Eric Karran

Eric Karran

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Eric Karran

Eric Karran

Publications by authors named "Eric Karran"

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The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.

Cell Rep 2019 Apr;27(4):1293-1306.e6

VIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium; UK Dementia Research Institute, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.099DOI Listing
April 2019

Precision pharmacology for Alzheimer's disease.

Pharmacol Res 2018 04 16;130:331-365. Epub 2018 Feb 16.

AXA Research Fund & Sorbonne University Chair, Paris, France; Sorbonne University, GRC No. 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Boulevard de l'hôpital, F-75013, Paris, France; Brain & Spine Institute (ICM), INSERM U 1127, CNRS UMR 7225, Boulevard de l'hôpital, F-75013, Paris, France; Institute of Memory and Alzheimer's Disease (IM2A), Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Boulevard de l'hôpital, F-75013, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.02.014DOI Listing
April 2018

Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.

Sci Rep 2018 04 4;8(1):5667. Epub 2018 Apr 4.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK.

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http://www.nature.com/articles/s41598-018-24029-3
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http://dx.doi.org/10.1038/s41598-018-24029-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884858PMC
April 2018

The amyloid cascade hypothesis: are we poised for success or failure?

J Neurochem 2016 10 3;139 Suppl 2:237-252. Epub 2016 Jun 3.

VIB Center for the Biology of Disease, VIB-Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/jnc.13632DOI Listing
October 2016

The Cellular Phase of Alzheimer's Disease.

Cell 2016 Feb;164(4):603-15

Center for Human Genetics, Universitaire Ziekenhuizen and LIND, KU Leuven, 3000 Leuven, Belgium; Institute of Neurology, University College London, Queen Square, WC1N 3BG London, UK; Alzheimer Research UK, Cambridge, CB21 6AD, UK.

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http://dx.doi.org/10.1016/j.cell.2015.12.056DOI Listing
February 2016

Recent trial shows that solanezumab has disease modifying effects.

Authors:
Eric Karran

BMJ 2015 Aug 28;351:h4528. Epub 2015 Aug 28.

Alzheimer's Research UK, Cambridge CB21 6AD, UK

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http://dx.doi.org/10.1136/bmj.h4528DOI Listing
August 2015

Report from the Alzheimer's Research UK Conference 2015.

Alzheimers Res Ther 2015 07 28;7(1):52. Epub 2015 Jul 28.

Alzheimer's Research UK, 3 Riverside, Granta Park, Cambridge, CB21 6 AD, UK.

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http://dx.doi.org/10.1186/s13195-015-0138-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517508PMC
July 2015

Eric Karran.

Nat Rev Drug Discov 2015 Apr 20;14(4):230-1. Epub 2015 Mar 20.

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http://dx.doi.org/10.1038/nrd4584DOI Listing
April 2015

A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease.

Ann Neurol 2014 Aug 2;76(2):185-205. Epub 2014 Jul 2.

Alzheimer's Research UK, Cambridge; Reta Lila Weston Laboratories, London; Department of Molecular Neuroscience, University College London, London, United Kingdom.

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http://doi.wiley.com/10.1002/ana.24188
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http://dx.doi.org/10.1002/ana.24188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204160PMC
August 2014

Antiamyloid therapy for Alzheimer's disease--are we on the right road?

N Engl J Med 2014 Jan;370(4):377-8

From Reta Lila Weston Laboratories and the Department of Molecular Neuroscience, University College London, London (E.K., J.H.), and Alzheimer's Research UK, Cambridge (E.K.) - both in the United Kingdom.

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http://dx.doi.org/10.1056/NEJMe1313943DOI Listing
January 2014

Current status of vaccination therapies in Alzheimer's disease.

Authors:
Eric Karran

J Neurochem 2012 Dec 11;123(5):647-51. Epub 2012 Oct 11.

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http://dx.doi.org/10.1111/jnc.12009DOI Listing
December 2012

Alzheimer's research UK: defeating dementia through research.

Authors:
Eric Karran

Stem Cells Transl Med 2012 Jun 30;1(6):449-50. Epub 2012 May 30.

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http://dx.doi.org/10.5966/sctm.2012-0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659715PMC
June 2012

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes.

Nat Neurosci 2012 Jan 29;15(3):349-57. Epub 2012 Jan 29.

Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases (LIND), University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/nn.3028DOI Listing
January 2012

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics.

Nat Rev Drug Discov 2011 Aug 19;10(9):698-712. Epub 2011 Aug 19.

Janssen Research and Development, Neuroscience Therapeutic Area, Turnhoutseweg 30, 2340 Beerse, Belgium. com

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http://dx.doi.org/10.1038/nrd3505DOI Listing
August 2011

Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.

J Biol Chem 2011 Mar 5;286(10):8677-87. Epub 2011 Jan 5.

Department of Molecular and Developmental Genetics, VIB, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M110.194860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048749PMC
March 2011

Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues.

Neuropharmacology 2010 Nov 21;59(6):367-74. Epub 2010 May 21.

Neuroscience Discovery Research, Neurodegeneration Drug Hunting Team, Eli Lilly and Company Limited, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00283908100012
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http://dx.doi.org/10.1016/j.neuropharm.2010.05.004DOI Listing
November 2010

Current and Future Perspectives in Psychiatric Drug Discovery.

Drug News Perspect 2009 Jul-Aug;22(6):360-4

Zebrafish Business Unit, Summit plc, Oxford, UK.

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http://dx.doi.org/10.1358/dnp.2009.22.6.1380328DOI Listing
December 2009

Development of homogeneous 384-well high-throughput screening assays for Abeta1-40 and Abeta1-42 using AlphaScreen technology.

J Biomol Screen 2008 Feb 23;13(2):101-11. Epub 2008 Jan 23.

Eli Lilly and Co. Ltd, Lilly Research Centre, Windlesham, Surrey, UK.

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http://dx.doi.org/10.1177/1087057107312778DOI Listing
February 2008

Neurodegenerative disorders and their treatment.

Drug News Perspect 2007 Jul-Aug;20(6):407-12

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January 2008

Neuroreplacement, growth factor, and small molecule neurotrophic approaches for treating Parkinson's disease.

Int Rev Neurobiol 2007 ;77:179-217

Eli Lilly and Co. Ltd., Lilly Research Centre, Erl Wood Manor, Windlesham Surrey GU20 6PH, United Kingdom.

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http://dx.doi.org/10.1016/S0074-7742(06)77006-4DOI Listing
September 2007

Translational sciences-turning drug-like molecules into medicines.

Drug News Perspect 2006 Dec;19(10):659-63

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December 2006

The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.

Circ Res 2003 Aug 17;93(3):e26-32. Epub 2003 Jul 17.

Discovery Biology (IPC351), Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK.

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http://dx.doi.org/10.1161/01.RES.0000086943.72932.71DOI Listing
August 2003

Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface.

Biochem J 2002 Mar;362(Pt 3):585-95

Department of Anesthesiology, University of Illinois at Chicago, 1819 W. Polk St. (M/C 519), Chicago, IL 60612, U.S.A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222422PMC
http://dx.doi.org/10.1042/0264-6021:3620585DOI Listing
March 2002