Eric Bouffet

Eric Bouffet

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Eric Bouffet

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Disrupted network connectivity in pediatric brain tumor survivors is a signature of injury.

J Comp Neurol 2019 Dec 7;527(17):2896-2909. Epub 2019 Jun 7.

Neurosciences and Mental Health Program, Research Institute, Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1002/cne.24717DOI Listing
December 2019

Predictors of neuropsychological late effects and white matter correlates in children treated for a brain tumor without radiation therapy.

Pediatr Blood Cancer 2019 Oct 16;66(10):e27924. Epub 2019 Jul 16.

Department of Psychology, Neurosciences and Mental Health Program, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.27924DOI Listing
October 2019

Re-irradiation for children with recurrent medulloblastoma in Toronto, Canada: a 20-year experience.

J Neurooncol 2019 Oct 29;145(1):107-114. Epub 2019 Aug 29.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1007/s11060-019-03272-2DOI Listing
October 2019

Intracranial Germ Cell Tumors in Adolescents and Young Adults: A 40-Year Multi-Institutional Review of Outcomes.

Int J Radiat Oncol Biol Phys 2019 Oct 22. Epub 2019 Oct 22.

Princess Margaret Cancer Centre, Toronto, Ontario, Canada; The Hospital for Sick Children, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2019.10.020DOI Listing
October 2019

Repeat irradiation for children with supratentorial high-grade glioma.

Pediatr Blood Cancer 2019 Sep 17;66(9):e27881. Epub 2019 Jun 17.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.27881DOI Listing
September 2019

SIOP and Childhood Cancer International mourn Jayne, Grace, and Bella.

Pediatr Blood Cancer 2019 Aug 6;66(8):e27801. Epub 2019 May 6.

International Society of Paediatric Oncology (SIOP), Zug, Switzerland.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pbc.27801
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http://dx.doi.org/10.1002/pbc.27801DOI Listing
August 2019

Redefining Ventricular Target Volume in Germinoma: Is Inclusion of Temporal Horns Necessary?

Int J Radiat Oncol Biol Phys 2019 Jul 30;104(4):852-858. Epub 2019 Mar 30.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03603016193056
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http://dx.doi.org/10.1016/j.ijrobp.2019.03.039DOI Listing
July 2019

Selumetinib in paediatric low-grade glioma: a new era?

Authors:
Eric Bouffet

Lancet Oncol 2019 Jul 28;20(7):900-901. Epub 2019 May 28.

Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(19)30304-3DOI Listing
July 2019

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

Cancer Cell 2019 Jul;36(1):51-67.e7

Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G0A4, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada; Division of Hematology-Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.002DOI Listing
July 2019

Critical review of the management of primary central nervous nongerminomatous germ cell tumors.

Pediatr Blood Cancer 2019 Jun 15;66(6):e27658. Epub 2019 Feb 15.

The Division of Hematology, Oncology and Blood and Marrow Transplant, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1002/pbc.27658DOI Listing
June 2019

Effective and safe tumor inhibition using vinblastine in medulloblastoma.

Pediatr Blood Cancer 2019 Jun 8;66(6):e27694. Epub 2019 Mar 8.

Programme in Developmental and Stem Cell Biology, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.27694DOI Listing
June 2019

Canadian patterns of practice for intracranial germ cell tumors in adolescents and young adults.

J Neurooncol 2019 Jun 1;143(2):289-296. Epub 2019 Apr 1.

BC Cancer, 600 W. 10th Avenue, Vancouver, BC, V5Z 4E1, Canada.

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http://dx.doi.org/10.1007/s11060-019-03159-2DOI Listing
June 2019

High-dose chemotherapy with autologous stem cell transplantation in infants and young children with ependymoma: A 10-year experience with the Head Start II protocol.

Pediatr Transplant 2019 06 23;23(4):e13421. Epub 2019 Apr 23.

Division of Neuro-oncology, Department of Pediatric Hematology-Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/petr.13421DOI Listing
June 2019

Facial emotion recognition in children treated for posterior fossa tumours and typically developing children: A divergence of predictors.

Neuroimage Clin 2019 12;23:101886. Epub 2019 Jun 12.

The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; University of Toronto, Toronto, ON M5S 3G3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2019.101886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603305PMC
June 2019

Diffuse intrinsic pontine glioma ventricular peritoneal shunt metastasis: a case report and literature review.

Childs Nerv Syst 2019 May 31;35(5):861-864. Epub 2019 Jan 31.

Pediatric Neuro-Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, M5H 1X8, Canada.

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http://dx.doi.org/10.1007/s00381-019-04069-4DOI Listing
May 2019

Presacral Medulloepithelioma: Case Report and Literature Review.

J Pediatr Hematol Oncol 2019 Apr 15. Epub 2019 Apr 15.

Division of Haematology/Oncology.

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http://dx.doi.org/10.1097/MPH.0000000000001460DOI Listing
April 2019

Phase I study of vinblastine and temsirolimus in pediatric patients with recurrent or refractory solid tumors: Canadian Cancer Trials Group Study IND.218.

Pediatr Blood Cancer 2019 03 4;66(3):e27540. Epub 2018 Nov 4.

Department of Pediatrics, University of Toronto and New Agent and Innovative Therapy Program, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/pbc.27540
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http://dx.doi.org/10.1002/pbc.27540DOI Listing
March 2019

Second rhabdoid tumor 8 years after treatment of atypical teratoid/rhabdoid tumor in a child with germline SMARCB1 mutation.

Pediatr Blood Cancer 2019 03 4;66(3):e27546. Epub 2018 Nov 4.

Pediatric Brain Tumour Program, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/pbc.27546
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http://dx.doi.org/10.1002/pbc.27546DOI Listing
March 2019

Science and health for all children with cancer.

Science 2019 Mar;363(6432):1182-1186

Board, International Society of Paediatric Oncology (SIOP), Zug, Switzerland.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aaw4892
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http://dx.doi.org/10.1126/science.aaw4892DOI Listing
March 2019

Feasibility of high-dose chemotherapy protocols to treat infants with malignant central nervous system tumors: Experience from a middle-income country.

Pediatr Blood Cancer 2019 01 24;66(1):e27464. Epub 2018 Sep 24.

Division of Pediatric Hematology/Oncology, King Hussein Cancer Center, Amman, Jordan.

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http://dx.doi.org/10.1002/pbc.27464DOI Listing
January 2019

The silent victims of the US embargo against Iran.

Lancet Oncol 2018 11 1;19(11):e580. Epub 2018 Nov 1.

The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S1470-2045(18)30751-4DOI Listing
November 2018

Video-Teleconferencing in Pediatric Neuro-Oncology: Ten Years of Experience.

J Glob Oncol 2018 09 18;4:1-7. Epub 2017 Apr 18.

Nisreen Amayiri, Maisa Swaidan, Najiyah Abuirmeileh, Maysa Al-Hussaini, Awni Musharbash, and Hadeel Halalsheh, King Hussein Cancer Center, Amman, Jordan; Tarik Tihan, University of California San Francisco, San Francisco, CA; James Drake, Uri Tabori, Ute Bartels, and Eric Bouffet, The Hospital for Sick Children, University of Toronto, Ontario, Canada; Ibrahim Qaddoumi, St Jude Children's Research Hospital, Memphis, TN.

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http://ascopubs.org/doi/10.1200/JGO.2016.008276
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http://dx.doi.org/10.1200/JGO.2016.008276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180801PMC
September 2018

Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.

J Clin Oncol 2018 07 10;36(19):1963-1972. Epub 2018 May 10.

Lindsey M. Hoffman and Nicholas K. Foreman, University of Colorado Denver; Lindsey M. Hoffman and Nicholas K. Foreman, Children's Hospital Colorado, Aurora, CO; Sophie E.M. Veldhuijzen van Zanten, Esther Hulleman, Gertjan J.L. Kaspers, Esther Sanchez, and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; William P. Vandertop, Academy of Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Niclas Colditz, Marion Hoffmann, Brigitte Bison, Monika Warmuth-Metz, and Christof M. Kramm, University Medical Center Goettingen, Goettingen; Torsten Pietsch and Gerrit H. Gielen, University of Bonn Medical Center, Bonn; David T.W. Jones, Dominik Sturm, Stefan M. Pfister, and Elke Pfaff, German Cancer Research Center, Hopp-Children's Cancer Center at the Nationale Centrum für Tumorerkrankungen Heidelberg, and German Consortium for Translational Cancer Research; Dominik Sturm, Stefan M. Pfister, and Elke Pfaff, Heidelberg University Hospital, Heidelberg, Germany; Joshua Baugh, Brooklyn Chaney, Adam Lane, Christine Fuller, Nancy Yanez Escorza, Renee Doughman, Rachid Drissi, James Leach, Blaise Jones, and Maryam Fouladi, Cincinnati Children's Hospital Medical Center, Cincinnati; Emmett Broxson, Wright State University and The Children's Medical Center, Dayton, OH; Lili Miles, Nemours Children's Hospital, Orlando, FL; Cynthia Hawkins, Ute Bartels, and Eric Bouffet, The Hospital for Sick Children, Toronto, Ontario; Anne Sophie Carret, Centre Hospitalier Universitaire Sainte-Justine; Nada Jabado, McGill University, Montreal, Quebec, Canada; Stewart Goldman, Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, IL; Sarah Leary, Seattle Children's Hospital, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA; Roger Packer, Children's National Health System; Javad Nazarian, Children's National Medical Center, Washington, DC; Katherine E. Warren, National Cancer Institute, Bethesda, MD; Alberto Broniscer, St Jude Children's Research Hospital, Memphis, TN; Mark W. Kieran, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA; Jane Minturn, Children's Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, Philadelphia; Melanie Comito, The Pennsylvania State University, Hershey, PA; Chie-Schin Shih, Indiana University, Indianapolis, IN; Soumen Khatua, The University of Texas MD Anderson Cancer Center; Murali Chintagumpala, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX; Timothy Hassall, Lady Cilento Children's Hospital, Brisbane, Queensland; David S. Ziegler, Kids Cancer Centre, Sydney Children's Hospital, Randwick; David S. Ziegler, University of New South Wales, Sydney, New South Wales; Nicholas Gottardo and Hetal Dholaria, Princess Margaret Hospital for Children, Perth, Western Australia, Australia; Martin Benesch, Medical University of Graz, Graz, Austria; Nathalie Boddaert. Stephanie Puget, and Raphaël Calmon, Hôpital Necker Enfants Malades; Pascale Varlet, Hôpital Sainte-Anne, Université Paris V Descartes, Sorbonne Paris Cité, Paris; Géraldine Giraud, David Castel, and Jacques Grill, Gustave Roussy, Université Paris-Sud, Université Paris-Saclay, Villejuif, France; Géraldine Giraud, Uppsala University, Uppsala, Sweden; Chris Jones, The Institute of Cancer Research, Sutton; Darren Hargrave, Great Ormond Street Hospital, London; Guirish A. Solanki, Birmingham Women's and Children's Hospital, Birmingham; Simon Bailey, Great North Children's Hospital, Victoria Wing, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom; Piergiorgio Modena and Marzia Giagnacovo, Sant' Anna Como General Hospital, Como; Manila Antonelli, Sapienza University of Rome, Rome; Veronica Biassoni and Maura Massimino, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan, Italy; Nicolas U. Gerber and Michael A. Grotzer, University Children's Hospital of Zurich, Zurich; André O. von Bueren, University Hospital of Geneva and University of Geneva, Geneva, Switzerland; and Filip Jadrijevic Cvrlje and Gertjan J.L. Kaspers, Children's Hospital Zagreb, Zagreb, Croatia.

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http://dx.doi.org/10.1200/JCO.2017.75.9308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075859PMC
July 2018

Long-term visual outcomes of craniopharyngioma in children.

J Neurooncol 2018 May 17;137(3):645-651. Epub 2018 Jan 17.

Division of Neurosurgery, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s11060-018-2762-3DOI Listing
May 2018

End-of-life care of children with diffuse intrinsic pontine glioma.

J Neurooncol 2018 May 3;138(1):147-153. Epub 2018 Feb 3.

Paediatric Neuro-Oncology Program, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G1X8, Canada.

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http://link.springer.com/10.1007/s11060-018-2781-0
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http://dx.doi.org/10.1007/s11060-018-2781-0DOI Listing
May 2018

Volumetric assessment of tumor size changes in pediatric low-grade gliomas: feasibility and comparison with linear measurements.

Neuroradiology 2018 Apr 30;60(4):427-436. Epub 2018 Jan 30.

Pediatric Neuroradiology, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1007/s00234-018-1979-3DOI Listing
April 2018

Phase II, Open-Label, Randomized, Multicenter Trial (HERBY) of Bevacizumab in Pediatric Patients With Newly Diagnosed High-Grade Glioma.

J Clin Oncol 2018 04 7;36(10):951-958. Epub 2018 Feb 7.

Jacques Grill, Marie-Cécile Le Deley, and Gilles Vassal, Institut Gustave-Roussy, Villejuif; Marie-Cécile Le Deley, Paris-Saclay and Paris-Sud Universities, CESP, Institut National de la Santé et de la Recherche Médicale, Orsay; Pascale Varlet, Sainte-Anne Hospital, Paris, France; Maura Massimino, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori, Milan; Felice Giangaspero, Sapienza University, Rome; Felice Giangaspero, IRCCS Neuromed, Pozzilli, Italy; Eric Bouffet, Hospital for Sick Children, Toronto, Ontario, Canada; Amedeo A. Azizi, Medical University of Vienna, Vienna, Austria; Geoffrey McCowage, Australasian Children's Cancer Trials, Clayton, Victoria, Australia; Adela Cañete, Hospital La Fe, Valencia, Spain; Frank Saran, The Royal Marsden Hospital; Chris Jones, The Institute of Cancer Research; Darren Hargrave, Great Ormond Street Hospital, London; Paul S. Morgan and Tim Jaspan, Nottingham University Hospitals, Queen's Medical Centre, Nottingham, United Kingdom; Helen Smith, Josep Garcia, Markus C. Elze, and Lauren Abrey, F. Hoffmann-La Roche Ltd, Basel, Switzerland; and Raphaël F. Rousseau, Gritstone Oncology, Emeryville, CA.

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http://dx.doi.org/10.1200/JCO.2017.76.0611DOI Listing
April 2018

Adolescents and young adults with brain tumors in the context of molecular advances in neuro-oncology.

Pediatr Blood Cancer 2018 Feb 19;65(2). Epub 2017 Oct 19.

Division of Hematology/Oncology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/pbc.26861DOI Listing
February 2018

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.

Cell 2018 02;172(5):1050-1062.e14

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.01.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346737PMC
February 2018

Reply to D.T.W. Jones et al.

J Clin Oncol 2018 01 15;36(1):97. Epub 2017 Nov 15.

Uri Tabori, Eric Bouffet, and Cynthia E. Hawkins, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://ascopubs.org/doi/10.1200/JCO.2017.76.0645
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http://dx.doi.org/10.1200/JCO.2017.76.0645DOI Listing
January 2018

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018

Isolated optic nerve gliomas: a multicenter historical cohort study.

J Neurosurg Pediatr 2017 Dec 6;20(6):549-555. Epub 2017 Oct 6.

1The Gilbert Israeli Neurofibromatosis Center, Dana Children's Hospital.

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http://dx.doi.org/10.3171/2017.6.PEDS17107DOI Listing
December 2017

Smaller hippocampal subfield volumes predict verbal associative memory in pediatric brain tumor survivors.

Hippocampus 2017 11 20;27(11):1140-1154. Epub 2017 Jul 20.

Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1002/hipo.22758DOI Listing
November 2017

Comprehensive Analysis of Hypermutation in Human Cancer.

Cell 2017 Nov 19;171(5):1042-1056.e10. Epub 2017 Oct 19.

Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849393PMC
November 2017

Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma.

Neuro Oncol 2017 Oct;19(11):1542-1552

Pediatric Neuro-Oncology, Dana-Farber Boston Children's Cancer Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA; The Royal Marsden Hospital, Sutton, Surrey, UK; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Department of Medical Oncology, Azienda USL-IRCCS Institute of Neurological Science, Bologna, Italy; Institut Curie and University Paris Descartes, Paris, France; Division of Haematology/Oncology at The Hospital for Sick Children, Toronto, Ontario, Canada; Sir James Spence Institute of Child Health Royal Victoria Infirmary, Newcastle, UK; Seattle Children's Hospital, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA; The Royal Children's Hospital, Children's Cancer Center, Melbourne, Australia; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA; Catholic University of the Sacred Heart, Rome, Italy; Cancer Clinical Research Unit, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Paediatric Oncology Unit, Great Ormond Street Hospital, London, UK; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA; Gustave Roussy, Department of Pediatric and Adolescent Oncology, University Paris-Sud, Université Paris-Saclay, Villejuif, France.

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http://dx.doi.org/10.1093/neuonc/nox109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737275PMC
October 2017

Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas.

J Clin Oncol 2017 Sep 20;35(25):2934-2941. Epub 2017 Jul 20.

Alvaro Lassaletta, Michal Zapotocky, Matthew Mistry, Vijay Ramaswamy, Marion Honnorat, Rahul Krishnatry, Ana Guerreiro Stucklin, Nataliya Zhukova, Anthony Arnoldo, Scott Ryall, Catriona Ling, Tara McKeown, Jim Loukides, James T. Rutka, Peter Dirks, Michael D. Taylor, Shiyi Chen, Ute Bartels, Annie Huang, Eric Bouffet, Cynthia Hawkins, and Uri Tabori, The Hospital for Sick Children, Toronto; Adam Fleming, McMaster Children's Hospital, McMaster University, Hamilton; Shayna Zelcer, Children's Hospital of Western Ontario, London, Ontario; David Eisenstat and Bev Wilson, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta; Anne Sophie Carret, Hospital Sainte Justine; Nada Jabado, McGill University, Montreal; Valerie Larouche, Centre Hospitalier Universitaire de Québec, Québec City, Quebec, Canada; Ofelia Cruz and Carmen de Torres, Hospital Sant Joan de Déu, Barcelona, Spain; Cheng-Ying Ho, University of Maryland School of Medicine, Baltimore, MD; Roger J. Packer, Children's National Health System, Washington, DC; Ruth Tatevossian, Ibrahim Qaddoumi, Julie H. Harreld, James D. Dalton, and David W. Ellison, St Jude Children's Research Hospital, Memphis, TN; Jean Mulcahy-Levy and Nicholas Foreman, Children's Hospital Colorado, Aurora, CO; Matthias A. Karajannis, Shiyang Wang, and Matija Snuderl, New York University Langone Medical Center, New York, NY; Amulya Nageswara Rao and Caterina Giannini, The Mayo Clinic, Rochester, MN; Mark Kieran and Keith L. Ligon, Dana-Farber Cancer Institute, Boston Children's Hospital, Boston, MA; Maria Luisa Garre, Paolo Nozza, Samantha Mascelli, and Alessandro Raso, Istituto Giannina Gaslini, Genoa, Italy; Sabine Mueller and Theodore Nicolaides, University of California, San Francisco, San Francisco, CA; Karen Silva and Romain Perbet, Hospices Civils de Lyon; Alexandre Vasiljevic, Cécile Faure Conter, and Didier Frappaz, Institute of Pediatric Hematology and Oncology, Lyon, France; Sarah Leary and Courtney Crane, Seattle Children's Hospital, Seattle, WA; Aden Chan and Ho-Keung Ng, The Chinese University of Hong Kong, Hong Kong; Zhi-Feng Shi and Ying Mao, Huashan Hospital, Fudan University, Shanghai, People's Republic of China; Elizabeth Finch, University of North Carolina, School of Medicine, Chapel Hill, NC; Peter Hauser, Semmelweis University, Budapest, Hungary; and David Sumerauer and Lenka Krskova, University Hospital Motol, Charles University, 2nd Medical School, Prague, Czech Republic.

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http://dx.doi.org/10.1200/JCO.2016.71.8726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791837PMC
September 2017

Contemporary survival endpoints: an International Diffuse Intrinsic Pontine Glioma Registry study.

Neuro Oncol 2017 09;19(9):1279-1280

Departments of Neurology, Neurosurgery and Pediatrics, Lucile Packard Children's Hospital at Stanford, Stanford, California; Department of Pediatrics, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada; Departments of Hematology-Oncology, Neuro-Oncology & Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois; Department of Hematology/Oncology, Seattle Children's Hospital, Seattle, Washington; Departments of Pediatrics, University of Colorado and Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Denver, Colorado; Center for Neuroscience and Behavioral Medicine, Children's National Medical Center, Washington D.C.; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Section of Pediatric Hematology/Oncology, Riley Children's Hospital, Indianapolis, Indiana; Department of Pediatrics, Texas Children's Hospital, Houston, Texas; Lady Cilento Children's Hospital, Brisbane, Australia; Princess Margaret Hospital for Children and Telethon Kid's Institute, Subiaco, Australia; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1093/neuonc/nox107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570207PMC
September 2017

Balancing grief and survival: Experiences of children with brain tumors and their parents.

J Psychosoc Oncol 2016 Sep-Oct;34(5):376-99. Epub 2016 Jul 19.

a Family Relations and Applied Nutrition Department , University of Guelph , Guelph , Ontario , Canada.

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http://dx.doi.org/10.1080/07347332.2016.1212448DOI Listing
August 2017

The clinical significance of equivocal findings on spinal MRI in children with medulloblastoma.

Pediatr Blood Cancer 2017 Aug 16;64(8). Epub 2017 Feb 16.

Division of Hematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.26472DOI Listing
August 2017

Parental spirituality in life-threatening pediatric cancer.

J Psychosoc Oncol 2017 May-Jun;35(3):323-334. Epub 2017 Feb 8.

h Department of Social Work , The Hospital for Sick Children , Toronto , ON , Canada.

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http://dx.doi.org/10.1080/07347332.2017.1292573DOI Listing
August 2017

Pain Management and Use of Opioids in Pediatric Oncology in India: A Qualitative Approach.

J Glob Oncol 2017 Aug 2;3(4):331-337. Epub 2016 Nov 2.

and , The Hospital for Sick Children, Toronto; , McMaster University, Hamilton, Ontario, Canada; , University of New South Wales, Sydney, New South Wales, Australia; and , , and , Tata Memorial Hospital, Mumbai, India.

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http://dx.doi.org/10.1200/JGO.2016.003483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560448PMC
August 2017

Intertumoral Heterogeneity within Medulloblastoma Subgroups.

Authors:
Florence M G Cavalli Marc Remke Ladislav Rampasek John Peacock David J H Shih Betty Luu Livia Garzia Jonathon Torchia Carolina Nor A Sorana Morrissy Sameer Agnihotri Yuan Yao Thompson Claudia M Kuzan-Fischer Hamza Farooq Keren Isaev Craig Daniels Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Ji Yeoun Lee Wieslawa A Grajkowska Marta Perek-Polnik Alexandre Vasiljevic Cecile Faure-Conter Anne Jouvet Caterina Giannini Amulya A Nageswara Rao Kay Ka Wai Li Ho-Keung Ng Charles G Eberhart Ian F Pollack Ronald L Hamilton G Yancey Gillespie James M Olson Sarah Leary William A Weiss Boleslaw Lach Lola B Chambless Reid C Thompson Michael K Cooper Rajeev Vibhakar Peter Hauser Marie-Lise C van Veelen Johan M Kros Pim J French Young Shin Ra Toshihiro Kumabe Enrique López-Aguilar Karel Zitterbart Jaroslav Sterba Gaetano Finocchiaro Maura Massimino Erwin G Van Meir Satoru Osuka Tomoko Shofuda Almos Klekner Massimo Zollo Jeffrey R Leonard Joshua B Rubin Nada Jabado Steffen Albrecht Jaume Mora Timothy E Van Meter Shin Jung Andrew S Moore Andrew R Hallahan Jennifer A Chan Daniela P C Tirapelli Carlos G Carlotti Maryam Fouladi José Pimentel Claudia C Faria Ali G Saad Luca Massimi Linda M Liau Helen Wheeler Hideo Nakamura Samer K Elbabaa Mario Perezpeña-Diazconti Fernando Chico Ponce de León Shenandoah Robinson Michal Zapotocky Alvaro Lassaletta Annie Huang Cynthia E Hawkins Uri Tabori Eric Bouffet Ute Bartels Peter B Dirks James T Rutka Gary D Bader Jüri Reimand Anna Goldenberg Vijay Ramaswamy Michael D Taylor

Cancer Cell 2017 06;31(6):737-754.e6

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163053PMC
June 2017

Challenges of Treating Childhood Medulloblastoma in a Country With Limited Resources: 20 Years of Experience at a Single Tertiary Center in Malaysia.

J Glob Oncol 2017 Apr 15;3(2):143-156. Epub 2016 Jun 15.

, , , , , , , , , , and , University of Malaya; and , University Malaya Cancer Research Institute, Kuala Lumpur, Malaysia; , Hospital for Sick Children, Toronto, Ontario, Canada; and , St Jude Children's Research Hospital, Memphis, TN.

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http://ascopubs.org/doi/10.1200/JGO.2015.002659
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http://dx.doi.org/10.1200/JGO.2015.002659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493270PMC
April 2017

Underlying undiagnosed inherited marrow failure syndromes among children with cancer.

Pediatr Blood Cancer 2017 02 31;64(2):302-305. Epub 2016 Aug 31.

Marrow Failure and Myelodysplasia Program, Division of Haematology and Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.26120DOI Listing
February 2017

Current therapy and the evolving molecular landscape of paediatric ependymoma.

Eur J Cancer 2017 01 18;70:34-41. Epub 2016 Nov 18.

The Hospital for Sick Children, Division of Hematology/Oncology, 555 University Avenue, Toronto, ON M5G, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.10.013DOI Listing
January 2017

Reducing cisplatin ototoxicity in children: some hope and many questions.

Authors:
Eric Bouffet

Lancet Oncol 2017 01 1;18(1):6-7. Epub 2016 Dec 1.

The Hospital for Sick Children, University of Toronto, Toronto, ON, M5G 1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(16)30630-1DOI Listing
January 2017

Intellectual Outcome in Molecular Subgroups of Medulloblastoma.

J Clin Oncol 2016 12 31;34(34):4161-4170. Epub 2016 Oct 31.

Iska Moxon-Emre, Michael D. Taylor, Eric Bouffet, David Malkin, Cynthia Hawkins, Normand Laperriere, Vijay Ramaswamy, Ute Bartels, Nadia Scantlebury, Laura Janzen, Nicole Law, and Donald J. Mabbott, Hospital for Sick Children; Iska Moxon-Emre, Michael D. Taylor, David Malkin, Cynthia Hawkins, Normand Laperriere, Laura Janzen, Nicole Law, and Donald J. Mabbott, University of Toronto; Iska Moxon-Emre and David Malkin, Pediatric Oncology Group of Ontario; Normand Laperriere, Princess Margaret Hospital, Toronto, ON, Canada; Kristina Hardy and Karin S. Walsh, Children's National Health System, Washington, DC; and Cynthia J. Campen, Lucile Packard Children's Hospital, Palo Alto, CA.

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http://dx.doi.org/10.1200/JCO.2016.66.9077DOI Listing
December 2016

Management and outcome of chordomas in the pediatric population: The Hospital for Sick Children experience and review of the literature.

J Clin Neurosci 2016 Dec 31;34:169-176. Epub 2016 Aug 31.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Division of Neurosurgery, Department of Surgery, Hospital for Sick Children, Suite 1503, 555 University Avenue, Toronto, ON M5G 1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jocn.2016.06.003DOI Listing
December 2016

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Authors:
Jonathon Torchia Brian Golbourn Shengrui Feng King Ching Ho Patrick Sin-Chan Alexandre Vasiljevic Joseph D Norman Paul Guilhamon Livia Garzia Natalia R Agamez Mei Lu Tiffany S Chan Daniel Picard Pasqualino de Antonellis Dong-Anh Khuong-Quang Aline C Planello Constanze Zeller Dalia Barsyte-Lovejoy Lucie Lafay-Cousin Louis Letourneau Mathieu Bourgey Man Yu Deena M A Gendoo Misko Dzamba Mark Barszczyk Tiago Medina Alexandra N Riemenschneider A Sorana Morrissy Young-Shin Ra Vijay Ramaswamy Marc Remke Christopher P Dunham Stephen Yip Ho-Keung Ng Jian-Qiang Lu Vivek Mehta Steffen Albrecht Jose Pimentel Jennifer A Chan Gino R Somers Claudia C Faria Lucia Roque Maryam Fouladi Lindsey M Hoffman Andrew S Moore Yin Wang Seung Ah Choi Jordan R Hansford Daniel Catchpoole Diane K Birks Nicholas K Foreman Doug Strother Almos Klekner Laszló Bognár Miklós Garami Péter Hauser Tibor Hortobágyi Beverly Wilson Juliette Hukin Anne-Sophie Carret Timothy E Van Meter Eugene I Hwang Amar Gajjar Shih-Hwa Chiou Hideo Nakamura Helen Toledano Iris Fried Daniel Fults Takafumi Wataya Chris Fryer David D Eisenstat Katrin Scheinemann Adam J Fleming Donna L Johnston Jean Michaud Shayna Zelcer Robert Hammond Samina Afzal David A Ramsay Nongnuch Sirachainan Suradej Hongeng Noppadol Larbcharoensub Richard G Grundy Rishi R Lulla Jason R Fangusaro Harriet Druker Ute Bartels Ronald Grant David Malkin C Jane McGlade Theodore Nicolaides Tarik Tihan Joanna Phillips Jacek Majewski Alexandre Montpetit Guillaume Bourque Gary D Bader Alyssa T Reddy G Yancey Gillespie Monika Warmuth-Metz Stefan Rutkowski Uri Tabori Mathieu Lupien Michael Brudno Ulrich Schüller Torsten Pietsch Alexander R Judkins Cynthia E Hawkins Eric Bouffet Seung-Ki Kim Peter B Dirks Michael D Taylor Anat Erdreich-Epstein Cheryl H Arrowsmith Daniel D De Carvalho James T Rutka Nada Jabado Annie Huang

Cancer Cell 2016 Dec;30(6):891-908

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500911PMC
December 2016

Profound clinical and radiological response to BRAF inhibition in a 2-month-old diencephalic child with hypothalamic/chiasmatic glioma.

Pediatr Blood Cancer 2016 11 11;63(11):2038-41. Epub 2016 Jul 11.

Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.26086DOI Listing
November 2016

Phase II Weekly Vinblastine for Chemotherapy-Naïve Children With Progressive Low-Grade Glioma: A Canadian Pediatric Brain Tumor Consortium Study.

J Clin Oncol 2016 10;34(29):3537-3543

Alvaro Lassaletta, Cynthia E. Hawkins, Rahul Krishnatry, Matthew Mistry, Anthony Arnoldo, Vijay Ramaswamy, Annie Huang, Ute Bartels, Uri Tabori, and Eric Bouffet, The Hospital for Sick Children, Toronto; Katrin Scheinemann, McMaster Children's Hospital; Shayna M. Zelcer, Children's Hospital of Western Ontario, London; Gregory Russell Pond, Ontario Clinical Oncology Group, McMaster University, Hamilton; Daniel Keene and Donna L. Johnston, Children's Hospital of Eastern Ontario, Ottawa, Ontario; Juliette Hukin and Ken Poskitt, British Columbia Children's Hospital, Vancouver, British Columbia; Beverley A. Wilson, University of Alberta Hospital; Lucie Lafay-Cousin, Alberta Children's Hospital, Calgary; David D. Eisenstat, Stollery Children's Hospital, Edmonton; Alberta; Nada Jabado, McGill University; Anne Sophie Carret, Hospital Sainte Justine, Montreal; Valerie Larouche, Centre Hospitalier Universitaire de Québec, Québec, Québec; and David D. Eisenstat, Cancer Care Manitoba, Winnipeg, Manitoba, Canada.

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http://dx.doi.org/10.1200/JCO.2016.68.1585DOI Listing
October 2016

An integrative molecular and genomic analysis of pediatric hemispheric low-grade gliomas: an update.

Childs Nerv Syst 2016 Oct 20;32(10):1789-97. Epub 2016 Sep 20.

Division of Pediatric Neuro-oncology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, M5G 1X8, ON, Canada.

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http://dx.doi.org/10.1007/s00381-016-3163-6DOI Listing
October 2016

Old chemotherapy makes a comeback: dual alkylator therapy for pediatric high-grade glioma.

Neuro Oncol 2016 10;18(10):1333-4

Division of Haematology/Oncology, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada (E.B., V.R.);

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http://dx.doi.org/10.1093/neuonc/now200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035534PMC
October 2016

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.

Authors:
Vijay Ramaswamy Thomas Hielscher Stephen C Mack Alvaro Lassaletta Tong Lin Kristian W Pajtler David T W Jones Betty Luu Florence M G Cavalli Kenneth Aldape Marc Remke Martin Mynarek Stefan Rutkowski Sridharan Gururangan Roger E McLendon Eric S Lipp Christopher Dunham Juliette Hukin David D Eisenstat Dorcas Fulton Frank K H van Landeghem Mariarita Santi Marie-Lise C van Veelen Erwin G Van Meir Satoru Osuka Xing Fan Karin M Muraszko Daniela P C Tirapelli Sueli M Oba-Shinjo Suely K N Marie Carlos G Carlotti Ji Yeoun Lee Amulya A Nageswara Rao Caterina Giannini Claudia C Faria Sofia Nunes Jaume Mora Ronald L Hamilton Peter Hauser Nada Jabado Kevin Petrecca Shin Jung Luca Massimi Massimo Zollo Giuseppe Cinalli László Bognár Almos Klekner Tibor Hortobágyi Sarah Leary Ralph P Ermoian James M Olson Jeffrey R Leonard Corrine Gardner Wieslawa A Grajkowska Lola B Chambless Jason Cain Charles G Eberhart Sama Ahsan Maura Massimino Felice Giangaspero Francesca R Buttarelli Roger J Packer Lyndsey Emery William H Yong Horacio Soto Linda M Liau Richard Everson Andrew Grossbach Tarek Shalaby Michael Grotzer Matthias A Karajannis David Zagzag Helen Wheeler Katja von Hoff Marta M Alonso Teresa Tuñon Ulrich Schüller Karel Zitterbart Jaroslav Sterba Jennifer A Chan Miguel Guzman Samer K Elbabaa Howard Colman Girish Dhall Paul G Fisher Maryam Fouladi Amar Gajjar Stewart Goldman Eugene Hwang Marcel Kool Harshad Ladha Elizabeth Vera-Bolanos Khalida Wani Frank Lieberman Tom Mikkelsen Antonio M Omuro Ian F Pollack Michael Prados H Ian Robins Riccardo Soffietti Jing Wu Phillipe Metellus Uri Tabori Ute Bartels Eric Bouffet Cynthia E Hawkins James T Rutka Peter Dirks Stefan M Pfister Thomas E Merchant Mark R Gilbert Terri S Armstrong Andrey Korshunov David W Ellison Michael D Taylor

J Clin Oncol 2016 07 6;34(21):2468-77. Epub 2016 Jun 6.

Vijay Ramaswamy, Stephen C. Mack, Alvaro Lassaletta, Betty Luu, Florence M.G. Cavalli, Uri Tabori, Ute Bartels, Eric Bouffet, Cynthia E. Hawkins, James T. Rutka, Peter Dirks, and Michael D. Taylor, The Hospital for Sick Children; Vijay Ramaswamy, Kenneth Aldape, James T. Rutka, and Michael D. Taylor, University of Toronto; Kenneth Aldape, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario; Christopher Dunham and Juliette Hukin, British Columbia Children's Hospital; Juliette Hukin, University of British Columbia, Vancouver, British Columbia; David D. Eisenstat, Dorcas Fulton, and Frank K.H. van Landeghem, University of Alberta, Edmonton; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Nada Jabado and Kevin Petrecca, McGill University, Montreal, Quebec, Canada; Thomas Hielscher, Kristian W. Pajtler, David T.W. Jones, Marcel Kool, Stefan M. Pfister, and Andrey Korshunov, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Marc Remke, University Hospital Düsseldorf, Düsseldorf; Martin Mynarek, Stefan Rutkowski, and Katja von Hoff, University Medical Center Hamburg-Eppendorf, Hamburg; Ulrich Schüller, Ludwig-Maximilians-Universität, Munich, Germany; Stephen C. Mack, Cleveland Clinic Foundation, Cleveland; Maryam Fouladi, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Tong Lin, Amar Gajjar, Thomas E. Merchant, and David W. Ellison, St Jude Children's Research Hospital, Memphis; Lola B. Chambless, Vanderbilt Medical Center, Nashville, TN; Sridharan Gururangan, Roger E. McLendon, and Eric S. Lipp, Duke University, Durham; Jing Wu, University of North Carolina at Chapel Hill, Chapel Hill, NC; Mariarita Santi, Children's Hospital of Philadelphia; Lyndsey Emery, Hospital of the University of Pennsylvania, Philadelphia; Ronald L. Hamilton and Ian F. Pollack, University of Pittsburgh School of Medicine; Frank Lieberman, University of Pittsburgh Medical Cen

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http://dx.doi.org/10.1200/JCO.2015.65.7825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962737PMC
July 2016

Proton beam therapy for medulloblastoma.

Lancet Oncol 2016 05 27;17(5):e173-4. Epub 2016 Apr 27.

Division of Haematology/Oncology, Hospital for Sick Children, Toronto ON, Canada.

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http://dx.doi.org/10.1016/S1470-2045(16)00156-XDOI Listing
May 2016