Erawan Borkham-Kamphorst

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH Aachen University Hospital, Germany. Electronic address:

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March 2019

Portal myofibroblasts are sensitive to CCN-mediated endoplasmic reticulum stress-related apoptosis with potential to attenuate biliary fibrogenesis.

Authors:

Erawan Borkham-Kamphorst Bettina Therese Steffen Eddy van de Leur Ute Haas Ralf Weiskirchen

Cell Signal 2018 11 22;51:72-85. Epub 2018 Jul 22.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH Aachen University Hospital, Germany. Electronic address:

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November 2018

-Glycosylation of Lipocalin 2 Is Not Required for Secretion or Exosome Targeting.

Authors:

Erawan Borkham-Kamphorst Eddy Van de Leur Steffen K Meurer Eva M Buhl Ralf Weiskirchen

Front Pharmacol 2018 25;9:426. Epub 2018 Apr 25.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany.

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April 2018

Data on Lipocalin 2 and phosphatidylinositol 3-kinase signaling in a methionine- and choline-deficient model of non-alcoholic steatohepatitis.

Authors:

Anastasia Asimakopoulou Erawan Borkham-Kamphorst Eddy Van de Leur Ralf Weiskirchen

Data Brief 2017 Aug 1;13:644-649. Epub 2017 Jul 1.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany.

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August 2017

Altered mitochondrial and peroxisomal integrity in lipocalin-2-deficient mice with hepatic steatosis.

Authors:

Anastasia Asimakopoulou Annabelle Fülöp Erawan Borkham-Kamphorst Eddy Van de Leur Nikolaus Gassler Thorsten Berger Birte Beine Helmut E Meyer Tak W Mak Carsten Hopf Corinna Henkel Ralf Weiskirchen

Biochim Biophys Acta Mol Basis Dis 2017 09 7;1863(9):2093-2110. Epub 2017 Apr 7.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany. Electronic address:

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September 2017

Adenoviral CCN gene transfers induce in vitro and in vivo endoplasmic reticulum stress and unfolded protein response.

Authors:

Erawan Borkham-Kamphorst Bettina Therese Steffen Eddy Van de Leur Lidia Tihaa Ute Haas Marius M Woitok Steffen K Meurer Ralf Weiskirchen

Biochim Biophys Acta 2016 11 22;1863(11):2604-2612. Epub 2016 Jul 22.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH Aachen University Hospital, Aachen, Germany. Electronic address:

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November 2016

Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis.

Authors:

Hans-Theo Schon Matthias Bartneck Erawan Borkham-Kamphorst Jacob Nattermann Twan Lammers Frank Tacke Ralf Weiskirchen

Front Pharmacol 2016 24;7:33. Epub 2016 Feb 24.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen Aachen, Germany.

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March 2016

The role of PDGF-D in healthy and fibrotic kidneys.

Authors:

Eva M Buhl Sonja Djudjaj Janka Babickova Barbara M Klinkhammer Erika Folestad Erawan Borkham-Kamphorst Ralf Weiskirchen Kelly Hudkins Charles E Alpers Ulf Eriksson Jürgen Floege Peter Boor

Kidney Int 2016 Apr 18;89(4):848-61. Epub 2016 Feb 18.

Division of Nephrology, RWTH University of Aachen, Aachen, Germany; Institute of Pathology, RWTH University of Aachen, Aachen, Germany; Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia. Electronic address:

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April 2016

The PDGF system and its antagonists in liver fibrosis.

Authors:

Erawan Borkham-Kamphorst Ralf Weiskirchen

Cytokine Growth Factor Rev 2016 Apr 30;28:53-61. Epub 2015 Oct 30.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany. Electronic address:

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April 2016

CCN1/CYR61 overexpression in hepatic stellate cells induces ER stress-related apoptosis.

Authors:

Erawan Borkham-Kamphorst Bettina T Steffen Eddy Van de Leur Ute Haas Lidia Tihaa Scott L Friedman Ralf Weiskirchen

Cell Signal 2016 Jan 26;28(1):34-42. Epub 2015 Oct 26.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH Aachen University Hospital, Germany. Electronic address:

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January 2016

Lipocalin-2 (NGAL/LCN2), a "help-me" signal in organ inflammation.

Authors:

Anastasia Asimakopoulou Erawan Borkham-Kamphorst Frank Tacke Ralf Weiskirchen

Hepatology 2016 Feb 31;63(2):669-71. Epub 2015 Jul 31.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany.

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February 2016

PDGF-D signaling in portal myofibroblasts and hepatic stellate cells proves identical to PDGF-B via both PDGF receptor type α and β.

Authors:

Erawan Borkham-Kamphorst Steffen K Meurer Eddy Van de Leur Ute Haas Lidia Tihaa Ralf Weiskirchen

Cell Signal 2015 Jul 27;27(7):1305-14. Epub 2015 Mar 27.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Germany. Electronic address:

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July 2015

Bile duct ligation in mice: induction of inflammatory liver injury and fibrosis by obstructive cholestasis.

Authors:

Carmen G Tag Sibille Sauer-Lehnen Sabine Weiskirchen Erawan Borkham-Kamphorst René H Tolba Frank Tacke Ralf Weiskirchen

J Vis Exp 2015 Feb 10(96). Epub 2015 Feb 10.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH Aachen University;

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February 2015

NLRP3 inflammasome expression is driven by NF-κB in cultured hepatocytes.

Authors:

Sorina Georgiana Boaru Erawan Borkham-Kamphorst Eddy Van de Leur Eric Lehnen Christian Liedtke Ralf Weiskirchen

Biochem Biophys Res Commun 2015 Mar 14;458(3):700-706. Epub 2015 Feb 14.

Institute of Molecular Pathobiochemistry, Gene Therapy and Clinical Chemistry and Pathobiochemistry, RWTH Aachen University, Aachen, Germany. Electronic address:

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March 2015

Platelet-derived growth factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities.

Authors:

Erawan Borkham-Kamphorst Pascal Alexi Lidia Tihaa Ute Haas Ralf Weiskirchen

Biochem Biophys Res Commun 2015 Feb 7;457(3):307-13. Epub 2015 Jan 7.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH Aachen University Hospital, Germany. Electronic address:

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February 2015

Lipocalin-2 (LCN2) regulates PLIN5 expression and intracellular lipid droplet formation in the liver.

Authors:

Anastasia Asimakopoulou Erawan Borkham-Kamphorst Marc Henning Eray Yagmur Nikolaus Gassler Christian Liedtke Thorsten Berger Tak W Mak Ralf Weiskirchen

Biochim Biophys Acta 2014 Oct 31;1842(10):1513-24. Epub 2014 Jul 31.

Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Aachen, Germany. Electronic address:

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October 2014

Human mesenchymal stem cells towards non-alcoholic steatohepatitis in an immunodeficient mouse model.

Authors:

Sandra Winkler Erawan Borkham-Kamphorst Peggy Stock Sandra Brückner Matthias Dollinger Ralf Weiskirchen Bruno Christ

Exp Cell Res 2014 Aug 28;326(2):230-9. Epub 2014 Apr 28.

Applied Molecular Hepatology Laboratory, Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University Hospital Leipzig, Liebigstraße 21, D-04103 Leipzig, Germany; Translational Centre for Regenerative Medicine (TRM), University of Leipzig, Leipzig, Germany. Electronic address:

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August 2014

The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling.

Authors:

Erawan Borkham-Kamphorst Christian Schaffrath Eddy Van de Leur Ute Haas Lidia Tihaa Steffen K Meurer Yulia A Nevzorova Christian Liedtke Ralf Weiskirchen

Biochim Biophys Acta 2014 May 31;1843(5):902-14. Epub 2014 Jan 31.

Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Germany. Electronic address:

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May 2014

Protective effects of lipocalin-2 (LCN2) in acute liver injury suggest a novel function in liver homeostasis.

Authors:

Erawan Borkham-Kamphorst Eddy van de Leur Henning W Zimmermann Karlin Raja Karlmark Lidia Tihaa Ute Haas Frank Tacke Thorsten Berger Tak W Mak Ralf Weiskirchen

Biochim Biophys Acta 2013 May 31;1832(5):660-73. Epub 2013 Jan 31.

Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Germany.

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May 2013

Proteomic profiling in Lipocalin 2 deficient mice under normal and inflammatory conditions.

Authors:

Kirsten Labbus Marc Henning Erawan Borkham-Kamphorst Cordelia Geisler Thorsten Berger Tak W Mak Ruth Knüchel Helmut E Meyer Ralf Weiskirchen Corinna Henkel

J Proteomics 2013 Jan 3;78:188-96. Epub 2012 Dec 3.

Institute of Pathology, RWTH University Hospital Aachen, Germany.

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January 2013

Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease.

Authors:

Sorina Georgiana Boaru Erawan Borkham-Kamphorst Lidia Tihaa Ute Haas Ralf Weiskirchen

J Inflamm (Lond) 2012 Nov 28;9(1):49. Epub 2012 Nov 28.

Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Pauwelsstr. 30, Aachen D-52074, Germany.

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November 2012

Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis.

Authors:

Ina V Martin Erawan Borkham-Kamphorst Stephanie Zok Claudia R C van Roeyen Ulf Eriksson Peter Boor Kanishka Hittatiya Hans-Peter Fischer Hermann E Wasmuth Ralf Weiskirchen Frank Eitner Jürgen Floege Tammo Ostendorf

Am J Pathol 2013 Jan 7;182(1):107-17. Epub 2012 Nov 7.

Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.

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January 2013

Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes.

Authors:

Hacer Sahin Erawan Borkham-Kamphorst Nicole T do O Marie-Luise Berres Michaela Kaldenbach Petra Schmitz Ralf Weiskirchen Christian Liedtke Konrad L Streetz Kathrin Maedler Christian Trautwein Hermann E Wasmuth

Hepatology 2013 Feb 8;57(2):797-805. Epub 2013 Jan 8.

Medical Department III and University Hospital Aachen, Aachen, Germany.

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February 2013

Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men.

Authors:

Erawan Borkham-Kamphorst Henning W Zimmermann Nikolaus Gassler Ute Bissels Andreas Bosio Frank Tacke Ralf Weiskirchen Sandip M Kanse

J Hepatol 2013 Jan 16;58(1):104-11. Epub 2012 Sep 16.

Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany.

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January 2013

Adenoviral CCN3/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis.

Authors:

Erawan Borkham-Kamphorst Sebastian Huss Eddy Van de Leur Ute Haas Ralf Weiskirchen

Liver Int 2012 Oct 15;32(9):1342-53. Epub 2012 Jun 15.

Institute of Clinical Chemistry and Pathobiochemistry, RWTH-University Hospital Aachen, Aachen, Germany.

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October 2012

A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and antimesangioproliferative effects.

Authors:

Claudia R C van Roeyen Peter Boor Erawan Borkham-Kamphorst Song Rong Uta Kunter Ina V Martin Ana Kaitovic Stefan Fleckenstein Bernard Perbal Christian Trautwein Ralf Weiskirchen Tammo Ostendorf Jürgen Floege

Am J Pathol 2012 May;180(5):1979-90

Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany.

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May 2012

Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice.

Authors:

Hacer Sahin Erawan Borkham-Kamphorst Christoph Kuppe Mirko Moreno Zaldivar Christoph Grouls Muhammad Al-samman Andreas Nellen Petra Schmitz Daniel Heinrichs Marie-Luise Berres Dennis Doleschel David Scholten Ralf Weiskirchen Marcus J Moeller Fabian Kiessling Christian Trautwein Hermann E Wasmuth

Hepatology 2012 May;55(5):1610-9

Medical Department III, University Hospital Aachen, Aachen, Germany.

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May 2012

CCN3/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC.

Authors:

Erawan Borkham-Kamphorst Claudia R van Roeyen Eddy Van de Leur Jürgen Floege Ralf Weiskirchen

J Cell Commun Signal 2012 Mar 5;6(1):11-25. Epub 2011 Jul 5.

Institute of Clinical Chemistry and Pathobiochemistry, RWTH-University Hospital, 52074, Aachen, Germany,

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March 2012

Induction of lipocalin-2 expression in acute and chronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1β through nuclear factor-κB activation.

Authors:

Erawan Borkham-Kamphorst Falko Drews Ralf Weiskirchen

Liver Int 2011 May 16;31(5):656-65. Epub 2011 Mar 16.

Institute of Clinical Chemistry and Pathobiochemistry, RWTH Aachen University Hospital, Aachen, Germany.

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May 2011

Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling.

Authors:

Steffen K Meurer Lidia Tihaa Erawan Borkham-Kamphorst Ralf Weiskirchen

Cell Signal 2011 Apr 10;23(4):683-99. Epub 2010 Dec 10.

Institute of Clinical Chemistry and Pathobiochemistry, RWTH-University Hospital, Aachen, Germany.

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April 2011

BMP-7 as antagonist of organ fibrosis.

Authors:

Ralf Weiskirchen Steffen K Meurer Olav A Gressner Jens Herrmann Erawan Borkham-Kamphorst Axel M Gressner

Front Biosci (Landmark Ed) 2009 Jun 1;14:4992-5012. Epub 2009 Jun 1.

Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Germany.

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June 2009

Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury.

Authors:

Erawan Borkham-Kamphorst Evgenia Kovalenko Claudia R C van Roeyen Nikolaus Gassler Michael Bomble Tammo Ostendorf Jürgen Floege Axel M Gressner Ralf Weiskirchen

Lab Invest 2008 Oct 28;88(10):1090-100. Epub 2008 Jul 28.

Institute of Clinical Chemistry and Pathobiochemistry, RWTH-University Hospital Aachen, Aachen, Germany.

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October 2008

Pro-fibrogenic potential of PDGF-D in liver fibrosis.

Authors:

Erawan Borkham-Kamphorst Claudia R C van Roeyen Tammo Ostendorf Jürgen Floege Axel M Gressner Ralf Weiskirchen

J Hepatol 2007 Jun 23;46(6):1064-74. Epub 2007 Feb 23.

Institute of Clinical Chemistry and Pathobiochemistry, and Division of Nephrology, RWTH-University Hospital Aachen, D-52074 Aachen, Germany.

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June 2007

The expression of CSRP2 encoding the LIM domain protein CRP2 is mediated by TGF-beta in smooth muscle and hepatic stellate cells.

Authors:

Jens Herrmann Erawan Borkham-Kamphorst Ute Haas Eddy Van de Leur Mario F Fraga Manel Esteller Axel M Gressner Ralf Weiskirchen

Biochem Biophys Res Commun 2006 Jul 22;345(4):1526-35. Epub 2006 May 22.

Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Germany.

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July 2006

Disruption of intermolecular disulfide bonds in PDGF-BB dimers by N-acetyl-L-cysteine does not prevent PDGF signaling in cultured hepatic stellate cells.

Authors:

Erawan Borkham-Kamphorst Steffen K Meurer Axel M Gressner Ralf Weiskirchen

Biochem Biophys Res Commun 2005 Dec 2;338(4):1711-8. Epub 2005 Nov 2.

Institute of Clinical Chemistry and Pathobiochemistry, RWTH-University Hospital Aachen, Germany.

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December 2005

Cryopreservation of hepatic stellate cells.

Authors:

Svenja Neyzen Eddy Van de Leur Erawan Borkham-Kamphorst Jens Herrmann Günter Hollweg Axel M Gressner Ralf Weiskirchen

J Hepatol 2006 May 2;44(5):910-7. Epub 2005 Aug 2.

Institute of Clinical Chemistry and Pathobiochemistry, RWTH-University Hospital, Pauwelsstr. 30, D-52074 Aachen, Germany.

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May 2006

Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrogenesis.

Authors:

Erawan Borkham-Kamphorst Doris Stoll Axel M Gressner Ralf Weiskirchen

Biochem Biophys Res Commun 2004 Aug;321(2):413-23

Institute of Clinical Chemistry and Pathobiochemistry, RWTH-University Hospital Aachen, Germany.

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August 2004

Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis.

Authors:

Erawan Borkham-Kamphorst Jens Herrmann Doris Stoll Jens Treptau Axel M Gressner Ralf Weiskirchen

Lab Invest 2004 Jun;84(6):766-77

Institute of Clinical Chemistry and Pathobiochemistry, RWTH-University Hospital, Aachen, Germany.

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June 2004

Inhibitory effect of soluble PDGF-beta receptor in culture-activated hepatic stellate cells.

Authors:

Erawan Borkham-Kamphorst Doris Stoll Axel M Gressner Ralf Weiskirchen

Biochem Biophys Res Commun 2004 Apr;317(2):451-62

Institute of Clinical Chemistry and Pathobiochemistry, RWTH-University Hospital, Aachen D-52074, Germany.

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April 2004

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