Publications by authors named "Eric Lécuyer"

47Publications

Translating Messages in Different Neighborhoods.

Dev Cell 2020 Sep;54(6):691-693

Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC, Canada; Division of Experimental Medicine, McGill University, Montréal, QC, Canada; Département de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, QC, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2020.09.006DOI Listing
September 2020

Staufen1 localizes to the mitotic spindle and controls the localization of RNA populations to the spindle.

J Cell Sci 2020 Jul 23;133(14). Epub 2020 Jul 23.

Département de biochimie et médecine moléculaire, Faculté de médecine, Université de Montréal, 2900 Édouard Montpetit, Montréal, QC H3T 1J4, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.247155DOI Listing
July 2020

Inter-dependent Centrosomal Co-localization of the cen and ik2 cis-Natural Antisense mRNAs in Drosophila.

Cell Rep 2020 03;30(10):3339-3352.e6

Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC, Canada; Département de Biochimie et Médecine Moléculaire and Programme de Biologie Moléculaire, Université de Montréal, Montréal, QC, Canada; Division of Experimental Medicine, McGill University, Montréal, QC, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2020.02.047DOI Listing
March 2020

Bioinformatics Approaches to Gain Insights into cis-Regulatory Motifs Involved in mRNA Localization.

Adv Exp Med Biol 2019 ;1203:165-194

Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-030-31434-7_7DOI Listing
December 2019

oRNAment: a database of putative RNA binding protein target sites in the transcriptomes of model species.

Nucleic Acids Res 2020 01;48(D1):D166-D173

Institut de Recherches Cliniques de Montréal (IRCM) Montréal, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkz986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145663PMC
January 2020

A ribosomal protein S5 isoform is essential for oogenesis and interacts with distinct RNAs in Drosophila melanogaster.

Sci Rep 2019 09 24;9(1):13779. Epub 2019 Sep 24.

Department of Biology, McGill University, 3649 Promenade Sir William Osler, Montréal, QC, H3G 0B1, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-50357-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760144PMC
September 2019

Prediction of mRNA subcellular localization using deep recurrent neural networks.

Bioinformatics 2019 07;35(14):i333-i342

School of Computer Science, McGill University, Montreal, QC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btz337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612824PMC
July 2019

Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.

Neuron 2019 09 1;103(5):802-819.e11. Epub 2019 Jul 1.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Stem Cell Program, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2019.05.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728177PMC
September 2019

Biological functions, regulatory mechanisms, and disease relevance of RNA localization pathways.

FEBS Lett 2018 09 5;592(17):2948-2972. Epub 2018 Sep 5.

Institut de recherches cliniques de Montréal (IRCM), QC, Canada.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/1873-3468.13228
Publisher Site
http://dx.doi.org/10.1002/1873-3468.13228DOI Listing
September 2018

Flying the RNA Nest: Drosophila Reveals Novel Insights into the Transcriptome Dynamics of Early Development.

J Dev Biol 2018 Mar 7;6(1). Epub 2018 Mar 7.

Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jdb6010005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875563PMC
March 2018

Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules.

Cell 2018 01;172(3):590-604.e13

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Stem Cell Program, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92039, USA; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore; Molecular Engineering Laboratory, A(∗)STAR, Singapore 138673, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2017.12.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969999PMC
January 2018

Optimized FISH methods for visualizing RNA localization properties in Drosophila and human tissues and cultured cells.

Methods 2017 08 28;126:156-165. Epub 2017 Jun 28.

Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec H2W 1R7, Canada; Département de Biochimie, Université de Montréal, Montréal, Québec H3T 1J4, Canada; Division of Experimental Medicine, McGill University, Montréal, Québec H4A 3J1, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2017.06.027DOI Listing
August 2017

RNA localization: Making its way to the center stage.

Biochim Biophys Acta Gen Subj 2017 Nov 16;1861(11 Pt B):2956-2970. Epub 2017 Jun 16.

Institut de recherches cliniques de Montréal (IRCM), 110 Avenue des Pins Ouest, Montreal, Quebec, Canada; Division of Experimental Medicine, McGill University, 1001 Decarie Boulevard, Montreal, Quebec, Canada; Department of Biochemistry and Molecular Medicine, University of Montreal, 2900 Boulevard Edouard-Montpetit, Montreal, Quebec, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbagen.2017.06.011DOI Listing
November 2017

CeFra-seq: Systematic mapping of RNA subcellular distribution properties through cell fractionation coupled to deep-sequencing.

Methods 2017 08 2;126:138-148. Epub 2017 Jun 2.

Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada; Département de Biochimie, Université de Montréal, Montréal, Québec, Canada; Division of Experimental Medicine, McGill University, Montréal, Québec, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2017.05.017DOI Listing
August 2017

Small Luggage for a Long Journey: Transfer of Vesicle-Enclosed Small RNA in Interspecies Communication.

Front Microbiol 2017 16;8:377. Epub 2017 Mar 16.

Institut de Recherches Cliniques de Montréal (IRCM), RNA Biology DepartmentMontreal, QC, Canada; Département de Biochimie, Université de MontréalMontreal, QC, Canada; Divison of Experimental Medicine, McGill UniversityMontreal, QC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2017.00377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352665PMC
March 2017

Biochemical Fractionation of Time-Resolved Drosophila Embryos Reveals Similar Transcriptomic Alterations in Replication Checkpoint and Histone mRNA Processing Mutants.

J Mol Biol 2017 10 3;429(21):3264-3279. Epub 2017 Feb 3.

Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, H2W 1R7, Canada; Département de Biochimie, Université de Montréal, Montréal, Québec, H2W 1R7, Canada; Division of Experimental Medicine, McGill University, Montréal, Québec, Canada. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00222836173006
Publisher Site
http://dx.doi.org/10.1016/j.jmb.2017.01.022DOI Listing
October 2017

[The embryonic DNA damage response: emerging functions of messenger RNA nuclear retention].

Med Sci (Paris) 2014 Dec 24;30(12):1070-3. Epub 2014 Dec 24.

Institut de recherches cliniques de Montréal (IRCM), laboratoire de biologie des ARN, 110 avenue des Pins, Ouest, Montréal H2W 1R7, Québec, Canada - Département de biochimie, Université de Montréal, Montréal, Québec, Canada - Division of experimental medicine, McGill University, Montréal, Québec, Canada.

View Article

Download full-text PDF

Source
http://www.medecinesciences.org/10.1051/medsci/20143012005
Publisher Site
http://dx.doi.org/10.1051/medsci/20143012005DOI Listing
December 2014

SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells.

PLoS Genet 2014 Dec 18;10(12):e1004768. Epub 2014 Dec 18.

Institute of Research in Immunology and Cancer - University of Montreal, Montreal, Quebec, Canada; Molecular Biology Program, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada; Department of Biochemistry, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada; Department of Pharmacology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1004768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270438PMC
December 2014

The functions and regulatory principles of mRNA intracellular trafficking.

Adv Exp Med Biol 2014 ;825:57-96

Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-1221-6_2DOI Listing
December 2014

Kit and Scl regulation of hematopoietic stem cells.

Curr Opin Hematol 2014 Jul;21(4):256-64

aInstitute of Research in Immunology and Cancer, University of Montreal bMolecular Biology Program, Faculty of Medicine, University of Montreal cInstitut de Recherches Cliniques de Montreal (IRCM) dDepartment of Biochemistry eDepartment of Pharmacology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOH.0000000000000052DOI Listing
July 2014

Developmentally regulated elimination of damaged nuclei involves a Chk2-dependent mechanism of mRNA nuclear retention.

Dev Cell 2014 May 15;29(4):468-81. Epub 2014 May 15.

Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada; Département de Biochimie, Université de Montréal, Montréal, QC H3T 1J4, Canada; Division of Experimental Medicine, McGill University, Montréal, QC H3A 1A3, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2014.03.025DOI Listing
May 2014

The many functions of mRNA localization during normal development and disease: from pillar to post.

Wiley Interdiscip Rev Dev Biol 2013 Nov-Dec;2(6):781-96. Epub 2013 Mar 18.

Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/wdev.113DOI Listing
April 2014

SPARCS: a web server to analyze (un)structured regions in coding RNA sequences.

Nucleic Acids Res 2013 Jul 8;41(Web Server issue):W480-5. Epub 2013 Jun 8.

School of Computer Science & McGill Centre for Bioinformatics, McGill University, Montréal, H3A 0C6 QC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkt461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692110PMC
July 2013

High resolution fluorescent in situ hybridization in Drosophila.

Authors:
Eric Lécuyer

Methods Mol Biol 2011 ;714:31-47

Institut de Recherches Cliniques de Montréal (IRCM), Ouest Montréal, QC, Canada.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-61779-005-8_3
Publisher Site
http://dx.doi.org/10.1007/978-1-61779-005-8_3DOI Listing
July 2011

Global implications of mRNA localization pathways in cellular organization.

Curr Opin Cell Biol 2009 Jun 25;21(3):409-15. Epub 2009 Feb 25.

Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario, Canada M5S 3E1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ceb.2009.01.027DOI Listing
June 2009

Mapping the gene expression universe.

Curr Opin Genet Dev 2008 Dec 20;18(6):506-12. Epub 2008 Sep 20.

Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gde.2008.08.003DOI Listing
December 2008

Fluorescent in situ hybridization protocols in Drosophila embryos and tissues.

Methods Mol Biol 2008 ;420:289-302

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-583-1_18DOI Listing
August 2008

[Unraveling the mRNA localization code].

Authors:
Eric Lécuyer

Med Sci (Paris) 2008 Apr;24(4):350-1

University of Toronto, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Room 504, Toronto, Ontario, M5S 3E1 Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/medsci/2008244350DOI Listing
April 2008

High-resolution fluorescent in situ hybridization of Drosophila embryos and tissues.

CSH Protoc 2008 Jun 1;2008:pdb.prot5019. Epub 2008 Jun 1.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/pdb.prot5019DOI Listing
June 2008

Protein stability and transcription factor complex assembly determined by the SCL-LMO2 interaction.

J Biol Chem 2007 Nov 17;282(46):33649-58. Epub 2007 Sep 17.

Institut de Recherche en Immunologie et Cancérologie, Department of Molecular Biology, Université de Montréal, Montréal, Québec H3C 2J7, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M703939200DOI Listing
November 2007

SCL assembles a multifactorial complex that determines glycophorin A expression.

Mol Cell Biol 2004 Feb;24(4):1439-52

Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC344179PMC
http://dx.doi.org/10.1128/mcb.24.4.1439-1452.2004DOI Listing
February 2004

SCL: from the origin of hematopoiesis to stem cells and leukemia.

Exp Hematol 2004 Jan;32(1):11-24

Institut de Recherche en Immunovirologie et Cancérologie (IRIC), Montreal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2003.10.010DOI Listing
January 2004

Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL.

J Biol Chem 2003 Apr 3;278(15):12680-7. Epub 2003 Feb 3.

Clinical Research Institute of Montréal, Montréal, Québec H2W 1R7, Canada.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M209870200
Publisher Site
http://dx.doi.org/10.1074/jbc.M209870200DOI Listing
April 2003

The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1.

Blood 2002 Oct;100(7):2430-40

Clinical Research Institute of Montreal and from the Departments of Pharmacology, Biochemistry, and Molecular Biology, Université de Montréal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2002-02-0568DOI Listing
October 2002