Eric E Schadt

Eric E Schadt

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Eric E Schadt

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Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2019 Jul;51(7):1192-1193

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41588-019-0449-0DOI Listing
July 2019

Structural variation at the CYP2C locus: Characterization of deletion and duplication alleles.

Hum Mutat 2019 Jul 1. Epub 2019 Jul 1.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1002/humu.23855DOI Listing
July 2019

Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons.

Sci Rep 2019 Jun 6;9(1):8350. Epub 2019 Jun 6.

Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.

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http://dx.doi.org/10.1038/s41598-019-44798-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554355PMC
June 2019

Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease.

J Am Coll Cardiol 2019 Jun;73(23):2946-2957

Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany; Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden; Department of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York; Clinical Gene Networks AB, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2019.03.520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590059PMC
June 2019

Deciphering bacterial epigenomes using modern sequencing technologies.

Nat Rev Genet 2019 03;20(3):157-172

Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41576-018-0081-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555402PMC
March 2019

Gut microbiota density influences host physiology and is shaped by host and microbial factors.

Elife 2019 Jan 22;8. Epub 2019 Jan 22.

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, United States.

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https://elifesciences.org/articles/40553
Publisher Site
http://dx.doi.org/10.7554/eLife.40553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342524PMC
January 2019

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Authors:
Nora Franceschini Claudia Giambartolomei Paul S de Vries Chris Finan Joshua C Bis Rachael P Huntley Ruth C Lovering Salman M Tajuddin Thomas W Winkler Misa Graff Maryam Kavousi Caroline Dale Albert V Smith Edith Hofer Elisabeth M van Leeuwen Ilja M Nolte Lingyi Lu Markus Scholz Muralidharan Sargurupremraj Niina Pitkänen Oscar Franzén Peter K Joshi Raymond Noordam Riccardo E Marioni Shih-Jen Hwang Solomon K Musani Ulf Schminke Walter Palmas Aaron Isaacs Adolfo Correa Alan B Zonderman Albert Hofman Alexander Teumer Amanda J Cox André G Uitterlinden Andrew Wong Andries J Smit Anne B Newman Annie Britton Arno Ruusalepp Bengt Sennblad Bo Hedblad Bogdan Pasaniuc Brenda W Penninx Carl D Langefeld Christina L Wassel Christophe Tzourio Cristiano Fava Damiano Baldassarre Daniel H O'Leary Daniel Teupser Diana Kuh Elena Tremoli Elmo Mannarino Enzo Grossi Eric Boerwinkle Eric E Schadt Erik Ingelsson Fabrizio Veglia Fernando Rivadeneira Frank Beutner Ganesh Chauhan Gerardo Heiss Harold Snieder Harry Campbell Henry Völzke Hugh S Markus Ian J Deary J Wouter Jukema Jacqueline de Graaf Jacqueline Price Janne Pott Jemma C Hopewell Jingjing Liang Joachim Thiery Jorgen Engmann Karl Gertow Kenneth Rice Kent D Taylor Klodian Dhana Lambertus A L M Kiemeney Lars Lind Laura M Raffield Lenore J Launer Lesca M Holdt Marcus Dörr Martin Dichgans Matthew Traylor Matthias Sitzer Meena Kumari Mika Kivimaki Mike A Nalls Olle Melander Olli Raitakari Oscar H Franco Oscar L Rueda-Ochoa Panos Roussos Peter H Whincup Philippe Amouyel Philippe Giral Pramod Anugu Quenna Wong Rainer Malik Rainer Rauramaa Ralph Burkhardt Rebecca Hardy Reinhold Schmidt Renée de Mutsert Richard W Morris Rona J Strawbridge S Goya Wannamethee Sara Hägg Sonia Shah Stela McLachlan Stella Trompet Sudha Seshadri Sudhir Kurl Susan R Heckbert Susan Ring Tamara B Harris Terho Lehtimäki Tessel E Galesloot Tina Shah Ulf de Faire Vincent Plagnol Wayne D Rosamond Wendy Post Xiaofeng Zhu Xiaoling Zhang Xiuqing Guo Yasaman Saba Abbas Dehghan Adrie Seldenrijk Alanna C Morrison Anders Hamsten Bruce M Psaty Cornelia M van Duijn Deborah A Lawlor Dennis O Mook-Kanamori Donald W Bowden Helena Schmidt James F Wilson James G Wilson Jerome I Rotter Joanna M Wardlaw John Deanfield Julian Halcox Leo-Pekka Lyytikäinen Markus Loeffler Michele K Evans Stéphanie Debette Steve E Humphries Uwe Völker Vilmundur Gudnason Aroon D Hingorani Johan L M Björkegren Juan P Casas Christopher J O'Donnell

Nat Commun 2018 12 3;9(1):5141. Epub 2018 Dec 3.

Intramural Administration Management Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-018-07340-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277418PMC
December 2018

B Cell Defects Observed in Knockout Mice Are a Consequence of a Mutation Frequently Found in Inbred Strains.

J Immunol 2018 09 16;201(5):1442-1451. Epub 2018 Jul 16.

Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016;

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http://dx.doi.org/10.4049/jimmunol.1800014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103850PMC
September 2018

Temporal genetic association and temporal genetic causality methods for dissecting complex networks.

Nat Commun 2018 09 28;9(1):3980. Epub 2018 Sep 28.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1038/s41467-018-06203-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162292PMC
September 2018

STAR Chimeric Post for rapid detection of circular RNA and fusion transcripts.

Bioinformatics 2018 07;34(14):2364-2370

Department of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1093/bioinformatics/bty091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041974PMC
July 2018

Mapping and characterizing N6-methyladenine in eukaryotic genomes using single-molecule real-time sequencing.

Genome Res 2018 07 15;28(7):1067-1078. Epub 2018 May 15.

Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

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http://dx.doi.org/10.1101/gr.231068.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028124PMC
July 2018

Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus.

Neuron 2018 07 21;99(1):64-82.e7. Epub 2018 Jun 21.

Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Icahn Institute of Genomic Sciences and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Next Generation Healthcare, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ 85287-5001, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551233PMC
July 2018

A Nasal Brush-based Classifier of Asthma Identified by Machine Learning Analysis of Nasal RNA Sequence Data.

Sci Rep 2018 Jun 11;8(1):8826. Epub 2018 Jun 11.

Icahn Institute for Genomics and Multiscale Biology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41598-018-27189-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995932PMC
June 2018

From smartphone to EHR: a case report on integrating patient-generated health data.

NPJ Digit Med 2018 20;1:23. Epub 2018 Jun 20.

1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai , New York, NY USA.

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http://dx.doi.org/10.1038/s41746-018-0030-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550195PMC
June 2018

The asthma mobile health study, smartphone data collected using ResearchKit.

Sci Data 2018 05 22;5:180096. Epub 2018 May 22.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/sdata.2018.96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963336PMC
May 2018

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2018 04 12;50(4):524-537. Epub 2018 Mar 12.

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41588-018-0058-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968830PMC
April 2018

Metagenomic binning and association of plasmids with bacterial host genomes using DNA methylation.

Nat Biotechnol 2018 01 11;36(1):61-69. Epub 2017 Dec 11.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1038/nbt.4037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762413PMC
January 2018

Germline deletion of Krüppel-like factor 14 does not increase risk of diet induced metabolic syndrome in male C57BL/6 mice.

Biochim Biophys Acta Mol Basis Dis 2017 12 28;1863(12):3277-3285. Epub 2017 Sep 28.

Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.09.021DOI Listing
December 2017

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 11 7;8(1):1414. Epub 2017 Nov 7.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-01008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676783PMC
November 2017

Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications.

Genome Med 2017 10 30;9(1):89. Epub 2017 Oct 30.

Department of Pathology and Laboratory Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1186/s13073-017-0478-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662094PMC
October 2017

EXPLORING THE REPRODUCIBILITY OF PROBABILISTIC CAUSAL MOLECULAR NETWORK MODELS.

Pac Symp Biocomput 2017 ;22:120-131

Icahn Institute and Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1498, New York, NY, 10029, USA*Co-first Authors.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161348PMC
http://dx.doi.org/10.1142/9789813207813_0013DOI Listing
July 2017

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 07 19;8(1):80. Epub 2017 Jul 19.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-00031-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517526PMC
July 2017

METHODS FOR CLUSTERING TIME SERIES DATA ACQUIRED FROM MOBILE HEALTH APPS.

Pac Symp Biocomput 2017 ;22:300-311

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1142/9789813207813_0029DOI Listing
June 2017

Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression.

Am J Hum Genet 2017 Jun 25;100(6):885-894. Epub 2017 May 25.

Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mental Illness Research Education and Clinical Center, James J. Peters VA Medical Center, Bronx, New York, NY 10468, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474225PMC
June 2017

Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.

Cell Stem Cell 2017 04 22;20(4):518-532.e9. Epub 2016 Dec 22.

Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.stem.2016.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384872PMC
April 2017

Heterozygous Pathogenic Variant in DACT1 Causes an Autosomal-Dominant Syndrome with Features Overlapping Townes-Brocks Syndrome.

Hum Mutat 2017 04 2;38(4):373-377. Epub 2017 Feb 2.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1002/humu.23171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390682PMC
April 2017

IDENTIFY CANCER DRIVER GENES THROUGH SHARED MENDELIAN DISEASE PATHOGENIC VARIANTS AND CANCER SOMATIC MUTATIONS.

Pac Symp Biocomput 2017 ;22:473-484

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl. New York City, NY 10029, USA.

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http://dx.doi.org/10.1142/9789813207813_0044DOI Listing
March 2017

Psychological and behavioural impact of returning personal results from whole-genome sequencing: the HealthSeq project.

Eur J Hum Genet 2017 02 4;25(3):280-292. Epub 2017 Jan 4.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/ejhg.2016.178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315514PMC
February 2017

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.

Authors:
Thomas R Webb Jeanette Erdmann Kathleen E Stirrups Nathan O Stitziel Nicholas G D Masca Henning Jansen Stavroula Kanoni Christopher P Nelson Paola G Ferrario Inke R König John D Eicher Andrew D Johnson Stephen E Hamby Christer Betsholtz Arno Ruusalepp Oscar Franzén Eric E Schadt Johan L M Björkegren Peter E Weeke Paul L Auer Ursula M Schick Yingchang Lu He Zhang Marie-Pierre Dube Anuj Goel Martin Farrall Gina M Peloso Hong-Hee Won Ron Do Erik van Iperen Jochen Kruppa Anubha Mahajan Robert A Scott Christina Willenborg Peter S Braund Julian C van Capelleveen Alex S F Doney Louise A Donnelly Rosanna Asselta Pier A Merlini Stefano Duga Nicola Marziliano Josh C Denny Christian Shaffer Nour Eddine El-Mokhtari Andre Franke Stefanie Heilmann Christian Hengstenberg Per Hoffmann Oddgeir L Holmen Kristian Hveem Jan-Håkan Jansson Karl-Heinz Jöckel Thorsten Kessler Jennifer Kriebel Karl L Laugwitz Eirini Marouli Nicola Martinelli Mark I McCarthy Natalie R Van Zuydam Christa Meisinger Tõnu Esko Evelin Mihailov Stefan A Escher Maris Alver Susanne Moebus Andrew D Morris Jarma Virtamo Majid Nikpay Oliviero Olivieri Sylvie Provost Alaa AlQarawi Neil R Robertson Karen O Akinsansya Dermot F Reilly Thomas F Vogt Wu Yin Folkert W Asselbergs Charles Kooperberg Rebecca D Jackson Eli Stahl Martina Müller-Nurasyid Konstantin Strauch Tibor V Varga Melanie Waldenberger Lingyao Zeng Rajiv Chowdhury Veikko Salomaa Ian Ford J Wouter Jukema Philippe Amouyel Jukka Kontto Børge G Nordestgaard Jean Ferrières Danish Saleheen Naveed Sattar Praveen Surendran Aline Wagner Robin Young Joanna M M Howson Adam S Butterworth John Danesh Diego Ardissino Erwin P Bottinger Raimund Erbel Paul W Franks Domenico Girelli Alistair S Hall G Kees Hovingh Adnan Kastrati Wolfgang Lieb Thomas Meitinger William E Kraus Svati H Shah Ruth McPherson Marju Orho-Melander Olle Melander Andres Metspalu Colin N A Palmer Annette Peters Daniel J Rader Muredach P Reilly Ruth J F Loos Alex P Reiner Dan M Roden Jean-Claude Tardif John R Thompson Nicholas J Wareham Hugh Watkins Cristen J Willer Nilesh J Samani Heribert Schunkert Panos Deloukas Sekar Kathiresan

J Am Coll Cardiol 2017 Feb;69(7):823-836

Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts; Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jacc.2016.11.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314135PMC
February 2017

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.

Authors:
Gregory T Jones Gerard Tromp Helena Kuivaniemi Solveig Gretarsdottir Annette F Baas Betti Giusti Ewa Strauss Femke N G Van't Hof Thomas R Webb Robert Erdman Marylyn D Ritchie James R Elmore Anurag Verma Sarah Pendergrass Iftikhar J Kullo Zi Ye Peggy L Peissig Omri Gottesman Shefali S Verma Jennifer Malinowski Laura J Rasmussen-Torvik Kenneth M Borthwick Diane T Smelser David R Crosslin Mariza de Andrade Evan J Ryer Catherine A McCarty Erwin P Böttinger Jennifer A Pacheco Dana C Crawford David S Carrell Glenn S Gerhard David P Franklin David J Carey Victoria L Phillips Michael J A Williams Wenhua Wei Ross Blair Andrew A Hill Thodor M Vasudevan David R Lewis Ian A Thomson Jo Krysa Geraldine B Hill Justin Roake Tony R Merriman Grzegorz Oszkinis Silvia Galora Claudia Saracini Rosanna Abbate Raffaele Pulli Carlo Pratesi Athanasios Saratzis Ana R Verissimo Suzannah Bumpstead Stephen A Badger Rachel E Clough Gillian Cockerill Hany Hafez D Julian A Scott T Simon Futers Simon P R Romaine Katherine Bridge Kathryn J Griffin Marc A Bailey Alberto Smith Matthew M Thompson Frank M van Bockxmeer Stefan E Matthiasson Gudmar Thorleifsson Unnur Thorsteinsdottir Jan D Blankensteijn Joep A W Teijink Cisca Wijmenga Jacqueline de Graaf Lambertus A Kiemeney Jes S Lindholt Anne Hughes Declan T Bradley Kathleen Stirrups Jonathan Golledge Paul E Norman Janet T Powell Steve E Humphries Stephen E Hamby Alison H Goodall Christopher P Nelson Natzi Sakalihasan Audrey Courtois Robert E Ferrell Per Eriksson Lasse Folkersen Anders Franco-Cereceda John D Eicher Andrew D Johnson Christer Betsholtz Arno Ruusalepp Oscar Franzén Eric E Schadt Johan L M Björkegren Leonard Lipovich Anne M Drolet Eric L Verhoeven Clark J Zeebregts Robert H Geelkerken Marc R van Sambeek Steven M van Sterkenburg Jean-Paul de Vries Kari Stefansson John R Thompson Paul I W de Bakker Panos Deloukas Robert D Sayers Seamus C Harrison Andre M van Rij Nilesh J Samani Matthew J Bown

Circ Res 2017 Jan 29;120(2):341-353. Epub 2016 Nov 29.

For the author affiliations, please see the Appendix.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253231PMC
January 2017

High-Throughput Characterization of Blood Serum Proteomics of IBD Patients with Respect to Aging and Genetic Factors.

PLoS Genet 2017 01 27;13(1):e1006565. Epub 2017 Jan 27.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271178PMC
January 2017

variancePartition: interpreting drivers of variation in complex gene expression studies.

BMC Bioinformatics 2016 Nov 25;17(1):483. Epub 2016 Nov 25.

Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA.

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http://dx.doi.org/10.1186/s12859-016-1323-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123296PMC
November 2016

Impact of Genomic Counseling on Informed Decision-Making among ostensibly Healthy Individuals Seeking Personal Genome Sequencing: the HealthSeq Project.

J Genet Couns 2016 10 22;25(5):1044-53. Epub 2016 Feb 22.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1498, New York, NY, USA.

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http://dx.doi.org/10.1007/s10897-016-9935-zDOI Listing
October 2016

Discover the network underlying the connections between aging and age-related diseases.

Sci Rep 2016 09 1;6:32566. Epub 2016 Sep 1.

Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, NY, 10029, USA.

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http://dx.doi.org/10.1038/srep32566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007654PMC
September 2016

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.

Science 2016 Aug;353(6301):827-30

Department of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York , NY 10029, USA. Clinical Gene Networks AB, Jungfrugatan 10, 114 44 Stockholm, Sweden. Department of Pathophysiology, Institute of Biomedicine and Translation Medicine, University of Tartu, Biomeedikum, Ravila 19, 50411, Tartu, Estonia. Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles Väg 2, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1126/science.aad6970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534139PMC
August 2016

A new molecular signature method for prediction of driver cancer pathways from transcriptional data.

Nucleic Acids Res 2016 06 20;44(11):e110. Epub 2016 Apr 20.

Icahn Institute for Genomics and Multiscale Biology, New York, 10029, USA

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http://dx.doi.org/10.1093/nar/gkw269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914110PMC
June 2016

Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks.

Bioinformatics 2016 06;32(12):i101-i110

Department of Genetics and Genomic Sciences Icahn Institute for Genomics and Multiscale Biology Harris Center for Precision Wellness, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA Department of Population Health Science and Policy, New York City, NY 10029, USA.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btw282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908366PMC
June 2016

Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease.

Gastroenterology 2016 05 4;150(5):1196-1207. Epub 2016 Feb 4.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085160012
Publisher Site
http://dx.doi.org/10.1053/j.gastro.2016.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842103PMC
May 2016

Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease.

Cell Syst 2016 03 3;2(3):196-208. Epub 2016 Mar 3.

Cardiovascular Genomics Group, Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Physiology, Institute of Biomedicine and Translation Medicine, University of Tartu, 51014 Tartu, Estonia; Clinical Gene Networks AB, 114 44 Stockholm, Sweden; Department of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Cardiovascular Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2016.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855300PMC
March 2016

exposures to environmental organic pollutants disrupt epigenetic marks linked to fetoplacental development.

Environ Epigenet 2016 Mar 10;2(1). Epub 2016 Feb 10.

Departments of Preventive Medicine, Pediatrics, Oncological Sciences, Obstetrics, Gynecology and Reproductive Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.

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http://dx.doi.org/10.1093/eep/dvv013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905724PMC
March 2016

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Authors:
Yingchang Lu Felix R Day Stefan Gustafsson Martin L Buchkovich Jianbo Na Veronique Bataille Diana L Cousminer Zari Dastani Alexander W Drong Tõnu Esko David M Evans Mario Falchi Mary F Feitosa Teresa Ferreira Åsa K Hedman Robin Haring Pirro G Hysi Mark M Iles Anne E Justice Stavroula Kanoni Vasiliki Lagou Rui Li Xin Li Adam Locke Chen Lu Reedik Mägi John R B Perry Tune H Pers Qibin Qi Marianna Sanna Ellen M Schmidt William R Scott Dmitry Shungin Alexander Teumer Anna A E Vinkhuyzen Ryan W Walker Harm-Jan Westra Mingfeng Zhang Weihua Zhang Jing Hua Zhao Zhihong Zhu Uzma Afzal Tarunveer Singh Ahluwalia Stephan J L Bakker Claire Bellis Amélie Bonnefond Katja Borodulin Aron S Buchman Tommy Cederholm Audrey C Choh Hyung Jin Choi Joanne E Curran Lisette C P G M de Groot Philip L De Jager Rosalie A M Dhonukshe-Rutten Anke W Enneman Elodie Eury Daniel S Evans Tom Forsen Nele Friedrich Frédéric Fumeron Melissa E Garcia Simone Gärtner Bok-Ghee Han Aki S Havulinna Caroline Hayward Dena Hernandez Hans Hillege Till Ittermann Jack W Kent Ivana Kolcic Tiina Laatikainen Jari Lahti Irene Mateo Leach Christine G Lee Jong-Young Lee Tian Liu Youfang Liu Stéphane Lobbens Marie Loh Leo-Pekka Lyytikäinen Carolina Medina-Gomez Karl Michaëlsson Mike A Nalls Carrie M Nielson Laticia Oozageer Laura Pascoe Lavinia Paternoster Ozren Polašek Samuli Ripatti Mark A Sarzynski Chan Soo Shin Nina Smolej Narančić Dominik Spira Priya Srikanth Elisabeth Steinhagen-Thiessen Yun Ju Sung Karin M A Swart Leena Taittonen Toshiko Tanaka Emmi Tikkanen Nathalie van der Velde Natasja M van Schoor Niek Verweij Alan F Wright Lei Yu Joseph M Zmuda Niina Eklund Terrence Forrester Niels Grarup Anne U Jackson Kati Kristiansson Teemu Kuulasmaa Johanna Kuusisto Peter Lichtner Jian'an Luan Anubha Mahajan Satu Männistö Cameron D Palmer Janina S Ried Robert A Scott Alena Stancáková Peter J Wagner Ayse Demirkan Angela Döring Vilmundur Gudnason Douglas P Kiel Brigitte Kühnel Massimo Mangino Barbara Mcknight Cristina Menni Jeffrey R O'Connell Ben A Oostra Alan R Shuldiner Kijoung Song Liesbeth Vandenput Cornelia M van Duijn Peter Vollenweider Charles C White Michael Boehnke Yvonne Boettcher Richard S Cooper Nita G Forouhi Christian Gieger Harald Grallert Aroon Hingorani Torben Jørgensen Pekka Jousilahti Mika Kivimaki Meena Kumari Markku Laakso Claudia Langenberg Allan Linneberg Amy Luke Colin A Mckenzie Aarno Palotie Oluf Pedersen Annette Peters Konstantin Strauch Bamidele O Tayo Nicholas J Wareham David A Bennett Lars Bertram John Blangero Matthias Blüher Claude Bouchard Harry Campbell Nam H Cho Steven R Cummings Stefan A Czerwinski Ilja Demuth Rahel Eckardt Johan G Eriksson Luigi Ferrucci Oscar H Franco Philippe Froguel Ron T Gansevoort Torben Hansen Tamara B Harris Nicholas Hastie Markku Heliövaara Albert Hofman Joanne M Jordan Antti Jula Mika Kähönen Eero Kajantie Paul B Knekt Seppo Koskinen Peter Kovacs Terho Lehtimäki Lars Lind Yongmei Liu Eric S Orwoll Clive Osmond Markus Perola Louis Pérusse Olli T Raitakari Tuomo Rankinen D C Rao Treva K Rice Fernando Rivadeneira Igor Rudan Veikko Salomaa Thorkild I A Sørensen Michael Stumvoll Anke Tönjes Bradford Towne Gregory J Tranah Angelo Tremblay André G Uitterlinden Pim van der Harst Erkki Vartiainen Jorma S Viikari Veronique Vitart Marie-Claude Vohl Henry Völzke Mark Walker Henri Wallaschofski Sarah Wild James F Wilson Loïc Yengo D Timothy Bishop Ingrid B Borecki John C Chambers L Adrienne Cupples Abbas Dehghan Panos Deloukas Ghazaleh Fatemifar Caroline Fox Terrence S Furey Lude Franke Jiali Han David J Hunter Juha Karjalainen Fredrik Karpe Robert C Kaplan Jaspal S Kooner Mark I McCarthy Joanne M Murabito Andrew P Morris Julia A N Bishop Kari E North Claes Ohlsson Ken K Ong Inga Prokopenko J Brent Richards Eric E Schadt Tim D Spector Elisabeth Widén Cristen J Willer Jian Yang Erik Ingelsson Karen L Mohlke Joel N Hirschhorn John Andrew Pospisilik M Carola Zillikens Cecilia Lindgren Tuomas Oskari Kilpeläinen Ruth J F Loos

Nat Commun 2016 Feb 1;7:10495. Epub 2016 Feb 1.

The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/ncomms10495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740398PMC
February 2016

A Next Generation Multiscale View of Inborn Errors of Metabolism.

Cell Metab 2016 Jan 17;23(1):13-26. Epub 2015 Dec 17.

Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, Box 1498, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715559PMC
January 2016

A Cytosine Methyltransferase Modulates the Cell Envelope Stress Response in the Cholera Pathogen [corrected].

PLoS Genet 2015 Nov 20;11(11):e1005666. Epub 2015 Nov 20.

Division of Infectious Disease, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654547PMC
November 2015

Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases.

Sci Rep 2015 Oct 19;5:15145. Epub 2015 Oct 19.

Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, NY, 10029, USA.

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http://dx.doi.org/10.1038/srep15145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609956PMC
October 2015