Eric E Swayze

Eric E Swayze

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Eric E Swayze

Eric E Swayze

Publications by authors named "Eric E Swayze"

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Targeting Huntingtin Expression in Patients with Huntington's Disease.

N Engl J Med 2019 06 6;380(24):2307-2316. Epub 2019 May 6.

From University College London (UCL) Huntington's Disease Centre, Department of Neurodegenerative Disease, Queen Square Institute of Neurology, UCL, and the U.K. Dementia Research Institute at UCL, London (S.J.T., E.J.W.), the Department of Clinical Neuroscience, Addenbrooke's Hospital, University of Cambridge, Cambridge (R.A.B., N.F.B.), Manchester Centre for Genomic Medicine, St. Mary's Hospital, Manchester University NHS Foundation Trust, and the Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester (D.C.), the University of Edinburgh and the U.K. Dementia Research Institute, Edinburgh (J.P.), the Institute of Clinical Sciences, College of Medical and Dental Sciences, University Hospital Birmingham, Birmingham (H.R.), and the Cardiff University Brain Repair Group, Brain Repair and Intracranial Neurotherapeutics Unit, Neuroscience and Mental Health Research Institute and School of Biosciences, Cardiff (A.R.) - all in the United Kingdom; the Centre for Huntington's Disease, Department of Medical Genetics, and the Division of Neurology, Department of Medicine, University of British Columbia, and the Centre for Molecular Medicine and Therapeutics, B.C. Children's Hospital, Vancouver, Canada (B.R.L.); the Department of Neurology, Ulm University, Huntington's Disease Centre, Ulm (G.B.L.), the Department of Neurology, Huntington Center North Rhine-Westphalia, Ruhr University Bochum, St. Josef-Hospital, Bochum (C.S.), and the Department of Neuropsychiatry, Charité-Universitätsmedizin Berlin, Deutsches Zentrum für Neurodegenerative Erkrankungen, Berlin (J.P.) - all in Germany; Ionis Pharmaceuticals, Carlsbad, CA (H.B.K., E.E.S., D.A.N., T.B., E.P., A.V.S., C.F.B., R.M.L.); and F. Hoffmann-La Roche, Basel, Switzerland (C.C., I.G., S.A.S.).

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http://dx.doi.org/10.1056/NEJMoa1900907DOI Listing
June 2019

Evaluation of the effect of 2'-O-methyl, fluoro hexitol, bicyclo and Morpholino nucleic acid modifications on potency of GalNAc conjugated antisense oligonucleotides in mice.

Bioorg Med Chem Lett 2018 12 10;28(23-24):3774-3779. Epub 2018 Oct 10.

Ionis Pharmaceuticals, Inc., 2855 Gazelle Ct., Carlsbad, CA 92010, United States.

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http://dx.doi.org/10.1016/j.bmcl.2018.10.011DOI Listing
December 2018

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model.

Mol Ther Nucleic Acids 2017 Sep 10;8:508-519. Epub 2017 Aug 10.

Center for Neurodegeneration and Experimental Therapeutics, University of Alabama, Birmingham, AL 35294, USA. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2017.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573879PMC
September 2017

Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.

Cell Rep 2016 09 25;16(10):2666-2685. Epub 2016 Aug 25.

Department of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710002PMC
September 2016

Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice.

Nucleic Acid Ther 2016 08 31;26(4):223-35. Epub 2016 Mar 31.

1 Department of Pharmacokinetics and Clinical Pharmacology, Ionis Pharmaceuticals , Carlsbad, California.

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http://dx.doi.org/10.1089/nat.2016.0607DOI Listing
August 2016

Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes.

Bioorg Med Chem Lett 2016 08 28;26(15):3690-3. Epub 2016 May 28.

Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.05.084DOI Listing
August 2016

Synergistic effect of phosphorothioate, 5'-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA.

Bioorg Med Chem Lett 2016 06 27;26(12):2817-2820. Epub 2016 Apr 27.

Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad, CA 92010, United States.

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http://dx.doi.org/10.1016/j.bmcl.2016.04.063DOI Listing
June 2016

A convenient synthesis of 5'-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acid.

Bioorg Med Chem Lett 2016 May 17;26(9):2194-7. Epub 2016 Mar 17.

Medicinal Chemistry, Ionis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.

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http://dx.doi.org/10.1016/j.bmcl.2016.03.070DOI Listing
May 2016

Design, synthesis, and duplex-stabilizing properties of conformationally constrained tricyclic analogues of LNA.

Org Biomol Chem 2016 Feb;14(6):2034-40

Department of Chemistry, Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, QC H3C 3J7, Canada.

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http://dx.doi.org/10.1039/c5ob02576aDOI Listing
February 2016

Synthetic CRISPR RNA-Cas9-guided genome editing in human cells.

Proc Natl Acad Sci U S A 2015 Dec 16;112(51):E7110-7. Epub 2015 Nov 16.

Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093

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http://dx.doi.org/10.1073/pnas.1520883112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697396PMC
December 2015

Identification and characterization of modified antisense oligonucleotides targeting DMPK in mice and nonhuman primates for the treatment of myotonic dystrophy type 1.

J Pharmacol Exp Ther 2015 Nov 1;355(2):329-40. Epub 2015 Sep 1.

Isis Pharmaceuticals Inc., Carlsbad, CA (S.K.P., S.L.J., A.K., H.S.Y., D.G., E.E.S., S.M.F., C.F.B., A.R.M.); Department of Neurology and Center of Neural Development and Disease, University of Rochester, Rochester, New York (T.M.W., C.A.T.); Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts (T.M.W.); and Department of Human Genetics, Centre Hospitalier Universitaire de Quebec, Quebec City, Canada (D.J., J.P.).

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http://dx.doi.org/10.1124/jpet.115.226969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613955PMC
November 2015

Solid-phase synthesis of 5'-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry.

Bioorg Med Chem Lett 2015 Oct 8;25(19):4127-30. Epub 2015 Aug 8.

Medicinal Chemistry, Isis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA 92010, United States.

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http://dx.doi.org/10.1016/j.bmcl.2015.08.019DOI Listing
October 2015

Synthesis and antisense properties of 2'-O-(2S-methoxypropyl)-RNA-modified gapmer antisense oligonucleotides.

ChemMedChem 2014 Sep 28;9(9):2040-4. Epub 2014 May 28.

Isis Pharmaceuticals, Inc. 2855 Gazelle Court, Carlsbad, CA 92010 (USA).

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http://dx.doi.org/10.1002/cmdc.201402099DOI Listing
September 2014

Synthesis and duplex-stabilizing properties of fluorinated N-methanocarbathymidine analogues locked in the C3'-endo conformation.

Angew Chem Int Ed Engl 2014 Sep 15;53(37):9893-7. Epub 2014 Jul 15.

Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095 (USA).

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http://dx.doi.org/10.1002/anie.201405283DOI Listing
September 2014

Differential effects on allele selective silencing of mutant huntingtin by two stereoisomers of α,β-constrained nucleic acid.

ACS Chem Biol 2014 Sep 25;9(9):1975-9. Epub 2014 Jul 25.

Isis Pharmaceuticals Inc. 2855 Gazelle Court, Carlsbad, California 92011, United States.

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http://dx.doi.org/10.1021/cb5003027DOI Listing
September 2014

Comparison of duplex stabilizing properties of 2'-fluorinated nucleic acid analogues with furanose and non-furanose sugar rings.

J Org Chem 2014 Sep 27;79(18):8877-81. Epub 2014 Aug 27.

Department of Medicinal Chemistry, Isis Pharmaceuticals, Inc. , 2855 Gazelle Court, Carlsbad, California 92010, United States.

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http://dx.doi.org/10.1021/jo501381qDOI Listing
September 2014

Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs.

Biochemistry 2014 Jul 11;53(28):4510-8. Epub 2014 Jul 11.

Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center , 6001 Forest Park Road, Dallas, Texas 75390-9041, United States.

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http://dx.doi.org/10.1021/bi500610rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108179PMC
July 2014

ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy.

Nucleic Acids Res 2013 Nov 9;41(20):9570-83. Epub 2013 Aug 9.

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA and Department of Medicinal Chemistry and Core Antisense Research, ISIS Pharmaceuticals, Carlsbad, CA 92010, USA.

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http://dx.doi.org/10.1093/nar/gkt693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814390PMC
November 2013

Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS.

Nucleic Acids Res 2013 Nov 19;41(21):9634-50. Epub 2013 Aug 19.

Isis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA and Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada.

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http://dx.doi.org/10.1093/nar/gkt725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834808PMC
November 2013

A constrained tricyclic nucleic acid analogue of α-L-LNA: investigating the effects of dual conformational restriction on duplex thermal stability.

J Org Chem 2013 Sep 4;78(18):9064-75. Epub 2013 Sep 4.

Department of Chemistry, Université de Montréal , Montréal, QC, H3C 3J7, Canada.

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http://dx.doi.org/10.1021/jo401170yDOI Listing
September 2013

Synthesis and biophysical properties of constrained D-altritol nucleic acids (cANA).

Org Lett 2013 Sep 13;15(17):4316-9. Epub 2013 Aug 13.

Department of Medicinal Chemistry, Isis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, California 92010, USA.

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http://dx.doi.org/10.1021/ol401730dDOI Listing
September 2013

Synthesis of cis- and trans-α-l-[4.3.0]bicyclo-DNA monomers for antisense technology: methods for the diastereoselective formation of bicyclic nucleosides.

J Org Chem 2013 Sep 4;78(18):9051-63. Epub 2013 Sep 4.

Department of Chemistry, Université de Montréal , Montréal, Québec H3C 3J7, Canada.

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http://dx.doi.org/10.1021/jo401166qDOI Listing
September 2013

Lipid nanoparticles improve activity of single-stranded siRNA and gapmer antisense oligonucleotides in animals.

ACS Chem Biol 2013 Jul 2;8(7):1402-6. Epub 2013 May 2.

Department of Medicinal Chemistry, Isis Pharmaceuticals, Inc. , 1896 Rutherford Road, Carlsbad, California 92008, United States.

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http://dx.doi.org/10.1021/cb4001316DOI Listing
July 2013

Synthesis, duplex stabilization and structural properties of a fluorinated carbocyclic LNA analogue.

Chembiochem 2013 Jan 28;14(1):58-62. Epub 2012 Nov 28.

Department of Medicinal Chemistry, Isis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.

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http://doi.wiley.com/10.1002/cbic.201200669
Publisher Site
http://dx.doi.org/10.1002/cbic.201200669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684079PMC
January 2013

Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.

Chem Commun (Camb) 2012 Aug 22;48(66):8195-7. Epub 2012 May 22.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1039/c2cc32286bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404228PMC
August 2012

Single-stranded siRNAs activate RNAi in animals.

Cell 2012 Aug;150(5):883-94

Core Antisense Research, Isis Pharmaceuticals Inc., Carlsbad, CA 92010, USA.

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http://dx.doi.org/10.1016/j.cell.2012.08.014DOI Listing
August 2012

Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.

Cell 2012 Aug;150(5):895-908

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1016/j.cell.2012.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444165PMC
August 2012

Structural requirements for hybridization at the 5'-position are different in α-l-LNA as compared to β-D-LNA.

Bioorg Med Chem Lett 2012 Jan 11;22(1):296-9. Epub 2011 Nov 11.

Department of Medicinal Chemistry, Isis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.11.012DOI Listing
January 2012

Insights from crystal structures into the opposite effects on RNA affinity caused by the S- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic acid.

Biochemistry 2012 Jan 29;51(1):7-9. Epub 2011 Dec 29.

Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States.

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http://dx.doi.org/10.1021/bi201810rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257178PMC
January 2012

Synthesis and biophysical evaluation of 3'-Me-α-L-LNA - Substitution in the minor groove of α-L-LNA duplexes.

Bioorg Med Chem Lett 2011 Aug 30;21(16):4690-4. Epub 2011 Jun 30.

Department of Medicinal Chemistry, Isis Pharmaceuticals, 1891 Rutherford Road, Carlsbad, CA 92008, United States.

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http://dx.doi.org/10.1016/j.bmcl.2011.06.104DOI Listing
August 2011

Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs.

Biol Chem 2011 Apr 7;392(4):315-25. Epub 2011 Feb 7.

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1515/BC.2011.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908450PMC
April 2011

Synthesis and biophysical characterization of R-6'-Me-α-L-LNA modified oligonucleotides.

Bioorg Med Chem Lett 2011 Feb 31;21(4):1122-5. Epub 2010 Dec 31.

Department of Medicinal Chemistry, Isis Pharmaceuticals, 1891 Rutherford Road, Carlsbad, CA 92008, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.12.119DOI Listing
February 2011

Replacing the 2'-oxygen with an exocyclic methylene group reverses the stabilization effects of α-L-LNA.

Bioorg Med Chem Lett 2011 Jan 14;21(1):588-91. Epub 2010 Oct 14.

Department of Medicinal Chemistry, Isis Pharmaceuticals, Inc, 1891 Rutherford Road, Carlsbad, CA 92008, United States.

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http://dx.doi.org/10.1016/j.bmcl.2010.10.025DOI Listing
January 2011

Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs.

Nucleic Acids Symp Ser (Oxf) 2008 (52):553-4

Medicinal Chemistry, Isis Pharmaceuticals, Inc., 1891 Rutherford Road, Carlsbad, CA 92008, USA.

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http://dx.doi.org/10.1093/nass/nrn280DOI Listing
November 2010

An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.

J Am Chem Soc 2010 Oct;132(42):14942-50

Department of Medicinal Chemistry, Isis Pharmaceuticals, Inc., 1891 Rutherford Road, Carlsbad, California 92008, USA.

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http://dx.doi.org/10.1021/ja105875eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993159PMC
October 2010

Inhibitor-induced structural change in the HCV IRES domain IIa RNA.

Proc Natl Acad Sci U S A 2010 Apr 1;107(16):7263-8. Epub 2010 Apr 1.

Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1073/pnas.0911896107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867761PMC
April 2010

RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform.

Annu Rev Pharmacol Toxicol 2010 ;50:259-93

Isis Pharmaceuticals, Inc., Carlsbad, California 92008, USA.

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http://dx.doi.org/10.1146/annurev.pharmtox.010909.105654DOI Listing
March 2010

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

J Org Chem 2010 Mar;75(5):1569-81

Department of Medicinal Chemistry, Isis Pharmaceuticals, 1896 Rutherford Road, Carlsbad, California 92008, USA.

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http://dx.doi.org/10.1021/jo902560fDOI Listing
March 2010

Activity of siRNAs with 2-thio-2'-O-methyluridine modification in mammalian cells.

Nucleosides Nucleotides Nucleic Acids 2009 Oct;28(10):902-10

Department of Medicinal Chemistry, Isis Pharmaceuticals Inc., Carlsbad, California 92008, USA.

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http://dx.doi.org/10.1080/15257770903316145DOI Listing
October 2009

The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis.

Mol Pharmacol 2007 Jan 6;71(1):73-82. Epub 2006 Oct 6.

Department of Molecular and Structural Biology, Isis Pharmaceuticals, Carlsbad, California, USA.

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http://dx.doi.org/10.1124/mol.106.025429DOI Listing
January 2007

Competition for RISC binding predicts in vitro potency of siRNA.

Nucleic Acids Res 2006 31;34(16):4467-76. Epub 2006 Aug 31.

ISIS Pharmaceuticals, Carlsbad Research Center, 1896 Rutherford Road, Carlsbad, CA 92008, USA.

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http://dx.doi.org/10.1093/nar/gkl589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636362PMC
October 2006

RNA interference by 2',5'-linked nucleic acid duplexes in mammalian cells.

Bioorg Med Chem Lett 2006 Jun 17;16(12):3238-40. Epub 2006 Apr 17.

Department of Medicinal Chemistry, Isis Pharmaceuticals, Inc., Carlsbad, CA 92008, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.03.053DOI Listing
June 2006

Trisaccharide mimetics of the aminoglycoside antibiotic neomycin.

Org Biomol Chem 2006 Apr 22;4(7):1328-37. Epub 2006 Feb 22.

Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA.

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http://dx.doi.org/10.1039/b517725aDOI Listing
April 2006

The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides.

Bioorg Med Chem Lett 2005 Nov;15(22):4919-22

Ibis Therapeutics, A Division of Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Carlsbad, CA 92008, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0501052
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http://dx.doi.org/10.1016/j.bmcl.2005.08.027DOI Listing
November 2005

An efficient synthesis of gougerotin and related analogues using solid- and solution-phase methodology.

Org Lett 2005 Aug;7(16):3429-32

Ibis Therapeutics, a Division of Isis Pharmaceuticals, Inc., 1896 Rutherford Avenue, Carlsbad, CA 52008, USA.

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http://dx.doi.org/10.1021/ol0507322DOI Listing
August 2005

Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

J Med Chem 2005 Feb;48(4):901-4

Department of Medicinal Chemistry, Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, California 92008, USA.

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http://dx.doi.org/10.1021/jm049167jDOI Listing
February 2005

Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site.

Angew Chem Int Ed Engl 2004 Dec;43(48):6735-8

Institut de biologie moléculaire et cellulaire UPR9002 CNRS, Université Louis Pasteur, 15 rue René Descartes, 67084 Strasbourg Cedex, France.

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http://dx.doi.org/10.1002/anie.200462092DOI Listing
December 2004