Eric A Sobie

Eric A Sobie

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Eric A Sobie

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An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity.

Methods Mol Biol 2018 ;1816:17-35

Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1007/978-1-4939-8597-5_2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561094PMC
March 2019

Slow Delayed Rectifier Current Protects Ventricular Myocytes From Arrhythmic Dynamics Across Multiple Species: A Computational Study.

Circ Arrhythm Electrophysiol 2018 10;11(10):e006558

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (M.V., R.A.D., E.A.S.).

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http://dx.doi.org/10.1161/CIRCEP.118.006558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326778PMC
October 2018

Ca Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations.

Front Physiol 2018 23;9:1194. Epub 2018 Aug 23.

Centro de Investigación e Innovación en Bioingeniería, Universitat Politècnica de València, Valencia, Spain.

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http://dx.doi.org/10.3389/fphys.2018.01194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116328PMC
August 2018

A privileged role for neuronal Na channels in regulating ventricular [Ca] and arrhythmias.

J Gen Physiol 2018 07 13;150(7):901-905. Epub 2018 Jun 13.

Department of Pharmacological Sciences, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY

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http://dx.doi.org/10.1085/jgp.201812120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028496PMC
July 2018

Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types.

NPJ Syst Biol Appl 2018 24;4:11. Epub 2018 Feb 24.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY USA.

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http://dx.doi.org/10.1038/s41540-018-0047-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825396PMC
February 2018

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.

Authors:
Alexandra B Keenan Sherry L Jenkins Kathleen M Jagodnik Simon Koplev Edward He Denis Torre Zichen Wang Anders B Dohlman Moshe C Silverstein Alexander Lachmann Maxim V Kuleshov Avi Ma'ayan Vasileios Stathias Raymond Terryn Daniel Cooper Michele Forlin Amar Koleti Dusica Vidovic Caty Chung Stephan C Schürer Jouzas Vasiliauskas Marcin Pilarczyk Behrouz Shamsaei Mehdi Fazel Yan Ren Wen Niu Nicholas A Clark Shana White Naim Mahi Lixia Zhang Michal Kouril John F Reichard Siva Sivaganesan Mario Medvedovic Jaroslaw Meller Rick J Koch Marc R Birtwistle Ravi Iyengar Eric A Sobie Evren U Azeloglu Julia Kaye Jeannette Osterloh Kelly Haston Jaslin Kalra Steve Finkbiener Jonathan Li Pamela Milani Miriam Adam Renan Escalante-Chong Karen Sachs Alex Lenail Divya Ramamoorthy Ernest Fraenkel Gavin Daigle Uzma Hussain Alyssa Coye Jeffrey Rothstein Dhruv Sareen Loren Ornelas Maria Banuelos Berhan Mandefro Ritchie Ho Clive N Svendsen Ryan G Lim Jennifer Stocksdale Malcolm S Casale Terri G Thompson Jie Wu Leslie M Thompson Victoria Dardov Vidya Venkatraman Andrea Matlock Jennifer E Van Eyk Jacob D Jaffe Malvina Papanastasiou Aravind Subramanian Todd R Golub Sean D Erickson Mohammad Fallahi-Sichani Marc Hafner Nathanael S Gray Jia-Ren Lin Caitlin E Mills Jeremy L Muhlich Mario Niepel Caroline E Shamu Elizabeth H Williams David Wrobel Peter K Sorger Laura M Heiser Joe W Gray James E Korkola Gordon B Mills Mark LaBarge Heidi S Feiler Mark A Dane Elmar Bucher Michel Nederlof Damir Sudar Sean Gross David F Kilburn Rebecca Smith Kaylyn Devlin Ron Margolis Leslie Derr Albert Lee Ajay Pillai

Cell Syst 2018 01 29;6(1):13-24. Epub 2017 Nov 29.

NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cels.2017.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799026PMC
January 2018

Ambiguous interactions between diastolic and SR Ca in the regulation of cardiac Ca release.

J Gen Physiol 2017 09 10;149(9):847-855. Epub 2017 Aug 10.

BioMET, Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, MD.

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http://dx.doi.org/10.1085/jgp.201711814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583714PMC
September 2017

Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics.

Front Physiol 2017 8;8:651. Epub 2017 Sep 8.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiNew York, NY, United States.

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http://dx.doi.org/10.3389/fphys.2017.00651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599787PMC
September 2017

Experimental and Computational Insight Into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity.

Circ Res 2017 Aug 22;121(4):411-423. Epub 2017 Jun 22.

From the Cardiovascular Research Center (J.M., T.J.C., D.K.C., D.S., S.S., R.J.H., K.D.C.), Department of Developmental and Regenerative Biology (D.A.K.), and Department of Pharmacology and Systems Therapeutics (E.A.S.), Icahn School of Medicine at Mount Sinai, New York; Department of Medicine, University of Washington Seattle (B.V.J.); and The Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, FL (J.M.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899516PMC
August 2017

Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility.

J Physiol 2017 04 28;595(7):2301-2317. Epub 2016 Dec 28.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1113/JP273191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374112PMC
April 2017

I love it when a plan comes together: Insight gained through convergence of competing mathematical models.

J Mol Cell Cardiol 2017 01 30;102:31-33. Epub 2016 Nov 30.

Department of Pharmacological Sciences, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2016.10.015DOI Listing
January 2017

Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking.

J Biol Chem 2016 10 7;291(44):23257-23267. Epub 2016 Sep 7.

From the Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029

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http://dx.doi.org/10.1074/jbc.M116.749747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087742PMC
October 2016

Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes.

Stem Cell Reports 2016 09 25;7(3):355-369. Epub 2016 Aug 25.

The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032183PMC
September 2016

There and back again: Iterating between population-based modeling and experiments reveals surprising regulation of calcium transients in rat cardiac myocytes.

J Mol Cell Cardiol 2016 07 30;96:38-48. Epub 2015 Jul 30.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733425PMC
July 2016

Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes.

PLoS Comput Biol 2016 07 25;12(7):e1005014. Epub 2016 Jul 25.

Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959759PMC
July 2016

Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms.

J Physiol 2016 05 4;594(9):2525-36. Epub 2016 Feb 4.

Greenberg Division of Cardiology, Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1113/JP270618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850194PMC
May 2016

Pathogenesis of the Novel Autoimmune-Associated Long-QT Syndrome.

Circulation 2015 Jul 20;132(4):230-40. Epub 2015 May 20.

From Cardiovascular Research Program, VA New York Harbor Healthcare System, Brooklyn (Y.Y., U.S., F.F., K.S., Z.L., Y.Q., N.E.-S., M.M.H., X.-C.J., M.B.); Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Italy (M.C., P.-L.C., F.L.-P., P.-E.L.); Departments of Medicine, Cell Biology and Pharmacology, State University of New York Downstate Medical Center, Brooklyn (U.S., F.F., Z.L., Y.Q., M.M.H., X.-C.J., M.B.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland (Z.Z.); Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison (C.J.); Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York (E.A.S.); Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institute, Stockholm, Sweden (M.W.-H.); Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Laval University, Quebec City, Canada (M.C.); and Department of Medicine, New York University School of Medicine, New York (M.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.009800DOI Listing
July 2015

Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression.

PLoS One 2014 10;9(7):e101316. Epub 2014 Jul 10.

The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101316PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092021PMC
March 2015

Calcium homeostasis in a local/global whole cell model of permeabilized ventricular myocytes with a Langevin description of stochastic calcium release.

Am J Physiol Heart Circ Physiol 2015 Mar 5;308(5):H510-23. Epub 2014 Dec 5.

Department of Applied Science, The College of William and Mary, Williamsburg, Virginia;

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http://dx.doi.org/10.1152/ajpheart.00296.2014DOI Listing
March 2015

Maximal acceleration of Ca2+ release refractoriness by β-adrenergic stimulation requires dual activation of kinases PKA and CaMKII in mouse ventricular myocytes.

J Physiol 2015 Mar 7;593(6):1495-507. Epub 2014 Oct 7.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1113/jphysiol.2014.278051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376426PMC
March 2015

The ryanodine receptor patchwork: knitting calcium spark dynamics.

Biophys J 2014 Dec;107(12):2749-2750

Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.10.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269797PMC
December 2014

Multifaceted roles of miR-1s in repressing the fetal gene program in the heart.

Cell Res 2014 Mar 31;24(3):278-92. Epub 2014 Jan 31.

Mindich Child Health and Development Institute, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1040, New York, NY 10029, USA.

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http://dx.doi.org/10.1038/cr.2014.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945888PMC
March 2014

Comprehensive analyses of ventricular myocyte models identify targets exhibiting favorable rate dependence.

PLoS Comput Biol 2014 Mar 27;10(3):e1003543. Epub 2014 Mar 27.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1003543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967944PMC
March 2014

Computer simulation of voltage sensitive calcium ion channels in a dendritic spine.

J Theor Biol 2013 Dec 30;338:87-93. Epub 2013 Aug 30.

Department of Physiology and Biotechnology and Bioengineering Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jtbi.2013.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860056PMC
December 2013

Yoga for the sinoatrial node: sarcoplasmic reticulum calcium release confers flexibility.

J Mol Cell Cardiol 2013 Jul 28;60:161-3. Epub 2013 Apr 28.

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http://dx.doi.org/10.1016/j.yjmcc.2013.04.020DOI Listing
July 2013

Decoding myocardial Ca²⁺ signals across multiple spatial scales: a role for sensitivity analysis.

J Mol Cell Cardiol 2013 May 28;58:92-9. Epub 2012 Sep 28.

Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2012.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746482PMC
May 2013

Alterations in T-tubule and dyad structure in heart disease: challenges and opportunities for computational analyses.

Cardiovasc Res 2013 May 7;98(2):233-9. Epub 2013 Feb 7.

Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1215, New York, NY 10029, USA.

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http://dx.doi.org/10.1093/cvr/cvt026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633159PMC
May 2013

Parameter sensitivity analysis of stochastic models provides insights into cardiac calcium sparks.

Biophys J 2013 Mar;104(5):1142-50

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1016/j.bpj.2012.12.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870797PMC
March 2013

Regression methods for parameter sensitivity analysis: applications to cardiac arrhythmia mechanisms.

Conf Proc IEEE Eng Med Biol Soc 2011 ;2011:4657-60

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1109/IEMBS.2011.6091153DOI Listing
July 2012

Stochastic simulation of cardiac ventricular myocyte calcium dynamics and waves.

Conf Proc IEEE Eng Med Biol Soc 2011 ;2011:4677-80

School of Systems Biology, George Mason University, Manassas, VA 20110,

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http://dx.doi.org/10.1109/IEMBS.2011.6091158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538105PMC
July 2012

Exploiting mathematical models to illuminate electrophysiological variability between individuals.

J Physiol 2012 Jun 10;590(11):2555-67. Epub 2012 Apr 10.

Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1113/jphysiol.2011.223313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424714PMC
June 2012

Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles.

J Mol Cell Cardiol 2012 Feb 13;52(2):304-11. Epub 2011 Jul 13.

Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2011.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217160PMC
February 2012

Unique properties of the ATP-sensitive K⁺ channel in the mouse ventricular cardiac conduction system.

Circ Arrhythm Electrophysiol 2011 Dec 9;4(6):926-35. Epub 2011 Oct 9.

Department of Pediatrics, NYU School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1161/CIRCEP.111.964643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247655PMC
December 2011

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis.

Heart Rhythm 2011 Nov 7;8(11):1749-55. Epub 2011 Jun 7.

Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15475271110067
Publisher Site
http://dx.doi.org/10.1016/j.hrthm.2011.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202650PMC
November 2011

Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity.

Cardiovasc Res 2011 Sep 24;91(4):598-605. Epub 2011 May 24.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1215, New York, NY 10029, USA.

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http://dx.doi.org/10.1093/cvr/cvr143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156908PMC
September 2011

Systems biology--biomedical modeling.

Sci Signal 2011 Sep 6;4(190):tr2. Epub 2011 Sep 6.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scisignal.2001989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188945PMC
September 2011

An introduction to dynamical systems.

Authors:
Eric A Sobie

Sci Signal 2011 Sep 13;4(191):tr6. Epub 2011 Sep 13.

Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scisignal.2001982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118930PMC
September 2011

An introduction to MATLAB.

Authors:
Eric A Sobie

Sci Signal 2011 Sep 13;4(191):tr7. Epub 2011 Sep 13.

Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scisignal.2001984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118934PMC
September 2011

Dynamics of calcium sparks and calcium leak in the heart.

Biophys J 2011 Sep 20;101(6):1287-96. Epub 2011 Sep 20.

Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/j.bpj.2011.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177068PMC
September 2011

Bistability in biochemical signaling models.

Authors:
Eric A Sobie

Sci Signal 2011 Sep 20;4(192):tr10. Epub 2011 Sep 20.

Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scisignal.2001964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118931PMC
September 2011

Computational modeling of the cell cycle.

Authors:
Eric A Sobie

Sci Signal 2011 Sep 20;4(192):tr11. Epub 2011 Sep 20.

Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scisignal.2001985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118933PMC
September 2011

Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes.

J Mol Cell Cardiol 2011 Jul 8;51(1):4-15. Epub 2011 Apr 8.

Departments of Pediatrics and Genetics and Genomic Sciences and the Child Health and Development Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2011.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103595PMC
July 2011

Complex and rate-dependent beat-to-beat variations in Ca2+ transients of canine Purkinje cells.

J Mol Cell Cardiol 2011 Apr 11;50(4):662-9. Epub 2011 Jan 11.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2010.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059096PMC
April 2011

Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization.

FASEB J 2011 Mar 17;25(3):851-62. Epub 2010 Nov 17.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794-8181, USA.

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http://dx.doi.org/10.1096/fj.10-168625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042840PMC
March 2011

Getting heart cells on the same wavelength: infrared triggering of Ca2+ transients in cardiac myocytes.

Authors:
Eric A Sobie

J Physiol 2011 Mar;589(Pt 6):1243-4

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1215, New York, NY 10029, USA.

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http://dx.doi.org/10.1113/jphysiol.2011.205906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082084PMC
March 2011

Spontaneous Ca2+ sparks and Ca2+ homeostasis in a minimal model of permeabilized ventricular myocytes.

Am J Physiol Heart Circ Physiol 2010 Dec 17;299(6):H1996-2008. Epub 2010 Sep 17.

Department of Applied Science, The College of William and Mary, Williamsburg, Virginia 23187, USA.

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http://dx.doi.org/10.1152/ajpheart.00293.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006298PMC
December 2010

Regression analysis for constraining free parameters in electrophysiological models of cardiac cells.

PLoS Comput Biol 2010 Sep 2;6(9):e1000914. Epub 2010 Sep 2.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1371/journal.pcbi.1000914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932676PMC
September 2010

Models of cardiac excitation-contraction coupling in ventricular myocytes.

Math Biosci 2010 Jul 25;226(1):1-15. Epub 2010 Mar 25.

The Department of Bionformatics and Computational Biology, George Mason University, VA, USA.

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http://dx.doi.org/10.1016/j.mbs.2010.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499386PMC
July 2010

Physiologic gating properties of unitary cardiac L-type Ca2+ channels.

Biochem Biophys Res Commun 2010 Jun 10;396(3):763-6. Epub 2010 May 10.

Department of Physiology and Pharmacology, CUNY Medical School, City College of New York, New York, NY 10031, USA.

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http://dx.doi.org/10.1016/j.bbrc.2010.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892242PMC
June 2010

Predicting local SR Ca(2+) dynamics during Ca(2+) wave propagation in ventricular myocytes.

Biophys J 2010 Jun;98(11):2515-23

Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1016/j.bpj.2010.02.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877363PMC
June 2010

Keeping the beat: life without SERCA--is it possible?

J Mol Cell Cardiol 2009 Aug 19;47(2):171-3. Epub 2009 May 19.

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http://dx.doi.org/10.1016/j.yjmcc.2009.05.005DOI Listing
August 2009

Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious model.

J Physiol 2009 Mar 19;587(Pt 6):1293-9. Epub 2009 Jan 19.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1113/jphysiol.2008.163915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674998PMC
March 2009

Parameter sensitivity analysis in electrophysiological models using multivariable regression.

Authors:
Eric A Sobie

Biophys J 2009 Feb;96(4):1264-74

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1016/j.bpj.2008.10.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717232PMC
February 2009

Moment closure for local control models of calcium-induced calcium release in cardiac myocytes.

Biophys J 2008 Aug 16;95(4):1689-703. Epub 2008 May 16.

Department of Applied Science, College of William and Mary, Williamsburg, Virginia, USA.

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http://dx.doi.org/10.1529/biophysj.107.125948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483752PMC
August 2008

New insights into the structure and function of couplons.

J Physiol 2008 Aug;586(16):3735

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1113/jphysiol.2008.159509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538929PMC
August 2008

Mathematical model of the neonatal mouse ventricular action potential.

Am J Physiol Heart Circ Physiol 2008 Jun 11;294(6):H2565-75. Epub 2008 Apr 11.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1152/ajpheart.01376.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032983PMC
June 2008

Teaching resources. Using web-based discussion forums as a model of the peer-review process and a tool for assessment.

Sci Signal 2008 ;1(9):tr2

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/stke.19tr2DOI Listing
April 2008

Inquiry learning. Integrating content detail and critical reasoning by peer review.

Science 2008 Feb;319(5867):1189-90

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/science.1149875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038128PMC
February 2008

Novel approach to real-time flash photolysis and confocal [Ca2+] imaging.

Pflugers Arch 2007 Jul 24;454(4):663-73. Epub 2007 Feb 24.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1215, New York, NY 10029, USA.

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http://dx.doi.org/10.1007/s00424-007-0229-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794040PMC
July 2007

Photochemical gating of intracellular Ca2+ release channels.

J Am Chem Soc 2007 May 11;129(17):5316-7. Epub 2007 Apr 11.

Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1021/ja069361qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536572PMC
May 2007

A probability density approach to modeling local control of calcium-induced calcium release in cardiac myocytes.

Biophys J 2007 Apr 19;92(7):2311-28. Epub 2007 Jan 19.

Department of Applied Science, College of William and Mary, Williamsburg, Virginia 23187, USA.

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http://dx.doi.org/10.1529/biophysj.106.099861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1864826PMC
April 2007

Expression of a sorcin missense mutation in the heart modulates excitation-contraction coupling.

FASEB J 2007 Feb 27;21(2):475-87. Epub 2006 Nov 27.

Division of Pediatric Cardiology, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1096/fj.06-6292comDOI Listing
February 2007

Restitution of Ca(2+) release and vulnerability to arrhythmias.

J Cardiovasc Electrophysiol 2006 May;17 Suppl 1:S64-S70

Division of Pediatric Cardiology, New York University School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1111/j.1540-8167.2006.00385.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1540408PMC
May 2006

The Ca 2+ leak paradox and rogue ryanodine receptors: SR Ca 2+ efflux theory and practice.

Prog Biophys Mol Biol 2006 Jan-Apr;90(1-3):172-85. Epub 2005 Jul 18.

Medical Biotechnology Center, University of Maryland Biotechnology Institute, 725 W. Lombard Street, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1016/j.pbiomolbio.2005.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1484520PMC
April 2006

Orphaned ryanodine receptors in the failing heart.

Proc Natl Acad Sci U S A 2006 Mar 6;103(11):4305-10. Epub 2006 Mar 6.

Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1073/pnas.0509324103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1449688PMC
March 2006

Ca2+ sparks in heart muscle.

J Muscle Res Cell Motil 2004 ;25(8):602-3

Institute of Molecular Cardiology, Medical Biotechnology Center University of Maryland Biotechnology Institute, Baltimore 21201, USA.

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November 2005

Local recovery of Ca2+ release in rat ventricular myocytes.

J Physiol 2005 Jun 7;565(Pt 2):441-7. Epub 2005 Apr 7.

Medical Biotechnology Center, 725 W. Lombard Street, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1113/jphysiol.2005.086496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464523PMC
June 2005

Calcium biology of the transverse tubules in heart.

Ann N Y Acad Sci 2005 Jun;1047:99-111

Medical Biotechnology Center and the Institute of Molecular Cardiology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1196/annals.1341.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1484521PMC
June 2005

Twenty years of calcium imaging: cell physiology to dye for.

Mol Interv 2005 Apr;5(2):112-27

Department of Pharmacology & Therapeutics and Division of Cardiology College of Medicine, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.1124/mi.5.2.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861218PMC
April 2005

The challenge of molecular medicine: complexity versus Occam's razor.

J Clin Invest 2003 Mar;111(6):801-3

Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1172/JCI18153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC153775PMC
March 2003

Local Ca(2+) signaling and EC coupling in heart: Ca(2+) sparks and the regulation of the [Ca(2+)](i) transient.

J Mol Cell Cardiol 2002 Aug;34(8):941-50

Medical Biotechnology Center and Institute of Molecular Cardiology, University of Maryland Biotechnology Institute, 725 W. Lombard Street, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1006/jmcc.2002.2032DOI Listing
August 2002

Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release.

Biophys J 2002 Jul;83(1):59-78

Medical Biotechnology Center, University of Maryland Biotechnology Center, Baltimore, Maryland 21201, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1302127PMC
http://dx.doi.org/10.1016/s0006-3495(02)75149-7DOI Listing
July 2002