Eric J Sundberg

Eric J Sundberg

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Eric J Sundberg

Publications by authors named "Eric J Sundberg"

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Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy.

Cell Res 2019 Jul 2. Epub 2019 Jul 2.

Divisions of Immunotherapy, University of Maryland Baltimore School of Medicine, Baltimore, MD, 21201, USA.

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http://dx.doi.org/10.1038/s41422-019-0184-1DOI Listing
July 2019

Direct CD137 costimulation of CD8 T cells promotes retention and innate-like function within nascent atherogenic foci.

Am J Physiol Heart Circ Physiol 2019 Jun 12;316(6):H1480-H1494. Epub 2019 Apr 12.

Department of Immunology, University of Connecticut Health School of Medicine , Farmington, Connecticut.

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http://dx.doi.org/10.1152/ajpheart.00088.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620679PMC
June 2019

Structural Basis of IL-1 Family Cytokine Signaling.

Front Immunol 2019 20;10:1412. Epub 2019 Jun 20.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States.

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http://dx.doi.org/10.3389/fimmu.2019.01412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596353PMC
June 2019

Roles of Adhesion to Epithelial Cells in Gastric Colonization by Helicobacter pylori.

Adv Exp Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Institute of Human Virology, University of Maryland School of Medicine, University of Maryland, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/5584_2019_359DOI Listing
April 2019

Small-Molecule Inhibitor of FosA Expands Fosfomycin Activity to Multidrug-Resistant Gram-Negative Pathogens.

Antimicrob Agents Chemother 2019 Mar 26;63(3). Epub 2019 Feb 26.

Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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http://dx.doi.org/10.1128/AAC.01524-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395921PMC
March 2019

Molecular Basis of Broad Spectrum -Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2.

ACS Cent Sci 2019 Mar 6;5(3):524-538. Epub 2019 Feb 6.

Institute of Human Virology, Department of Microbiology & Immunology, and Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.

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http://dx.doi.org/10.1021/acscentsci.8b00917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439443PMC
March 2019

High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3.

Sci Rep 2018 Nov 30;8(1):17512. Epub 2018 Nov 30.

Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

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http://www.nature.com/articles/s41598-018-35754-0
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http://dx.doi.org/10.1038/s41598-018-35754-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269442PMC
November 2018

Common Challenges in Studying the Structure and Function of Bacterial Proteins: Case Studies from Helicobacter pylori.

Methods Mol Biol 2017 ;1535:77-93

Institute of Human Virology, University of Maryland School of Medicine, 725 W. Lombard St., Baltimore, MD, 21201, USA.

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http://dx.doi.org/10.1007/978-1-4939-6673-8_6DOI Listing
January 2018

A structural model of flagellar filament switching across multiple bacterial species.

Nat Commun 2017 10 16;8(1):960. Epub 2017 Oct 16.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.

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http://dx.doi.org/10.1038/s41467-017-01075-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643327PMC
October 2017

IL-1 Family Cytokines Use Distinct Molecular Mechanisms to Signal through Their Shared Co-receptor.

Immunity 2017 09;47(3):510-523.e4

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849085PMC
September 2017

Getting oriented with antibodies.

Biochem J 2017 02;474(4):517-519

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, U.S.A.

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http://dx.doi.org/10.1042/BCJ20160996DOI Listing
February 2017

Motility and adhesion through type IV pili in Gram-positive bacteria.

Biochem Soc Trans 2016 12;44(6):1659-1666

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, U.S.A.

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http://dx.doi.org/10.1042/BST20160221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830096PMC
December 2016

Molecular basis for epitope recognition by non-neutralizing anti-gp41 antibody F240.

Sci Rep 2016 11 9;6:36685. Epub 2016 Nov 9.

Division of Vaccine Research of Institute of Human Virology, the University of Maryland School of Medicine, Baltimore, USA.

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http://dx.doi.org/10.1038/srep36685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101508PMC
November 2016

Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA.

Nat Microbiol 2016 10 17;2:16188. Epub 2016 Oct 17.

Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität, Pettenkoferstraße 9a, München D-80336, Germany.

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http://dx.doi.org/10.1038/nmicrobiol.2016.188DOI Listing
October 2016

The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo.

Glycobiology 2016 08 25;26(8):834-49. Epub 2016 May 25.

Baltimore Veterans Affairs Medical Center, 10 North Greene Street, Baltimore, MD 21201, USA Center for Vaccine Development, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA

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http://dx.doi.org/10.1093/glycob/cww060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884327PMC
August 2016

Type IV pili promote early biofilm formation by Clostridium difficile.

Pathog Dis 2016 08 30;74(6). Epub 2016 Jun 30.

Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA Department of Veterans Affairs, VA Maryland Health Care System, Baltimore, MD 21201, USA

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http://dx.doi.org/10.1093/femspd/ftw061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985507PMC
August 2016

Diverse oligomeric states of CEACAM IgV domains.

Proc Natl Acad Sci U S A 2015 Nov 19;112(44):13561-6. Epub 2015 Oct 19.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201

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http://dx.doi.org/10.1073/pnas.1509511112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640789PMC
November 2015

Structure of the N-terminal dimerization domain of CEACAM7.

Acta Crystallogr F Struct Biol Commun 2015 Sep 25;71(Pt 9):1169-75. Epub 2015 Aug 25.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1107/S2053230X15013576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555925PMC
September 2015

An Intrinsically Disordered Region in the Proapoptotic ASPP2 Protein Binds to the Helicobacter pylori Oncoprotein CagA.

Biochemistry 2015 Jun 20;54(21):3337-47. Epub 2015 May 20.

‡Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1021/acs.biochem.5b00084DOI Listing
June 2015

A Decoy Peptide that Disrupts TIRAP Recruitment to TLRs Is Protective in a Murine Model of Influenza.

Cell Rep 2015 Jun 18;11(12):1941-52. Epub 2015 Jun 18.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490105PMC
June 2015

Integrin engagement by the helical RGD motif of the Helicobacter pylori CagL protein is regulated by pH-induced displacement of a neighboring helix.

J Biol Chem 2015 May 2;290(20):12929-40. Epub 2015 Apr 2.

From the Institute of Human Virology and the Departments of Medicine and Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201,

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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.641829
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http://dx.doi.org/10.1074/jbc.M115.641829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432307PMC
May 2015

Structural and evolutionary analyses show unique stabilization strategies in the type IV pili of Clostridium difficile.

Structure 2015 Feb 15;23(2):385-96. Epub 2015 Jan 15.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2014.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318773PMC
February 2015

Molecular interactions in interleukin and toll-like receptor signaling pathways.

Curr Pharm Des 2014 ;20(8):1244-58

Institute of Human Virology, Department of Medicine, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201 USA.

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December 2014

Molecular determinants of agonist and antagonist signaling through the IL-36 receptor.

J Immunol 2014 Jul 16;193(2):921-30. Epub 2014 Jun 16.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201; and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201

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http://dx.doi.org/10.4049/jimmunol.1400538DOI Listing
July 2014

Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies.

Proc Natl Acad Sci U S A 2014 May 21;111(18):6714-9. Epub 2014 Apr 21.

Institute of Human Virology and Departments of Biochemistry and Molecular Biology, Medicine, and Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.

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http://dx.doi.org/10.1073/pnas.1322908111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020096PMC
May 2014

Liquid-liquid diffusion crystallization improves the X-ray diffraction of EndoS, an endo-β-N-acetylglucosaminidase from Streptococcus pyogenes with activity on human IgG.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 Dec 29;69(Pt 12):1405-10. Epub 2013 Nov 29.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://scripts.iucr.org/cgi-bin/paper?S1744309113030650
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http://dx.doi.org/10.1107/S1744309113030650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855731PMC
December 2013

Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain.

Proc Natl Acad Sci U S A 2013 Nov 5;110(47):19036-41. Epub 2013 Nov 5.

Departments of Microbiology and Immunology, Medicine, and Microbiology and Immunology, and Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201.

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http://dx.doi.org/10.1073/pnas.1313575110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839745PMC
November 2013

With an antibody whose duty's double, a step towards ending asthma trouble?

Authors:
Eric J Sundberg

Biochem J 2013 Apr;451(2):e1-3

Institute of Human Virology, Department of Medicine, Department of Microbiology and Immunology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1042/BJ20130305DOI Listing
April 2013

R753Q polymorphism inhibits Toll-like receptor (TLR) 2 tyrosine phosphorylation, dimerization with TLR6, and recruitment of myeloid differentiation primary response protein 88.

J Biol Chem 2012 Nov 19;287(45):38327-37. Epub 2012 Sep 19.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1074/jbc.M112.375493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488101PMC
November 2012

Dissecting protein-protein interactions using directed evolution.

Biochemistry 2011 Apr 1;50(13):2394-402. Epub 2011 Mar 1.

Boston Biomedical Research Institute, 64 Grove Street, Watertown, Massachusetts 02472, United States.

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http://dx.doi.org/10.1021/bi102019cDOI Listing
April 2011

HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide.

Nat Immunol 2011 Jan 5;12(1):54-61. Epub 2010 Dec 5.

Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.1967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018327PMC
January 2011

Assessing energetic contributions to binding from a disordered region in a protein-protein interaction .

Biochemistry 2010 Nov;49(43):9256-68

W. M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1021/bi1008968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964404PMC
November 2010

A single, engineered protein therapeutic agent neutralizes exotoxins from both Staphylococcus aureus and Streptococcus pyogenes.

Clin Vaccine Immunol 2010 Nov 22;17(11):1781-9. Epub 2010 Sep 22.

Department of Biochemistry, University of Illinois, 600 S. Mathews Ave., Urbana, IL 61801, USA.

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http://cvi.asm.org/cgi/doi/10.1128/CVI.00277-10
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http://dx.doi.org/10.1128/CVI.00277-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976085PMC
November 2010

HLA-B*35-Px-mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses.

J Exp Med 2009 Dec 14;206(13):2959-66. Epub 2009 Dec 14.

The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA 02129. USA.

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http://dx.doi.org/10.1084/jem.20091386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806456PMC
December 2009

Structural basis of antibody-antigen interactions.

Authors:
Eric J Sundberg

Methods Mol Biol 2009 ;524:23-36

Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA.

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http://dx.doi.org/10.1007/978-1-59745-450-6_2DOI Listing
July 2009

Molecular recognition of diverse ligands by T-cell receptors.

Authors:
Eric J Sundberg

Methods Mol Biol 2009 ;524:347-59

Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA.

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http://dx.doi.org/10.1007/978-1-59745-450-6_25DOI Listing
July 2009

Regulation of Ca2+/calmodulin kinase II by a small C-terminal domain phosphatase.

Biochem J 2008 Jun;412(3):507-16

Department of Health Sciences, Sargent College, Boston University, 635 Commonwealth Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1042/BJ20071582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724867PMC
June 2008

TCR recognition of peptide/MHC class II complexes and superantigens.

Semin Immunol 2007 Aug 7;19(4):262-71. Epub 2007 Jun 7.

Boston Biomedical Research Institute, Watertown, MA 02472, USA.

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http://dx.doi.org/10.1016/j.smim.2007.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949352PMC
August 2007

Recombinant expression and purification of the N-terminal extracellular domain of the parathyroid hormone receptor.

Protein Expr Purif 2007 Jul 6;54(1):87-93. Epub 2007 Mar 6.

Department of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.

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http://dx.doi.org/10.1016/j.pep.2007.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1925138PMC
July 2007

Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists.

Nat Med 2007 Jun 21;13(6):725-9. Epub 2007 May 21.

Department of Biochemistry, University of Illinois, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1038/nm1584DOI Listing
June 2007

Long-range cooperative binding effects in a T cell receptor variable domain.

Proc Natl Acad Sci U S A 2006 Jun 20;103(26):9867-72. Epub 2006 Jun 20.

Boston Biomedical Research Institute, Watertown, MA 02472, USA.

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http://dx.doi.org/10.1073/pnas.0600220103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502545PMC
June 2006

Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction.

Structure 2005 Dec;13(12):1775-87

Center for Advanced Research in Biotechnology, W.M. Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09692126050035
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http://dx.doi.org/10.1016/j.str.2005.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746401PMC
December 2005

Characterization of T cell receptors engineered for high affinity against toxic shock syndrome toxin-1.

J Mol Biol 2005 Oct;353(2):308-21

Department of Biochemistry, University of Illinois, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.jmb.2005.08.041DOI Listing
October 2005

Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution.

J Mol Biol 2005 Apr;347(4):683-91

Center for Advanced Research in Biotechnology, W. M. Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.jmb.2005.01.070DOI Listing
April 2005

Cloning, expression and interaction of human T-cell receptors with the bacterial superantigen SSA.

Eur J Biochem 2004 Oct;271(20):4075-83

Cátedra de Inmunología and Instituto de Estudios de la Inmunidad Humoral (IDEHU), CONICET, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.

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http://dx.doi.org/10.1111/j.1432-1033.2004.04345.xDOI Listing
October 2004

Structural mechanism governing cis and trans isomeric states and an intramolecular switch for cis/trans isomerization of a non-proline peptide bond observed in crystal structures of scorpion toxins.

J Mol Biol 2004 Aug;341(5):1189-204

Center for Structural and Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, People's Republic of China.

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http://dx.doi.org/10.1016/j.jmb.2004.06.067DOI Listing
August 2004

Dissecting cooperative and additive binding energetics in the affinity maturation pathway of a protein-protein interface.

J Biol Chem 2003 Dec 27;278(50):50412-21. Epub 2003 Sep 27.

Center for Advanced Research in Biotechnology, W. M. Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA.

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http://dx.doi.org/10.1074/jbc.M306848200DOI Listing
December 2003

Exploration of the P6/P7 region of the peptide-binding site of the human class II major histocompatability complex protein HLA-DR1.

J Biol Chem 2003 Nov 1;278(45):44904-12. Epub 2003 Sep 1.

Massachusetts Institute of Technology, Department of Chemistry, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1074/jbc.M307652200DOI Listing
November 2003

Structural, energetic, and functional analysis of a protein-protein interface at distinct stages of affinity maturation.

Structure 2003 Sep;11(9):1151-61

Center for Advanced Research in Biotechnology, W.M. Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD 20850, USA.

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September 2003

Molecular recognition in antibody-antigen complexes.

Adv Protein Chem 2002 ;61:119-60

Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA.

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April 2003

Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes.

Structure 2002 May;10(5):687-99

Center for Advanced Research in Biotechnology, W.M. Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD 20850, USA.

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May 2002

Minor structural changes in a mutated human melanoma antigen correspond to dramatically enhanced stimulation of a CD4+ tumor-infiltrating lymphocyte line.

J Mol Biol 2002 May;319(2):449-61

Center for Advanced Research in Biotechnology, W. M. Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD 20850, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360200370
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http://dx.doi.org/10.1016/S0022-2836(02)00370-4DOI Listing
May 2002

Quantifying the energetics of cooperativity in a ternary protein complex.

Biochemistry 2002 Apr;41(16):5177-84

Institute of Medical Microbiology and Immunology, University of Copenhagen, Blegdamsvej 3C, DK-2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1021/bi0200209DOI Listing
April 2002

So many ways of getting in the way: diversity in the molecular architecture of superantigen-dependent T-cell signaling complexes.

Curr Opin Immunol 2002 Feb;14(1):36-44

Center for Advanced Research in Biotechnology, WM Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD 20850, USA.

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February 2002