Eric B Dammer

Eric B Dammer

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Eric B Dammer

Eric B Dammer

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Transcriptional regulation of homeostatic and disease-associated-microglial genes by IRF1, LXRβ, and CEBPα.

Glia 2019 10 13;67(10):1958-1975. Epub 2019 Jul 13.

Department of Neurology, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1002/glia.23678DOI Listing
October 2019

Proteomics Links Ubiquitin Chain Topology Change to Transcription Factor Activation.

Mol Cell 2019 Oct 20;76(1):126-137.e7. Epub 2019 Aug 20.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics & Research and Development of New Drug of Chinese Academy of Medical Sciences, Institute of Lifeomics, Beijing 102206, P.R. China; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery of Ministry of Education, School of Pharmaceutical Sciences, School of Medicine, Wuhan University, Wuhan 430072, P.R. China; Guizhou University School of Medicine, Guiyang 550025, P.R. China. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.07.001DOI Listing
October 2019

Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease.

Cell Rep 2019 Oct;29(2):301-316.e10

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.104DOI Listing
October 2019

Transcriptome Network Analysis Identifies CXCL13-CXCR5 Signaling Modules in the Prostate Tumor Immune Microenvironment.

Sci Rep 2019 Oct 18;9(1):14963. Epub 2019 Oct 18.

Department of Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, GA, 30310, USA.

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http://dx.doi.org/10.1038/s41598-019-46491-3DOI Listing
October 2019

Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer's Disease.

Proteomes 2019 Aug 27;7(3). Epub 2019 Aug 27.

Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.3390/proteomes7030030DOI Listing
August 2019

Ionizing Radiation induction of cholesterol biosynthesis in Lung tissue.

Sci Rep 2019 Aug 29;9(1):12546. Epub 2019 Aug 29.

Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America.

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http://dx.doi.org/10.1038/s41598-019-48972-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715797PMC
August 2019

Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2.

J Proteome Res 2019 Jun 14;18(6):2571-2584. Epub 2019 May 14.

Department of Pharmacology and Chemical Biology, Rollins Research Center , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.

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http://dx.doi.org/10.1021/acs.jproteome.9b00103DOI Listing
June 2019

Effects of Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease.

Front Mol Neurosci 2018 18;11:454. Epub 2018 Dec 18.

Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States.

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http://dx.doi.org/10.3389/fnmol.2018.00454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305300PMC
December 2018

Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease.

Proteomics 2018 10;18(20):e1800108

Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1002/pmic.201800108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283072PMC
October 2018

Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease.

Mol Neurodegener 2018 10 4;13(1):52. Epub 2018 Oct 4.

Department of Neurology, Emory University School of Medicine, Whitehead Building-Suite 505C, 615 Michael Street, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1186/s13024-018-0282-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172707PMC
October 2018

Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy.

J Neuropathol Exp Neurol 2018 Jan;77(1):40-49

Boston University Alzheimer's Disease and CTE Center; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts; Center for Neurodegenerative Disease, Emory University School of Medicine; Department of Biochemistry, Emory University School of Medicine; Department of Neurology, Emory University School of Medicine, Atlanta, Georgia; Department of Anatomy and Neurobiology; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts; VA Boston Healthcare System, Boston, Massachusetts; and Department of Veterans Affairs Medical Center, Bedford, Massachusetts.

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http://dx.doi.org/10.1093/jnen/nlx100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939631PMC
January 2018

Integrating Next-Generation Genomic Sequencing and Mass Spectrometry To Estimate Allele-Specific Protein Abundance in Human Brain.

J Proteome Res 2017 09 9;16(9):3336-3347. Epub 2017 Aug 9.

Division of Neurology, Department of Veterans Affairs Medical Center , Decatur, Georgia 30033, United States.

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http://dx.doi.org/10.1021/acs.jproteome.7b00324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698003PMC
September 2017

Peripheral Blood MicroRNA Expression Profiles in Alzheimer's Disease: Screening, Validation, Association with Clinical Phenotype and Implications for Molecular Mechanism.

Mol Neurobiol 2016 10 26;53(8):5772-81. Epub 2015 Oct 26.

Department of Neurology & Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

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http://dx.doi.org/10.1007/s12035-015-9484-8DOI Listing
October 2016

MicroRNA-146a represses LRP2 translation and leads to cell apoptosis in Alzheimer's disease.

FEBS Lett 2016 07 8;590(14):2190-200. Epub 2016 Jul 8.

Department of Neurology & Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, China.

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http://dx.doi.org/10.1002/1873-3468.12229DOI Listing
July 2016

Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase.

J Biol Chem 2016 Feb 16;291(7):3280-90. Epub 2015 Dec 16.

From the Department of Pediatrics, Division of Pulmonology, Allergy/Immunology, Cystic Fibrosis and Sleep and the Emory-Children's Center for Cystic Fibrosis Research, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, the Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908,

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http://dx.doi.org/10.1074/jbc.M115.706853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751374PMC
February 2016

The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration.

Transl Neurodegener 2015 30;4:18. Epub 2015 Sep 30.

Department of Neurology & Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 China.

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http://dx.doi.org/10.1186/s40035-015-0041-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596472PMC
October 2015

Melatonin for sleep disorders and cognition in dementia: a meta-analysis of randomized controlled trials.

Am J Alzheimers Dis Other Demen 2015 Aug;30(5):439-47

Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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http://dx.doi.org/10.1177/1533317514568005DOI Listing
August 2015

Proteomics of protein post-translational modifications implicated in neurodegeneration.

Transl Neurodegener 2014 30;3(1):23. Epub 2014 Oct 30.

Department of Neurology,Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, GA 30322 USA.

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http://dx.doi.org/10.1186/2047-9158-3-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323146PMC
February 2015

Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins.

Proteomics 2015 Jan 17;15(2-3):508-519. Epub 2014 Dec 17.

Department of Biochemistry, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322.

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http://dx.doi.org/10.1002/pmic.201400189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404162PMC
January 2015

Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease.

Alzheimers Res Ther 2013 13;5(3):32. Epub 2013 Jun 13.

Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, 615 Michael Street NE, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1186/alzrt186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054949PMC
August 2014

Aggregates of small nuclear ribonucleic acids (snRNAs) in Alzheimer's disease.

Brain Pathol 2014 Jul 14;24(4):344-51. Epub 2014 Apr 14.

Center for Neurodegenerative Disease, Emory University, Atlanta, GA; Department of Neurology, Emory University School of Medicine, Atlanta, GA.

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http://dx.doi.org/10.1111/bpa.12133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096308PMC
July 2014

Quantitative proteomics reveals significant changes in cell shape and an energy shift after IPTG induction via an optimized SILAC approach for Escherichia coli.

J Proteome Res 2013 Dec 14;12(12):5978-88. Epub 2013 Nov 14.

State Key Laboratory of Proteomics, National Engineering Research Center for Protein Drugs, Beijing Proteome Research Center, National Center for Protein Sciences Beijing, Beijing Institute of Radiation Medicine , Beijing 102206, P. R. China.

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http://dx.doi.org/10.1021/pr400775wDOI Listing
December 2013

Tissue-type plasminogen activator mediates neuronal detection and adaptation to metabolic stress.

J Cereb Blood Flow Metab 2013 Nov 24;33(11):1761-9. Epub 2013 Jul 24.

Department of Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1038/jcbfm.2013.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824174PMC
November 2013

Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes.

J Neuropathol Exp Neurol 2013 Nov;72(11):1009-15

From the Department of Neurology (CMH, HR, AIL, JJL, TSW), Center for Neurodegenerative Disease (CMH, HR, NTS, EBD, DMD, MG, AIL, JJL, TSW), Departments of Biochemistry (NTS) and Human Genetics (EBD, TSW), and Pathology and Laboratory Medicine (MG), Emory University School of Medicine, Atlanta, Georgia; Department of Pathology, University of Washington, Seattle, Washington (TJM); Departments of Pathology and Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland (JCT); National Institute of Aging, National Institutes of Health, Bethesda, Maryland (MT); and Atlanta Veterans Administration Medical Center, Atlanta, Georgia (TSW).

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https://academic.oup.com/jnen/article-lookup/doi/10.1097/01.
Publisher Site
http://dx.doi.org/10.1097/01.jnen.0000435847.59828.dbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037931PMC
November 2013

Neuron enriched nuclear proteome isolated from human brain.

J Proteome Res 2013 Jul 17;12(7):3193-206. Epub 2013 Jun 17.

Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1021/pr400246tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734798PMC
July 2013

Expression, purification and proteomic analysis of recombinant histone H4 acetylated at lysine 16.

Proteomics 2013 May 26;13(10-11):1687-91. Epub 2013 Apr 26.

Department of Biology, Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1002/pmic.201300025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771349PMC
May 2013

cAMP-stimulated phosphorylation of diaphanous 1 regulates protein stability and interaction with binding partners in adrenocortical cells.

Mol Biol Cell 2013 Mar 16;24(6):848-57. Epub 2013 Jan 16.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093-0704, USA.

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http://dx.doi.org/10.1091/mbc.E12-08-0597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596254PMC
March 2013

Protein profiling of active cysteine cathepsins in living cells using an activity-based probe containing a cell-penetrating peptide.

J Proteome Res 2012 Dec 30;11(12):5763-72. Epub 2012 Oct 30.

Britton Chance Center for Biomedical Photonics, Department of Biomedical Engineering, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology (HUST), Wuhan, China.

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http://pubs.acs.org/doi/10.1021/pr300575u
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http://dx.doi.org/10.1021/pr300575uDOI Listing
December 2012

Asparaginyl endopeptidase cleaves TDP-43 in brain.

Proteomics 2012 Aug;12(15-16):2455-63

Department of Neurology, Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1002/pmic.201200006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787696PMC
August 2012

Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc.

Endocrinology 2012 Jul 14;153(7):3258-68. Epub 2012 May 14.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093-0704, USA.

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http://dx.doi.org/10.1210/en.2011-2088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380297PMC
July 2012

Phosphorylation of CtBP1 by cAMP-dependent protein kinase modulates induction of CYP17 by stimulating partnering of CtBP1 and 2.

J Biol Chem 2008 Mar 9;283(11):6925-34. Epub 2008 Jan 9.

School of Biology and Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332-0230, USA.

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http://dx.doi.org/10.1074/jbc.M708432200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730192PMC
March 2008

Multiple Signaling Pathways Coordinate CYP17 Gene Expression in the Human Adrenal Cortex.

Acta Chim Slov 2008 Jan;55(1):53-57

School of Biology and Parker H. Petit Institute for Bioengineering & Biosciences, Georgia Institute of Technology, Atlanta, GA 30332-0230.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809372PMC
January 2008

Transcriptional regulation of adrenocortical steroidogenic gene expression.

Drug Metab Rev 2007 ;39(2-3):371-88

School of Biology and Parker H. Petit Institute for Bioengineering & Biosciences, Georgia Institute of Technology, Atlanta, Georgia 30332-0230, USA.

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http://dx.doi.org/10.1080/03602530701498828 DOI Listing
October 2007

Coregulator exchange and sphingosine-sensitive cooperativity of steroidogenic factor-1, general control nonderepressed 5, p54, and p160 coactivators regulate cyclic adenosine 3',5'-monophosphate-dependent cytochrome P450c17 transcription rate.

Mol Endocrinol 2007 Feb 22;21(2):415-38. Epub 2006 Nov 22.

School of Biology, Parker H. Petit Institute for Bioengineering & Biosciences, Georgia Institute of Technology, 310 Ferst Drive, Atlanta, Georgia 30332-0230, USA.

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http://dx.doi.org/10.1210/me.2006-0361DOI Listing
February 2007