Eric Batchelor

Eric Batchelor

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Eric Batchelor

Eric Batchelor

Publications by authors named "Eric Batchelor"

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p53 pulse modulation differentially regulates target gene promoters to regulate cell fate decisions.

Mol Syst Biol 2019 09;15(9):e8685

Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.15252/msb.20188685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761572PMC
September 2019

Protein stability of p53 targets determines their temporal expression dynamics in response to p53 pulsing.

J Cell Biol 2019 04 11;218(4):1282-1297. Epub 2019 Feb 11.

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

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http://www.jcb.org/lookup/doi/10.1083/jcb.201803063
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http://dx.doi.org/10.1083/jcb.201803063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446860PMC
April 2019

Tuning of mRNA stability through altering 3'-UTR sequences generates distinct output expression in a synthetic circuit driven by p53 oscillations.

Sci Rep 2019 04 12;9(1):5976. Epub 2019 Apr 12.

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41598-019-42509-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461691PMC
April 2019

CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level.

Nucleic Acids Res 2017 Nov;45(20):12039-12053

Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/nar/gkx843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714203PMC
November 2017

Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response.

Mol Cell 2017 Sep 31;67(6):1013-1025.e9. Epub 2017 Aug 31.

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657607PMC
September 2017

Flexible CRISPR library construction using parallel oligonucleotide retrieval.

Nucleic Acids Res 2017 Jun;45(11):e101

Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/nar/gkx181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499874PMC
June 2017

Recent progress and open challenges in modeling p53 dynamics in single cells.

Curr Opin Syst Biol 2017 Jun 25;3:54-59. Epub 2017 Mar 25.

Department of Biology, Technische Universität Darmstadt, Schnittspahnstrasse 13, 64287 Darmstadt, Germany.

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http://dx.doi.org/10.1016/j.coisb.2017.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650191PMC
June 2017

Determining the Limitations and Benefits of Noise in Gene Regulation and Signal Transduction through Single Cell, Microscopy-Based Analysis.

J Mol Biol 2017 04 11;429(8):1143-1154. Epub 2017 Mar 11.

Systems Biology Unit, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2017.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402475PMC
April 2017

Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma.

Oncotarget 2017 Feb;8(9):14860-14875

Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.18632/oncotarget.14740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362450PMC
February 2017

Single-cell Gene Expression Profiling Using FACS and qPCR with Internal Standards.

J Vis Exp 2017 02 25(120). Epub 2017 Feb 25.

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute;

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http://dx.doi.org/10.3791/55219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409306PMC
February 2017

p53 Pulses Diversify Target Gene Expression Dynamics in an mRNA Half-Life-Dependent Manner and Delineate Co-regulated Target Gene Subnetworks.

Cell Syst 2016 04 7;2(4):272-82. Epub 2016 Apr 7.

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, MSC 1500, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2016.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853828PMC
April 2016

Using computational modeling and experimental synthetic perturbations to probe biological circuits.

Methods Mol Biol 2015 ;1244:259-76

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room B1B42, 10 Center Dr., MSC 1500, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/978-1-4939-1878-2_12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311997PMC
August 2015

Modeling cell heterogeneity: from single-cell variations to mixed cells.

Pac Symp Biocomput 2013 :445-50

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20894, USA.

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December 2013

Promoter decoding of transcription factor dynamics.

Mol Syst Biol 2013 Nov 5;9:703. Epub 2013 Nov 5.

Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/msb.2013.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039376PMC
November 2013

p53 dynamics control cell fate.

Science 2012 Jun;336(6087):1440-4

Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1218351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162876PMC
June 2012

Suppressing variation in synthetic circuits.

Mol Syst Biol 2011 Aug 2;7:520. Epub 2011 Aug 2.

Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/msb.2011.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202793PMC
August 2011

Stimulus-dependent dynamics of p53 in single cells.

Mol Syst Biol 2011 May;7:488

Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/msb.2011.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130553PMC
May 2011

A synthetic-natural hybrid oscillator in human cells.

Proc Natl Acad Sci U S A 2010 Sep 13;107(39):17047-52. Epub 2010 Sep 13.

Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1005615107
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http://dx.doi.org/10.1073/pnas.1005615107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947868PMC
September 2010

Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.

Cell 2010 Jul;142(1):89-100

Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2010.05.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003696PMC
July 2010

Fourier analysis and systems identification of the p53 feedback loop.

Proc Natl Acad Sci U S A 2010 Jul 9;107(30):13550-5. Epub 2010 Jul 9.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1073/pnas.1001107107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922141PMC
July 2010

The ups and downs of p53: understanding protein dynamics in single cells.

Nat Rev Cancer 2009 05 9;9(5):371-7. Epub 2009 Apr 9.

Harvard Medical School Systems Biology, Boston, MA 02115, USA.

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http://www.nature.com/articles/nrc2604
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http://dx.doi.org/10.1038/nrc2604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892289PMC
May 2009

Imaging OmpR localization in Escherichia coli.

Mol Microbiol 2006 Mar;59(6):1767-78

Department of Physics, University of Pennsylvania, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2006.05048.xDOI Listing
March 2006

Continuous control in bacterial regulatory circuits.

J Bacteriol 2004 Nov;186(22):7618-25

Department of Physics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://jb.asm.org/cgi/doi/10.1128/JB.186.22.7618-7625.2004
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http://dx.doi.org/10.1128/JB.186.22.7618-7625.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524909PMC
November 2004

Robustness and the cycle of phosphorylation and dephosphorylation in a two-component regulatory system.

Proc Natl Acad Sci U S A 2003 Jan 9;100(2):691-6. Epub 2003 Jan 9.

Department of Physics and Astronomy, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0234782100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC141058PMC
January 2003