Publications by authors named "Eric J Snijder"

100Publications

Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements.

Nucleic Acids Res 2020 12;48(22):12436-12452

Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Nijenborgh 7, 9747 AG, Groningen, the Netherlands.

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December 2020

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2.

J Virol 2020 11 9;94(23). Epub 2020 Nov 9.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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November 2020

Coronavirus discovery by metagenomic sequencing: a tool for pandemic preparedness.

J Clin Virol 2020 Oct 21;131:104594. Epub 2020 Aug 21.

Department of Medical Microbiology, Leiden University Medical Center (LUMC), Leiden, the Netherlands.

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October 2020

A molecular pore spans the double membrane of the coronavirus replication organelle.

Science 2020 09 6;369(6509):1395-1398. Epub 2020 Aug 6.

Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2333 ZC, Netherlands.

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September 2020

Single-Round Infectious Particle Production by DNA-Launched Infectious Clones of Bungowannah Pestivirus.

Viruses 2020 08 4;12(8). Epub 2020 Aug 4.

Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany.

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August 2020

Double-Membrane Vesicles as Platforms for Viral Replication.

Trends Microbiol 2020 Dec 11;28(12):1022-1033. Epub 2020 Jun 11.

Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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December 2020

A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis.

PLoS Biol 2020 06 8;18(6):e3000715. Epub 2020 Jun 8.

Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.

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June 2020

Mind the gap: Micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae.

J Struct Biol 2019 12 16;208(3):107389. Epub 2019 Sep 16.

Department of Cell and Chemical Biology, Section Electron Microscopy, Leiden University Medical Center, Leiden 2333 ZC, The Netherlands. Electronic address:

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December 2019

The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity.

Front Microbiol 2019 7;10:1813. Epub 2019 Aug 7.

Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands.

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August 2019

Adaptive Mutations in Replicase Transmembrane Subunits Can Counteract Inhibition of Equine Arteritis Virus RNA Synthesis by Cyclophilin Inhibitors.

J Virol 2019 09 28;93(18). Epub 2019 Aug 28.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.

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September 2019

Origins of Enterovirus Replication Organelles Established by Whole-Cell Electron Microscopy.

mBio 2019 06 11;10(3). Epub 2019 Jun 11.

Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands

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June 2019

Cyclophilins and cyclophilin inhibitors in nidovirus replication.

Virology 2018 09 12;522:46-55. Epub 2018 Jul 12.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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September 2018

Transcriptional and Translational Landscape of Equine Torovirus.

J Virol 2018 09 16;92(17). Epub 2018 Aug 16.

Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom

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September 2018

Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture.

Virology 2018 04 15;517:148-156. Epub 2017 Dec 15.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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April 2018

Host Factors in Coronavirus Replication.

Curr Top Microbiol Immunol 2018;419:1-42

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.

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June 2019

Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles.

Antiviral Res 2017 07 28;143:230-236. Epub 2017 Apr 28.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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July 2017

Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes.

Virus Res 2017 04 6;234:58-73. Epub 2017 Feb 6.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.

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April 2017

Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model.

Virus Res 2017 01 10;228:7-13. Epub 2016 Nov 10.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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January 2017

A novel role for poly(C) binding proteins in programmed ribosomal frameshifting.

Nucleic Acids Res 2016 07 2;44(12):5491-503. Epub 2016 Jun 2.

Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK

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July 2016

Identification and Characterization of a Ribose 2'-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales.

J Virol 2016 08 11;90(15):6675-6685. Epub 2016 Jul 11.

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China

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August 2016

Biogenesis and architecture of arterivirus replication organelles.

Virus Res 2016 07 9;220:70-90. Epub 2016 Apr 9.

Electron Microscopy Section, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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July 2016

Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive.

Virology 2016 Jan 23;487:68-74. Epub 2015 Oct 23.

Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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January 2016

Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses.

Nucleic Acids Res 2015 Sep 24;43(17):8416-34. Epub 2015 Aug 24.

Department of Medical Microbiology, Leiden University Medical Center, Leiden, 2300 RC, Leiden, The Netherlands Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119899 Moscow, Russia Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119899 Moscow, Russia

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September 2015

Suramin inhibits chikungunya virus replication through multiple mechanisms.

Antiviral Res 2015 Sep 22;121:39-46. Epub 2015 Jun 22.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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September 2015

Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity.

Bioorg Med Chem Lett 2015 Aug 23;25(15):2923-6. Epub 2015 May 23.

University of Maryland, Baltimore County, Department of Chemistry & Biochemistry, 1000 Hilltop Circle, Baltimore, MD 21250, USA. Electronic address:

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August 2015

In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2.

Vet Microbiol 2015 Jul 30;178(1-2):132-7. Epub 2015 Apr 30.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. Electronic address:

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July 2015

Temporal SILAC-based quantitative proteomics identifies host factors involved in chikungunya virus replication.

Proteomics 2015 Jul 22;15(13):2267-80. Epub 2015 Apr 22.

Department of Immunohematology and Blood transfusion, Leiden University Medical Center, ZA, Leiden, The Netherlands.

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July 2015

Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication.

J Virol 2015 Apr 4;89(8):4457-69. Epub 2015 Feb 4.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands

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April 2015

Proteolytic processing of the porcine reproductive and respiratory syndrome virus replicase.

Virus Res 2015 Apr 31;202:48-59. Epub 2014 Dec 31.

Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD, USA; Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA. Electronic address:

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April 2015

What we know but do not understand about nidovirus helicases.

Virus Res 2015 Apr 8;202:12-32. Epub 2014 Dec 8.

Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Russia. Electronic address:

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April 2015

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities.

Proc Natl Acad Sci U S A 2014 Sep 2;111(37):E3900-9. Epub 2014 Sep 2.

Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7257, Aix-Marseille Université, 13288 Marseille, France;

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September 2014

An in vitro assay to study chikungunya virus RNA synthesis and the mode of action of inhibitors.

J Gen Virol 2014 Dec 18;95(Pt 12):2683-2692. Epub 2014 Aug 18.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.

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December 2014

Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes.

J Biol Chem 2014 Sep 29;289(37):25783-96. Epub 2014 Jul 29.

Cancer Research Center of Marseille (CRCM), CNRS UMR7258, INSERM U1068, Institut Paoli-Calmettes, Aix-Marseille Université, F-13009 Marseille, France,

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September 2014

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.

J Antimicrob Chemother 2014 Oct 20;69(10):2770-84. Epub 2014 Jun 20.

Laboratory for Virology and Experimental Chemotherapy, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium.

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October 2014

Transactivation of programmed ribosomal frameshifting by a viral protein.

Proc Natl Acad Sci U S A 2014 May 13;111(21):E2172-81. Epub 2014 May 13.

Department of Veterinary and Biomedical Sciences and Department of Biology/Microbiology, South Dakota State University, Brookings, SD 57007;Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506;

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May 2014

Viral OTU deubiquitinases: a structural and functional comparison.

PLoS Pathog 2014 Mar 27;10(3):e1003894. Epub 2014 Mar 27.

Department of Microbiology, University of Manitoba, Winnipeg, Canada.

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March 2014

The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling.

J Gen Virol 2014 Apr 17;95(Pt 4):874-882. Epub 2014 Jan 17.

Department of Microbiology and Immunology, University of Maryland at Baltimore, 685 West Baltimore St, Room 380, Baltimore, MD 21201, USA.

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April 2014

Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase.

Nucleic Acids Res 2014 Mar 24;42(5):3464-77. Epub 2013 Dec 24.

State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100193, China, Department of Medical Microbiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands, Clinical Medicine Research Center, Affiliated Hospital of Guangdong Medical College, Guangdong 524001, China, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China, Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China and Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow 119991, Russia.

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March 2014

Arterivirus molecular biology and pathogenesis.

J Gen Virol 2013 Oct 12;94(Pt 10):2141-2163. Epub 2013 Aug 12.

Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.

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October 2013

Characterization of synthetic Chikungunya viruses based on the consensus sequence of recent E1-226V isolates.

PLoS One 2013 1;8(8):e71047. Epub 2013 Aug 1.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.

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March 2014

The footprint of genome architecture in the largest genome expansion in RNA viruses.

PLoS Pathog 2013 18;9(7):e1003500. Epub 2013 Jul 18.

Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.

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February 2014

Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells.

Proc Natl Acad Sci U S A 2013 Feb 11;110(9):E838-47. Epub 2013 Feb 11.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.

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February 2013

Cyclophilin inhibitors block arterivirus replication by interfering with viral RNA synthesis.

J Virol 2013 Feb 14;87(3):1454-64. Epub 2012 Nov 14.

Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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February 2013

Efficient -2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein.

Proc Natl Acad Sci U S A 2012 Oct 4;109(43):E2920-8. Epub 2012 Oct 4.

Departments of Veterinary and Biomedical Science and Biology/Microbiology, South Dakota State University, Brookings, SD 57007, USA.

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October 2012

Development and characterization of an infectious cDNA clone of the modified live virus vaccine strain of equine arteritis virus.

Clin Vaccine Immunol 2012 Aug 27;19(8):1312-21. Epub 2012 Jun 27.

Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, Kentucky, USA.

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August 2012

Organ tropism of murine coronavirus does not correlate with the expression levels of the membrane-anchored or secreted isoforms of the carcinoembryonic antigen-related cell adhesion molecule 1 receptor.

J Gen Virol 2012 Sep 6;93(Pt 9):1918-1923. Epub 2012 Jun 6.

Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, The Netherlands.

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September 2012

Mechanism of nucleic acid unwinding by SARS-CoV helicase.

PLoS One 2012 15;7(5):e36521. Epub 2012 May 15.

Christopher Bond Life Sciences Center, Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine, Columbia, Missouri, United States of America.

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September 2012

Mesoniviridae: a proposed new family in the order Nidovirales formed by a single species of mosquito-borne viruses.

Arch Virol 2012 Aug 24;157(8):1623-8. Epub 2012 Apr 24.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands.

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August 2012

Identification of porcine reproductive and respiratory syndrome virus ORF1a-encoded non-structural proteins in virus-infected cells.

J Gen Virol 2012 Apr 18;93(Pt 4):829-839. Epub 2012 Jan 18.

Department of Biology/Microbiology, South Dakota State University, Brookings, SD, USA.

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April 2012

Arterivirus minor envelope proteins are a major determinant of viral tropism in cell culture.

J Virol 2012 Apr 18;86(7):3701-12. Epub 2012 Jan 18.

Department of Swine Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.

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April 2012

Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15.

J Virol 2012 Apr 18;86(7):3839-50. Epub 2012 Jan 18.

Department of Veterinary and Biomedical Science/Department of Biology-Microbiology, South Dakota State University, Brookings, South Dakota, USA.

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April 2012

Ultrastructural characterization of arterivirus replication structures: reshaping the endoplasmic reticulum to accommodate viral RNA synthesis.

J Virol 2012 Mar 21;86(5):2474-87. Epub 2011 Dec 21.

Electron Microscopy Section, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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March 2012

Arterivirus and nairovirus ovarian tumor domain-containing Deubiquitinases target activated RIG-I to control innate immune signaling.

J Virol 2012 Jan 9;86(2):773-85. Epub 2011 Nov 9.

Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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January 2012

The SARS-coronavirus nsp7+nsp8 complex is a unique multimeric RNA polymerase capable of both de novo initiation and primer extension.

Nucleic Acids Res 2012 Feb 29;40(4):1737-47. Epub 2011 Oct 29.

Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, PO Box 9600, 2300RC Leiden, The Netherlands.

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February 2012

Cyclosporin A inhibits the replication of diverse coronaviruses.

J Gen Virol 2011 Nov 13;92(Pt 11):2542-2548. Epub 2011 Jul 13.

Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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November 2011

Development and RNA-synthesizing activity of coronavirus replication structures in the absence of protein synthesis.

J Virol 2011 Jun 23;85(11):5669-73. Epub 2011 Mar 23.

Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

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June 2011

Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production.

J Gen Virol 2011 May 9;92(Pt 5):1097-1106. Epub 2011 Feb 9.

Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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May 2011

Characterization of equine humoral antibody response to the nonstructural proteins of equine arteritis virus.

Clin Vaccine Immunol 2011 Feb 8;18(2):268-79. Epub 2010 Dec 8.

Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, Kentucky 40546-0099, USA.

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February 2011

Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture.

PLoS Pathog 2010 Nov 4;6(11):e1001176. Epub 2010 Nov 4.

Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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November 2010

The PRRSV replicase: exploring the multifunctionality of an intriguing set of nonstructural proteins.

Virus Res 2010 Dec 7;154(1-2):61-76. Epub 2010 Aug 7.

Department of Veterinary and Biomedical Science/Department of Bio-microbiology, South Dakota State University, Brookings, SD 57007-1396, USA.

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December 2010

The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle.

J Virol 2010 Aug 19;84(15):7869-79. Epub 2010 May 19.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.

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August 2010

In vitro reconstitution of SARS-coronavirus mRNA cap methylation.

PLoS Pathog 2010 Apr 22;6(4):e1000863. Epub 2010 Apr 22.

Architecture et Fonction des Macromolécules Biologiques, CNRS and Universités d'Aix-Marseille I et II, UMR 6098, ESIL Case 925, Marseille, France.

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April 2010

Arterivirus Nsp1 modulates the accumulation of minus-strand templates to control the relative abundance of viral mRNAs.

PLoS Pathog 2010 Feb 19;6(2):e1000772. Epub 2010 Feb 19.

Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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February 2010

Structure of the X (ADRP) domain of nsp3 from feline coronavirus.

Acta Crystallogr D Biol Crystallogr 2009 Dec 17;65(Pt 12):1292-300. Epub 2009 Nov 17.

EMBL Hamburg Outstation, c/o DESY, D-22603 Hamburg, Germany.

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December 2009

The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent.

Nucleic Acids Res 2010 Jan 29;38(1):203-14. Epub 2009 Oct 29.

Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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January 2010

Structure of the C-terminal domain of nsp4 from feline coronavirus.

Acta Crystallogr D Biol Crystallogr 2009 Aug 17;65(Pt 8):839-46. Epub 2009 Jul 17.

EMBL Hamburg Outstation, D-22603 Hamburg, Germany.

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August 2009

Biochemical characterization of arterivirus nonstructural protein 11 reveals the nidovirus-wide conservation of a replicative endoribonuclease.

J Virol 2009 Jun 18;83(11):5671-82. Epub 2009 Mar 18.

Department of Medical Microbiology, Molecular Virology Laboratory, Leiden University Medical Center, RC Leiden, The Netherlands.

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June 2009

Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property.

Protein Sci 2009 Jan;18(1):6-16

Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.

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January 2009