Dr. Erhe Gao, MD, PhD - Temple University School of Medicine - Professor

Dr. Erhe Gao

MD, PhD

Temple University School of Medicine

Professor

Philadelphia, PA | United States

Main Specialties: Cardiovascular Disease

Dr. Erhe Gao, MD, PhD - Temple University School of Medicine - Professor

Dr. Erhe Gao

MD, PhD

Introduction

Primary Affiliation: Temple University School of Medicine - Philadelphia, PA , United States

Specialties:

Publications

144Publications

2907Reads

1557Profile Views

2905PubMed Central Citations

Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway.

PLoS One 2013 21;8(6):e66234. Epub 2013 Jun 21.

Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America ; Chaoyang Hospital, Capital Medical University, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066234PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689757PMC
October 2017
19 Reads
22 Citations
3.234 Impact Factor

CREG protects from myocardial ischemia/reperfusion injury by regulating myocardial autophagy and apoptosis.

Biochim Biophys Acta Mol Basis Dis 2017 08 11;1863(8):1893-1903. Epub 2016 Nov 11.

Cardiovascular Research Institute and Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, Liaoning, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.11.015DOI Listing
August 2017
25 Reads
5 Citations
4.882 Impact Factor

OSM mitigates post-infarction cardiac remodeling and dysfunction by up-regulating autophagy through Mst1 suppression.

Biochim Biophys Acta Mol Basis Dis 2017 08 4;1863(8):1951-1961. Epub 2016 Nov 4.

Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.11.004DOI Listing
August 2017
56 Reads
3 Citations
4.882 Impact Factor

Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.

J Pineal Res 2017 Jan 25;62(1). Epub 2016 Oct 25.

Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

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http://dx.doi.org/10.1111/jpi.12368DOI Listing
January 2017
32 Reads
10 Citations
9.600 Impact Factor

β2-Adrenergic receptor-dependent chemokine receptor 2 expression regulates leukocyte recruitment to the heart following acute injury.

Proc Natl Acad Sci U S A 2016 12 12;113(52):15126-15131. Epub 2016 Dec 12.

Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140

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http://dx.doi.org/10.1073/pnas.1611023114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206565PMC
December 2016
16 Reads
5 Citations
9.810 Impact Factor

Vasopressin type 1A receptor deletion enhances cardiac contractility, β-adrenergic receptor sensitivity and acute cardiac injury-induced dysfunction.

Clin Sci (Lond) 2016 Nov 2;130(22):2017-2027. Epub 2016 Sep 2.

Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, U.S.A.

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http://dx.doi.org/10.1042/CS20160363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334456PMC
November 2016
26 Reads
1 Citation
5.600 Impact Factor

Defective branched chain amino acid catabolism contributes to cardiac dysfunction and remodeling following myocardial infarction.

Am J Physiol Heart Circ Physiol 2016 11 19;311(5):H1160-H1169. Epub 2016 Aug 19.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China; and.

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http://dx.doi.org/10.1152/ajpheart.00114.2016DOI Listing
November 2016
30 Reads
11 Citations
3.840 Impact Factor

Cardiac Fibroblast GRK2 Deletion Enhances Contractility and Remodeling Following Ischemia/Reperfusion Injury.

Circ Res 2016 Oct 6;119(10):1116-1127. Epub 2016 Sep 6.

From the Department of Pharmacology, Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA (M.C.W., B.P.W., E.G., A.Y., W.J.K.); and Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China (A.Y.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085864PMC
http://dx.doi.org/10.1161/CIRCRESAHA.116.309538DOI Listing
October 2016
39 Reads
9 Citations
11.020 Impact Factor

Melatonin prevents adverse myocardial infarction remodeling via Notch1/Mfn2 pathway.

Free Radic Biol Med 2016 08 5;97:408-417. Epub 2016 Jul 5.

Department of Cardiology, Chengdu Military General Hospital, Chengdu 610083, China; Third Military Medical University, Chongqing 400042, China. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.06.015DOI Listing
August 2016
17 Reads
7 Citations
5.740 Impact Factor

Leukocyte-Expressed β2-Adrenergic Receptors Are Essential for Survival After Acute Myocardial Injury.

Circulation 2016 Jul 30;134(2):153-67. Epub 2016 Jun 30.

From Center for Translational Medicine (L.A.G., A.M.G., C.J.T., J.E.G., A.A.R., E.G., R.L.C., J.E.R., W.J.K., D.G.T.), Department of Pharmacology (E.G., J.E.R., W.J.K., D.G.T.), and Department of Clinical Sciences (D.Y.), Temple University School of Medicine, Philadelphia, PA; Department of Surgery, Division of Cardiothoracic Surgery, Emory University School of Medicine and Carlyle Fraser Heart Center, Atlanta, GA (J.W.C.); and Spanish National Center for Cardiovascular Research, Madrid, Spain (A.P.G., B.I.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120587PMC
July 2016
72 Reads
9 Citations
14.430 Impact Factor

The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-β1 pathway.

Sci Rep 2016 07 25;6:29975. Epub 2016 Jul 25.

Department of Cardiology, Chengdu Military General Hospital, Chengdu 610083, China.

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http://dx.doi.org/10.1038/srep29975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958998PMC
July 2016
9 Reads
4 Citations
5.080 Impact Factor

Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.

Circ Res 2016 04 14;118(8):1208-22. Epub 2016 Mar 14.

From the Division of Cardiovascular Medicine (F.A., V.K.V., Y.G., H.L., T.F.) and Department of Pharmacology (S.P., Y.G.), Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA (J.Z., N.E.H., S.R., J.S., A.Y., S.S., E.G., W.K., M.M., R.K.); and Department of Medical Biophysics, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada (J.R.W.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843504PMC
April 2016
24 Reads
9 Citations
11.020 Impact Factor

A peptide of the RGS domain of GRK2 binds and inhibits Gα(q) to suppress pathological cardiac hypertrophy and dysfunction.

Sci Signal 2016 Mar 22;9(420):ra30. Epub 2016 Mar 22.

Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA. Department of Pharmacology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1126/scisignal.aae0549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015886PMC
March 2016
29 Reads
7 Citations
6.280 Impact Factor

Melatonin facilitates adipose-derived mesenchymal stem cells to repair the murine infarcted heart via the SIRT1 signaling pathway.

J Pineal Res 2016 Mar 17;60(2):178-92. Epub 2015 Dec 17.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.

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http://dx.doi.org/10.1111/jpi.12299DOI Listing
March 2016
17 Reads
17 Citations
9.600 Impact Factor

BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes.

J Mol Cell Cardiol 2016 Mar 19;92:10-20. Epub 2016 Jan 19.

Center of Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA; Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789075PMC
March 2016
22 Reads
13 Citations
4.660 Impact Factor

Luteolin alleviates post-infarction cardiac dysfunction by up-regulating autophagy through Mst1 inhibition.

J Cell Mol Med 2016 Jan 5;20(1):147-56. Epub 2015 Nov 5.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

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http://dx.doi.org/10.1111/jcmm.12714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717847PMC
January 2016
31 Reads
6 Citations

Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction.

Am J Physiol Heart Circ Physiol 2016 Jan 20;310(2):H250-61. Epub 2015 Nov 20.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shannxi, China;

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http://ajpheart.physiology.org/content/ajpheart/310/2/H250.f
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http://ajpheart.physiology.org/lookup/doi/10.1152/ajpheart.0
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http://dx.doi.org/10.1152/ajpheart.00372.2015DOI Listing
January 2016
57 Reads
11 Citations
3.840 Impact Factor

Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy.

Circ Res 2015 Dec 29;117(12):1001-12. Epub 2015 Oct 29.

From the Center for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA (C.J.T., A.C., A.G.V., B.P.W., J.H., J.I., J.I.G., J.K.C., E.G., W.J.K.); and Department of Biostatistics and Bioinformatics, Fox Chase Cancer Center, Philadelphia, PA (Y.Z.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.306961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825669PMC
December 2015
11 Reads
3 Citations
11.020 Impact Factor

Toll-like receptor 9-activation during onset of myocardial ischemia does not influence infarct extension.

PLoS One 2014 15;9(8):e104407. Epub 2014 Aug 15.

Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Center for Heart Failure Research, University of Oslo, Oslo, Norway; Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway; K.G. Jebsen Cardiac Research Center, University of Oslo, Oslo, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104407PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134200PMC
November 2015
13 Reads
3 Citations
3.234 Impact Factor

Pharmacological Elevation of Circulating Bioactive Phosphosphingolipids Enhances Myocardial Recovery After Acute Infarction.

Stem Cells Transl Med 2015 Nov 14;4(11):1333-43. Epub 2015 Sep 14.

Gill Heart Institute and Division of Cardiovascular Medicine, University of Kentucky, Lexington, Kentucky, USA, and Veterans Affairs Medical Center, Lexington, Kentucky, USA

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http://dx.doi.org/10.5966/sctm.2014-0273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622401PMC
November 2015
18 Reads
7 Citations
3.600 Impact Factor

Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation.

Mol Cell Biol 2015 Oct 20;35(19):3312-23. Epub 2015 Jul 20.

Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA Department of Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China

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http://dx.doi.org/10.1128/MCB.00229-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561731PMC
October 2015
8 Reads
8 Citations
4.780 Impact Factor

Notch3/Akt signaling contributes to OSM-induced protection against cardiac ischemia/reperfusion injury.

Apoptosis 2015 Sep;20(9):1150-63

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, 127 West Changle Road, Xi'an, 710032, Shaanxi, China.

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http://dx.doi.org/10.1007/s10495-015-1148-7DOI Listing
September 2015
6 Reads
3 Citations
3.685 Impact Factor

Cardiac Dysfunction in HIV-1 Transgenic Mouse: Role of Stress and BAG3.

Clin Transl Sci 2015 Aug 24;8(4):305-10. Epub 2015 Aug 24.

Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/cts.12331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841629PMC
August 2015
22 Reads
6 Citations
2.110 Impact Factor

S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction.

Mol Ther 2015 Aug 25;23(8):1320-1330. Epub 2015 May 25.

Molecular and Translational Cardiology, Department of Internal Medicine III, Heidelberg University Hospital, Heidelberg, Germany; Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany; uniQure GmbH Germany, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1038/mt.2015.93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817858PMC
August 2015
16 Reads
3 Citations
6.230 Impact Factor

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition.

Cell Rep 2015 Jul 25;12(1):23-34. Epub 2015 Jun 25.

Center for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517182PMC
July 2015
9 Reads
60 Citations
7.210 Impact Factor

TNF-α antagonism ameliorates myocardial ischemia-reperfusion injury in mice by upregulating adiponectin.

Am J Physiol Heart Circ Physiol 2015 Jun 17;308(12):H1583-91. Epub 2015 Apr 17.

Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China;

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http://dx.doi.org/10.1152/ajpheart.00346.2014DOI Listing
June 2015
29 Reads
5 Citations
3.840 Impact Factor

Lin28a protects against cardiac ischaemia/reperfusion injury in diabetic mice through the insulin-PI3K-mTOR pathway.

J Cell Mol Med 2015 Jun 16;19(6):1174-82. Epub 2015 Feb 16.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

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http://dx.doi.org/10.1111/jcmm.12369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459833PMC
June 2015
11 Reads
5 Citations

Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction.

Circ Res 2015 Jun 22;117(1):52-64. Epub 2015 Apr 22.

From the Center for Translational Medicine (M.K., E.N., J.J., S.K.V., P.K., E.V., V.N.S.G., C.B., E.G., T.L., J.E., W.J.K.), Cardiovascular Research Center (S.R.H.), Department of Physiology (S.R.H.), and Department of Pharmacology (T.L., W.J.K., R.K.), Temple University School of Medicine, Philadelphia, PA; and Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL (T.A., A.R.M., E.V., V.R., E.L., A.I., S.M., G.Q., R.K.).

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http://circres.ahajournals.org/content/circresaha/early/2015
Web Search
http://circres.ahajournals.org/cgi/doi/10.1161/CIRCRESAHA.11
Publisher Site
http://dx.doi.org/10.1161/CIRCRESAHA.117.305990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482130PMC
June 2015
35 Reads
96 Citations
11.020 Impact Factor

Oncostatin M (OSM) protects against cardiac ischaemia/reperfusion injury in diabetic mice by regulating apoptosis, mitochondrial biogenesis and insulin sensitivity.

J Cell Mol Med 2015 Jun 8;19(6):1296-307. Epub 2015 Mar 8.

Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/jcmm.12501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459845PMC
June 2015
7 Reads
11 Citations

TNF-α inhibitor protects against myocardial ischemia/reperfusion injury via Notch1-mediated suppression of oxidative/nitrative stress.

Free Radic Biol Med 2015 May 11;82:114-21. Epub 2015 Feb 11.

Department of Cardiology, Chengdu Military General Hospital, Chengdu 610083, China. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.02.002DOI Listing
May 2015
9 Reads
11 Citations
5.740 Impact Factor

Consequence of the tumor-associated conversion to cyclin D1b.

EMBO Mol Med 2015 May;7(5):628-47

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Department of Urology, Thomas Jefferson University, Philadelphia, PA, USA Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA

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http://dx.doi.org/10.15252/emmm.201404242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492821PMC
May 2015
26 Reads
5 Citations
8.665 Impact Factor

G-protein-coupled receptor kinase 2-mediated desensitization of adiponectin receptor 1 in failing heart.

Circulation 2015 Apr 18;131(16):1392-404. Epub 2015 Feb 18.

From Department of Emergency Medicine (Y.W., W.B.L., Y.W., G.L., J.-J.L., X.W., Y.Y., X.-L.M.) and Center for Translational Medicine, Department of Medicine (X.-L.M.), Thomas Jefferson University, Philadelphia, PA; and Center for Translational Medicine, Temple University, Philadelphia, PA (E.G., W.J.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.015248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406820PMC
April 2015
12 Reads
10 Citations
14.430 Impact Factor

Ca²⁺ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance.

Am J Physiol Heart Circ Physiol 2015 Mar 9;308(6):H637-50. Epub 2015 Jan 9.

Center of Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania; Division of Nephrology, Temple University School of Medicine, Philadelphia, Pennsylvania;

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http://dx.doi.org/10.1152/ajpheart.00720.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360055PMC
March 2015
17 Reads
11 Citations
3.840 Impact Factor

Vitamin D receptor activation protects against myocardial reperfusion injury through inhibition of apoptosis and modulation of autophagy.

Antioxid Redox Signal 2015 Mar 14;22(8):633-50. Epub 2015 Jan 14.

1 Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai, China .

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http://dx.doi.org/10.1089/ars.2014.5887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346660PMC
March 2015
19 Reads
27 Citations
7.410 Impact Factor

Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction.

Sci Transl Med 2015 Mar;7(277):277ra31

Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA. Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa0154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768806PMC
March 2015
30 Reads
30 Citations
15.843 Impact Factor

Cellular repressor of E1A-stimulated gene overexpression in bone mesenchymal stem cells protects against rat myocardial infarction.

Int J Cardiol 2015 Mar 27;183:232-41. Epub 2015 Jan 27.

Cardiovascular Research Institute, Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang 110016, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2015.01.059DOI Listing
March 2015
9 Reads
3 Citations
4.040 Impact Factor

TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury.

Basic Res Cardiol 2014 12;109(5):415. Epub 2014 Jul 12.

Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, 15 Changle West Road, Xi'an, 710032, China.

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http://dx.doi.org/10.1007/s00395-014-0415-zDOI Listing
February 2015
21 Reads
29 Citations
5.414 Impact Factor

Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity.

Circ Res 2015 Jan 10;116(1):70-9. Epub 2014 Oct 10.

From the Department of Medicine, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA (J.L., E.G., A.V., R.Y., L.G., G.L.R.); Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium (S.G., F.v.R.); Inflammation Research Center, Flanders Institute for Biotechnology (VIB), Ghent, Belgium (S.G., F.v.R.); and INSERM UMR-1060, Laboratoire CarMeN, Université Lyon 1, Faculté de médecine, Rockefeller et Charles Merieux Lyon-Sud, Lyon, France (L.G.). Current address for E.G.: Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.304472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282606PMC
January 2015
15 Reads
33 Citations
11.020 Impact Factor

GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity.

Circ Res 2014 Dec 20;115(12):976-85. Epub 2014 Oct 20.

From the Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA (J.E.H., J.I.G.); and Center for Translational Medicine (J.E.H., L.A.G., E.G. J.I.G., J.K.C., D.G.T., W.J.K.) and Cardiovascular Research Center (C.A.M., S.R.H.), Temple University School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.304475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258119PMC
December 2014
18 Reads
15 Citations
11.020 Impact Factor

GRK2 in the heart: a GPCR kinase and beyond.

Antioxid Redox Signal 2014 Nov 13;21(14):2032-43. Epub 2014 May 13.

Department of Pharmacology and Center for Translational Medicine, Temple University School of Medicine , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/ars.2014.5876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208598PMC
November 2014
29 Reads
6 Citations
7.410 Impact Factor

Activation of liver-X-receptor α but not liver-X-receptor β protects against myocardial ischemia/reperfusion injury.

Circ Heart Fail 2014 Nov 2;7(6):1032-41. Epub 2014 Oct 2.

From the Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China (Q.H., J.P., A.Y., B.H.); Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (W.B.L., X.-L.M.); and Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA (E.G., W.J.K.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527689PMC
November 2014
25 Reads
17 Citations
5.891 Impact Factor

β-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling.

Circulation 2014 Nov 9;130(20):1800-11. Epub 2014 Sep 9.

From the Center for Translational Medicine (D.G.T., E.G., J.S, R.L.C., L.A.G., W.J.K., J.Y.C.), Department of Pharmacology (D.G.T., W.J.K.), Cardiovascular Research Center (W.Z., V.D.M., L.A.B., C.A.M., C.D.T., R.C.C., S.R.H.), Department of Physiology (L.A.B., C.A.M., S.R.H., A.M.F.), Department of Clinical Sciences (D.Y.), and Department of Medicine (J.Y.C., A.M.F.), Temple University School of Medicine, Philadelphia, PA; and the Division of Cardiology, Fourth Military Medical University, Xian, People's Republic of China (X.L.).

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http://circ.ahajournals.org/content/early/2014/09/09/CIRCULA
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http://circ.ahajournals.org/cgi/doi/10.1161/CIRCULATIONAHA.1
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November 2014
33 Reads
15 Citations
14.430 Impact Factor

Epigenetic upregulation of endogenous VEGF-A reduces myocardial infarct size in mice.

PLoS One 2014 26;9(2):e89979. Epub 2014 Feb 26.

Department of Biotechnology and Molecular Medicine, A.I.Virtanen Institute, University of Eastern Finland, Kuopio, Finland ; Research Unit and Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935957PMC
October 2014
37 Reads
7 Citations
3.234 Impact Factor

Adiponectin regulates SR Ca(2+) cycling following ischemia/reperfusion via sphingosine 1-phosphate-CaMKII signaling in mice.

J Mol Cell Cardiol 2014 Sep 20;74:183-92. Epub 2014 May 20.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address:

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September 2014
16 Reads
3 Citations
4.660 Impact Factor

AGGF1 protects from myocardial ischemia/reperfusion injury by regulating myocardial apoptosis and angiogenesis.

Apoptosis 2014 Aug;19(8):1254-68

Department of Pathology, Physiology and Pathophysiology, Beijing AnZhen Hospital the Key Laboratory of Remodeling-Related Cardiovascular Diseases, School of Basic Medical Sciences, Capital Medical University, No.10 Xitoutiao, You An Men, Beijing, 100069, China.

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August 2014
21 Reads
13 Citations
3.685 Impact Factor

Cardiomyocyte-specific deletion of Gsk3α mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure.

J Am Coll Cardiol 2014 Aug;64(7):696-706

Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jacc.2014.04.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142642PMC
August 2014
19 Reads
13 Citations
16.503 Impact Factor

A novel and efficient model of coronary artery ligation in the mouse.

Methods Mol Biol 2013 ;1037:299-311

Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA, USA.

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July 2014
6 Reads
7 Citations

Cardiac fibroblast glycogen synthase kinase-3β regulates ventricular remodeling and dysfunction in ischemic heart.

Circulation 2014 07 4;130(5):419-30. Epub 2014 Jun 4.

From the Center for Translational Medicine (H.L., F.A., J.Z., J.E.U., R.J.V., Y.G., E.G., T.F.), Department of Clinical Sciences (D.Y.), and Section of Cardiology (E.J.T., T.F.), Temple University School of Medicine, Philadelphia, PA; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada (J.W.); and Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN (H.L., F.A., Y.G., T.F.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.008364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153405PMC
July 2014
30 Reads
31 Citations
14.430 Impact Factor

Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium.

Am J Physiol Heart Circ Physiol 2014 Jul 9;307(1):H66-72. Epub 2014 May 9.

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania; Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania

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http://dx.doi.org/10.1152/ajpheart.00166.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080174PMC
July 2014
33 Reads
9 Citations
3.840 Impact Factor

S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4.

EMBO Mol Med 2014 Jun 6;6(6):778-94. Epub 2014 Apr 6.

Section of Molecular and Translational Cardiology, Department of Internal Medicine III, Heidelberg University Hospital Heidelberg University, Heidelberg, Germany Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim Heidelberg University Hospital Heidelberg University, Heidelberg, Germany

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http://embomolmed.embopress.org/cgi/doi/10.15252/emmm.201303
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http://dx.doi.org/10.15252/emmm.201303498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203355PMC
June 2014
35 Reads
11 Citations
8.665 Impact Factor

Inhibition of Fas-associated death domain-containing protein (FADD) protects against myocardial ischemia/reperfusion injury in a heart failure mouse model.

PLoS One 2013 13;8(9):e73537. Epub 2013 Sep 13.

Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America ; Department of Gerontology, Beijing Chaoyang Hospital-Affiliate of Beijing Capital Medical University, Beijing, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772851PMC
June 2014
9 Reads
7 Citations
3.234 Impact Factor

Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways.

Apoptosis 2014 Apr;19(4):567-80

Department of Pathology, Physiology and Pathophysiology, Beijing AnZhen Hospital the Key Laboratory of Remodeling-Related Cardiovascular Diseases, School of Basic Medical Sciences, Capital Medical University, Ministry of Education, No. 10 Xitoutiao You An Men, Beijing, 100069, China.

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April 2014
7 Reads
18 Citations
3.685 Impact Factor

Induced overexpression of phospholemman S68E mutant improves cardiac contractility and mortality after ischemia-reperfusion.

Am J Physiol Heart Circ Physiol 2014 Apr 31;306(7):H1066-77. Epub 2014 Jan 31.

Center of Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania;

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http://dx.doi.org/10.1152/ajpheart.00861.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962630PMC
April 2014
10 Reads
2 Citations
3.840 Impact Factor

Negative impact of β-arrestin-1 on post-myocardial infarction heart failure via cardiac and adrenal-dependent neurohormonal mechanisms.

Hypertension 2014 Feb 11;63(2):404-12. Epub 2013 Nov 11.

Department of Pharmaceutical Sciences, Nova Southeastern University College of Pharmacy, 3200 S University Dr, HPD Bldg/Room 1338, Fort Lauderdale, FL 33328.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889868PMC
February 2014
29 Reads
23 Citations
6.480 Impact Factor

Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation.

Circ Res 2014 Feb 7;114(5):792-805. Epub 2014 Jan 7.

From the Department of Emergency Medicine (Y.W., X.W., W.B.L., Y.Y., J.-J.L., X.-L.M.) and Department of Pathology (D.B.), Thomas Jefferson University, Philadelphia, PA; and Department of Physiology, Cardiovascular Research Center (R.S., K.P.) and Center for Translational Medicine (E.G., W.K.), Temple University, Philadelphia, PA.

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http://dx.doi.org/10.1161/CIRCRESAHA.114.302439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961763PMC
February 2014
59 Reads
15 Citations
11.020 Impact Factor

Regulation of nuclear factor κB (NF-κB) in the nucleus of cardiomyocytes by G protein-coupled receptor kinase 5 (GRK5).

J Biol Chem 2013 Dec 29;288(50):35683-9. Epub 2013 Oct 29.

From the Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861620PMC
December 2013
15 Reads
16 Citations
4.573 Impact Factor

Differential regulation of TNF receptor 1 and receptor 2 in adiponectin expression following myocardial ischemia.

Int J Cardiol 2013 Oct 5;168(3):2201-6. Epub 2013 Mar 5.

Department of Physiology, Shanxi Medical University, Taiyuan 030001, China; Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, United States. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676729PMC
October 2013
24 Reads
2 Citations
4.040 Impact Factor

Aldosterone increases cardiac vagal tone via G protein-coupled oestrogen receptor activation.

J Physiol 2013 Sep 22;591(17):4223-35. Epub 2013 Jul 22.

E. Brailoiu: Center for Translational Medicine, Temple University School of Medicine, MERB, 3500 N. Broad Street, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1113/jphysiol.2013.257204DOI Listing
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September 2013
16 Reads
16 Citations
5.040 Impact Factor

C1q/tumor necrosis factor-related protein-9, a novel adipocyte-derived cytokine, attenuates adverse remodeling in the ischemic mouse heart via protein kinase A activation.

Circulation 2013 Sep;128(11 Suppl 1):S113-20

Departments of Geriatrics (Y.S., H.S., X.W.) and Cardiovascular Surgery (W.Y., D.Y.), Xijing Hospital, the Fourth Military Medical University, Xi'an, China; Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Y.S., W.Y., Y.Y., W.B.L., X.W., Y.W., H.S., X.-L.M.); and Center for Translational Medicine, Temple University Medical School, Philadelphia, PA (E.G., W.J.K.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824619PMC
September 2013
12 Reads
23 Citations
14.430 Impact Factor

Sevoflurane preconditioning attenuates myocardial ischemia/reperfusion injury via caveolin-3-dependent cyclooxygenase-2 inhibition.

Circulation 2013 Sep;128(11 Suppl 1):S121-9

Department of Anesthesiology, the First Affiliated Hospital (J.Z., Y.Z., L.J., L.W., B.L.), Department of Pathophysiology (F.W.), and Department of Physiology, Key Laboratory of Cellular Physiology, Ministry of Education (Y.W.), Shanxi Medical University, Taiyuan, China; Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (W.B.L., X.-L.M., Y.W.); and Center for Translational Research, Temple University, Philadelphia, PA (E.G., W.J.K.).

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September 2013
28 Reads
14 Citations
14.430 Impact Factor

Notch1 cardioprotection in myocardial ischemia/reperfusion involves reduction of oxidative/nitrative stress.

Basic Res Cardiol 2013 Sep 30;108(5):373. Epub 2013 Aug 30.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, 15 Changlexi Road, Xi'an 710032, China.

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September 2013
16 Reads
16 Citations
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Integrated wall stress: a new methodological approach to assess ventricular workload and myocardial contractile reserve.

J Transl Med 2013 Aug 7;11:183. Epub 2013 Aug 7.

Nemours Cardiac Center and Nemours Biomedical Research, Alfred I, duPont Hospital for Children, 1600 Rockland Rd, Wilmington, DE 19103, USA.

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http://dx.doi.org/10.1186/1479-5876-11-183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750700PMC
August 2013
11 Reads
2 Citations
3.930 Impact Factor

GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility.

Cell Commun Signal 2013 Aug 28;11:64. Epub 2013 Aug 28.

Department of Pharmaceutical Sciences, Laboratory for the Study of Neurohormonal Control of the Circulation, Nova Southeastern University College of Pharmacy, Fort Lauderdale, FL 33328, USA.

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August 2013
29 Reads
21 Citations
3.380 Impact Factor

Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection.

Mol Cell Biol 2013 Aug 17;33(16):3321-9. Epub 2013 Jun 17.

Department of Pharmacology and Toxicology, Biocenter Oulu, University of Oulu, Oulu, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753900PMC
August 2013
7 Reads
12 Citations
4.780 Impact Factor

Increased expression of pigment epithelium-derived factor in aged mesenchymal stem cells impairs their therapeutic efficacy for attenuating myocardial infarction injury.

Eur Heart J 2013 Jun 23;34(22):1681-90. Epub 2011 May 23.

Department of Cardiovascular Surgery, Institute of Cardiovascular Disease of Chinese PLA, Xijing Hospital, the Fourth Military Medical University, No.127, West Changle Road, Xi'an, Shaanxi Province 710032, China.

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http://dx.doi.org/10.1093/eurheartj/ehr131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675387PMC
June 2013
9 Reads
15 Citations
15.200 Impact Factor

Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury.

Eur Heart J 2013 Jun 3;34(24):1834-45. Epub 2012 Feb 3.

Department of Cardiology, Shanghai Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.

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June 2013
48 Reads
29 Citations
15.203 Impact Factor

Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart.

Basic Res Cardiol 2013 May 5;108(3):329. Epub 2013 Mar 5.

Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, 147 West Changle Rd, Xian, 710032, China.

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May 2013
51 Reads
23 Citations
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GSK-3α is a central regulator of age-related pathologies in mice.

J Clin Invest 2013 Apr 15;123(4):1821-32. Epub 2013 Mar 15.

Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://www.jci.org/articles/view/64398
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613907PMC
April 2013
14 Reads
39 Citations
13.215 Impact Factor

Coordinated regulation of cardiac Na(+)/Ca (2+) exchanger and Na (+)-K (+)-ATPase by phospholemman (FXYD1).

Adv Exp Med Biol 2013 ;961:175-90

Center of Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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March 2013
11 Reads
8 Citations

Cardioprotection of controlled and cardiac-specific over-expression of A(2A)-adenosine receptor in the pressure overload.

PLoS One 2012 6;7(7):e39919. Epub 2012 Jul 6.

Department of Physiology, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391213PMC
March 2013
11 Reads
8 Citations
3.234 Impact Factor

Lymphotoxin-α is a novel adiponectin expression suppressor following myocardial ischemia/reperfusion.

Am J Physiol Endocrinol Metab 2013 Mar 29;304(6):E661-7. Epub 2013 Jan 29.

Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602691PMC
March 2013
4 Reads
2 Citations
3.790 Impact Factor

Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling.

Circ Res 2013 Feb 25;112(3):498-509. Epub 2012 Oct 25.

Cardiovascular Research Center, Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562387PMC
February 2013
32 Reads
42 Citations
11.020 Impact Factor

Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNFα-initiated oxidative signaling contributes to exacerbated cardiac injury in diabetic mice.

Basic Res Cardiol 2013 Jan 5;108(1):315. Epub 2012 Dec 5.

Department of Emergency Medicine, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408949PMC
January 2013
37 Reads
21 Citations
5.414 Impact Factor

Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.

ACS Chem Biol 2012 Nov 21;7(11):1830-9. Epub 2012 Aug 21.

Life Sciences Institute and the Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500392PMC
November 2012
17 Reads
47 Citations
5.331 Impact Factor

The alternative crosstalk between RAGE and nitrative thioredoxin inactivation during diabetic myocardial ischemia-reperfusion injury.

Am J Physiol Endocrinol Metab 2012 Oct 24;303(7):E841-52. Epub 2012 Jul 24.

Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi’an, China.

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http://dx.doi.org/10.1152/ajpendo.00075.2012DOI Listing
October 2012
18 Reads
7 Citations
3.790 Impact Factor

Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication.

Circ Res 2012 Sep 2;111(8):1048-53. Epub 2012 Aug 2.

Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752304PMC
September 2012
16 Reads
27 Citations
11.020 Impact Factor

CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy.

Cell Cycle 2012 Jul 15;11(14):2747-55. Epub 2012 Jul 15.

Department of Cancer Biology at Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cc.21127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409014PMC
July 2012
13 Reads
45 Citations

C1q/tumor necrosis factor-related protein-3, a newly identified adipokine, is a novel antiapoptotic, proangiogenic, and cardioprotective molecule in the ischemic mouse heart.

Circulation 2012 Jun 31;125(25):3159-69. Epub 2012 May 31.

Department of Cardiovascular Surgery, Xijing Hospital, the Fourth Military Medical University, 127 Changle West Road, Xi'an, Shaanxi Province, PR. China, 710032.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391311PMC
June 2012
20 Reads
34 Citations
14.430 Impact Factor

Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection.

Arterioscler Thromb Vasc Biol 2012 Apr 9;32(4):934-42. Epub 2012 Feb 9.

Department of Physiology, Shanxi Medical University, Taiyuan, China.

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http://dx.doi.org/10.1161/ATVBAHA.111.242164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312581PMC
April 2012
5 Reads
18 Citations
6.000 Impact Factor

Loss of cadherin-binding proteins β-catenin and plakoglobin in the heart leads to gap junction remodeling and arrhythmogenesis.

Mol Cell Biol 2012 Mar 17;32(6):1056-67. Epub 2012 Jan 17.

Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/MCB.06188-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295003PMC
March 2012
13 Reads
29 Citations
4.780 Impact Factor

Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia.

J Cell Sci 2012 Feb 15;125(Pt 4):1058-67. Epub 2012 Mar 15.

Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1242/jcs.098640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311935PMC
February 2012
24 Reads
28 Citations
5.432 Impact Factor

Constitutive overexpression of phosphomimetic phospholemman S68E mutant results in arrhythmias, early mortality, and heart failure: potential involvement of Na+/Ca2+ exchanger.

Am J Physiol Heart Circ Physiol 2012 Feb 11;302(3):H770-81. Epub 2011 Nov 11.

Division of Nephrology, Thomas Jefferson Univ., 833 Chestnut St., Suite 700, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1152/ajpheart.00733.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353790PMC
February 2012
69 Reads
20 Citations
3.840 Impact Factor

Gi-biased β2AR signaling links GRK2 upregulation to heart failure.

Circ Res 2012 Jan 15;110(2):265-74. Epub 2011 Dec 15.

Institute of Molecular Medicine, Peking University, Beijing 100871, China. Weizhong Zhu, MD, PhD, Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282829PMC
January 2012
17 Reads
22 Citations
11.020 Impact Factor

Loss of fibulin-2 protects against progressive ventricular dysfunction after myocardial infarction.

J Mol Cell Cardiol 2012 Jan 9;52(1):273-82. Epub 2011 Nov 9.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390264PMC
January 2012
11 Reads
9 Citations
4.660 Impact Factor

Glycogen synthase kinase-3α limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death.

Circulation 2012 Jan 15;125(1):65-75. Epub 2011 Nov 15.

Center for Translational Medicine, Thomas Jefferson University, College Building, Rm 316, 1025 Walnut St., Philadelphia, PA 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365497PMC
January 2012
8 Reads
19 Citations
14.430 Impact Factor

Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density.

Am J Physiol Heart Circ Physiol 2011 Nov 2;301(5):H1932-40. Epub 2011 Sep 2.

Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1152/ajpheart.00755.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213957PMC
November 2011
23 Reads
13 Citations
3.840 Impact Factor

Reduced cardioprotective action of adiponectin in high-fat diet-induced type II diabetic mice and its underlying mechanisms.

Antioxid Redox Signal 2011 Oct 11;15(7):1779-88. Epub 2011 Apr 11.

Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1089/ars.2010.3722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159116PMC
October 2011
6 Reads
19 Citations
7.410 Impact Factor

Downregulation of adiponectin induced by tumor necrosis factor α is involved in the aggravation of posttraumatic myocardial ischemia/reperfusion injury.

Crit Care Med 2011 Aug;39(8):1935-43

Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xián, China.

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http://dx.doi.org/10.1097/CCM.0b013e31821b85dbDOI Listing
August 2011
48 Reads
8 Citations
6.310 Impact Factor

Cytosolic phospholipase A(2)α protects against ischemia/reperfusion injury in the heart.

Clin Transl Sci 2011 Aug;4(4):236-42

Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/j.1752-8062.2011.00294.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170125PMC
August 2011
7 Reads
5 Citations
2.110 Impact Factor

G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.

Circulation 2011 May 25;123(18):1953-62. Epub 2011 Apr 25.

George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.988642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113597PMC
May 2011
20 Reads
43 Citations
14.430 Impact Factor

Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange.

Am J Physiol Heart Circ Physiol 2011 Mar 30;300(3):H859-68. Epub 2010 Dec 30.

Division of Nephrology and Center of Translational Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1152/ajpheart.00894.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064295PMC
March 2011
8 Reads
20 Citations
3.840 Impact Factor

A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse.

Circ Res 2010 Dec 21;107(12):1445-53. Epub 2010 Oct 21.

Center for Translational Medicine, George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Thomas Jefferson University, 1025 Walnut St, Room 302, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.110.223925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005817PMC
December 2010
43 Reads
123 Citations
11.020 Impact Factor

Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms.

Circ Res 2010 Oct 2;107(9):1140-9. Epub 2010 Sep 2.

George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Center for Translational Medicine, Jefferson Medical College, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.110.221010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966514PMC
October 2010
49 Reads
50 Citations
11.020 Impact Factor

Phospholemman: a novel cardiac stress protein.

Clin Transl Sci 2010 Aug;3(4):189-96

Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/j.1752-8062.2010.00213.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013348PMC
August 2010
30 Reads
11 Citations
2.110 Impact Factor

Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo.

Circ Res 2010 May 1;106(10):1635-45. Epub 2010 Apr 1.

Center for Translational Medicine and Cardiology Division, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.211482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895414PMC
May 2010
12 Reads
28 Citations
11.020 Impact Factor

Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction.

J Biol Chem 2010 May 29;285(21):16378-86. Epub 2010 Mar 29.

Department of Pharmaceutical Sciences, Nova Southeastern University College of Pharmacy, Ft Lauderdale, Florida 33328, USA.

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http://dx.doi.org/10.1074/jbc.M109.077859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871505PMC
May 2010
11 Reads
38 Citations
4.570 Impact Factor

Cardiomyocyte-derived adiponectin is biologically active in protecting against myocardial ischemia-reperfusion injury.

Am J Physiol Endocrinol Metab 2010 Mar 22;298(3):E663-70. Epub 2009 Dec 22.

Dept. of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1152/ajpendo.00663.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838529PMC
March 2010
17 Reads
23 Citations
3.790 Impact Factor

Phospholemman and beta-adrenergic stimulation in the heart.

Am J Physiol Heart Circ Physiol 2010 Mar 11;298(3):H807-15. Epub 2009 Dec 11.

Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1152/ajpheart.00877.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838560PMC
March 2010
10 Reads
20 Citations
3.840 Impact Factor

Adiponectin: an indispensable molecule in rosiglitazone cardioprotection following myocardial infarction.

Circ Res 2010 Feb 25;106(2):409-17. Epub 2009 Nov 25.

Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, 15 West Changle Rd, Xian, China, 710032.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.211797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818803PMC
February 2010
6 Reads
28 Citations
11.020 Impact Factor

Induced overexpression of Na+/Ca2+ exchanger transgene: altered myocyte contractility, [Ca2+]i transients, SR Ca2+ contents, and action potential duration.

Am J Physiol Heart Circ Physiol 2009 Aug 12;297(2):H590-601. Epub 2009 Jun 12.

Department of Medicine, Division of Nephrology, Center of Translational Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1152/ajpheart.00190.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724197PMC
August 2009
5 Reads
19 Citations
3.840 Impact Factor

Is erythropoietin behind maladaptive anemic heart failure?

Am J Physiol Heart Circ Physiol 2009 Mar 23;296(3):H559-60. Epub 2009 Jan 23.

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http://dx.doi.org/10.1152/ajpheart.00045.2009DOI Listing
March 2009
2 Reads
3.840 Impact Factor

INO-4885 [5,10,15,20-tetra[N-(benzyl-4'-carboxylate)-2-pyridinium]-21H,23H-porphine iron(III) chloride], a peroxynitrite decomposition catalyst, protects the heart against reperfusion injury in mice.

J Pharmacol Exp Ther 2009 Mar 25;328(3):777-84. Epub 2008 Nov 25.

Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1124/jpet.108.144352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663530PMC
March 2009
15 Reads
10 Citations
3.970 Impact Factor

Rosiglitazone inhibits hypercholesterolaemia-induced myeloperoxidase upregulation--a novel mechanism for the cardioprotective effects of PPAR agonists.

Cardiovasc Res 2009 Feb 14;81(2):344-52. Epub 2008 Nov 14.

Department of Emergency Medicine, Thomas Jefferson University, 1020 Sansom Street, Thompson Building, Room 241, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1093/cvr/cvn308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721644PMC
February 2009
29 Reads
16 Citations
5.940 Impact Factor

BMP-2 and FGF-2 synergistically facilitate adoption of a cardiac phenotype in somatic bone marrow c-kit+/Sca-1+ stem cells.

Clin Transl Sci 2008 Sep;1(2):116-25

Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/j.1752-8062.2008.00034.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863128PMC
September 2008
11 Reads
8 Citations
2.110 Impact Factor

G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.

Circ Res 2008 Aug 17;103(4):413-22. Epub 2008 Jul 17.

Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, 1025 Walnut St, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.107.168336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679955PMC
August 2008
18 Reads
82 Citations
11.020 Impact Factor

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes.

Proc Natl Acad Sci U S A 2008 Aug 18;105(34):12457-62. Epub 2008 Aug 18.

George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1073/pnas.0803153105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527933PMC
August 2008
14 Reads
78 Citations
9.810 Impact Factor

Simultaneous administration of insulin-like growth factor-1 and darbepoetin alfa protects the rat myocardium against myocardial infarction and enhances angiogenesis.

Clin Transl Sci 2008 May;1(1):13-20

George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Center for Translational Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/j.1752-8062.2008.00008.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016870PMC
May 2008
7 Reads
8 Citations
2.110 Impact Factor

Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress.

Circulation 2008 Mar 3;117(11):1378-87. Epub 2008 Mar 3.

Center for Translational Medicine and George Zallie and Family Laboratory of Cardiovascular Gene Therapy, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.107.752618DOI Listing
March 2008
16 Reads
38 Citations
14.430 Impact Factor

Tonic beta-adrenergic drive provokes proinflammatory and proapoptotic changes in aging mouse heart.

Rejuvenation Res 2008 Feb;11(1):215-26

Department of Anesthesiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1089/rej.2007.0609DOI Listing
February 2008
5 Reads
6 Citations
3.310 Impact Factor

Nitrative thioredoxin inactivation as a cause of enhanced myocardial ischemia/reperfusion injury in the aging heart.

Free Radic Biol Med 2007 Jul 24;43(1):39-47. Epub 2007 Mar 24.

Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2007.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949486PMC
July 2007
5 Reads
16 Citations
5.740 Impact Factor

Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart.

Am J Physiol Heart Circ Physiol 2007 Jul 23;293(1):H60-8. Epub 2007 Mar 23.

Center for Translational Medicine, George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1152/ajpheart.00227.2007DOI Listing
July 2007
9 Reads
24 Citations
3.840 Impact Factor

Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue.

Circulation 2007 May 30;115(19):2506-15. Epub 2007 Apr 30.

Center for Translational Medicine and George Zallie and Family Laboratory of Cardiovascular Gene Therapy, Thomas Jefferson University, 1025 Walnut St, Room 317, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.671701DOI Listing
May 2007
20 Reads
63 Citations
14.430 Impact Factor

Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.

Circulation 2006 Sep 4;114(12):1258-68. Epub 2006 Sep 4.

Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.622415DOI Listing
September 2006
8 Reads
46 Citations
14.430 Impact Factor

Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis.

Circulation 2006 Sep 11;114(13):1395-402. Epub 2006 Sep 11.

Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.625061DOI Listing
September 2006
9 Reads
21 Citations
14.430 Impact Factor

Chronic beta-adrenergic receptor stimulation induces cardiac apoptosis and aggravates myocardial ischemia/reperfusion injury by provoking inducible nitric-oxide synthase-mediated nitrative stress.

J Pharmacol Exp Ther 2006 Aug 30;318(2):469-75. Epub 2006 Mar 30.

Department of Anesthesiology, Suite G8490, 111 South 11th Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1124/jpet.106.102160DOI Listing
August 2006
13 Reads
16 Citations
3.970 Impact Factor

S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction.

Mol Ther 2005 Dec 15;12(6):1120-9. Epub 2005 Sep 15.

Medizinische Universitätsklinik und Poliklinik III, Otto Meyerhof Zentrum, Universität zu Heidelberg, INF 350, 69115 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ymthe.2005.08.002DOI Listing
December 2005
40 Reads
23 Citations
6.230 Impact Factor

Adenosine A1 antagonism attenuates beta-adrenergic-resistant sudden hypoxic cardiac insufficiency.

Acad Emerg Med 2005 May;12(5):389-95

Merck Manuals, UN-D100, Merck & Co., Inc., 785 Jolly Road, Blue Bell, PA 19422, USA.

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http://dx.doi.org/10.1197/j.aem.2005.02.006DOI Listing
May 2005
2 Reads
2.010 Impact Factor

Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion.

Circulation 2005 Jan 20;111(1):90-6. Epub 2004 Dec 20.

Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pa, USA.

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http://dx.doi.org/10.1161/01.CIR.0000151613.90994.17DOI Listing
January 2005
15 Reads
25 Citations
14.430 Impact Factor

Heart infarct in NOD-SCID mice: therapeutic vasculogenesis by transplantation of human CD34+ cells and low dose CD34+KDR+ cells.

FASEB J 2004 Sep 1;18(12):1392-4. Epub 2004 Jul 1.

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5541, USA.

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http://dx.doi.org/10.1096/fj.03-0879fjeDOI Listing
September 2004
21 Reads
27 Citations
5.040 Impact Factor

Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected].

Proc Natl Acad Sci U S A 2004 Aug 26;101(31):11471-6. Epub 2004 Jul 26.

Department of Emergency Medicine, Thomas Jefferson University, 1020 Sansom Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1073/pnas.0402941101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC509224PMC
August 2004
43 Reads
49 Citations
9.810 Impact Factor

Antiapoptotic mechanisms of benidipine in the ischemic/reperfused heart.

Br J Pharmacol 2004 Jun 1;142(4):627-34. Epub 2004 Jun 1.

Department of Emergency Medicine, Thomas Jefferson University, 1020 Sansom Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1038/sj.bjp.0705847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575055PMC
June 2004
3 Reads
7 Citations
4.840 Impact Factor

Critical timing of L-arginine treatment in post-ischemic myocardial apoptosis-role of NOS isoforms.

Cardiovasc Res 2004 Jun;62(3):568-77

Department of Emergency Medicine, Thomas Jefferson University, 1020 Sansom Street, Thompson Building, Room 239, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.cardiores.2004.01.025DOI Listing
June 2004
3 Reads
6 Citations
5.940 Impact Factor

Anti-apoptotic effects of rosiglitazone in hypercholesterolemic rabbits subjected to myocardial ischemia and reperfusion.

Cardiovasc Res 2004 Apr;62(1):135-44

Department of Emergency Medicine, Thomas Jefferson University, 1020 Sansom Street, Thompson Building, Room 241, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.cardiores.2003.12.027DOI Listing
April 2004
20 Reads
30 Citations
5.940 Impact Factor

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