Dr. Eric L Hargreaves, Ph.D. - Robert Wood Johnson Medical School, Rutgers University

Dr. Eric L Hargreaves

Ph.D.

Robert Wood Johnson Medical School, Rutgers University

New Brunswick, NJ | United States

Main Specialties: Other

Additional Specialties: Deep Brain Stimulation fro Movement Disorders, Hippocampal Plasticity LTP Navigational and memory systems


Top Author

Dr. Eric L Hargreaves, Ph.D. - Robert Wood Johnson Medical School, Rutgers University

Dr. Eric L Hargreaves

Ph.D.

Introduction

After 20 years in the learning and memory field studying the electrophysiology of the Hippocampal system, in rodents and non-human primates, I now apply my expertise clinically using Deep Brain Stimulation to combat Movement Disorders like Parkinson's Disease in the Basal Ganglia. I function as the clinical neurophysiologist during implantation, and subsequently function as the lead DBS programmer during postoperative management.

As of December 2017 have been involved in over 275 DBS related surgical procedures, including over 150 initial lead implantations. Postoperatively our group tends to manage approximately 175 patients with DBS.

I have publications in the field of neuroplasticity that encompass the phenomenon of Kindling, Long term potentiation (LTP), Primed-burst Potentiation (PBP), NMDA antagonism.

I have also published In the field of rodent hippocampal navigation including hippocampal place cells and entorhinal grid cells.

In Neurosurgery for the past seven years have published in my active field in DBS both postoperative programming, and intraoperative recording. Additionally, have participated in the research involving our brain tumor ablation program utilizing Laser-induced Thermal Therapy.

Primary Affiliation: Robert Wood Johnson Medical School, Rutgers University - New Brunswick, NJ , United States

Specialties:

Additional Specialties:


View Dr. Eric L Hargreaves’s Resume / CV

Education

Sep 1993
University of Western Ontario Canada
Ph.D.
Psychobiology
Sep 1988
University of Western Ontario Canada
M.A.
Psychobiology
May 1985
University of Victoria B.C. Canada
B.Sc.
Psychology, Comp Sci.

Experience

Jul 2009
Clinical Deep Brain Stimulation Neurophysiologist
Instructor
Division of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey
Jul 2003
Postdoctoral Research Associate
Research Associate
Center for Neural Science, New York University, Manhattan, New York
Oct 2000
Postdoctoral Research Associate
Research Associate
Department of Neurobiology and Anatomy, University of Texa Medical School @ Houston, Texas
Oct 1998
Postdoctoral Research Associate
Research Associate
Department of Physiology and Pharmacology, State University of New York @ Brooklyn, SUNY Downstate, Brooklyn, New York
Jun 1997
Postdoctoral Research position
Post Doctoral position
Psychology Department, Univerity of Otago, Dunedin, New Zealand
Sep 1993
Natural Sciences and Engineering Research Council Postdoctoral Fellowship
Recipient
Psychology Department, McGill University, Montreal Canada

Publications

37Publications

368Reads

675Profile Views

606PubMed Central Citations

Assessment of Optimal Imaging Protocol Sequences After Laser-Induced Thermal Therapy for Intracranial Tumors.

Neurosurgery 2018 Sep;83(3):471-479

Section of Neurosurgery, Rutgers, Cancer Institute of New Jersey, New Brunswick, New Jersey.

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http://dx.doi.org/10.1093/neuros/nyx439DOI Listing
September 2018
26 Reads
3.620 Impact Factor

Effects of variable power on tissue ablation dynamics during magnetic resonance-guided laser-induced thermal therapy with the Visualase system.

Int J Hyperthermia 2018 09 18;34(6):764-772. Epub 2017 Sep 18.

a Division of Neurosurgery , Rutgers University, Robert Wood Johnson Medical School , New Brunswick , NJ , USA.

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https://www.tandfonline.com/doi/full/10.1080/02656736.2017.1
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http://dx.doi.org/10.1080/02656736.2017.1376355DOI Listing
September 2018
15 Reads
2.645 Impact Factor

Optimizing computational feature sets for subthalamic nucleus localization in DBS surgery with feature selection.

Clin Neurophysiol 2015 May 3;126(5):975-82. Epub 2014 Sep 3.

Department of Neurology, Rutgers - Robert Wood Johnson Medical School, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2014.05.039DOI Listing
May 2015
7 Reads
2 Citations
3.100 Impact Factor

The rationale driving the evolution of deep brain stimulation to constant-current devices.

Neuromodulation 2015 Feb 29;18(2):85-8; discussion 88-9. Epub 2014 Aug 29.

Reed Neurological Research Center, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/ner.12227DOI Listing
February 2015
40 Reads
12 Citations
1.785 Impact Factor

Magnetic resonance-guided laser ablation improves local control for postradiosurgery recurrence and/or radiation necrosis.

Neurosurgery 2014 Jun;74(6):658-67; discussion 667

*Department of Radiation Oncology and ‡Neurosurgery, Rutgers University-Robert Wood Johnson Medical School, New Brunswick, New Jersey.

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http://pdfs.journals.lww.com/neurosurgery/2014/06000/Magneti
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1227/NEU.0000000000000332DOI Listing
June 2014
9 Reads
12 Citations
3.620 Impact Factor

Volumetric trends associated with MRI-guided laser-induced thermal therapy (LITT) for intracranial tumors.

Lasers Surg Med 2013 Aug 14;45(6):362-9. Epub 2013 Jun 14.

Division of Neurosurgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08902, USA.

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http://dx.doi.org/10.1002/lsm.22151DOI Listing
August 2013
9 Reads
6 Citations
2.620 Impact Factor

Deep brain stimulation lead fixation after Stimloc failure.

J Clin Neurosci 2012 Dec 23;19(12):1715-8. Epub 2012 Sep 23.

Division of Neurosurgery, Robert Wood Johnson Medical School, Clinical Academic Building, Suite 2100, 125 Paterson St., New Brunswick, New Jersey 08901, USA.

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http://dx.doi.org/10.1016/j.jocn.2012.02.017DOI Listing
December 2012
8 Reads
1 Citation
1.320 Impact Factor

Depth-time interpolation of feature trends extracted from mobile microelectrode data with kernel functions.

Stereotact Funct Neurosurg 2012 19;90(1):51-8. Epub 2012 Jan 19.

Department of Neurology, UMDNJ - Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA. wongst @ umdnj.edu

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http://dx.doi.org/10.1159/000334494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291885PMC
July 2012
6 Reads
1 Citation
1.480 Impact Factor

Conserved fMRI and LFP signals during new associative learning in the human and macaque monkey medial temporal lobe.

Neuron 2012 May;74(4):743-52

Center for Neural Science, New York University, New York, NY 10003, USA.

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http://dx.doi.org/10.1016/j.neuron.2012.03.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969034PMC
May 2012
11 Reads
6 Citations
15.054 Impact Factor

Cohesiveness of spatial and directional representations recorded from neural ensembles in the anterior thalamus, parasubiculum, medial entorhinal cortex, and hippocampus.

Hippocampus 2007 ;17(9):826-41

Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, TX 77225, USA.

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http://dx.doi.org/10.1002/hipo.20316DOI Listing
January 2008
6 Reads
22 Citations
4.162 Impact Factor

Hippocampal place cells: parallel input streams, subregional processing, and implications for episodic memory.

Hippocampus 2006 ;16(9):755-64

Department of Neurobiology & Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, University of Texas Medical School at Houston, Houston, Texas 77225, USA.

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http://dx.doi.org/10.1002/hipo.20203DOI Listing
November 2006
8 Reads
84 Citations
4.162 Impact Factor

Major dissociation between medial and lateral entorhinal input to dorsal hippocampus.

Science 2005 Jun;308(5729):1792-4

Department of Neurobiology and Anatomy, W. M. Keck Center for the Neurobiology of Learning and Memory, Post Office Box 20708, University of Texas Medical School at Houston, Houston, TX 77225, USA.

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http://dx.doi.org/10.1126/science.1110449DOI Listing
June 2005
5 Reads
178 Citations
31.480 Impact Factor

Dendritic BC1 RNA: modulation by kindling-induced afterdischarges.

Brain Res Mol Brain Res 2005 Jan;133(1):110-8

Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.

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http://dx.doi.org/10.1016/j.molbrainres.2004.10.008DOI Listing
January 2005
5 Reads

Telemetry system for reliable recording of action potentials from freely moving rats.

Hippocampus 2002 ;12(4):505-13

Department of Physiology, SUNY Health Sciences Center at Brooklyn, New York 11203, USA.

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http://www.utdallas.edu/~tres/spatial/Muller2.pdf
Web Search
http://doi.wiley.com/10.1002/hipo.10040
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http://dx.doi.org/10.1002/hipo.10040DOI Listing
March 2003
7 Reads
3 Citations
4.162 Impact Factor

A double dissociation within the hippocampus of dopamine D1/D5 receptor and beta-adrenergic receptor contributions to the persistence of long-term potentiation.

Neuroscience 1999 ;92(2):485-97

Department of Psychology and the Neuroscience Research Centre, University of Otago, Dunedin, New Zealand.

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September 1999
11 Reads
38 Citations
3.360 Impact Factor

Abolition of long-term stability of new hippocampal place cell maps by NMDA receptor blockade.

Science 1998 Jun;280(5372):2121-6

Department of Physiology, SUNY Health Science Center Brooklyn, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.

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June 1998
9 Reads
100 Citations
31.480 Impact Factor

A dose of MK801 previously shown to impair spatial learning in the radial maze attenuates primed burst potentiation in the dentate gyrus of freely moving rats.

Behav Neurosci 1997 Feb;111(1):35-48

Department of Psychology, McGill University, Montreal, Quebec, Canada.

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February 1997
7 Reads
2.730 Impact Factor

Reaching to ipsilateral or contralateral targets: within-hemisphere visuomotor processing cannot explain hemispatial differences in motor control.

Exp Brain Res 1996 Dec;112(3):496-504

Department of Psychology, University of Western Ontario, London, Canada.

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December 1996
6 Reads
15 Citations
2.040 Impact Factor

Detailed behavioral analysis of water maze acquisition under APV or CNQX: contribution of sensorimotor disturbances to drug-induced acquisition deficits.

Behav Neurosci 1996 Feb;110(1):86-102

Department of Psychology, University of Western Ontario, London, Canada.

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February 1996
11 Reads
18 Citations
2.730 Impact Factor

Detailed behavioral analysis of water maze acquisition under systemic NMDA or muscarinic antagonism: nonspatial pretraining eliminates spatial learning deficits.

Behav Neurosci 1996 Feb;110(1):103-16

Department of Psychology, University of Western Ontario, London, Canada.

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February 1996
10 Reads
19 Citations
2.730 Impact Factor

Fyn tyrosine kinase is required for normal amygdala kindling.

Epilepsy Res 1995 Oct;22(2):107-14

Department of Psychology, University of Western Ontario, London, Canada.

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October 1995
13 Reads
8 Citations
2.020 Impact Factor

p-chlorophenylalanine-induced serotonin depletion: reduction in exploratory locomotion but no obvious sensory-motor deficits.

Behav Brain Res 1995 Jun;68(2):229-37

Neuroscience Program, University of Western Ontario, London, Canada.

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June 1995
10 Reads
9 Citations
3.030 Impact Factor

A multivariate assessment of spontaneous locomotor activity in the Mongolian gerbil (Meriones unguiculatus): influences of age and sex.

Physiol Behav 1995 May;57(5):893-9

Department of Psychology, University of Western Ontario, London, Canada.

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May 1995
7 Reads
2.980 Impact Factor

MK801-induced hyperactivity: duration of effects in rats.

Pharmacol Biochem Behav 1995 May;51(1):13-9

Department of Psychology, University of Western Ontario, London, Canada.

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May 1995
8 Reads
5 Citations
2.781 Impact Factor

Brain temperature- and behavior-related changes in the dentate gyrus field potential during sleep, cold water immersion, radiant heating, and urethane anesthesia.

Brain Res 1994 Sep;658(1-2):135-44

Department of Psychology, University of Western Ontario, London, Canada.

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September 1994
10 Reads
1 Citation
2.843 Impact Factor

Reductions in body temperature and spontaneous activity in rats exposed to horizontal rotation: abolition following chemical labyrinthectomy.

Physiol Behav 1994 Aug;56(2):319-24

Neuroscience Program, University of Western Ontario, London, Canada.

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August 1994
7 Reads
6 Citations
2.980 Impact Factor

Sexually dimorphic spatial learning varies seasonally in two populations of deer mice.

Brain Res 1994 Jan;635(1-2):18-26

Social Science Centre, University of Western Ontario, London, Canada.

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January 1994
8 Reads
17 Citations
2.843 Impact Factor

Polypropylene pellets as an inexpensive reusable substitute for milk in the Morris milk maze.

J Neurosci Methods 1993 Sep;49(3):193-7

Department of Psychology, University of Western Ontario, London, Canada.

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September 1993
11 Reads
2.025 Impact Factor

Spatial learning in an enclosed eight-arm radial maze in rats with sodium arsanilate-induced labyrinthectomies.

Behav Neural Biol 1993 May;59(3):253-7

Neuroscience Program, University of Western Ontario, London, Canada.

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May 1993
9 Reads
13 Citations

An examination of the relations between hippocampal long-term potentiation, kindling, afterdischarge, and place learning in the water maze.

Hippocampus 1993 Apr;3(2):153-63

Department of Psychology, University of Western Ontario, London, Canada.

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http://dx.doi.org/10.1002/hipo.450030208DOI Listing
April 1993
7 Reads
4 Citations
4.162 Impact Factor

Serotonin-dependent cerebral activation: effects of methiothepin and other serotonergic antagonists.

Brain Res 1992 Nov;597(1):16-23

Psychology Department, University of British Columbia, Vancouver, Canada.

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November 1992
8 Reads
2.843 Impact Factor

Evidence for different neurochemical contributions to long-term potentiation and to kindling and kindling-induced potentiation: role of NMDA and urethane-sensitive mechanisms.

Exp Neurol 1992 Jun;116(3):330-8

Department of Psychology, University of Western Ontario, London, Canada.

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June 1992
8 Reads
5 Citations
4.700 Impact Factor

Sodium arsanilate-induced vestibular dysfunction in meadow voles (Microtus pennsylvanicus): effects on posture, spontaneous locomotor activity and swimming behavior.

Behav Brain Res 1992 Mar;47(1):13-22

Department of Psychology, University of Western Ontario, London, Canada.

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March 1992
11 Reads
3 Citations
3.030 Impact Factor

Hyperactivity, hyper-reactivity, and sensorimotor deficits induced by low doses of the N-methyl-D-aspartate non-competitive channel blocker MK801.

Behav Brain Res 1992 Mar;47(1):23-33

Department of Psychology, University of Western Ontario, London, Canada.

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March 1992
10 Reads
4 Citations
3.030 Impact Factor

Sodium arsanilate-induced vestibular dysfunction in rats: effects on open-field behavior and spontaneous activity in the automated digiscan monitoring system.

Pharmacol Biochem Behav 1990 Aug;36(4):875-81

Department of Psychology, University of Western Ontario, London, Canada.

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August 1990
9 Reads
10 Citations
2.781 Impact Factor

Learning and behavioral-long-term potentiation: importance of controlling for motor activity.

J Neurosci 1990 May;10(5):1472-8

Department of Psychology, University of Western Ontario, London, Canada.

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May 1990
10 Reads
4 Citations
6.344 Impact Factor

Top co-authors

Shabbar F Danish
Shabbar F Danish

University of Pennsylvania

7
Nitesh V Patel
Nitesh V Patel

New Jersey Medical School

4
James J Knierim
James J Knierim

Zanvyl Krieger Mind/Brain Institute

3
Stephen Wong
Stephen Wong

Houston Methodist Research Institute

2
Inah Lee
Inah Lee

Seoul National University

2
M Shapiro
M Shapiro

Albert-Ludwigs-Universität

1
Robert U Muller
Robert U Muller

SUNY Downstate Medical Center

1
Bruno Rivard
Bruno Rivard

The Robert F Furchgott Center for Neural and Behavioral Science

1
John L Kubie
John L Kubie

The Robert F. Furchgott Center for Neural and Behavioral Science

1
J Hall
J Hall

University of Wollongong

1