilius Anne Kinhult-Stählbom Lena Kilander RoseMarie Brundin Letizia Concari Seppo Helisalmi Anne Maria Koivisto Annakaisa Haapasalo Vincent Dermecourt Nathalie Fievet Olivier Hanon Carole Dufouil Alexis Brice Karen Ritchie Bruno Dubois Jayanadra J Himali C Dirk Keene JoAnn Tschanz Annette L Fitzpatrick Walter A Kukull Maria Norton Thor Aspelund Eric B Larson Ron Munger Jerome I Rotter Richard B Lipton María J Bullido Albert Hofman Thomas J Montine Eliecer Coto Eric Boerwinkle Ronald C Petersen Victoria Alvarez Fernando Rivadeneira Eric M Reiman Maura Gallo Christopher J O'Donnell Joan S Reisch Amalia Cecilia Bruni Donald R Royall Martin Dichgans Mary Sano Daniela Galimberti Peter St George-Hyslop Elio Scarpini Debby W Tsuang Michelangelo Mancuso Ubaldo Bonuccelli Ashley R Winslow Antonio Daniele Chuang-Kuo Wu Oliver Peters Benedetta Nacmias Matthias Riemenschneider Reinhard Heun Carol Brayne David C Rubinsztein Jose Bras Rita Guerreiro Ammar Al-Chalabi Christopher E Shaw John Collinge David Mann Magda Tsolaki Jordi Clarimón Rebecca Sussams Simon Lovestone Michael C O'Donovan Michael J Owen Timothy W Behrens Simon Mead Alison M Goate Andre G Uitterlinden Clive Holmes Carlos Cruchaga Martin Ingelsson David A Bennett John Powell Todd E Golde Caroline Graff Philip L De Jager Kevin Morgan Nilufer Ertekin-Taner Onofre Combarros Bruce M Psaty Peter Passmore Steven G Younkin Claudine Berr Vilmundur Gudnason Dan Rujescu Dennis W Dickson Jean-François Dartigues Anita L DeStefano Sara Ortega-Cubero Hakon Hakonarson Dominique Campion Merce Boada John Keoni Kauwe Lindsay A Farrer Christine Van Broeckhoven M Arfan Ikram Lesley Jones Jonathan L Haines Christophe Tzourio Lenore J Launer Valentina Escott-Price Richard Mayeux Jean-François Deleuze Najaf Amin Peter A Holmans Margaret A Pericak-Vance Philippe Amouyel Cornelia M van Duijn Alfredo Ramirez Li-San Wang Jean-Charles Lambert Sudha Seshadri Julie Williams Gerard D Schellenberg

Nat Genet 2017 09 17;49(9):1373-1384. Epub 2017 Jul 17.

Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669039PMC
September 2017

Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

Alzheimers Dement 2017 Jul 7;13(7):727-738. Epub 2017 Feb 7.

Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA; Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University Schools of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University Schools of Public Health, Boston, MA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2016.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496797PMC
July 2017

Prevalence, Patterns, and Predictors of Depression Treatment among Community-Dwelling Elderly Individuals with Dementia in the United States.

Am J Geriatr Psychiatry 2017 Jul 6;25(7):803-813. Epub 2017 Mar 6.

Banner Alzheimer's Institute, Phoenix, AZ; Department of Psychiatry, University of Arizona College of Medicine, Phoenix, AZ; Arizona Alzheimer's Consortium, Phoenix, AZ.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10647481173025
Publisher Site
http://dx.doi.org/10.1016/j.jagp.2017.03.003DOI Listing
July 2017

Alzheimer disease in 2016: Putting AD treatments and biomarkers to the test.

Authors:
Eric M Reiman

Nat Rev Neurol 2017 Feb 13;13(2):74-76. Epub 2017 Jan 13.

Banner Alzheimer's Institute, 901 E. Willetta Street, Phoenix, Arizona 85006, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneurol.2017.1DOI Listing
February 2017

Hyperbolic Space Sparse Coding with Its Application on Prediction of Alzheimer's Disease in Mild Cognitive Impairment.

Med Image Comput Comput Assist Interv 2016 Oct 2;9900:326-334. Epub 2016 Oct 2.

School of Computing, Informatics, and Decision Systems Engineering, Arizona State Univ., Tempe, AZ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-319-46720-7_38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217478PMC
October 2016

Alzheimer's disease: Attack on amyloid-β protein.

Authors:
Eric M Reiman

Nature 2016 09;537(7618):36-7

Banner Alzheimer's Institute, Phoenix, Arizona 85006 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/537036aDOI Listing
September 2016

A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers.

Front Aging Neurosci 2016 28;8:231. Epub 2016 Sep 28.

Center on Aging Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnagi.2016.00231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039208PMC
September 2016

Upper-Extremity Dual-Task Function: An Innovative Method to Assess Cognitive Impairment in Older Adults.

Front Aging Neurosci 2016 7;8:167. Epub 2016 Jul 7.

Arizona Center on Aging, Department of Medicine, College of Medicine, University of Arizona, TucsonAZ, USA; Interdisciplinary Consortium on Advanced Motion Performance, Department of Surgery, College of Medicine, University of Arizona, TucsonAZ, USA; Department of Biomedical Engineering, University of Arizona, TucsonAZ, USA; Banner Alzheimer's Institute, University of Arizona, TucsonAZ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnagi.2016.00167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935727PMC
July 2016

Gender Differences in Alzheimer Disease: Brain Atrophy, Histopathology Burden, and Cognition.

J Neuropathol Exp Neurol 2016 Jun 12. Epub 2016 Jun 12.

From the Banner Sun Health Research Institute, Sun City, Arizona (JRF, AJI, LIS, KJD, CMB, SJ, TGB, GES);Department of Economics, Arizona State University, Tempe, Arizona (EVA, JW);Neurological Institute, Phoenix, Arizona (MNS);Mayo Clinic Arizona, Scottsdale, Arizona (RJC, CHA, BKW, ED-D);Department of Neurology, University of Arizona, Tucson, Arizona (SZR, GLA);Banner Alzheimer Institute, Phoenix, Arizona (ADB, KC, EMR).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnen/nlw047DOI Listing
June 2016

What are we willing to accept for preventing Alzheimer's disease? - Investigators' reply.

Lancet Neurol 2016 06 9;15(7):660-661. Epub 2016 May 9.

Banner Alzheimer's Institute, Phoenix, AZ 85006, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(16)30055-2DOI Listing
June 2016

APPLYING SPARSE CODING TO SURFACE MULTIVARIATE TENSOR-BASED MORPHOMETRY TO PREDICT FUTURE COGNITIVE DECLINE.

Proc IEEE Int Symp Biomed Imaging 2016 Apr;2016:646-650

School of Computing, Informatics, and Decision Systems Engineering, Arizona State Univ., Tempe, AZ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/ISBI.2016.7493350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974012PMC
April 2016

Ketones block amyloid entry and improve cognition in an Alzheimer's model.

Neurobiol Aging 2016 Mar 7;39:25-37. Epub 2015 Dec 7.

Department of Neurology, Barrow Neurological Institute, St. Joseph Hospital and Medical Center, Phoenix, AZ, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2015.11.018DOI Listing
March 2016

Alzheimer Disease Biomarkers as Outcome Measures for Clinical Trials in MCI.

Alzheimer Dis Assoc Disord 2015 Apr-Jun;29(2):101-9

*Medical Imaging Unit, Biomedical Engineering Department, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Bergamo †Laboratory of Epidemiology and Neuroimaging, IRCCS Fatebenefratelli, Brescia §Department of Decision Science, Bocconi University, Milan, Italy ‡Department of Engineering, University of Cambridge **Institute of Brain, Behaviour, and Mental Health University of Cambridge, Cambridge ∥Banner Alzheimer's Institute, Phoenix, AZ ¶Helen Wills Neuroscience Institute, University of California, Berkeley, CA #Hannover Medical School, Clinic for Nuclear Medicine, Hannover, Germany ††Departments of Internal Medicine and Psychiatry, University Hospitals and University of Geneva, Geneva, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WAD.0000000000000071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437812PMC
February 2016

Characterizing Apolipoprotein E ε4 Carriers and Noncarriers With the Clinical Diagnosis of Mild to Moderate Alzheimer Dementia and Minimal β-Amyloid Peptide Plaques.

JAMA Neurol 2015 Oct;72(10):1124-31

Arizona Alzheimer's Consortium, Phoenix, Arizona7Banner Alzheimer's Institute, Phoenix, Arizona8University of Arizona, Phoenix9Arizona State University, Phoenix10Translational Genomics Research Institute, Phoenix, Arizona.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2015.1721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833059PMC
October 2015

Florbetapir PET, FDG PET, and MRI in Down syndrome individuals with and without Alzheimer's dementia.

Alzheimers Dement 2015 Aug 4;11(8):994-1004. Epub 2015 Apr 4.

Arizona Alzheimer's Consortium, Phoenix, AZ, USA; College of Medicine, University of Arizona, Phoenix, AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA; Translational Genomics Research Institute, Phoenix, AZ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2015.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543530PMC
August 2015

Memory, executive, and multidomain subtle cognitive impairment: clinical and biomarker findings.

Neurology 2015 Jul 17;85(2):144-53. Epub 2015 Jun 17.

From the Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research (J.B.T., M.B., L.M.S., J.Q.T.), and Department of Psychiatry (S.E.A.), University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; Banner Alzheimer's Institute (K.C., E.M.R.), Phoenix, AZ; Center for Biomedical Image Computing and Analytics (M.R., C.D.), Philadelphia, PA; Mayo Clinic College of Medicine (C.R.J.), Rochester, MN; and Center for Imaging of Neurodegenerative Diseases (M.W.W.), Department of Radiology, San Francisco VA Medical Center/University of California San Francisco.

View Article

Download full-text PDF

Source
http://www.neurology.org/content/85/2/144.full.pdf
Web Search
http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000173
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000001738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515043PMC
July 2015

Disrupted Frontoparietal Network Mediates White Matter Structure Dysfunction Associated with Cognitive Decline in Hypertension Patients.

J Neurosci 2015 Jul;35(27):10015-24

State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, Beijing 100875, China, Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing 100700, China, and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.5113-14.2015DOI Listing
July 2015

The Alzheimer's Disease Neuroimaging Initiative 2 PET Core: 2015.

Alzheimers Dement 2015 Jul;11(7):757-71

Department of Neurology, Center for Alzheimer's Care, Imaging and Research, University of Utah, Salt Lake City, UT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2015.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510459PMC
July 2015

A potential role for the midbrain in integrating fat-free mass determined energy needs: An H2 (15) O PET study.

Hum Brain Mapp 2015 Jun 13;36(6):2406-15. Epub 2015 Mar 13.

Obesity and Diabetes Clinical Research Section, NIDDK-NIH, DHHS, Phoenix, Arizona; Department of Neurology, University of Leipzig, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hbm.22780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410621PMC
June 2015

Improved power for characterizing longitudinal amyloid-β PET changes and evaluating amyloid-modifying treatments with a cerebral white matter reference region.

J Nucl Med 2015 Apr 5;56(4):560-6. Epub 2015 Mar 5.

Banner Alzheimer's Institute, Phoenix, Arizona Arizona Alzheimer's Consortium, Phoenix, Arizona Division of Neurogenomics, Translational Genomics Research Institute, Phoenix, Arizona; and Department of Psychiatry, University of Arizona, Tucson, Arizona.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2967/jnumed.114.149732DOI Listing
April 2015

Measurement of longitudinal β-amyloid change with 18F-florbetapir PET and standardized uptake value ratios.

J Nucl Med 2015 Apr 5;56(4):567-74. Epub 2015 Mar 5.

Helen Wills Neuroscience Institute, University of California, Berkeley, California Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2967/jnumed.114.148981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313473PMC
April 2015

A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease.

Alzheimers Res Ther 2015 14;7(1):35. Epub 2015 Apr 14.

Alzheimer's Disease Research Unit, Yale University School of Medicine, New Haven, Connecticut USA ; Department of Neurology, Yale University School of Medicine, New Haven, Connecticut USA ; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13195-015-0119-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396171PMC
April 2015

Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes.

Neurobiol Aging 2015 Feb 2;36(2):583-91. Epub 2014 Oct 2.

Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA; Arizona Alzheimer's Consortium, Phoenix, AZ, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2014.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315763PMC
February 2015

Rarity of the Alzheimer disease-protective APP A673T variant in the United States.

Authors:
Li-San Wang Adam C Naj Robert R Graham Paul K Crane Brian W Kunkle Carlos Cruchaga Josue D Gonzalez Murcia Lisa Cannon-Albright Clinton T Baldwin Henrik Zetterberg Kaj Blennow Walter A Kukull Kelley M Faber Nicole Schupf Maria C Norton JoAnn T Tschanz Ronald G Munger Christopher D Corcoran Ekaterina Rogaeva Chiao-Feng Lin Beth A Dombroski Laura B Cantwell Amanda Partch Otto Valladares Hakon Hakonarson Peter St George-Hyslop Robert C Green Alison M Goate Tatiana M Foroud Regina M Carney Eric B Larson Timothy W Behrens John S K Kauwe Jonathan L Haines Lindsay A Farrer Margaret A Pericak-Vance Richard Mayeux Gerard D Schellenberg Marilyn S Albert Roger L Albin Liana G Apostolova Steven E Arnold Robert Barber Michael Barmada Lisa L Barnes Thomas G Beach James T Becker Gary W Beecham Duane Beekly David A Bennett Eileen H Bigio Thomas D Bird Deborah Blacker Bradley F Boeve James D Bowen Adam Boxer James R Burke Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Steven L Carroll Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Steven T DeKosky F Yesim Demirci Malcolm Dick Dennis W Dickson Ranjan Duara Nilufer Ertekin-Taner Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Jonathan D Glass Neill R Graff-Radford John H Growdon Ronald L Hamilton Kara L Hamilton-Nelson Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gail P Jarvik Gregory A Jicha Lee-Way Jin Gyungah Jun Gyungah Jun M Ilyas Kamboh Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Gei Li Andrew P Lieberman Oscar L Lopez Kathryn L Lunetta Constantine G Lyketsos Wendy J Mack Daniel C Marson Eden R Martin Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee W Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Thomas J Montine John C Morris Jill R Murrell John M Olichney Joseph E Parisi William Perry Elaine Peskind Ronald C Petersen Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Eric M Reiman Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Howard J Rosen Roger N Rosenberg Mary Sano Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Debby W Tsuang Vivianna M Van Deerlin Linda J Van Eldik Badri N Vardarajan Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Sarah Wishnek Randall L Woltjer Clinton B Wright Steven G Younkin Chang-En Yu Lei Yu

JAMA Neurol 2015 Feb;72(2):209-16

Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2014.2157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324097PMC
February 2015

Homozygosity of the autosomal dominant Alzheimer disease presenilin 1 E280A mutation.

Neurology 2015 Jan 3;84(2):206-8. Epub 2014 Dec 3.

From the Neuroscience Research Institute (K.S.K., M.L.A.), University of California, Santa Barbara; Grupo de Neurociencias de Antioquia (C.M., L.L., G.G., L.M., S.M., S.R.R., H.L., M.G., F.L.), Universidad de Antioquia, Medellín, Colombia; Banner Alzheimer's Institute (J.B.L., P.N.T., E.M.R.), Phoenix, AZ; and Genentech (W.C., S.S., C.H.), South San Francisco, CA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000001130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336083PMC
January 2015

An empirically derived composite cognitive test score with improved power to track and evaluate treatments for preclinical Alzheimer's disease.

Alzheimers Dement 2014 Nov 21;10(6):666-74. Epub 2014 Apr 21.

Banner Alzheimer's Institute, Phoenix, AZ, USA; Arizona Alzheimer's Consortium, Phoenix, AZ, USA; Department of Psychiatry, University of Arizona, Tucson, AZ, USA; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2014.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201904PMC
November 2014

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.

Authors:
Adam C Naj Gyungah Jun Christiane Reitz Brian W Kunkle William Perry Yo Son Park Gary W Beecham Ruchita A Rajbhandary Kara L Hamilton-Nelson Li-San Wang John S K Kauwe Matthew J Huentelman Amanda J Myers Thomas D Bird Bradley F Boeve Clinton T Baldwin Gail P Jarvik Paul K Crane Ekaterina Rogaeva M Michael Barmada F Yesim Demirci Carlos Cruchaga Patricia L Kramer Nilufer Ertekin-Taner John Hardy Neill R Graff-Radford Robert C Green Eric B Larson Peter H St George-Hyslop Joseph D Buxbaum Denis A Evans Julie A Schneider Kathryn L Lunetta M Ilyas Kamboh Andrew J Saykin Eric M Reiman Philip L De Jager David A Bennett John C Morris Thomas J Montine Alison M Goate Deborah Blacker Debby W Tsuang Hakon Hakonarson Walter A Kukull Tatiana M Foroud Eden R Martin Jonathan L Haines Richard P Mayeux Lindsay A Farrer Gerard D Schellenberg Margaret A Pericak-Vance Marilyn S Albert Roger L Albin Liana G Apostolova Steven E Arnold Robert Barber Lisa L Barnes Thomas G Beach James T Becker Duane Beekly Eileen H Bigio James D Bowen Adam Boxer James R Burke Nigel J Cairns Laura B Cantwell Chuanhai Cao Chris S Carlson Regina M Carney Minerva M Carrasquillo Steven L Carroll Helena C Chui David G Clark Jason Corneveaux David H Cribbs Elizabeth A Crocco Charles DeCarli Steven T DeKosky Malcolm Dick Dennis W Dickson Ranjan Duara Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Jonathan D Glass John H Growdon Ronald L Hamilton Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gregory A Jicha Lee-Way Jin Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Chiao-Feng Lin Oscar L Lopez Constantine G Lyketsos Wendy J Mack Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Jill R Murrell John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson Elaine Peskind Ronald C Petersen Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg John M Ringman Erik D Roberson Howard J Rosen Roger N Rosenberg Mary Sano Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Otto Valladares Vivianna M Van Deerlin Linda J Van Eldik Badri N Vardarajan Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Sarah Wishnek Randall L Woltjer Clinton B Wright Steven G Younkin Chang-En Yu Lei Yu

JAMA Neurol 2014 Nov;71(11):1394-404

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2014.1491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314944PMC
November 2014

Pituitary adenylate cyclase-activating polypeptide protects against β-amyloid toxicity.

Neurobiol Aging 2014 Sep 22;35(9):2064-71. Epub 2014 Mar 22.

Department of Neurology, Barrow Neurological Institute, St. Joseph Hospital and Medical Center, Dignity Health Organization, Phoenix, AZ, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2014.03.022DOI Listing
September 2014

Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis.

Neurology 2014 Jul 13;83(3):253-60. Epub 2014 Jun 13.

From the Departments of Neurology (D.C.R., J.C.M., R.J.B.), Biostatistics (C.X.), and Psychiatry (A.G.), Washington University School of Medicine, St. Louis, MO; Neurologische Klinik Ludwig-Maximilians-Universität Munich and German Center for Neurodegenerative Diseases (A.D.), Munich, Germany; Department of Neurosciences (P.S.A.), University of California San Diego; Mental Health Research Institute (C.L.M.), University of Melbourne, Australia; Grupo de Neurociencias de Antioquia (N.A.-B., F.L., S.M.), Universidad de Antioquia, Medellín, Colombia; Department of Neurology (E.M.), University of Pittsburgh, PA; Department of Neurology (T.B.), University of Washington, Seattle; Banner Alzheimer's Institute (J.B.S.L., E.M.R., P.N.T.), Phoenix, AZ; Neuroscience Research Australia and University of New South Wales (P.R.S.), Sydney, Australia; Edith Cowan University (R.M.), Western Australia; Easton Center for Alzheimer's Disease Research at UCLA (J.M.R.), Los Angeles, CA; Department of Neurology (R.P.M.), Columbia University, New York, NY; Queen Square Institute of Neurology (N.C.F.), University College London; Department of Neurology (S.S.), Warren Alpert Medical School, Brown University, Providence, RI; and Center for Alzheimer Research and Treatment (R.S.), Brigham and Women's Hospital and Massachusetts General Hospital, Boston.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000000596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117367PMC
July 2014

Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease.

Alzheimers Res Ther 2013 3;5(5):38. Epub 2013 Sep 3.

Arizona Alzheimer's Consortium, Phoenix, AZ USA ; Department of Neurology, Mayo Clinic Arizona, 13400 E. Shea Boulevard, Scottsdale, AZ 85259, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/alzrt204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979087PMC
June 2014

Brain glucose and acetoacetate metabolism: a comparison of young and older adults.

Neurobiol Aging 2014 Jun 1;35(6):1386-95. Epub 2013 Dec 1.

Research Center on Aging, Université de Sherbrooke, Sherbrooke, Quebec, Canada; Department of Physiology and Biophysics, Université de Sherbrooke, Sherbrooke, Quebec, Canada; Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2013.11.027DOI Listing
June 2014

Endpoints in preclinical Alzheimer's disease trials.

J Clin Psychiatry 2014 Jun;75(6):661-2

Banner Alzheimer's Institute, 901 E Willetta St, Phoenix, AZ 85006

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4088/JCP.14com09235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459723PMC
June 2014

Pituitary adenylate cyclase-activating polypeptide is reduced in Alzheimer disease.

Neurology 2014 May 9;82(19):1724-8. Epub 2014 Apr 9.

From the Barrow Neurological Institute (P.H., L.C.B., J.Y., Z.T., J.S.), St. Joseph Hospital and Medical Center, Dignity Health Organization, Phoenix; Translational Genomics Research Institute (W.L.), Phoenix, AZ; Department of Neurosurgery (Z.T.), The First Hospital of Kunming Medical University, Kunming, China; Civin Laboratory for Neuropathology (T.G.B.), Banner Sun Health Research Institute, Sun City; Department of Neurology (R.J.C.), Mayo Clinic Arizona, Scottsdale; and Banner Alzheimer's Institute (E.M.R.), Phoenix, AZ.

View Article

Download full-text PDF

Source
http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000041
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000000417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032204PMC
May 2014

Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition.

Acta Neuropathol Commun 2014 Mar 6;2:26. Epub 2014 Mar 6.

Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/2051-5960-2-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008258PMC
March 2014

Association of amyloid burden, brain atrophy and memory deficits in aged apolipoprotein ε4 mice.

Curr Alzheimer Res 2014 Mar;11(3):283-90

Department of Neurology, Barrow Neurological Institute, St. Joseph Hospital and Medical Center, 500 W Thomas Road, Suite 300, Phoenix AZ 85013, USA.

View Article

Download full-text PDF

Source
March 2014

Subjective cognitive decline: self and informant comparisons.

Alzheimers Dement 2014 Jan 3;10(1):93-8. Epub 2013 Apr 3.

Banner Alzheimer's Institute, Mayo Clinic, Scottsdale, AZ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2013.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732500PMC
January 2014

Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study.

JAMA Neurol 2014 Jan;71(1):11-22

Banner Alzheimer's Institute, Phoenix, Arizona6Arizona Alzheimer's Consortium, Phoenix9Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona11Department of Psychiatry, University of Arizona School of Medicine, Phoenix.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2013.4544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056558PMC
January 2014

Alzheimer's disease and other dementias: advances in 2013.

Authors:
Eric M Reiman

Lancet Neurol 2014 Jan;13(1):3-5

Banner Alzheimer's Institute and Banner Research, University of Arizona College of Medicine, Translational Genomics Research Institute, and Arizona Alzheimer's Consortium, Phoenix, AZ, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(13)70257-6DOI Listing
January 2014

Neuropathologic heterogeneity does not impair florbetapir-positron emission tomography postmortem correlates.

J Neuropathol Exp Neurol 2014 Jan;73(1):72-80

From the Avid Radiopharmaceuticals (CMC, ML, APC, ADJ, MAM, MJP, DMS), Philadelphia, Pennsylvania; Banner Sun Health Research Institute (BND, GS, MM, MNS, LIS, TGB), Sun City, Arizona; Biospective Inc. and Montreal Neurological Institute (BJB, SPZ), McGill University, Montreal, Canada; Duke University Medical Center (REC, PMD), Durham, North Carolina; Banner Alzheimer's Institute (ASF, EMR), Phoenix, Arizona; Nova SE University (CHS), Ft Lauderdale, Florida; and Rush University Medical Center (JAS), Chicago, Illinois.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/NEN.0000000000000028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037918PMC
January 2014

Overfeeding over 24 hours does not activate brown adipose tissue in humans.

J Clin Endocrinol Metab 2013 Dec 30;98(12):E1956-60. Epub 2013 Sep 30.

MD, Obesity and Diabetes Clinical Research Section, National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases, 4212 North 16th Street (Fifth Floor), Phoenix, AZ 85016.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2013-2387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849677PMC
December 2013

Clinical and multimodal biomarker correlates of ADNI neuropathological findings.

Acta Neuropathol Commun 2013 Oct 9;1:65. Epub 2013 Oct 9.

Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/2051-5960-1-65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893373PMC
October 2013

Genetic susceptibility for Alzheimer disease neuritic plaque pathology.

JAMA Neurol 2013 Sep;70(9):1150-7

Departments of Neurology and Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas2Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2013.2815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773291PMC
September 2013

Ushering in the study and treatment of preclinical Alzheimer disease.

Nat Rev Neurol 2013 Jul 11;9(7):371-81. Epub 2013 Jun 11.

Banner Alzheimer's Institute, 901 East Willetta Street, Phoenix, AZ 85006, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneurol.2013.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084675PMC
July 2013