Eric B Haura

Eric B Haura

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Eric B Haura

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GMSimpute: a generalized two-step Lasso approach to impute missing values in label-free mass spectrum analysis.

Bioinformatics 2019 Jun 14. Epub 2019 Jun 14.

Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL.

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http://dx.doi.org/10.1093/bioinformatics/btz488DOI Listing
June 2019

Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets.

Cell Chem Biol 2019 Jun 26. Epub 2019 Jun 26.

Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Department of Oncologic Sciences, University of South Florida, Tampa, FL 33620, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.06.003DOI Listing
June 2019

Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development.

Oncotarget 2019 Mar 5;10(19):1760-1774. Epub 2019 Mar 5.

Biomedical Data Science Department, Dartmouth College, Hanover, NH, USA.

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http://dx.doi.org/10.18632/oncotarget.26678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442994PMC
March 2019

Bidirectional Adaptive Signaling between cancer and stromal cells: mechanisms and therapeutics.

Expert Rev Proteomics 2018 09 28;15(9):697-699. Epub 2018 Sep 28.

a Departments of Thoracic Oncology , Moffitt Cancer Center , Tampa , FL , USA.

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http://dx.doi.org/10.1080/14789450.2018.1521276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435031PMC
September 2018

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.

Authors:
Xuemei Ji Yohan Bossé Maria Teresa Landi Jiang Gui Xiangjun Xiao David Qian Philippe Joubert Maxime Lamontagne Yafang Li Ivan Gorlov Mariella de Biasi Younghun Han Olga Gorlova Rayjean J Hung Xifeng Wu James McKay Xuchen Zong Robert Carreras-Torres David C Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert Chu Chen M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier A Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer Doherty Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske Judith Manz Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard Houlston John McLaughlin Victoria Stevens David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song María Soler Artigas Martin D Tobin Louise V Wain Fangyi Gu Jinyoung Byun Ahsan Kamal Dakai Zhu Rachel F Tyndale Wei-Qi Wei Stephen Chanock Paul Brennan Christopher I Amos

Nat Commun 2018 08 13;9(1):3221. Epub 2018 Aug 13.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.

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http://dx.doi.org/10.1038/s41467-018-05074-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089967PMC
August 2018

Development of a Targeted Smoking Relapse-Prevention Intervention for Cancer Patients.

J Cancer Educ 2018 04;33(2):440-447

Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center, 4115 E Fowler Ave, Tampa, FL, 33617, USA.

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http://dx.doi.org/10.1007/s13187-016-1089-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288399PMC
April 2018

Patient, caregiver and physician perspectives on participating in a thoracic rapid tissue donation program.

Patient Educ Couns 2018 04 28;101(4):703-710. Epub 2017 Nov 28.

Morsani College of Medicine, Department of Oncologic Science, University of South Florida, 12901 Bruce B Downs Blvd., Tampa, FL 33612, United States; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, United States.

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http://dx.doi.org/10.1016/j.pec.2017.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878993PMC
April 2018

Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population.

Carcinogenesis 2018 03;39(3):336-346

Biomedical Data Science Department, Dartmouth College, Hanover, NH, USA.

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http://dx.doi.org/10.1093/carcin/bgx113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248554PMC
March 2018

CAR-T cells and combination therapies: What's next in the immunotherapy revolution?

Pharmacol Res 2018 03 1;129:194-203. Epub 2017 Dec 1.

Dept. of Immunology, H. Lee Moffitt Cancer Center and Research Institute. Tampa, FL, United States; Dept. of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, United States; Dept. of Oncological Sciences, Morsani School of Medicine, University of South Florida, United States.

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http://dx.doi.org/10.1016/j.phrs.2017.11.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828987PMC
March 2018

Cell signaling heterogeneity is modulated by both cell-intrinsic and -extrinsic mechanisms: An integrated approach to understanding targeted therapy.

PLoS Biol 2018 03 9;16(3):e2002930. Epub 2018 Mar 9.

Integrated Mathematical Oncology Department, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.2002930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844524PMC
March 2018

Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer.

J Proteome Res 2018 01 22;17(1):63-75. Epub 2017 Nov 22.

H. Lee Moffitt Cancer Center & Research Institute , Tampa, Florida 33612-9497, United States.

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http://dx.doi.org/10.1021/acs.jproteome.7b00329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021760PMC
January 2018

Polypharmacology-based ceritinib repurposing using integrated functional proteomics.

Nat Chem Biol 2017 Dec 9;13(12):1222-1231. Epub 2017 Oct 9.

Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

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http://dx.doi.org/10.1038/nchembio.2489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909815PMC
December 2017

Cell-surface marker discovery for lung cancer.

Oncotarget 2017 Dec 7;8(69):113373-113402. Epub 2017 Dec 7.

Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

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http://dx.doi.org/10.18632/oncotarget.23009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768334PMC
December 2017

A Bayesian pick-the-winner design in a randomized phase II clinical trial.

Oncotarget 2017 Oct 7;8(51):88376-88385. Epub 2017 Jul 7.

Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

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http://dx.doi.org/10.18632/oncotarget.19088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687612PMC
October 2017

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

Authors:
James D McKay Rayjean J Hung Younghun Han Xuchen Zong Robert Carreras-Torres David C Christiani Neil E Caporaso Mattias Johansson Xiangjun Xiao Yafang Li Jinyoung Byun Alison Dunning Karen A Pooley David C Qian Xuemei Ji Geoffrey Liu Maria N Timofeeva Stig E Bojesen Xifeng Wu Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier Alberto Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher A Haiman Lynne R Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Henricus F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer A Doherty Matt P Barnett Chu Chen Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske H-Erich Wichmann Judith Manz Thomas R Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances A Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard S Houlston John McLaughlin Victoria L Stevens Philippe Joubert Maxime Lamontagne David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song Linda Kachuri María Soler Artigas Martin D Tobin Louise V Wain Thorunn Rafnar Thorgeir E Thorgeirsson Gunnar W Reginsson Kari Stefansson Dana B Hancock Laura J Bierut Margaret R Spitz Nathan C Gaddis Sharon M Lutz Fangyi Gu Eric O Johnson Ahsan Kamal Claudio Pikielny Dakai Zhu Sara Lindströem Xia Jiang Rachel F Tyndale Georgia Chenevix-Trench Jonathan Beesley Yohan Bossé Stephen Chanock Paul Brennan Maria Teresa Landi Christopher I Amos

Nat Genet 2017 Jul 12;49(7):1126-1132. Epub 2017 Jun 12.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

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http://dx.doi.org/10.1038/ng.3892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510465PMC
July 2017

The neuropilin 2 isoform NRP2b uniquely supports TGFβ-mediated progression in lung cancer.

Sci Signal 2017 01 17;10(462). Epub 2017 Jan 17.

Division of Hematology/Oncology, Department of Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1126/scisignal.aag0528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969810PMC
January 2017

Strategies for power calculations in predictive biomarker studies in survival data.

Oncotarget 2016 Dec;7(49):80373-80381

Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

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http://dx.doi.org/10.18632/oncotarget.12124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348326PMC
December 2016

APOSTL: An Interactive Galaxy Pipeline for Reproducible Analysis of Affinity Proteomics Data.

J Proteome Res 2016 12 21;15(12):4747-4754. Epub 2016 Oct 21.

Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute , Tampa, Florida 33612-9497, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231908PMC
December 2016

Phosphoproteomics Reveals MAPK Inhibitors Enhance MET- and EGFR-Driven AKT Signaling in KRAS-Mutant Lung Cancer.

Mol Cancer Res 2016 10 15;14(10):1019-1029. Epub 2016 Jul 15.

Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065770PMC
http://dx.doi.org/10.1158/1541-7786.MCR-15-0506DOI Listing
October 2016

Preclinical Modeling of KIF5B-RET Fusion Lung Adenocarcinoma.

Mol Cancer Ther 2016 10 5;15(10):2521-2529. Epub 2016 Aug 5.

Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida. Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. Department of Oncology Sciences, University of South Florida College of Medicine, Tampa, Florida.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289739PMC
October 2016

New twists in the AXL(e) of tumor progression.

Sci Signal 2016 10 4;9(448):fs14. Epub 2016 Oct 4.

Department of Thoracic Oncology and Chemical Biology and Molecular Medicine Program, H. Lee Moffitt Cancer Center, Tampa, FL 33611, USA.

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http://dx.doi.org/10.1126/scisignal.aai7619DOI Listing
October 2016

Smoking relapse-prevention intervention for cancer patients: Study design and baseline data from the surviving SmokeFree randomized controlled trial.

Contemp Clin Trials 2016 09 25;50:84-9. Epub 2016 Jul 25.

H. Lee Moffitt Cancer Center & Research Institute, 12902 USF Magnolia Drive, Tampa, FL 33612, United States; University of South Florida, 4202 E. Fowler Avenue, Tampa, FL 33620, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cct.2016.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564185PMC
September 2016

Acquired ALK L1152R Mutation Confers Resistance to Ceritinib and Predicts Response to Alectinib.

J Thorac Oncol 2016 07 16;11(7):e87-8. Epub 2016 Apr 16.

Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.03.018DOI Listing
July 2016

A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma.

J Thorac Oncol 2016 06 23;11(6):838-49. Epub 2016 Feb 23.

Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877210PMC
June 2016

Activity-Based Proteomics Reveals Heterogeneous Kinome and ATP-Binding Proteome Responses to MEK Inhibition in KRAS Mutant Lung Cancer.

Proteomes 2016 Jun 27;4(2):16. Epub 2016 Apr 27.

Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; (J.-Y.K.); (P.A.S.); (A.L.B.).

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http://dx.doi.org/10.3390/proteomes4020016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217344PMC
June 2016

Target Identification in Small Cell Lung Cancer via Integrated Phenotypic Screening and Activity-Based Protein Profiling.

Mol Cancer Ther 2016 Feb 15;15(2):334-42. Epub 2016 Jan 15.

Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747823PMC
February 2016

Transforming growth factor β signaling overcomes dasatinib resistance in lung cancer.

PLoS One 2014 11;9(12):e114131. Epub 2014 Dec 11.

Molecular Oncology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114131PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263601PMC
September 2015

Charting Immune Signaling Proteomes En Route to New Therapeutic Strategies.

Cancer Immunol Res 2015 Jul 16;3(7):714-20. Epub 2015 Jun 16.

Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491034PMC
July 2015

Interleukin polymorphisms associated with overall survival, disease-free survival, and recurrence in non-small cell lung cancer patients.

Mol Carcinog 2015 Jun 18;54 Suppl 1:E172-84. Epub 2015 Jan 18.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center Research Institute, Tampa, Florida.

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http://dx.doi.org/10.1002/mc.22275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475444PMC
June 2015

Evaluating kinase ATP uptake and tyrosine phosphorylation using multiplexed quantification of chemically labeled and post-translationally modified peptides.

Methods 2015 Jun 14;81:41-9. Epub 2015 Mar 14.

Molecular Oncology, Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, United States; Chemical Biology and Molecular Medicine, Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2015.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460980PMC
June 2015

Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer.

J Natl Cancer Inst 2015 Jan 1;107(1):358. Epub 2014 Dec 1.

Department of Medicine (CC, RG, MZ, FJK), Genetics Institute (RG, FJK), Genetics and Genomics Graduate Program (RG, FJK), and Molecular Genetics and Microbiology (ZC, YG, CH, LW), University of Florida, Gainesville, FL; Department of Cancer Biology and Informatics, the Scripps Research Institute, Jupiter, FL (ALA, MF); Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC (ALA); Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL (CH); Cancer Informatics Core (EAW), Department of Molecular Oncology (BEE, WDC), and Department of Thoracic Oncology (EBH), Moffitt Cancer Center, Tampa, FL; Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL (MZK).

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http://jnci.oxfordjournals.org/content/107/1/dju358.full.pdf
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http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/dju358
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http://dx.doi.org/10.1093/jnci/dju358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271078PMC
January 2015

Adaptive responses to dasatinib-treated lung squamous cell cancer cells harboring DDR2 mutations.

Cancer Res 2014 Dec 27;74(24):7217-7228. Epub 2014 Oct 27.

Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326029PMC
December 2014

Identification of kinase inhibitor targets in the lung cancer microenvironment by chemical and phosphoproteomics.

Mol Cancer Ther 2014 Nov 4;13(11):2751-62. Epub 2014 Sep 4.

Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Vienna, Austria. Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-14
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http://dx.doi.org/10.1158/1535-7163.MCT-14-0152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221415PMC
November 2014

The ethical imperative of risk disclosure in research: the answer is always yes.

Am J Bioeth 2014 ;14(4):18-9

a Moffitt Cancer Center and University of South Florida.

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http://dx.doi.org/10.1080/15265161.2014.889242DOI Listing
October 2014

Deploying ibrutinib to lung cancer: another step in the quest towards drug repurposing.

J Natl Cancer Inst 2014 Sep 10;106(9). Epub 2014 Sep 10.

Departments of Thoracic Oncology (EBH) and Drug Discovery (UR), Chemical Biology and Molecular Medicine Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

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http://dx.doi.org/10.1093/jnci/dju250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072366PMC
September 2014

SHP2E76K mutant promotes lung tumorigenesis in transgenic mice.

Carcinogenesis 2014 Aug 30;35(8):1717-25. Epub 2014 Jan 30.

Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Division of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Department of Oncologic Sciences, University of South Florida College of Medicine and

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http://carcin.oxfordjournals.org/content/early/2014/02/18/ca
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http://www.carcin.oxfordjournals.org/cgi/doi/10.1093/carcin/
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http://dx.doi.org/10.1093/carcin/bgu025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123642PMC
August 2014

Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer.

J Thorac Oncol 2014 Jul;9(7):974-82

*Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; †Janssen R&D, Spring House, PA; §Department of Anatomic Pathology; and ‡Department of Biostatistics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

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http://dx.doi.org/10.1097/JTO.0000000000000193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057975PMC
July 2014

TGF-β-inducible microRNA-183 silences tumor-associated natural killer cells.

Proc Natl Acad Sci U S A 2014 Mar 28;111(11):4203-8. Epub 2014 Feb 28.

Departments of Immunology, Molecular Oncology, Thoracic Oncology, Cancer Epidemiology, and Anatomic Pathology, Moffitt Cancer Center, Tampa, FL 33612.

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http://dx.doi.org/10.1073/pnas.1319269111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964044PMC
March 2014

GSK3 alpha and beta are new functionally relevant targets of tivantinib in lung cancer cells.

ACS Chem Biol 2014 Feb 20;9(2):353-8. Epub 2013 Nov 20.

Department of Drug Discovery, ‡Department of Thoracic Oncology, and §Molecular Oncology and Proteomics, H. Lee Moffitt Cancer Center & Research Institute , Tampa, Florida 33612-9497, United States.

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http://dx.doi.org/10.1021/cb400660aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944088PMC
February 2014

Obatoclax mesylate, a pan-bcl-2 inhibitor, in combination with docetaxel in a phase 1/2 trial in relapsed non-small-cell lung cancer.

J Thorac Oncol 2014 Jan;9(1):121-5

*H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; †Arlington Cancer Center, Arlington, Texas; ‡Mayo Clinic Arizona, Scottsdale, Arizona; §Georgetown University Hospital, Washington, District of Columbia; ‖University of Maryland, Greenebaum Cancer Center, Baltimore, Maryland; ¶Tower Cancer Research Foundation, Beverly Hills, California; #MedStar Research Institute, Hyattsville, Maryland; and **formerly Gemin X Pharmaceuticals, an indirect wholly owned subsidiary of Teva Pharmaceutical Industries Ltd., Petach Tikva, Israel.

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http://dx.doi.org/10.1097/JTO.0000000000000027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666503PMC
January 2014

Stakeholder perceptions of thoracic rapid tissue donation: An exploratory study.

Soc Sci Med 2013 Dec 6;99:35-41. Epub 2013 Sep 6.

Cancer Prevention and Control, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA; College of Medicine, Department of Oncologic Science, University of South Florida, 12901 Bruce B. Downs Boulevard, MDC 44, Tampa, FL 33612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.socscimed.2013.08.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869974PMC
December 2013

Signaling control by epidermal growth factor receptor and MET: rationale for cotargeting strategies in lung cancer.

J Clin Oncol 2013 Nov 7;31(32):4148-50. Epub 2013 Oct 7.

H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

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http://dx.doi.org/10.1200/JCO.2013.50.8234DOI Listing
November 2013

Non-canonical IKKs, IKKϵ and TBK1, as novel therapeutic targets in the treatment of non-small cell lung cancer.

Expert Opin Ther Targets 2013 Oct 28;17(10):1109-12. Epub 2013 Aug 28.

H. Lee Moffitt Cancer Center and Research Institute, Department of Thoracic Oncology and Chemical Biology and Molecular Medicine Program , 12902 Magnolia Dr. Tampa, FL 33612 , USA

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http://www.tandfonline.com/doi/full/10.1517/14728222.2013.83
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http://dx.doi.org/10.1517/14728222.2013.833188DOI Listing
October 2013

Phase II trial of a GM-CSF-producing and CD40L-expressing bystander cell line combined with an allogeneic tumor cell-based vaccine for refractory lung adenocarcinoma.

J Immunother 2013 Oct;36(8):442-50

*Department of Oncologic Sciences, University of South Florida †H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL ‡MD Anderson Cancer Center, Houston, TX §Karmanos Cancer Institute, Wayne State University, Detroit, MI.

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http://dx.doi.org/10.1097/CJI.0b013e3182a80237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846277PMC
October 2013

A miniaturized chemical proteomic approach for target profiling of clinical kinase inhibitors in tumor biopsies.

J Proteome Res 2013 Sep 20;12(9):4005-17. Epub 2013 Aug 20.

Department of Protein Biochemistry and Proteomics, Technological Centre of the Palacký University, Centre of the Region Haná for Biotechnological and Agricultural Research, Olomouc, Czech Republic.

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http://dx.doi.org/10.1021/pr400309pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127982PMC
September 2013

The NAD+ synthesis enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT1) regulates ribosomal RNA transcription.

J Biol Chem 2013 Jul 4;288(29):20908-17. Epub 2013 Jun 4.

Department of Molecular Oncology, Moffitt Cancer Center, Tampa, Florida 33612, USA.

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http://dx.doi.org/10.1074/jbc.M113.470302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774361PMC
July 2013

Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells.

Proc Natl Acad Sci U S A 2013 Jul 8;110(30):12414-9. Epub 2013 Jul 8.

Department ofThoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

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http://dx.doi.org/10.1073/pnas.1220674110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725062PMC
July 2013

Tripartite motif containing 28 (Trim28) can regulate cell proliferation by bridging HDAC1/E2F interactions.

J Biol Chem 2012 Nov 11;287(48):40106-18. Epub 2012 Oct 11.

Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.380865
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504725PMC
November 2012

Curcumin: a novel Stat3 pathway inhibitor for chemoprevention of lung cancer.

Eur J Cancer Prev 2012 Sep;21(5):407-12

Department of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, University of South Florida College of Medicine, Tampa, Florida 33612, USA.

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http://dx.doi.org/10.1097/CEJ.0b013e32834ef194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319490PMC
September 2012

Suspected methotrexate toxicity from omeprazole: a case review of carboxypeptidase G2 use in a methotrexate-experienced patient with methotrexate toxicity and a review of the literature.

J Pharm Pract 2012 Aug 1;25(4):477-85. Epub 2012 May 1.

Department of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1177/0897190012442717DOI Listing
August 2012

From modules to medicine: How modular domains and their associated networks can enable personalized medicine.

Authors:
Eric B Haura

FEBS Lett 2012 Aug 7;586(17):2580-5. Epub 2012 May 7.

Department of Thoracic Oncology Program and Experimental Therapeutics Program, The H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

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http://doi.wiley.com/10.1016/j.febslet.2012.04.036
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084654PMC
August 2012

Intranuclear delivery of a novel antibody-derived radiosensitizer targeting the DNA-dependent protein kinase catalytic subunit.

Int J Radiat Oncol Biol Phys 2012 Jul 2;83(3):1023-30. Epub 2011 Dec 2.

Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, GA 30912, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2011.08.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698569PMC
July 2012

Phosphoproteomics identifies driver tyrosine kinases in sarcoma cell lines and tumors.

Cancer Res 2012 May 29;72(10):2501-11. Epub 2012 Mar 29.

Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641440PMC
May 2012

Optimisation of Downscaled Tandem Affinity Purifications to Identify Core Protein Complexes.

J Integr OMICS 2012 May;2(1):55-68

Department of Thoracic Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

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http://dx.doi.org/10.5584/jiomics.v2i1.81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785125PMC
May 2012

Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors.

J Med Chem 2012 Mar 15;55(5):2474-8. Epub 2012 Feb 15.

Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA.

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http://dx.doi.org/10.1021/jm201289rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516226PMC
March 2012

An essential role for Stat3 in regulating IgG immune complex-induced pulmonary inflammation.

FASEB J 2011 Dec 22;25(12):4292-300. Epub 2011 Aug 22.

Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1096/fj.11-187955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236634PMC
December 2011

Prognostic and predictive value of a malignancy-risk gene signature in early-stage non-small cell lung cancer.

J Natl Cancer Inst 2011 Dec 8;103(24):1859-70. Epub 2011 Dec 8.

Department of Biostatistics, Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

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http://dx.doi.org/10.1093/jnci/djr420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243673PMC
December 2011

The potential benefits of BIM in the further pursuit of biomarker discovery in cancer therapeutics.

Cancer Discov 2011 Sep;1(4):289-90

Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.

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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-11-0193DOI Listing
September 2011

JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling.

Mol Cancer Ther 2011 Mar 7;10(3):481-94. Epub 2011 Jan 7.

Thoracic Oncology and Experimental Therapeutics Programs H. Lee Moffitt Cancer Center and Research Institute MRC3 East, Room 3056F, 12902 Magnolia Drive Tampa, Florida 33612-9497, USA.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-10
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http://dx.doi.org/10.1158/1535-7163.MCT-10-0502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084653PMC
March 2011