Publications by authors named "Erdinc Aydın"

95 Publications

Reattachment of Rhegmatogenous Retinal Detachment via Fibrin Tissue Adhesive.

Korean J Ophthalmol 2021 Feb 18. Epub 2021 Feb 18.

Eye Clinic, Liv Hospital, Istanbul, TURKEY.

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http://dx.doi.org/10.3341/kjo.2020.0020DOI Listing
February 2021

Analysis of central macular thickness and choroidal thickness changes in patients with cardiovascular risk factors.

Eye (Lond) 2020 11 28;34(11):2068-2075. Epub 2020 Jan 28.

Cardiology Clinic, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey.

Objectives: The aim of this study was to evaluate central macular thickness (CMT) and choroidal thickness (CT) in the eyes of patients with cardiovascular risk factors (CVRF).

Methods: A cross-sectional, prospective observational study of 92 patients with CVRF and 21 healthy individuals was conducted. Patients were divided into four groups according to the SCORE system. CMT was evaluated via spectral-domain-optical coherence tomography (SD-OCT). CT at five defined points (subfoveal) [SF] and nasal 500 μm [N0.5] and 1500 μm [N1.5] and 500 μm [T0.5] and temporal 1500 μm [T1.5] from the center of the fovea were measured via enhanced depth imaging (EDI)-OCT.

Results: Mean SFCT at right eyes (RE) and left eyes (LE) were 311.21 ± 77.7 μm and 303.5 ± 49.6 μm, respectively, in patients with mild CVRF (Group 1); 266.5 ± 63.2 μm and 267.0 ± 62.6 μm, respectively, in patients with moderate CVRF (Group 2); 264.7 ± 57.5 μm and 272.3 ± 64.6 μm, respectively, in patients with high CVRF (Group 3); 272.3 ± 64.6 μm and 271.2 ± 63.4 μm, respectively, in patients with very high-risk CVRF (with coronary arterial disease (CAD) (Group 4); and 352.0 ± 74.4 μm and 363.1 ± 89.0 μm, respectively, in the control group. CT (at both eyes) was significantly lower at the subfoveal location in all study groups (P < 0.05), but at nasal and at temporal quadrants of group 3 and group 4 (P < 0.05). No significant difference in CMT was detected between the study and control groups.

Conclusions: This study demonstrated that CVRF might result in a remarkably thinner CT. Furthermore, subretinal drusenoid deposits were detected at a higher rate in the patients with CVRF than controls, and that rate increased in accordance with the severity of CAD. In the future, changes in CT may be used as a promising novel biomarker as part of the SCORE system prior to the development of CAD.
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http://dx.doi.org/10.1038/s41433-020-0775-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784908PMC
November 2020

Proliferating Trichilemmal Tumor of the Auricula: A Very Rare Locus.

Indian J Otolaryngol Head Neck Surg 2019 Nov 3;71(Suppl 2):1436-1438. Epub 2018 Nov 3.

1Otorhinolaryngology Department, Medical Faculty, Başkent University, Ankara, Turkey.

Proliferating trichilemmal tumor (PTT) is a rare but morphologically characteristic tumor, derived from the external root sheath. They are commonly localized as a solitary lesion on the scalp. They rarely occur in other regions. PTTs generally behave in a benign fashion, up to 20% of the lesions may undergo malignant transformation into squamous carcinoma. We present an elderly woman with a cystic swelling on the crus of auricular helix diagnosed as PTT. To our knowledge, this is the first case in the English literature, of PTT of the auricula.
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http://dx.doi.org/10.1007/s12070-018-1522-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841841PMC
November 2019

The Impact of Serum 25-Hydroxyvitamin D3 Levels on Allergic Rhinitis.

Ear Nose Throat J 2019 Sep 30:145561319874310. Epub 2019 Sep 30.

Başkent University Medical Faculty, Otorhinolaryngology Department, Ankara, Turkey.

We aimed to clarify the relation between allergic rhinitis and the serum levels of 25-hydroxivitamin D in the adult population. The study group consisted of 86 patients with allergic rhinitis who were diagnosed with the help of history of allergy, positive signs for allergy, blood samples, and positive skin prick tests; while the control group included 43 age- and sex-matched healthy volunteers with negative skin prick tests. The demographic data, medical history, findings in the physical examinations, serum levels of total immunoglobulin E (IgE) and 25-hydroxyvitamin D, and skin prick test results of the groups were noted. A total of 129 patients fulfilling the necessary criteria were enrolled. The median serum 25-hydroxyvitamin D levels in the study group were significantly lower compared to the control group ( = .014). In the study group, median serum vitamin D levels were significantly higher in men, compared to women ( = .03). There was a significant negative correlation between IgE and vitamin D levels in the allergic rhinitis group ( = .028, = -0.246). This study showed that patients with allergic rhinitis might be more vulnerable to have lower serum levels of vitamin D. Thus, vitamin D supplementation as an adjunctive therapy may be considered in those patients.
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http://dx.doi.org/10.1177/0145561319874310DOI Listing
September 2019

The effect of the smoking on choroidal thickness, central macular vascular and optic disc perfusion.

Photodiagnosis Photodyn Ther 2019 Dec 20;28:142-145. Epub 2019 Sep 20.

Izmir Katip Celebi University Hospital, Turkey.

Objectives: To compare choroidal thickness, central macular vascular perfusion and optic disc perfusion in smokers and non-smokers.

Methods: Smoker participants defined group I and non-smoker participants(group II) Optical coherence tomography angiography (OCTA) performed to all volunteers and choroidal thickness, central macular vascular and optic disc perfusion were measured.

Results: In group I, 30 eyes of the 30 participants (6 male and 24 female) evaluated and in group II, 32 eyes of the 32 participants (13 male and 19 female) evaluated. The mean age of the volunteers were 43.09 ± 14.28 and 42.2 ± 8.24 year-old in group I and group II, respectively. The mean choroidal thickness were 345 ± 74 μm and 301.6 ± 71 μm in group I and group II, respectively (p = 0.022). The mean optic disc perfusions were 45.17 ± 1.46% and 45.25 ± 1.43% in group I and group II, respectively (p = 0.82). The mean central macular vascular perfusions were 20.20 ± 7.17% and 18.65 ± 7.46% in group I and group II, respectively (p = 0.4). There are a negative correlation between macular vascular perfusion, optic disc perfusion and smoking period (p = 0.32 and 0.62, respectively.) CONCLUSION: Our study revealed that smoking statistically significantly effected choroidal thickness but effected central macular vascular and optic disc perfusion changes were not statistically significant.
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http://dx.doi.org/10.1016/j.pdpdt.2019.09.005DOI Listing
December 2019

Lingual Tonsil Hypertrophy in Patients With Allergic Rhinitis.

Am J Rhinol Allergy 2020 Jan 14;34(1):87-92. Epub 2019 Sep 14.

Otorhinolaryngology Department, Medical Faculty, Başkent University, Ankara, Turkey.

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http://dx.doi.org/10.1177/1945892419875086DOI Listing
January 2020

Central Serous Chorioretinopathy: A Complication Associated with Behçet’s Disease Treatment

Turk J Ophthalmol 2019 02;49(1):40-43

Dokuz Eylül University Faculty of Medicine, Department of Ophthalmology, İzmir, Turkey

Central serous chorioretinopathy (CSCR) is characterized by a well-defined serous choroidal detachment of the retinal pigment epithelium with one or more focal lesions of the neurosensory retina. Risk factors for CSCR are psychosocial stress, increased endogenous catecholamine, and increased endogenous cortisol. Systemic steroids can cause ocular side effects such as cataract development, increased intraocular pressure, and less frequently the development of CSCR, which can resolve spontaneously with close follow-up and simple treatment modification. CSCR should be considered in patients who complain of worsening vision under steroid treatment for pathologies requiring steroid therapy. In this study we present two patients, one man and one woman, who developed acute CSCR while under systemic steroid treatment for Behçet’s disease.
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http://dx.doi.org/10.4274/tjo.galenos.2018.83479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416479PMC
February 2019

The Increment of Choroidal Thickness in Euthyroid Graves' Ophthalmopathy: Is It an Early Sign of Venous Congestion?

J Ophthalmol 2018 28;2018:5891531. Epub 2018 Aug 28.

Department of Endocrinology and Metabolic Diseases, Ataturk Education and Research Hospital, Katip Celebi University, Izmir, Turkey.

Objective: Clinical manifestations of Graves' ophthalmopathy (GO) are caused by the overcompression of orbital tissues within the restricted orbital bone cavity. Impaired ocular blood flow may disrupt the retinal microstructure and functions. In this study, we aimed to investigate the macular and choroidal thickness changes in GO compared with healthy subjects.

Materials And Methods: The study group comprised 50 adult patients with previously diagnosed Graves' disease with ophthalmopathy who were on antithyroid treatment. For the assessment of GO activity, the VISA (vision, inflammation, strabismus, and appearance) inflammatory score was used. When euthyroidism was achieved without side effects, the patients were referred to the ophthalmology clinic for spectral-domain optical coherence tomography (SD-OCT) evaluation.

Results: Subfoveal, mean, and temporal choroidal thicknesses were increased significantly in the study group according to the controls. The mean choroidal thickness was elevated.

Conclusions: This elevation is because of the intraorbital inflammation even in this nonsevere GO group. Choroidal thickness might be affected from the venous obstruction and congestion in patients with GO. The elevation of the choroidal thickness might be an early sign of venous congestion that occurs before the elevation of intraocular pressure.
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http://dx.doi.org/10.1155/2018/5891531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136459PMC
August 2018

Assessment of Parotid and Submandibular Glands With Shear Wave Elastography Following Radioactive Iodine Therapy for Papillary Thyroid Carcinoma.

J Ultrasound Med 2019 Feb 19;38(2):357-362. Epub 2018 Jul 19.

Department of Radiology, Faculty of Medicine, Baskent University, Ankara, Turkey.

Objectives: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy. Radioactive iodine (RAI) therapy is used for remnant ablation following thyroidectomy. Side effects such as dysphagia, xerostomia, and sialoadenitis may occur. We aimed to determine the differences in the parotid and submandibulary glands between healthy patients and patients with PTC who had undergone RAI therapy and have dry mouth symptoms using both shear wave elastography and ultrasonography.

Methods: We enrolled 30 patients with PTC who had undergone RAI therapy following surgery and 30 healthy controls. Ultrasonography and shear wave elastography of submandibular and parotid glands were performed. The volume of the submandibular glands and the thickness of parotid glands were determined. Ten independent measurements were obtained from each gland, with the region of interest placed at different points on the glands. The mean shear wave velocities (SWVs) were calculated and compared between the patients and controls.

Results: In the PTC group, there was a significant reduction in the volume of the submandibular glands (P < .05) and in the thickness of the parotid glands (P < .05) compared with the control group. The mean SWVs of the parotid glands and submandibular glands were significantly higher in the PTC group compared with the control group (P < .0001). The SWVs of the parotid glands were higher than the SWVs of the submandibular glands (P < .0001).

Conclusions: Shear wave elastography could be a noninvasive and easy assessment method of parotid and submandibular glands in patients who had undergone RAI therapy and experience dry mouth.
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http://dx.doi.org/10.1002/jum.14695DOI Listing
February 2019

Relationships among retropalatal airway, pharyngeal length, and craniofacial structures determined by magnetic resonance imaging in patients with obstructive sleep apnea.

Sleep Breath 2019 Mar 5;23(1):103-115. Epub 2018 May 5.

Department of Biostatistics, Faculty of Veterinary Medicine, Selcuk University, Konya, Turkey.

Background: The integration of anatomical and nonanatomical parameters will improve our ability to predict the outcomes of OSA treatment. Currently, no standardized, quantitative classification of upper airway anatomical traits is available. The retropalatal (RP) airway is the most important area to consider when planning anatomical treatment. However, current evaluation methods feature qualitative conventional endoscopy. Here, we describe a quantitative magnetic resonance imaging (MRI) method used to classify RP airway patterns.

Methods: We recruited 117 males; 20 simple snorers and 97 patients with OSA. Lateral/anteroposterior ratios were calculated in three parallel planes and RP patterns were classified accordingly. Lateral wall soft tissue structures, skeletal dimensions representing those planes, pharyngeal lengths, and skeletal and vertical axis ratios were also measured.

Results: Both the cross-sectional area at the hard palate level and the RP lateral dimension were associated with OSA. OSA patients had longer pharynges than controls. The oblique pattern was associated with narrow lateral dimensions. The vertical pattern was associated with a narrow nasopharynx but a longer pharynx. The airway ratio at the hard palate level and the skeletal ratios of all three planes were negatively correlated with the vertical axis ratio and together explained 40.8% of the variance in the vertical axis ratio.

Conclusions: The data suggest that anatomical imbalances between the craniofacial skeletal and soft tissue structures affect pharyngeal airway morphology in all three dimensions. The dimensions of the nasopharynx, the cross-sectional area at the hard palate level, and pharyngeal length were associated not only with the RP patterns but also with OSA severity. This study affords insights into upper airway anatomy and RP patterns and may help diagnose OSA patients and aid in the selection of an appropriate therapy.
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http://dx.doi.org/10.1007/s11325-018-1667-xDOI Listing
March 2019

Effect of mometasone furoate nasal spray on the DNA of nasal mucosal cells

Turk J Med Sci 2018 Apr 30;48(2):339-345. Epub 2018 Apr 30.

Background/aim: Allergic rhinitis (AR) is a respiratory disease caused by inflammation of the nasal mucosa. Intranasal corticosteroids (ICs) are an effective treatment for AR; however, their use has been associated with atrophy in nasal mucosae. Because DNA damage has been linked to several chronic diseases, we hypothesize that use of ICs could cause DNA damage in nasal mucosa cells, leading to mucosal atrophy and septal perforation. Materials and methods: Sixty patients with moderate or severe AR were divided randomly into two groups. Mometasone furoate (MF) and antihistamine tablets (desloratadine) were given to the study (IC) group. Physiologic saline and desloratadine were given to the control ((serum physiologic (SP)) group. Nasal irrigation fluid was taken from patients before study commencement and after 4 weeks of treatment. The comet assay was applied to detect DNA damage in nasal mucosa cells. Results: Nineteen patients were excluded, leaving a study population of 41 patients (IC group: 17 patients; SP group: 24 patients). Genotoxic damage was evaluated by comet assay. Conclusion: Treatment with MF spray for 4 weeks does not cause DNA breaks within cells in the nasal mucosa. These results could form the basis of clinical trials involving treatment with different ICs over longer treatment periods.
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http://dx.doi.org/10.3906/sag-1711-3DOI Listing
April 2018

Benign Paroxysmal Positional Vertigo in Pregnancy.

Turk Arch Otorhinolaryngol 2017 Jun 1;55(2):83-86. Epub 2017 Jun 1.

Department of Otorhinolaryngology, Başkent University Ankara Hospital, Ankara, Turkey.

Benign paroxysmal positional vertigo (BPPV) is a clinical entity characterized by acute, brief paroxysmal attacks of rotational vertigo induced by head position changes. It is the most common peripheral vestibular pathology and is seen more frequently in women. However, to our knowledge, there is very limited data on the association between BPPV and pregnancy in both English and Turkish literature. We present four pregnant women diagnosed with BPPV for the first time during gestation and revise the etiological factors of BPPV and the role of pregnancy-related changes in BPPV.
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http://dx.doi.org/10.5152/tao.2017.2079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782948PMC
June 2017

Shrinkage of Nasal Mucosa and Cartilage During Formalin Fixation.

Balkan Med J 2017 Sep 29;34(5):458-463. Epub 2017 May 29.

Departments of Biochemistry, Başkent University School of Medicine, Ankara, Turkey.

Background: After resection, specimens are subjected to formalin fixation during histological processing. This procedure can result in tissue shrinkage, with the amount of shrinkage related to tissue composition and tissue type.

Aims: To evaluate the shrinkage of nasal mucosa and cartilage tissue and compare differences in shrinkage after resection, after formalin fixation, and during microscopic examination to understand differences in the rate of shrinkage of different tissue types.

Study Design: Animal experimentation.

Methods: Fresh nasal septa were excised from sheep (10 mm diameter in 40 sheep and 20 mm diameter in 40 sheep). The mucosa was separated from one side of the cartilage, with the contralateral mucosa remaining attached to the cartilage. Specimen diameters were measured in situ, after resection, after fixation for 6 or 24 hours (10% formalin), and during microscopic examination.

Results: There were no differences between the in situ and after resection diameters of any tissue components (free mucosa, mucosa attached to cartilage, and cartilage) of all nasal specimens (10- or 20-mm diameter and 6- or 24-hour fixation). However, significant shrinkage occurred between resection and after-fixation. Regarding tissue specimens that were fixed for different durations (6 or 24 hours), we observed a significantly smaller mean tissue diameter in specimens fixed for 24 hours versus those fixed for 6 hours for mucosa attached to cartilage (in the 10-mm diameter after-fixation samples), free mucosa (in the 20-mm diameter after-fixation samples), mucosa attached to cartilage (in the 20-mm diameter after-fixation and microscopic measurement samples), and cartilage (in the 20-mm diameter after-fixation samples). Tissue shrinkage was greatest in free mucosal tissue and least in cartilage.

Conclusion: These results should be considered when evaluating patients undergoing surgical procedures for nasal cavity and paranasal sinus malignancies. Surgical margins should be measured before fixation or evaluated if possible before fixation and shrinkage.
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http://dx.doi.org/10.4274/balkanmedj.2015.1470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635634PMC
September 2017

Audio-Vestibular Findings in Increased Intracranial Hypertension Syndrome.

J Int Adv Otol 2017 Apr 13;13(1):100-104. Epub 2017 Jan 13.

Department of Otorhinolaryngology, Başkent University Alanya Hospital, Antalya, Turkey.

Objective: Idiopathic intracranial hypertension (IIH) can be manifested by audiological and vestibular complaints. The aim of the present study is to determine the audio-vestibular pathologies and their pathophysiologies in this syndrome by performing current audio-vestibular tests.

Materials And Methods: The study was performed prospectively on 40 individuals (20 IIH patients, 20 healthy volunteers). Pure tone audiometry, tympanometry, vestibular evoked myogenic potentials, and electronystagmography tests were performed in both groups and the results were compared.

Results: The mean age of both groups was found to be 30.2±18.7. There were 11 females and 9 males in each group. The study group patients had significantly worse hearing levels. Pure tone averages were significantly higher in both ears of the study group (p<0.05). Ten patients (50%) in the study group and one healthy volunteer (5%) had pathologic ENG, possibly related to central pathologies (p=0.008). Eight patients (40%) and one (5%) control had variable abnormal VEMP records (p=0008).

Conclusion: Many IIH patients initially visit otolaryngology clinics since cochlear and vestibular systems are frequently affected in this condition. Our test results suggest inner ear pathologies in these patients. Higher incidence of inferior vestibular nerve and/or saccule dysfunction is detected as a novelty. Increased intracranial pressure may affect the inner ear with similar mechanisms as in hydrops.
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http://dx.doi.org/10.5152/iao.2016.2626DOI Listing
April 2017

A Rare Patient With Orbital Apex Syndrome, Anterior Uveitis, and Necrotizing Scleritis Due to Herpes Zoster Ophthalmicus.

J Craniofac Surg 2016 Nov;27(8):e750-e752

*Department of Ophthalmology, Faculty of Medicine†Eye Clinic, Ataturk Training and Research Hospital, Izmir Katip Celebi University‡Department of Ophthalmology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

The purpose of this study was to describe a patient of orbital apex syndrome, anterior uveitis, secondary glaucoma, corneal dellen, and necrotizing scleritis following an attack of herpes zoster ophthalmicus, and the placement of a pericardial patch graft. A 64-year-old male patient with blepharoptosis of his right eye and multiple vesicles on the forehead, nose and cheeks, limitation on all gazes, blepharoptosis, and exophthalmia was eventually diagnosed with ophthalmic zona with orbital apex syndrome. After the treatment with systemic antiviral and steroid, there was complete recovery of the unilateral vesicular eruption, ophthalmoplegia, and ptosis at the third month follow-up. However, anterior uveitis, necrotizing scleritis, secondary glaucoma, and corneal dellen developed during follow-up. At the ninth month, pericardial patch graft (Tutoplast) was placed due to progression of the scleral thinning. Graft vascularization was completed. Careful and long-term follow-up of patients with ophthalmic zona is required for possible ophthalmic complications of varicella zoster virus infections. A pericardial patch graft might be placed due to the development of necrotizing scleritis.
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http://dx.doi.org/10.1097/SCS.0000000000003098DOI Listing
November 2016

A Rare Tumor in the Cervical Sympathetic Trunk: Ganglioneuroblastoma.

Case Rep Otolaryngol 2016 14;2016:1454932. Epub 2016 Nov 14.

Department of Otorhinolaryngology, Baskent University Faculty of Medicine, 06500 Ankara, Turkey.

Ganglioneuroblastoma is a rare tumor with moderate malignancy, which is composed of mature ganglion cells and seen in sympathetic ganglia and adrenal medulla. The diagnosis is possible after cytological and immunohistochemical studies following a needle biopsy or surgical excision. There is no consensus regarding the need for chemo- or radiotherapy after surgery. In this case report, clinical behavior and diagnosis and treatment of the rare tumor cervical ganglioneuroblastoma were discussed.
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http://dx.doi.org/10.1155/2016/1454932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124665PMC
November 2016

A Rare Complication of Tonsillectomy: Subcutaneous Emphysema.

Turk Arch Otorhinolaryngol 2016 Dec 1;54(4):172-174. Epub 2016 Dec 1.

Department of Otorhinolaryngology, Başkent University School of Medicine Hospital, Ankara, Turkey.

Tonsillectomy is one of the surgical procedures that are frequently performed by ear, nose, and throat surgeons. The procedure is associated with many intraoperative and postoperative complications, and the nature of the operation site hampers surgical interventions. Cervicofacial subcutaneous emphysema is characterized by the presence of air within the fascial planes of the head-neck region because of various reasons. It may develop iatrogenically or spontaneously because of trauma. Herein, we report a 4-year-old male patient who presented to our clinic with complaints of frequent tonsillitis and snoring and who developed subcutaneous emphysema involving only the maxillofacial region following tonsillectomy. In addition, treatment strategies have been discussed, taking current literature into account.
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http://dx.doi.org/10.5152/tao.2016.1888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782958PMC
December 2016

Choroidal and central foveal thickness in patients with scleroderma and its systemic associations.

Clin Exp Optom 2017 Nov 18;100(6):656-662. Epub 2016 Nov 18.

Department of Rheumatology, Izmir Katip Celebi University, Faculty of Medicine, Izmir, Turkey.

Background: The aim was to investigate the morphological changes in the fovea and choroid in patients with scleroderma and its systemic associations.

Methods: Thirty-four scleroderma patients and 31 healthy controls were enrolled. Choroidal thickness (CT) at five defined points (subfoveal [sfCT] and 1.0 [N1.0] and 3.0 µm nasal [N3.0] and 1.0 [T1.0] and 3.0 µm temporal [T3.0] from the centre of the fovea) and central foveal thickness were measured.

Results: The mean central foveal thickness (right eye 229.3 ± 28.6 versus 232.6 ± 29.7 and left eye 219.8 ± 21.4 versus 223.3 ± 21.9 µm) and sfCT (right eye 326.4 ± 56.5 versus 327.3 ± 62.1 and left eye 316.7 ± 53.4 versus 317.6 ± 51.6 µm) values were not different in patients with scleroderma compared with the controls (p > 0.05). The mean CT at N1.0, N3.0, T1.0 and T3.0 did not differ among these groups in both eyes (p > 0.05). There was no difference in the mean central foveal thickness and CT of both eyes in diffuse and limited scleroderma (p > 0.05). A negative correlation was found between anti-nuclear antibody positivity and CT at T3 and N3 (respectively, r = -0.439 and r = -0.383, p < 0.05).

Conclusion: Choroidal thickness at five points and central foveal thickness in both eyes did not significantly differ in scleroderma patients compared with healthy controls. Choroidal thickness at the T3 and N3 points showed a negative correlation with anti-nuclear antibody positivity.
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http://dx.doi.org/10.1111/cxo.12498DOI Listing
November 2017

A Rare Cause of Hemifacial Spasm: Papillary Oncocytic Cystadenoma.

Balkan Med J 2016 Sep 1;33(5):569-572. Epub 2016 Sep 1.

Department of Otorhinolaryngology, Başkent University School of Medicine, Ankara, Turkey.

Background: Hemifacial spasm is a sudden, involuntary and synchronous spasm of the facial muscles. The most frequent cause of this condition is compression of the facial nerves due to vascular pathologies. The most commonly used method of treatment is Botulinum toxin injection. However, the gold standard treatment is surgical treatment.

Case Report: A 64-year-old male patient with hemifacial spasms, which had occurred due to a rare parotid mass that had been surgically treated, is presented in this case.

Conclusion: This case report demonstrates that longstanding parotid gland masses may compress the facial nerves and cause demyelination in the nerve and thus may cause spasms in the facial muscles.
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http://dx.doi.org/10.5152/balkanmedj.2016.150849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056665PMC
September 2016

Middle Ear Resonance Frequency in Pilots and Pilot Candidates.

Aerosp Med Hum Perform 2016;87(10):876-881

Department of Otolaryngology, Baskent University, Faculty of Medicine, Ankara, Turkey.

Background: Barotrauma is a frequent problem in aviation medicine. Eustachian tube dysfunction plays a critical role in the pathogenesis of barotrauma. Function of the Eustachian tube can be indirectly assessed by multifrequency tympanometry, which provides valuable information about the resistance and permeability of the middle ear in a wide frequency range. The aim of this study was to research whether multifrequency tympanometry could be used for assessing middle ear impairments in pilots.

Methods: There were 140 pilots and pilot candidates between the ages of 20-55 with normal otoscopic examination who were evaluated by audiological test batteries. Body mass index values, flight hours, audiometric pure tone thresholds, tympanometry and multifrequency tympanometry test results were noted.

Results: There was statistically significant decrease in the multifrequency tympanometry measurements of the left and right ears of the pilots with 200-3000 flight hours compared to pilot candidates, and similarly, the pilots with 3000-10,000 flight hours compared to pilot candidates.

Discussion: Multifrequency tympanometry values changed between pilot candidates and pilots. However, the values of multifrequency tympanometry did not change due to flight hours. This test battery should not be used for follow up of pilots in the clinic. Tuncer MM, Babakurban ST, Aydin E. Middle ear resonance frequency in pilots and pilot candidates. Aerosp Med Hum Perform. 2016; 87(10):876-881.
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http://dx.doi.org/10.3357/AMHP.4554.2016DOI Listing
January 2017

FCN2 c.772G>T polymorphism is associated with chronic adenoiditis and/or tonsillitis, but not -4 A>G and -602 G>A.

Int J Pediatr Otorhinolaryngol 2016 Aug 20;87:1-4. Epub 2016 May 20.

Department of Medical Genetics, Faculty of Medicine, Baskent University, 06490 Ankara, Turkey.

Objective: Ficolins are complement activating peptides that play a role in the initial host defense against infectious pathogens. In the present study, we investigated the relationship between single nucleotide polymorphisms (SNPs) in the ficolin 2 gene (FCN2) and chronic adenotonsillitis in pediatric cases.

Study Design: Case-control study.

Methods: A total of 101 pediatric patients diagnosed with chronic adenotonsillitis and 100 healthy children were enrolled in the study. Genotypes of FCN2 promoter SNPs - 602 G>A and -4 A>G, and the exonic SNP c.772G>T were determined by light SNP assay after realtime PCR analysis using genomic DNA samples obtained from peripheral blood samples of all participants.

Results: Of the 101 chronic tonsillitis patients, 38 were girls and 63 were boys; the mean age was 5.2 ± 2.3 years. The c.772G>T SNP frequency was significantly higher in chronic adenotonsillitis cases compared to the control group (p = 0.00); however, no significant difference was determined at positions -602 G>A or -4 A>G (p > 0.05).

Conclusions: The FCN2 c.772G>T genotype appears to be associated with predisposition to chronic adenotonsillitis in the pediatric age group. This nucleotide change is likely to influence the level of gene expression and contribute to the development of disease.
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http://dx.doi.org/10.1016/j.ijporl.2016.05.017DOI Listing
August 2016

Increased melatonin levels in aqueous humor of patients with proliferative retinopathy in type 2 diabetes mellitus.

Int J Ophthalmol 2016 18;9(5):721-4. Epub 2016 May 18.

Gaziosmanpasa University Faculty of Medicine, Biochemistry, Tokat 60250, Turkey.

Aim: To report the association between melatonin levels in aqueous humor and serum, and diabetic retinopathy (DR) grade in type 2 diabetic patients.

Methods: Aqueous humor and plasma samples from 26 patients with DR (in nonproliferative and proliferative stages) and 14 control subjects were collected during cataract surgery after 6 p.m. Melatonin concentrations were determined using an enzyme-linked immunosorbent assay (ELISA).

Results: Melatonin levels were significantly higher in the aqueous humor of patients with proliferative diabetic retinopathy (PDR) [18.57±2.67 pg/mL (range 15.20-23.06) vs 13.63±2.71 pg/mL (range 10.20-20.20), P=0.0001], but not in those with nonproliferative retinopathy (NPDR) [13.79±2.56 pg/mL (range 9.80-20.10) vs 13.63±2.71 pg/mL (range 10.20-20.20), P=0.961] compared to controls. There was decrement in the plasma melatonin level of patients with PDR, but no significant differences between the plasma melatonin levels of the study groups [5.37±1.74 pg/mL (range 2.85-8.65) vs 6.11±1.90 pg/mL (range 3.13-9.41), P=0.293], or between control and DR groups [NPDR 6.11±1.90 pg/mL (range 3.13-9.41) vs control 6.15±1.91 pg/mL (range 2.18-9.86); PDR (5.37±1.74 pg/mL (range 2.85-8.65) vs control 6.15±1.91 pg/mL (range 2.18-9.86), P=0.808, P=0.264].

Conclusion: Elevated melatonin levels in aqueous humor in PDR may indicate the level to be associated with DR severity.
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http://dx.doi.org/10.18240/ijo.2016.05.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886868PMC
June 2016

Adenoidectomy: current approaches and review of the literature.

Kulak Burun Bogaz Ihtis Derg 2016 May-Jun;26(3):181-90

Baskent University Faculty of Medicine, Department of Otorhinolaryngology, 06490 Bahçelievler, Ankara, Turkey.

Adenoid is a secondary lymphoid organ located in the nasopharynx. Due to its location, it plays an important role in the host defense of the upper respiratory tract. Immunoglobulin G3 and immunoglobulin A1 antibodies are prevalent antibodies in the adenoid tissue. Adenoidal hypertrophy is a common condition in children causing symptoms such as mouth breathing, nasal discharge, snoring, sleep apnea, and hyponasal speech. It also plays a role in the pathogenesis of rhinosinusitis, recurrent otitis media, and otitis media with effusion. Currently, adenoidectomy is one of the most commonly performed pediatric surgical procedures worldwide. Although there is still poor evidence in the literature, recurrent upper respiratory infections, otitis media with effusion, and obstructive sleep apnea syndrome are considered to be the main indications of adenoidectomy. Adenoidectomy can be carried out with several techniques and instruments. Although rare, surgery possesses some risks and may cause emotional distress both for the patient and the family. Non-surgical treatments such as intranasal steroids are also used in the treatment of adenoid hypertrophy. In this review, we discuss the current literature on the adenoid function, adenoidectomy indications, and treatment of adenoid hypertrophy.
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http://dx.doi.org/10.5606/kbbihtisas.2016.32815DOI Listing
March 2017

Recurrent Pleomorphic Adenoma of the Submandibular Gland.

Turk Arch Otorhinolaryngol 2016 Mar 1;54(1):43-46. Epub 2016 Mar 1.

Department of Medical Pathology, Başkent University School of Medicine Hospital, Ankara, Turkey.

Pleomorphic adenoma (PA) is the most common benign tumor of salivary glands. Most PAs occur in the parotid (80%), followed by the submandibular gland (10%) and minor salivary and sublingual glands (10%). Submandibular gland PAs usually manifest in the submandibular area as a painless hard mass. Although several recurrent parotid gland PA cases have been reported in the literature, recurrent submandibular gland PA is quite rare. Complete surgical removal of tumor of the submandibular gland and keeping the capsule intact are important to prevent recurrence. Here we present a rare case of submandibular gland PA recurrence that occurred 5 years after the first surgery and methods to prevent recurrence.
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http://dx.doi.org/10.5152/tao.2016.1281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782975PMC
March 2016

Changes in body composition and growth pattern after adenotonsillectomy in prepubertal children.

Int J Pediatr Otorhinolaryngol 2016 Feb 21;81:46-50. Epub 2015 Dec 21.

Department of Pediatrics, Division of Pediatric Endocrinology, Baskent University, Ankara 06490, Turkey. Electronic address:

Objective: Adenotonsillar hypertrophy and chronic tonsillitis are associated with growth interruption during childhood, while adenotonsillectomy has been associated with growth improvement and increased body mass index (BMI). However, no reported study has investigated the effect of adenotonsillectomy on the proportion of body muscle and fat mass. The aim of this prospective study was to evaluate the effect of adenoidectomy and adenotonsillectomy on body muscle and fat composition in prepubertal children.

Methods: Thirty prepubertal children (22 boys, 8 girls; 3-9 years of age) were followed up for 6 months after adenoidectomy or adenotonsillectomy. Twenty-eight age-matched healthy children (12 boys, 16 girls) were followed for the same period, as controls. Data on dietary habits and physical activity were obtained from parent-completed questionnaires at baseline and 6 months. Height and weight z-scores, the amount and percentage of body fat and muscle mass, BMI z-scores, relative BMI and basal metabolic rate were evaluated before and 6 months after surgery with bioelectrical impedance analysis.

Results: After 6 months, body muscle mass and basal metabolic rate scores were significantly higher than at baseline in both groups (P<0.05). The rate of increase was not different between the groups. In the study group, the relative BMI scores improved significantly (P<0.05). Increases in body fat mass, body fat percentage, height z-scores, weight z-scores and BMI z-scores were not significantly different between the groups at 6 months (P>0.05). The number of overweight and obese children did not change significantly in either group (P<0.05).

Conclusions: Adenotonsillectomy led to improvement in relative BMI and promoted healthy weight gain without increased body fat percentage in prepubertal children.
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http://dx.doi.org/10.1016/j.ijporl.2015.12.005DOI Listing
February 2016

The Importance and Place of Adenotonsillectomy in Syndromic Children.

Turk Arch Otorhinolaryngol 2015 Dec 1;53(4):163-167. Epub 2015 Dec 1.

Department of Otorhinolaryngology, Başkent University School of Medicine, Ankara, Turkey.

Objective: Upper airway obstruction and sleeping disorders are important issues in syndromic children, including mouth, lower-upper jaw, or all facial abnormalities. Tonsillectomy and/or adenoidectomy is required because of systemic problems and upper airway obstruction that increase the existing systemic problems, except those anomalies. However, tonsillectomy and/or adenoidectomy are mostly avoided because of the tendency to cause both intubation/perioperative systemic problems and respiratory complications in the postoperative period and in delays in the oral intake. However, these surgeries are sometimes required. In this context, we present our experience related with performing tonsillectomy and/or adenoidectomy in syndromic children admitted to our hospital.

Methods: We retrospectively examined the data on tonsillectomy and/or adenoidectomy performed in syndromic patients in our clinic between 2001 and 2011.

Results: We did not observe any postoperative complications in adenoidectomy and/or tonsillectomy performed by the same surgeon in 14 syndromic cases.

Conclusion: It should be noted that respiratory problems may arise from many different anatomical regions in syndromic patients. Therefore, surgery should be performed taking into consideration all of these factors in these patients. These patients must be hospitalized in the postoperative period.
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http://dx.doi.org/10.5152/tao.2015.1348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782981PMC
December 2015

Evaluation of Hearing Loss in Pilots.

Turk Arch Otorhinolaryngol 2015 Dec 1;53(4):155-162. Epub 2015 Dec 1.

Department of Otorhinolaryngology, Başkent University School of Medicine, Ankara, Turkey.

Objective: High-intensity noise sources with an increase in air traffic and sudden changes in atmospheric pressure can cause hearing loss in pilots. The main goal of this research is to examine hearing loss due to age, the total flight hours and aircraft types and to evaluate the effects of personal conditions that can influence the hearing level.

Methods: We examined the data of 234 Turkish pilots aged between 25 and 54 years who were examined due to the aviation Law for annual control from January 2005 to January 2014 at Başkent University Medical Faculty, Ankara Hospital. The audiometric results of the pilots were used. While 1, 2, 3, 4, 6, and 8 KHz were used for the airway threshold, 1, 2, and 4 KHz were used for the bone conduction threshold.

Results: According to the data of the 234 pilots, there was a significant correlation between high-frequency hearing loss and the total flight hours and pilots' ages. The average hearing loss was higher, particularly in the left ear, in pilots using helicopters than in those using other aircraft types. There was no statistically significant correlation between hearing loss and diabetes, hypercholesterolemia, high blood pressure, anemia, obesity, and smoking.

Conclusion: A significant correlation was observed between high frequency hearing loss and the total flight hours, pilots' age, and aircraft types in our study.
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http://dx.doi.org/10.5152/tao.2015.1330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782980PMC
December 2015

[Aberrant parapharyngeal internal carotid artery: a case series].

Kulak Burun Bogaz Ihtis Derg 2015 ;25(6):361-6

Department of Otolaryngology, Medical Faculty of Başkent University, 06490 Bahçelievler, Ankara, Turkey.

In this article, we report eight elderly cases who were diagnosed with aberrant internal carotid artery at the Department of Otorhinolaryngology and Head and Neck Surgery of Başkent University Ankara Hospital. Three cases had dysphagia, two cases had foreign body sensation in the throat, one case had increased tinnitus, and one case had complaints of aspiration which was not previously reported in the literature and chocking sensation. One patient was asymptomatic. Five cases had kink form of aberrant parapharyngeal internal carotid artery, one case had tortuosity and one case had both tortuosity and kink form. In one case, internal carotid artery was in form of 90 degrees angle in the right side and S-shaped in the left side, which was not described in the classification.
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http://dx.doi.org/10.5606/kbbihtisas.2015.37605DOI Listing
June 2016

Sex differences in adult craniofacial parameters.

Surg Radiol Anat 2015 Nov 3;37(9):1069-78. Epub 2015 May 3.

Department of Otolaryngology-Head and Neck Surgery, Baskent University, Saray Mah. Yunusemre Cad. No. 1, Alanya, 07400, Antalya, Turkey.

Purpose: To compare normal male and female craniofacial parameters in adults and evaluate associations of sex and intercochlear distance with other craniofacial parameters.

Methods: In 60 normal adults (30 men and 30 women) who had no otitis media, craniofacial parameters were measured retrospectively on two-dimensional reformatted computed tomography scans.

Results: Compared with women, men had significantly greater mean osseous auditory tube length, cartilaginous auditory tube length, mastoid length, intercochlear distance, sella to posterior nasal spine distance, sella to basion distance, and nasopharynx sagittal area. The intercochlear distance was significantly correlated with mastoid depth, midpoint of the pharyngeal opening distance, sella to nasion distance, and nasopharynx sagittal area and inversely with angle of the auditory tube. Most men and women had Körner septum present, and mean thickness of Körner septum was significantly greater in men than women.

Conclusions: Some craniofacial parameters, especially vertical parameters, differ with sex. These differences begin in childhood and continue in adulthood. Sex must be considered when planning a craniofacial morphologic study, and results of a craniofacial morphologic study should be evaluated with caution when there is no sex matching of the patient and control groups.
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http://dx.doi.org/10.1007/s00276-015-1477-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615669PMC
November 2015

Benign paroxysmal positional vertigo after nonotologic surgery: case series.

J Maxillofac Oral Surg 2015 Mar 28;14(Suppl 1):113-5. Epub 2012 Jun 28.

Departments of Endodontics, Faculty of Dentistry, Alanya Medical and Research Center, Baskent University, Ankara, Turkey.

Benign paroxysmal positional vertigo is one of the most common types of vertigo caused by peripheral vestibular dysfunction. Although head trauma, migraine, long-term bed rest, Ménière disease, viral labyrinthitis, and upper respiratory tract infections are believed to be predisposing factors, most cases of benign paroxysmal positional vertigo are idiopathic. Ear surgery is another cause, but after non-otologic surgery, attacks of benign paroxysmal positional vertigo are rare. We describe three cases of benign paroxysmal positional vertigo attacks after non-otologic surgery (one patient after a nasal septoplasty and two patients after dental endodontic treatment) and discuss the pathophysiological mechanism of benign paroxysmal positional vertigo seen after non-otologic surgery, its diagnosis and treatment.
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http://dx.doi.org/10.1007/s12663-012-0356-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379224PMC
March 2015