Eranga N Vithana

Eranga N Vithana

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Eranga N Vithana

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Integration of Genetic and Biometric Risk Factors for Detection of Primary Angle Closure Glaucoma.

Authors:
Monisha E Nongpiur Chiea-Chuen Khor Ching-Yu Cheng Rahat Husain Pui Yi Boey Annabel Chew Ching Lin Ho Tina T Wong Shamira Perera Tien Yin Wong Eranga N Vithana Tin Aung

Am J Ophthalmol 2019 Dec 1;208:160-165. Epub 2019 Aug 1.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ajo.2019.07.022DOI Listing
December 2019

Primary angle closure glaucoma genomic associations and disease mechanism.

Authors:
Chang Liu Monisha E Nongpiur Chiea-Chuen Khor Eranga N Vithana Tin Aung

Curr Opin Ophthalmol 2019 Dec 27. Epub 2019 Dec 27.

Singapore Eye Research Institute and Singapore National Eye Centre.

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http://dx.doi.org/10.1097/ICU.0000000000000645DOI Listing
December 2019

Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.

Authors:
Adriana I Iglesias Aniket Mishra Veronique Vitart Yelena Bykhovskaya René Höhn Henriët Springelkamp Gabriel Cuellar-Partida Puya Gharahkhani Jessica N Cooke Bailey Colin E Willoughby Xiaohui Li Seyhan Yazar Abhishek Nag Anthony P Khawaja Ozren Polašek David Siscovick Paul Mitchell Yih Chung Tham Jonathan L Haines Lisa S Kearns Caroline Hayward Yuan Shi Elisabeth M van Leeuwen Kent D Taylor Pieter Bonnemaijer Jerome I Rotter Nicholas G Martin Tanja Zeller Richard A Mills Emmanuelle Souzeau Sandra E Staffieri Jost B Jonas Irene Schmidtmann Thibaud Boutin Jae H Kang Sionne E M Lucas Tien Yin Wong Manfred E Beutel James F Wilson André G Uitterlinden Eranga N Vithana Paul J Foster Pirro G Hysi Alex W Hewitt Chiea Chuen Khor Louis R Pasquale Grant W Montgomery Caroline C W Klaver Tin Aung Norbert Pfeiffer David A Mackey Christopher J Hammond Ching-Yu Cheng Jamie E Craig Yaron S Rabinowitz Janey L Wiggs Kathryn P Burdon Cornelia M van Duijn Stuart MacGregor

Nat Commun 2019 01 8;10(1):155. Epub 2019 Jan 8.

Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4029, Australia.

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http://www.nature.com/articles/s41467-018-07819-1
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http://dx.doi.org/10.1038/s41467-018-07819-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325104PMC
January 2019

Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci in Patients with Early Stages of Angle-Closure Disease.

Authors:
Monisha E Nongpiur Ching-Yu Cheng Roopam Duvesh Saravanan Vijayan Mani Baskaran Chiea-Chuen Khor John Allen Srinivasan Kavitha Rengaraj Venkatesh David Goh Rahat Husain Pui Yi Boey Desmond Quek Ching Lin Ho Tina T Wong Shamira Perera Tien Yin Wong Subbiah R Krishnadas Periasamy Sundaresan Tin Aung Eranga N Vithana

Ophthalmology 2018 05 6;125(5):664-670. Epub 2018 Jan 6.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore; Duke-National University of Singapore Medical School, Singapore, Republic of Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2017.11.016DOI Listing
May 2018

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.

Authors:
Adriana I Iglesias Aniket Mishra Veronique Vitart Yelena Bykhovskaya René Höhn Henriët Springelkamp Gabriel Cuellar-Partida Puya Gharahkhani Jessica N Cooke Bailey Colin E Willoughby Xiaohui Li Seyhan Yazar Abhishek Nag Anthony P Khawaja Ozren Polašek David Siscovick Paul Mitchell Yih Chung Tham Jonathan L Haines Lisa S Kearns Caroline Hayward Yuan Shi Elisabeth M van Leeuwen Kent D Taylor Pieter Bonnemaijer Jerome I Rotter Nicholas G Martin Tanja Zeller Richard A Mills Emmanuelle Souzeau Sandra E Staffieri Jost B Jonas Irene Schmidtmann Thibaud Boutin Jae H Kang Sionne E M Lucas Tien Yin Wong Manfred E Beutel James F Wilson André G Uitterlinden Eranga N Vithana Paul J Foster Pirro G Hysi Alex W Hewitt Chiea Chuen Khor Louis R Pasquale Grant W Montgomery Caroline C W Klaver Tin Aung Norbert Pfeiffer David A Mackey Christopher J Hammond Ching-Yu Cheng Jamie E Craig Yaron S Rabinowitz Janey L Wiggs Kathryn P Burdon Cornelia M van Duijn Stuart MacGregor

Nat Commun 2018 05 14;9(1):1864. Epub 2018 May 14.

Statistical Genetics, QIMR Berghofer Medical Research Institute, QLD 4029, Brisbane, Australia.

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http://dx.doi.org/10.1038/s41467-018-03646-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951816PMC
May 2018

Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma.

Authors:
Yukihiro Shiga Masato Akiyama Koji M Nishiguchi Kota Sato Nobuhiro Shimozawa Atsushi Takahashi Yukihide Momozawa Makoto Hirata Koichi Matsuda Taiki Yamaji Motoki Iwasaki Shoichiro Tsugane Isao Oze Haruo Mikami Mariko Naito Kenji Wakai Munemitsu Yoshikawa Masahiro Miyake Kenji Yamashiro Kenji Kashiwagi Takeshi Iwata Fumihiko Mabuchi Mitsuko Takamoto Mineo Ozaki Kazuhide Kawase Makoto Aihara Makoto Araie Tetsuya Yamamoto Yoshiaki Kiuchi Makoto Nakamura Yasuhiro Ikeda Koh-Hei Sonoda Tatsuro Ishibashi Koji Nitta Aiko Iwase Shiroaki Shirato Yoshitaka Oka Mamoru Satoh Makoto Sasaki Nobuo Fuse Yoichi Suzuki Ching-Yu Cheng Chiea Chuen Khor Mani Baskaran Shamira Perera Tin Aung Eranga N Vithana Jessica N Cooke Bailey Jae H Kang Louis R Pasquale Jonathan L Haines Janey L Wiggs Kathryn P Burdon Puya Gharahkhani Alex W Hewitt David A Mackey Stuart MacGregor Jamie E Craig R Rand Allingham Micheal Hauser Adeyinka Ashaye Donald L Budenz Stephan Akafo Susan E I Williams Yoichiro Kamatani Toru Nakazawa Michiaki Kubo

Hum Mol Genet 2018 04;27(8):1486-1496

Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

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http://dx.doi.org/10.1093/hmg/ddy053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251544PMC
April 2018

Social, health and ocular factors associated with primary open-angle glaucoma amongst Chinese Singaporeans.

Authors:
Nathalie Chiam Mani Baskaran Zheng Li Shamira Perera David Goh Rahat Husain Chiea Chuen Khor Ching-Yu Cheng Tin Aung Eranga N Vithana

Clin Exp Ophthalmol 2018 01 9;46(1):25-34. Epub 2017 Aug 9.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1111/ceo.13008DOI Listing
January 2018

Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function.

Authors:
Mei-Chin Lee William Shei Anita S Chan Boon-Tin Chua Shuang-Ru Goh Yaan-Fun Chong Maryam H Hilmy Monisha E Nongpiur Mani Baskaran Chiea-Chuen Khor Tin Aung Walter Hunziker Eranga N Vithana

Hum Mol Genet 2017 10;26(20):4011-4027

Ocular Genetics Research Group, Singapore Eye Research Institute, Singapore 169856, Singapore.

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http://academic.oup.com/hmg/article/26/20/4011/4016579/Prima
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http://dx.doi.org/10.1093/hmg/ddx292DOI Listing
October 2017

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.

Authors:
Tin Aung Mineo Ozaki Mei Chin Lee Ursula Schlötzer-Schrehardt Gudmar Thorleifsson Takanori Mizoguchi Robert P Igo Aravind Haripriya Susan E Williams Yury S Astakhov Andrew C Orr Kathryn P Burdon Satoko Nakano Kazuhiko Mori Khaled Abu-Amero Michael Hauser Zheng Li Gopalakrishnan Prakadeeswari Jessica N Cooke Bailey Alina Popa Cherecheanu Jae H Kang Sarah Nelson Ken Hayashi Shin-Ichi Manabe Shigeyasu Kazama Tomasz Zarnowski Kenji Inoue Murat Irkec Miguel Coca-Prados Kazuhisa Sugiyama Irma Järvelä Patricio Schlottmann S Fabian Lerner Hasnaa Lamari Yildirim Nilgün Mukharram Bikbov Ki Ho Park Soon Cheol Cha Kenji Yamashiro Juan C Zenteno Jost B Jonas Rajesh S Kumar Shamira A Perera Anita S Y Chan Nino Kobakhidze Ronnie George Lingam Vijaya Tan Do Deepak P Edward Lourdes de Juan Marcos Mohammad Pakravan Sasan Moghimi Ryuichi Ideta Daniella Bach-Holm Per Kappelgaard Barbara Wirostko Samuel Thomas Daniel Gaston Karen Bedard Wenda L Greer Zhenglin Yang Xueyi Chen Lulin Huang Jinghong Sang Hongyan Jia Liyun Jia Chunyan Qiao Hui Zhang Xuyang Liu Bowen Zhao Ya-Xing Wang Liang Xu Stéphanie Leruez Pascal Reynier George Chichua Sergo Tabagari Steffen Uebe Matthias Zenkel Daniel Berner Georg Mossböck Nicole Weisschuh Ursula Hoja Ulrich-Christoph Welge-Luessen Christian Mardin Panayiota Founti Anthi Chatzikyriakidou Theofanis Pappas Eleftherios Anastasopoulos Alexandros Lambropoulos Arkasubhra Ghosh Rohit Shetty Natalia Porporato Vijayan Saravanan Rengaraj Venkatesh Chandrashekaran Shivkumar Narendran Kalpana Sripriya Sarangapani Mozhgan R Kanavi Afsaneh Naderi Beni Shahin Yazdani Alireza Lashay Homa Naderifar Nassim Khatibi Antonio Fea Carlo Lavia Laura Dallorto Teresa Rolle Paolo Frezzotti Daniela Paoli Erika Salvi Paolo Manunta Yosai Mori Kazunori Miyata Tomomi Higashide Etsuo Chihara Satoshi Ishiko Akitoshi Yoshida Masahide Yanagi Yoshiaki Kiuchi Tsutomu Ohashi Toshiya Sakurai Takako Sugimoto Hideki Chuman Makoto Aihara Masaru Inatani Masahiro Miyake Norimoto Gotoh Fumihiko Matsuda Nagahisa Yoshimura Yoko Ikeda Morio Ueno Chie Sotozono Jin Wook Jeoung Min Sagong Kyu Hyung Park Jeeyun Ahn Marisa Cruz-Aguilar Sidi M Ezzouhairi Abderrahman Rafei Yaan Fun Chong Xiao Yu Ng Shuang Ru Goh Yueming Chen Victor H K Yong Muhammad Imran Khan Olusola O Olawoye Adeyinka O Ashaye Idakwo Ugbede Adeola Onakoya Nkiru Kizor-Akaraiwe Chaiwat Teekhasaenee Yanin Suwan Wasu Supakontanasan Suhanya Okeke Nkechi J Uche Ifeoma Asimadu Humaira Ayub Farah Akhtar Ewa Kosior-Jarecka Urszula Lukasik Ignacio Lischinsky Vania Castro Rodolfo Perez Grossmann Gordana Sunaric Megevand Sylvain Roy Edward Dervan Eoin Silke Aparna Rao Priti Sahay Pablo Fornero Osvaldo Cuello Delia Sivori Tamara Zompa Richard A Mills Emmanuelle Souzeau Paul Mitchell Jie Jin Wang Alex W Hewitt Michael Coote Jonathan G Crowston Sergei Y Astakhov Eugeny L Akopov Anton Emelyanov Vera Vysochinskaya Gyulli Kazakbaeva Rinat Fayzrakhmanov Saleh A Al-Obeidan Ohoud Owaidhah Leyla Ali Aljasim Balram Chowbay Jia Nee Foo Raphael Q Soh Kar Seng Sim Zhicheng Xie Augustine W O Cheong Shi Qi Mok Hui Meng Soo Xiao Yin Chen Su Qin Peh Khai Koon Heng Rahat Husain Su-Ling Ho Axel M Hillmer Ching-Yu Cheng Francisco A Escudero-Domínguez Rogelio González-Sarmiento Frederico Martinon-Torres Antonio Salas Kessara Pathanapitoon Linda Hansapinyo Boonsong Wanichwecharugruang Naris Kitnarong Anavaj Sakuntabhai Hip X Nguyn Giang T T Nguyn Trình V Nguyn Werner Zenz Alexander Binder Daniela S Klobassa Martin L Hibberd Sonia Davila Stefan Herms Markus M Nöthen Susanne Moebus Robyn M Rautenbach Ari Ziskind Trevor R Carmichael Michele Ramsay Lydia Álvarez Montserrat García Héctor González-Iglesias Pedro P Rodríguez-Calvo Luis Fernández-Vega Cueto Çilingir Oguz Nevbahar Tamcelik Eray Atalay Bilge Batu Dilek Aktas Burcu Kasım M Roy Wilson Anne L Coleman Yutao Liu Pratap Challa Leon Herndon Rachel W Kuchtey John Kuchtey Karen Curtin Craig J Chaya Alan Crandall Linda M Zangwill Tien Yin Wong Masakazu Nakano Shigeru Kinoshita Anneke I den Hollander Eija Vesti John H Fingert Richard K Lee Arthur J Sit Bradford J Shingleton Ningli Wang Daniele Cusi Raheel Qamar Peter Kraft Margaret A Pericak-Vance Soumya Raychaudhuri Steffen Heegaard Tero Kivelä André Reis Friedrich E Kruse Robert N Weinreb Louis R Pasquale Jonathan L Haines Unnur Thorsteinsdottir Fridbert Jonasson R Rand Allingham Dan Milea Robert Ritch Toshiaki Kubota Kei Tashiro Eranga N Vithana Shazia Micheal Fotis Topouzis Jamie E Craig Michael Dubina Periasamy Sundaresan Kari Stefansson Janey L Wiggs Francesca Pasutto Chiea Chuen Khor

Nat Genet 2017 07 29;49(7):993-1004. Epub 2017 May 29.

Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.1038/ng.3875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685441PMC
July 2017

Genome-wide association study of Parkinson's disease in East Asians.

Authors:
Jia Nee Foo Louis C Tan Ishak D Irwan Wing-Lok Au Hui Qi Low Kumar-M Prakash Azlina Ahmad-Annuar Jinxin Bei Anne Yy Chan Chiung Mei Chen Yi-Chun Chen Sun Ju Chung Hao Deng Shen-Yang Lim Vincent Mok Hao Pang Zhong Pei Rong Peng Hui-Fang Shang Kyuyoung Song Ai Huey Tan Yih-Ru Wu Tin Aung Ching-Yu Cheng Fook Tim Chew Soo-Hong Chew Siow-Ann Chong Richard P Ebstein Jimmy Lee Seang-Mei Saw Adeline Seow Mythily Subramaniam E-Shyong Tai Eranga N Vithana Tien-Yin Wong Khai Koon Heng Wee-Yang Meah Chiea Chuen Khor Hong Liu Furen Zhang Jianjun Liu Eng-King Tan

Hum Mol Genet 2017 01;26(1):226-232

Department of Neurology, National Neuroscience Institute, Singapore.

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http://dx.doi.org/10.1093/hmg/ddw379DOI Listing
January 2017

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics.

Authors:
Henriët Springelkamp Adriana I Iglesias Aniket Mishra René Höhn Robert Wojciechowski Anthony P Khawaja Abhishek Nag Ya Xing Wang Jie Jin Wang Gabriel Cuellar-Partida Jane Gibson Jessica N Cooke Bailey Eranga N Vithana Puya Gharahkhani Thibaud Boutin Wishal D Ramdas Tanja Zeller Robert N Luben Ekaterina Yonova-Doing Ananth C Viswanathan Seyhan Yazar Angela J Cree Jonathan L Haines Jia Yu Koh Emmanuelle Souzeau James F Wilson Najaf Amin Christian Müller Cristina Venturini Lisa S Kearns Jae Hee Kang Yih Chung Tham Tiger Zhou Elisabeth M van Leeuwen Stefan Nickels Paul Sanfilippo Jiemin Liao Herma van der Linde Wanting Zhao Leonieke M E van Koolwijk Li Zheng Fernando Rivadeneira Mani Baskaran Sven J van der Lee Shamira Perera Paulus T V M de Jong Ben A Oostra André G Uitterlinden Qiao Fan Albert Hofman E-Shyong Tai Johannes R Vingerling Xueling Sim Roger C W Wolfs Yik Ying Teo Hans G Lemij Chiea Chuen Khor Rob Willemsen Karl J Lackner Tin Aung Nomdo M Jansonius Grant Montgomery Philipp S Wild Terri L Young Kathryn P Burdon Pirro G Hysi Louis R Pasquale Tien Yin Wong Caroline C W Klaver Alex W Hewitt Jost B Jonas Paul Mitchell Andrew J Lotery Paul J Foster Veronique Vitart Norbert Pfeiffer Jamie E Craig David A Mackey Christopher J Hammond Janey L Wiggs Ching-Yu Cheng Cornelia M van Duijn Stuart MacGregor

Hum Mol Genet 2017 01;26(2):438-453

Statistical Genetics, QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Australia.

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http://dx.doi.org/10.1093/hmg/ddw399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968632PMC
January 2017

CYP1B1 and MYOC Mutations in Vietnamese Primary Congenital Glaucoma Patients.

Authors:
Tan Do William Shei Pham Thi Minh Chau Doan Le Trang Victor H K Yong Xiao Yu Ng Yue Ming Chen Tin Aung Eranga N Vithana

J Glaucoma 2016 05;25(5):e491-8

*Vietnam National Institute of Ophthalmology, Hanoi, Vietnam †Singapore Eye Research Institute ‡Department of Ophthalmology, National University Health System & National University of Singapore §Singapore National Eye Centre ∥Neuroscience and Behavioral Disorders (NBD) Program, Duke-NUS Graduate Medical School, Singapore, Singapore.

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http://dx.doi.org/10.1097/IJG.0000000000000331DOI Listing
May 2016

Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma.

Authors:
Chiea Chuen Khor Tan Do Hongyan Jia Masakazu Nakano Ronnie George Khaled Abu-Amero Roopam Duvesh Li Jia Chen Zheng Li Monisha E Nongpiur Shamira A Perera Chunyan Qiao Hon-Tym Wong Hiroshi Sakai Mônica Barbosa de Melo Mei-Chin Lee Anita S Chan Yaakub Azhany Thi Lam Huong Dao Yoko Ikeda Rodolfo A Perez-Grossmann Tomasz Zarnowski Alexander C Day Jost B Jonas Pancy O S Tam Tuan Anh Tran Humaira Ayub Farah Akhtar Shazia Micheal Paul T K Chew Leyla A Aljasim Tanuj Dada Tam Thi Luu Mona S Awadalla Naris Kitnarong Boonsong Wanichwecharungruang Yee Yee Aung Jelinar Mohamed-Noor Saravanan Vijayan Sripriya Sarangapani Rahat Husain Aliza Jap Mani Baskaran David Goh Daniel H Su Huaizhou Wang Vernon K Yong Leonard W Yip Tuyet Bach Trinh Manchima Makornwattana Thanh Thu Nguyen Edgar U Leuenberger Ki-Ho Park Widya Artini Wiyogo Rajesh S Kumar Celso Tello Yasuo Kurimoto Suman S Thapa Kessara Pathanapitoon John F Salmon Yong Ho Sohn Antonio Fea Mineo Ozaki Jimmy S M Lai Visanee Tantisevi Chaw Chaw Khaing Takanori Mizoguchi Satoko Nakano Chan-Yun Kim Guangxian Tang Sujie Fan Renyi Wu Hailin Meng Thi Thuy Giang Nguyen Tien Dat Tran Morio Ueno Jose Maria Martinez Norlina Ramli Yin Mon Aung Rigo Daniel Reyes Stephen A Vernon Seng Kheong Fang Zhicheng Xie Xiao Yin Chen Jia Nee Foo Kar Seng Sim Tina T Wong Desmond T Quek Rengaraj Venkatesh Srinivasan Kavitha Subbiah R Krishnadas Nagaswamy Soumittra Balekudaru Shantha Boon-Ang Lim Jeanne Ogle José P C de Vasconcellos Vital P Costa Ricardo Y Abe Bruno B de Souza Chelvin C Sng Maria C Aquino Ewa Kosior-Jarecka Guillermo Barreto Fong Vania Castro Tamanaja Ricardo Fujita Yuzhen Jiang Naushin Waseem Sancy Low Huan Nguyen Pham Sami Al-Shahwan E Randy Craven Muhammad Imran Khan Rrima Dada Kuldeep Mohanty Muneeb A Faiq Alex W Hewitt Kathryn P Burdon Eng Hui Gan Anuwat Prutthipongsit Thipnapa Patthanathamrongkasem Mary Ann T Catacutan Irene R Felarca Chona S Liao Emma Rusmayani Vira Wardhana Istiantoro Giulia Consolandi Giulia Pignata Carlo Lavia Prin Rojanapongpun Lerprat Mangkornkanokpong Sunee Chansangpetch Jonathan C H Chan Bonnie N K Choy Jennifer W H Shum Hlaing May Than Khin Thida Oo Aye Thi Han Victor H Yong Xiao-Yu Ng Shuang Ru Goh Yaan Fun Chong Martin L Hibberd Mark Seielstad Eileen Png Sarah J Dunstan Nguyen Van Vinh Chau Jinxin Bei Yi Xin Zeng Abhilasha Karkey Buddha Basnyat Francesca Pasutto Daniela Paoli Paolo Frezzotti Jie Jin Wang Paul Mitchell John H Fingert R Rand Allingham Michael A Hauser Soon Thye Lim Soo Hong Chew Richard P Ebstein Anavaj Sakuntabhai Kyu Hyung Park Jeeyun Ahn Greet Boland Harm Snippe Richard Stead Raquel Quino Su Nyunt Zaw Urszula Lukasik Rohit Shetty Mimiwati Zahari Hyoung Won Bae Nay Lin Oo Toshiaki Kubota Anita Manassakorn Wing Lau Ho Laura Dallorto Young Hoon Hwang Christine A Kiire Masako Kuroda Zeiras Eka Djamal Jovell Ian M Peregrino Arkasubhra Ghosh Jin Wook Jeoung Tung S Hoan Nuttamon Srisamran Thayanithi Sandragasu Saw Htoo Set Vi Huyen Doan Shomi S Bhattacharya Ching-Lin Ho Donald T Tan Ramanjit Sihota Seng-Chee Loon Kazuhiko Mori Shigeru Kinoshita Anneke I den Hollander Raheel Qamar Ya-Xing Wang Yik Y Teo E-Shyong Tai Curt Hartleben-Matkin David Lozano-Giral Seang Mei Saw Ching-Yu Cheng Juan C Zenteno Chi Pui Pang Huong T T Bui Owen Hee Jamie E Craig Deepak P Edward Michiko Yonahara Jamil Miguel Neto Maria L Guevara-Fujita Liang Xu Robert Ritch Ahmad Tajudin Liza-Sharmini Tien Y Wong Saleh Al-Obeidan Nhu Hon Do Periasamy Sundaresan Clement C Tham Paul J Foster Lingam Vijaya Kei Tashiro Eranga N Vithana Ningli Wang Tin Aung

Nat Genet 2016 May 4;48(5):556-62. Epub 2016 Apr 4.

Singapore Eye Research Institute, Singapore National Eye Centre and Eye ACP, Duke-National University of Singapore, Singapore.

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http://www.nature.com/articles/ng.3540
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http://dx.doi.org/10.1038/ng.3540DOI Listing
May 2016

Linking a genome-wide association study signal to a LRRK2 coding variant in Parkinson's disease.

Authors:
Jia Nee Foo Sun Ju Chung Louis C Tan Herty Liany Ho-Sung Ryu Myunghee Hong Tat Hung Koh Ishak D Irwan Wing-Lok Au Kumar-M Prakash Tin Aung Ching-Yu Cheng Siow-Ann Chong Chiea Chuen Khor Jimmy Lee E-Shyong Tai Eranga N Vithana Tien-Yin Wong Kyuyoung Song Jianjun Liu Eng-King Tan

Mov Disord 2016 Apr 21;31(4):484-7. Epub 2015 Dec 21.

Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore.

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http://dx.doi.org/10.1002/mds.26495DOI Listing
April 2016

Lens status influences the association between CFH polymorphisms and age-related macular degeneration: findings from two population-based studies in Singapore.

Authors:
Chee Wai Wong Jiemin Liao Gemmy C Cheung Chiea Chuen Khor Eranga N Vithana Jie Jin Wang Paul Mitchell Tin Aung Tien Y Wong Ching-Yu Cheng

PLoS One 2015 18;10(3):e0119570. Epub 2015 Mar 18.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore, Singapore; Duke-NUS Graduate Medical School, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119570PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364964PMC
March 2016

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.

Authors:
Jessica N Cooke Bailey Stephanie J Loomis Jae H Kang R Rand Allingham Puya Gharahkhani Chiea Chuen Khor Kathryn P Burdon Hugues Aschard Daniel I Chasman Robert P Igo Pirro G Hysi Craig A Glastonbury Allison Ashley-Koch Murray Brilliant Andrew A Brown Donald L Budenz Alfonso Buil Ching-Yu Cheng Hyon Choi William G Christen Gary Curhan Immaculata De Vivo John H Fingert Paul J Foster Charles Fuchs Douglas Gaasterland Terry Gaasterland Alex W Hewitt Frank Hu David J Hunter Anthony P Khawaja Richard K Lee Zheng Li Paul R Lichter David A Mackey Peter McGuffin Paul Mitchell Sayoko E Moroi Shamira A Perera Keating W Pepper Qibin Qi Tony Realini Julia E Richards Paul M Ridker Eric Rimm Robert Ritch Marylyn Ritchie Joel S Schuman William K Scott Kuldev Singh Arthur J Sit Yeunjoo E Song Rulla M Tamimi Fotis Topouzis Ananth C Viswanathan Shefali Setia Verma Douglas Vollrath Jie Jin Wang Nicole Weisschuh Bernd Wissinger Gadi Wollstein Tien Y Wong Brian L Yaspan Donald J Zack Kang Zhang Epic-Norfolk Eye Study Robert N Weinreb Margaret A Pericak-Vance Kerrin Small Christopher J Hammond Tin Aung Yutao Liu Eranga N Vithana Stuart MacGregor Jamie E Craig Peter Kraft Gareth Howell Michael A Hauser Louis R Pasquale Jonathan L Haines Janey L Wiggs

Nat Genet 2016 Feb 11;48(2):189-94. Epub 2016 Jan 11.

Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.

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http://search.proquest.com/openview/9583d4c1af74c01602d422b2
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http://www.nature.com/doifinder/10.1038/ng.3482
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http://dx.doi.org/10.1038/ng.3482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731307PMC
February 2016

Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus.

Authors:
Michael A Hauser Inas F Aboobakar Yutao Liu Shiroh Miura Benjamin T Whigham Pratap Challa Joshua Wheeler Andrew Williams Cecelia Santiago-Turla Xuejun Qin Robyn M Rautenbach Ari Ziskind Michèle Ramsay Steffen Uebe Lingyun Song Alexias Safi Eranga N Vithana Takanori Mizoguchi Satoko Nakano Toshiaki Kubota Ken Hayashi Shin-ichi Manabe Shigeyasu Kazama Yosai Mori Kazunori Miyata Nagahisa Yoshimura Andre Reis Gregory E Crawford Francesca Pasutto Trevor R Carmichael Susan E I Williams Mineo Ozaki Tin Aung Chiea-Chuen Khor W Daniel Stamer Allison E Ashley-Koch R Rand Allingham

Hum Mol Genet 2015 Nov 25;24(22):6552-63. Epub 2015 Aug 25.

Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA, Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Duke, National University of Singapore, Singapore, Singapore.

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http://hmg.oxfordjournals.org/content/early/2015/09/12/hmg.d
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http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv
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http://dx.doi.org/10.1093/hmg/ddv347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614704PMC
November 2015

A common variant near TGFBR3 is associated with primary open angle glaucoma.

Authors:
Zheng Li R Rand Allingham Masakazu Nakano Liyun Jia Yuhong Chen Yoko Ikeda Baskaran Mani Li-Jia Chen Changwon Kee David F Garway-Heath Sarangapani Sripriya Nobuo Fuse Khaled K Abu-Amero Chukai Huang Prasanthi Namburi Kathryn Burdon Shamira A Perera Puya Gharahkhani Ying Lin Morio Ueno Mineo Ozaki Takanori Mizoguchi Subbiah Ramasamy Krishnadas Essam A Osman Mei Chin Lee Anita S Y Chan Liza-Sharmini A Tajudin Tan Do Aurelien Goncalves Pascal Reynier Hong Zhang Rupert Bourne David Goh David Broadway Rahat Husain Anil K Negi Daniel H Su Ching-Lin Ho Augusto Azuara Blanco Christopher K S Leung Tina T Wong Azhany Yakub Yutao Liu Monisha E Nongpiur Jong Chul Han Do Nhu Hon Balekudaru Shantha Bowen Zhao Jinghong Sang NiHong Zhang Ryuichi Sato Kengo Yoshii Songhomita Panda-Jonas Allison E Ashley Koch Leon W Herndon Sayoko E Moroi Pratap Challa Jia Nee Foo Jin-Xin Bei Yi-Xin Zeng Cameron P Simmons Tran Nguyen Bich Chau Philomenadin Ferdinamarie Sharmila Merwyn Chew Blanche Lim Pansy O S Tam Elaine Chua Xiao Yu Ng Victor H K Yong Yaan Fun Chong Wee Yang Meah Saravanan Vijayan Sohn Seongsoo Wang Xu Yik Ying Teo Jessica N Cooke Bailey Jae H Kang Jonathan L Haines Ching Yu Cheng Seang-Mei Saw E-Shyong Tai Julia E Richards Robert Ritch Douglas E Gaasterland Louis R Pasquale Jianjun Liu Jost B Jonas Dan Milea Ronnie George Saleh A Al-Obeidan Kazuhiko Mori Stuart Macgregor Alex W Hewitt Christopher A Girkin Mingzhi Zhang Periasamy Sundaresan Lingam Vijaya David A Mackey Tien Yin Wong Jamie E Craig Xinghuai Sun Shigeru Kinoshita Janey L Wiggs Chiea-Chuen Khor Zhenglin Yang Chi Pui Pang Ningli Wang Michael A Hauser Kei Tashiro Tin Aung Eranga N Vithana

Hum Mol Genet 2015 Jul 10;24(13):3880-92. Epub 2015 Apr 10.

Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore,

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http://dx.doi.org/10.1093/hmg/ddv128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459396PMC
July 2015

Aggregate Effects of Intraocular Pressure and Cup-to-Disc Ratio Genetic Variants on Glaucoma in a Multiethnic Asian Population.

Authors:
Yih-Chung Tham Jiemin Liao Eranga N Vithana Chiea-Chuen Khor Yik-Ying Teo E-Shyong Tai Tien Y Wong Tin Aung Ching-Yu Cheng

Ophthalmology 2015 Jun 4;122(6):1149-57. Epub 2015 Mar 4.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore; Duke-NUS Graduate Medical School Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2015.01.024DOI Listing
June 2015

Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.

Authors:
Tin Aung Mineo Ozaki Takanori Mizoguchi R Rand Allingham Zheng Li Aravind Haripriya Satoko Nakano Steffen Uebe Jeffrey M Harder Anita S Y Chan Mei Chin Lee Kathryn P Burdon Yury S Astakhov Khaled K Abu-Amero Juan C Zenteno Yildirim Nilgün Tomasz Zarnowski Mohammad Pakravan Leen Abu Safieh Liyun Jia Ya Xing Wang Susan Williams Daniela Paoli Patricio G Schlottmann Lulin Huang Kar Seng Sim Jia Nee Foo Masakazu Nakano Yoko Ikeda Rajesh S Kumar Morio Ueno Shin-Ichi Manabe Ken Hayashi Shigeyasu Kazama Ryuichi Ideta Yosai Mori Kazunori Miyata Kazuhisa Sugiyama Tomomi Higashide Etsuo Chihara Kenji Inoue Satoshi Ishiko Akitoshi Yoshida Masahide Yanagi Yoshiaki Kiuchi Makoto Aihara Tsutomu Ohashi Toshiya Sakurai Takako Sugimoto Hideki Chuman Fumihiko Matsuda Kenji Yamashiro Norimoto Gotoh Masahiro Miyake Sergei Y Astakhov Essam A Osman Saleh A Al-Obeidan Ohoud Owaidhah Leyla Al-Jasim Sami Al Shahwan Rhys A Fogarty Paul Leo Yaz Yetkin Çilingir Oğuz Mozhgan Rezaei Kanavi Afsaneh Naderi Beni Shahin Yazdani Evgeny L Akopov Kai-Yee Toh Gareth R Howell Andrew C Orr Yufen Goh Wee Yang Meah Su Qin Peh Ewa Kosior-Jarecka Urszula Lukasik Mandy Krumbiegel Eranga N Vithana Tien Yin Wong Yutao Liu Allison E Ashley Koch Pratap Challa Robyn M Rautenbach David A Mackey Alex W Hewitt Paul Mitchell Jie Jin Wang Ari Ziskind Trevor Carmichael Rangappa Ramakrishnan Kalpana Narendran Rangaraj Venkatesh Saravanan Vijayan Peiquan Zhao Xueyi Chen Dalia Guadarrama-Vallejo Ching Yu Cheng Shamira A Perera Rahat Husain Su-Ling Ho Ulrich-Christoph Welge-Luessen Christian Mardin Ursula Schloetzer-Schrehardt Axel M Hillmer Stefan Herms Susanne Moebus Markus M Nöthen Nicole Weisschuh Rohit Shetty Arkasubhra Ghosh Yik Ying Teo Matthew A Brown Ignacio Lischinsky Jonathan G Crowston Michae Coote Bowen Zhao Jinghong Sang Nihong Zhang Qisheng You Vera Vysochinskaya Panayiota Founti Anthoula Chatzikyriakidou Alexandros Lambropoulos Eleftherios Anastasopoulos Anne L Coleman M Roy Wilson Douglas J Rhee Jae Hee Kang Inna May-Bolchakova Steffen Heegaard Kazuhiko Mori Wallace L M Alward Jost B Jonas Liang Xu Jeffrey M Liebmann Balram Chowbay Elke Schaeffeler Matthias Schwab Fabian Lerner Ningli Wang Zhenglin Yang Paolo Frezzotti Shigeru Kinoshita John H Fingert Masaru Inatani Kei Tashiro André Reis Deepak P Edward Louis R Pasquale Toshiaki Kubota Janey L Wiggs Francesca Pasutto Fotis Topouzis Michael Dubina Jamie E Craig Nagahisa Yoshimura Periasamy Sundaresan Simon W M John Robert Ritch Michael A Hauser Chiea-Chuen Khor

Nat Genet 2015 Jun;47(6):689

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http://dx.doi.org/10.1038/ng0615-689cDOI Listing
June 2015

A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.

Authors:
Tin Aung Mineo Ozaki Takanori Mizoguchi R Rand Allingham Zheng Li Aravind Haripriya Satoko Nakano Steffen Uebe Jeffrey M Harder Anita S Y Chan Mei Chin Lee Kathryn P Burdon Yury S Astakhov Khaled K Abu-Amero Juan C Zenteno Yildirim Nilgün Tomasz Zarnowski Mohammad Pakravan Leen Abu Safieh Liyun Jia Ya Xing Wang Susan Williams Daniela Paoli Patricio G Schlottmann Lulin Huang Kar Seng Sim Jia Nee Foo Masakazu Nakano Yoko Ikeda Rajesh S Kumar Morio Ueno Shin-ichi Manabe Ken Hayashi Shigeyasu Kazama Ryuichi Ideta Yosai Mori Kazunori Miyata Kazuhisa Sugiyama Tomomi Higashide Etsuo Chihara Kenji Inoue Satoshi Ishiko Akitoshi Yoshida Masahide Yanagi Yoshiaki Kiuchi Makoto Aihara Tsutomu Ohashi Toshiya Sakurai Takako Sugimoto Hideki Chuman Fumihiko Matsuda Kenji Yamashiro Norimoto Gotoh Masahiro Miyake Sergei Y Astakhov Essam A Osman Saleh A Al-Obeidan Ohoud Owaidhah Leyla Al-Jasim Sami Al Shahwan Rhys A Fogarty Paul Leo Yaz Yetkin Çilingir Oğuz Mozhgan Rezaei Kanavi Afsaneh Nederi Beni Shahin Yazdani Evgeny L Akopov Kai-Yee Toh Gareth R Howell Andrew C Orr Yufen Goh Wee Yang Meah Su Qin Peh Ewa Kosior-Jarecka Urszula Lukasik Mandy Krumbiegel Eranga N Vithana Tien Yin Wong Yutao Liu Allison E Ashley Koch Pratap Challa Robyn M Rautenbach David A Mackey Alex W Hewitt Paul Mitchell Jie Jin Wang Ari Ziskind Trevor Carmichael Rangappa Ramakrishnan Kalpana Narendran Rangaraj Venkatesh Saravanan Vijayan Peiquan Zhao Xueyi Chen Dalia Guadarrama-Vallejo Ching Yu Cheng Shamira A Perera Rahat Husain Su-Ling Ho Ulrich-Christoph Welge-Luessen Christian Mardin Ursula Schloetzer-Schrehardt Axel M Hillmer Stefan Herms Susanne Moebus Markus M Nöthen Nicole Weisschuh Rohit Shetty Arkasubhra Ghosh Yik Ying Teo Matthew A Brown Ignacio Lischinsky Jonathan G Crowston Michael Coote Bowen Zhao Jinghong Sang Nihong Zhang Qisheng You Vera Vysochinskaya Panayiota Founti Anthoula Chatzikyriakidou Alexandros Lambropoulos Eleftherios Anastasopoulos Anne L Coleman M Roy Wilson Douglas J Rhee Jae Hee Kang Inna May-Bolchakova Steffen Heegaard Kazuhiko Mori Wallace L M Alward Jost B Jonas Liang Xu Jeffrey M Liebmann Balram Chowbay Elke Schaeffeler Matthias Schwab Fabian Lerner Ningli Wang Zhenglin Yang Paolo Frezzotti Shigeru Kinoshita John H Fingert Masaru Inatani Kei Tashiro André Reis Deepak P Edward Louis R Pasquale Toshiaki Kubota Janey L Wiggs Francesca Pasutto Fotis Topouzis Michael Dubina Jamie E Craig Nagahisa Yoshimura Periasamy Sundaresan Simon W M John Robert Ritch Michael A Hauser Chiea-Chuen Khor

Nat Genet 2015 Apr 23;47(4):387-92. Epub 2015 Feb 23.

1] Singapore Eye Research Institute, Singapore. [2] Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. [3] Division of Human Genetics, Genome Institute of Singapore, Singapore.

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http://dx.doi.org/10.1038/ng.3226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605818PMC
April 2015

Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians.

Authors:
Ching-Yu Cheng Kenji Yamashiro Li Jia Chen Jeeyun Ahn Lulin Huang Lvzhen Huang Chui Ming G Cheung Masahiro Miyake Peter D Cackett Ian Y Yeo Augustinus Laude Ranjana Mathur Junxiong Pang Kar Seng Sim Adrian H Koh Peng Chen Shu Yen Lee Doric Wong Choi Mun Chan Boon Kwang Loh Yaoyao Sun Sonia Davila Isao Nakata Hideo Nakanishi Yumiko Akagi-Kurashige Norimoto Gotoh Akitaka Tsujikawa Fumihiko Matsuda Keisuke Mori Shin Yoneya Yoichi Sakurada Hiroyuki Iijima Tomohiro Iida Shigeru Honda Timothy Yuk Yau Lai Pancy Oi Sin Tam Haoyu Chen Shibo Tang Xiaoyan Ding Feng Wen Fang Lu Xiongze Zhang Yi Shi Peiquan Zhao Bowen Zhao Jinghong Sang Bo Gong Rajkumar Dorajoo Jian-Min Yuan Woon-Puay Koh Rob M van Dam Yechiel Friedlander Yin Lin Martin L Hibberd Jia Nee Foo Ningli Wang Chang Hua Wong Gavin S Tan Sang Jun Park Mayuri Bhargava Lingam Gopal Thet Naing Jiemin Liao Peng Guan Ong Paul Mitchell Peng Zhou Xuefeng Xie Jinlong Liang Junpu Mei Xin Jin Seang-Mei Saw Mineo Ozaki Takinori Mizoguchi Yasuo Kurimoto Se Joon Woo Hum Chung Hyeong-Gon Yu Joo Young Shin Dong Ho Park In Taek Kim Woohyok Chang Min Sagong Sang-Joon Lee Hyun Woong Kim Ji Eun Lee Yi Li Jianjun Liu Yik Ying Teo Chew Kiat Heng Tock Han Lim Suk-Kyun Yang Kyuyoung Song Eranga N Vithana Tin Aung Jin Xin Bei Yi Xin Zeng E Shyong Tai Xiao Xin Li Zhenglin Yang Kyu-Hyung Park Chi Pui Pang Nagahisa Yoshimura Tien Yin Wong Chiea Chuen Khor

Nat Commun 2015 Mar 30;6:6817. Epub 2015 Mar 30.

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http://dx.doi.org/10.1038/ncomms7817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400603PMC
March 2015

Biochemical properties and aggregation propensity of transforming growth factor-induced protein (TGFBIp) and the amyloid forming mutants.

Authors:
R Lakshminarayanan Shyam S Chaurasia Elavazhagan Murugan Anandalakshmi Venkatraman Shu-Ming Chai Eranga N Vithana Roger W Beuerman Jodhbir S Mehta

Ocul Surf 2015 Jan 8;13(1):9-25. Epub 2014 Oct 8.

Singapore Eye Research Institute, Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Singapore National Eye Centre, Singapore, Singapore; Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jtos.2014.04.003DOI Listing
January 2015

New loci and coding variants confer risk for age-related macular degeneration in East Asians.

Authors:
Ching-Yu Cheng Kenji Yamashiro Li Jia Chen Jeeyun Ahn Lulin Huang Lvzhen Huang Chui Ming G Cheung Masahiro Miyake Peter D Cackett Ian Y Yeo Augustinus Laude Ranjana Mathur Junxiong Pang Kar Seng Sim Adrian H Koh Peng Chen Shu Yen Lee Doric Wong Choi Mun Chan Boon Kwang Loh Yaoyao Sun Sonia Davila Isao Nakata Hideo Nakanishi Yumiko Akagi-Kurashige Norimoto Gotoh Akitaka Tsujikawa Fumihiko Matsuda Keisuke Mori Shin Yoneya Yoichi Sakurada Hiroyuki Iijima Tomohiro Iida Shigeru Honda Timothy Yuk Yau Lai Pancy Oi Sin Tam Haoyu Chen Shibo Tang Xiaoyan Ding Feng Wen Fang Lu Xiongze Zhang Yi Shi Peiquan Zhao Bowen Zhao Jinghong Sang Bo Gong Rajkumar Dorajoo Jian-Min Yuan Woon-Puay Koh Rob M van Dam Yechiel Friedlander Ying Lin Martin L Hibberd Jia Nee Foo Ningli Wang Chang Hua Wong Gavin S Tan Sang Jun Park Mayuri Bhargava Lingam Gopal Thet Naing Jiemin Liao Peng Guan Ong Paul Mitchell Peng Zhou Xuefeng Xie Jinlong Liang Junpu Mei Xin Jin Seang-Mei Saw Mineo Ozaki Takanori Mizoguchi Yasuo Kurimoto Se Joon Woo Hum Chung Hyeong-Gon Yu Joo Young Shin Dong Ho Park In Taek Kim Woohyok Chang Min Sagong Sang-Joon Lee Hyun Woong Kim Ji Eun Lee Yi Li Jianjun Liu Yik Ying Teo Chew Kiat Heng Tock Han Lim Suk-Kyun Yang Kyuyoung Song Eranga N Vithana Tin Aung Jin Xin Bei Yi Xin Zeng E Shyong Tai Xiao Xin Li Zhenglin Yang Kyu-Hyung Park Chi Pui Pang Nagahisa Yoshimura Tien Yin Wong Chiea Chuen Khor

Nat Commun 2015 Jan 28;6:6063. Epub 2015 Jan 28.

1] Singapore Eye Research Institute, Singapore 169856, Singapore [2] Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore [3] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.

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http://dx.doi.org/10.1038/ncomms7063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317498PMC
January 2015

Association of common SIX6 polymorphisms with peripapillary retinal nerve fiber layer thickness: the Singapore Chinese Eye Study.

Authors:
Ching-Yu Cheng R Rand Allingham Tin Aung Yih-Chung Tham Michael A Hauser Eranga N Vithana Chiea Chuen Khor Tien Yin Wong

Invest Ophthalmol Vis Sci 2014 Dec 23;56(1):478-83. Epub 2014 Dec 23.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1167/iovs.14-15863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544593PMC
December 2014

Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract.

Authors:
Jiemin Liao Xinyi Su Peng Chen Xu Wang Liang Xu Xiang Li Lennard Thean Clement Tan Ava G Tan Wan-Ting Tay Gyungah Jun Yingfeng Zheng Merwyn Chew Ya Xing Wang Queenie S Tan Veluchamy A Barathi Barbara E Klein Seang-Mei Saw Eranga N Vithana E-Shyong Tai Sudha K Iyengar Paul Mitchell Chiea-Chuen Khor Tin Aung Jie Jin Wang Jost B Jonas Yik-Ying Teo Tien Yin Wong Ching-Yu Cheng

Hum Mol Genet 2014 Nov 20;23(22):6119-28. Epub 2014 Jun 20.

Singapore Eye Research Institute, Singapore National Eye Center, Singapore 168751, Singapore, Department of Ophthalmology, Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore, Duke-National University of Singapore Graduate Medical School, Singapore 169857, Singapore,

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http://dx.doi.org/10.1093/hmg/ddu315DOI Listing
November 2014

CMPK1 and RBP3 are associated with corneal curvature in Asian populations.

Authors:
Peng Chen Masahiro Miyake Qiao Fan Jiemin Liao Kenji Yamashiro Mohammad K Ikram Merywn Chew Eranga N Vithana Chiea-Chuen Khor Tin Aung E-Shyong Tai Tien-Yin Wong Yik-Ying Teo Nagahisa Yoshimura Seang-Mei Saw Ching-Yu Cheng

Hum Mol Genet 2014 Nov 24;23(22):6129-36. Epub 2014 Jun 24.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore, Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore, Duke-NUS Graduate Medical School, Singapore 169857, Singapore,

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http://dx.doi.org/10.1093/hmg/ddu322DOI Listing
November 2014

Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma.

Authors:
Yuhong Chen Ying Lin Eranga N Vithana Liyun Jia Xianbo Zuo Tien Yin Wong Li Jia Chen Xianjun Zhu Pancy O S Tam Bo Gong Shaohong Qian Zheng Li Xiaoqi Liu Baskaran Mani Qian Luo Celeste Guzman Christopher K S Leung Xiaobo Li Wenjun Cao Quanyao Yang Clement C Y Tham Yilian Cheng Xuejun Zhang Ningli Wang Tin Aung Chiea Chuen Khor Chi Pui Pang Xinghuai Sun Zhenglin Yang

Nat Genet 2014 Oct 31;46(10):1115-9. Epub 2014 Aug 31.

1] Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China. [2] School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. [3] Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China. [4].

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http://dx.doi.org/10.1038/ng.3078DOI Listing
October 2014

Clinical and genetic aspects of the TGFBI-associated corneal dystrophies.

Authors:
R Lakshminarayanan Shyam S Chaurasia Venkatraman Anandalakshmi Shu-Ming Chai Elavazhagan Murugan Eranga N Vithana Roger W Beuerman Jodhbir S Mehta

Ocul Surf 2014 Oct 18;12(4):234-51. Epub 2014 Jul 18.

Singapore Eye Research Institute, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore National Eye Centre, Singapore; Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jtos.2013.12.002DOI Listing
October 2014

Transethnic replication of association of CTG18.1 repeat expansion of TCF4 gene with Fuchs' corneal dystrophy in Chinese implies common causal variant.

Authors:
Chao Xing Xin Gong Imran Hussain Chiea-Chuen Khor Donald T H Tan Tin Aung Jodhbir S Mehta Eranga N Vithana V Vinod Mootha

Invest Ophthalmol Vis Sci 2014 Oct 8;55(11):7073-8. Epub 2014 Oct 8.

University of Texas Southwestern Medical Center, McDermott Center for Human Growth and Development/Center for Human Genetics, Dallas, Texas, United States University of Texas Southwestern Medical Center, Department of Ophthalmology, Dallas, Texas, United States.

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http://dx.doi.org/10.1167/iovs.14-15390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224583PMC
October 2014

Analysis of non-synonymous-coding variants of Parkinson's disease-related pathogenic and susceptibility genes in East Asian populations.

Authors:
Jia Nee Foo Louis C Tan Herty Liany Tat Hung Koh Ishak D Irwan Yen Yek Ng Azlina Ahmad-Annuar Wing-Lok Au Tin Aung Anne Y Y Chan Siow-Ann Chong Sun Ju Chung Yusun Jung Chiea Chuen Khor Juyeon Kim Jimmy Lee Shen-Yang Lim Vincent Mok Kumar-M Prakash Kyuyoung Song E-Shyong Tai Eranga N Vithana Tien-Yin Wong Eng-King Tan Jianjun Liu

Hum Mol Genet 2014 Jul 23;23(14):3891-7. Epub 2014 Feb 23.

Human Genetics, Genome Institute of Singapore, A*STAR, Singapore Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore

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http://dx.doi.org/10.1093/hmg/ddu086DOI Listing
July 2014

Expression of the primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 in endothelial and epithelial cell junctions in the eye.

Authors:
Mei Chin Lee Anita S Y Chan Shuang Ru Goh Maryam Hazly Hilmy Monisha E Nongpiur Wanjin Hong Tin Aung Walter Hunziker Eranga N Vithana

Invest Ophthalmol Vis Sci 2014 May 6;55(6):3833-41. Epub 2014 May 6.

Singapore Eye Research Institute, Singapore Duke-NUS Graduate Medical School, Singapore Department of Ophthalmology, National University of Singapore, Singapore.

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http://dx.doi.org/10.1167/iovs.14-14145DOI Listing
May 2014

ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma.

Authors:
Monisha E Nongpiur Chiea Chuen Khor Hongyan Jia Belinda K Cornes Li-Jia Chen Chunyan Qiao K Saidas Nair Ching-Yu Cheng Liang Xu Ronnie George Do Tan Khaled Abu-Amero Shamira A Perera Mineo Ozaki Takanori Mizoguchi Yasuo Kurimoto Sancy Low Liza-Sharmini A Tajudin Ching-Lin Ho Clement C Y Tham Ileana Soto Paul T K Chew Hon-Tym Wong Balekudaru Shantha Masako Kuroda Essam A Osman Guangxian Tang Sujie Fan Hailin Meng Hua Wang Bo Feng Victor H K Yong Serena M L Ting Yang Li Ya-Xing Wang Zheng Li Raghavan Lavanya Ren-Yi Wu Ying-Feng Zheng Daniel H Su Seng-Chee Loon Vernon K Y Yong R Rand Allingham Michael A Hauser Nagaswamy Soumittra Vedam L Ramprasad Naushin Waseem Azhany Yaakub Kee-Seng Chia Govindasamy Kumaramanickavel Tina T Wong Alicia C How Tran Nguyen Bich Chau Cameron P Simmons Jin-Xin Bei Yi-Xin Zeng Shomi S Bhattacharya Mingzhi Zhang Donald T Tan Yik-Ying Teo Saleh A Al-Obeidan Do Nhu Hon E-Shyong Tai Seang-Mei Saw Paul J Foster Lingam Vijaya Jost B Jonas Tien-Yin Wong Simon W M John Chi-Pui Pang Eranga N Vithana Ningli Wang Tin Aung

PLoS Genet 2014 Mar 6;10(3):e1004089. Epub 2014 Mar 6.

Singapore Eye Research Institute and Singapore National Eye Centre, Singapore; Department of Ophthalmology, National University Health System & National University of Singapore, Singapore.

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http://dx.doi.org/10.1371/journal.pgen.1004089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945113PMC
March 2014

Genotype-phenotype correlation analysis for three primary angle closure glaucoma-associated genetic polymorphisms.

Authors:
Xin Wei Monisha E Nongpiur Mark S de Leon Mani Baskaran Shamira A Perera Alicia C How Eranga N Vithana Chiea-Chuen Khor Tin Aung

Invest Ophthalmol Vis Sci 2014 Feb 24;55(2):1143-8. Epub 2014 Feb 24.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1167/iovs.13-13552DOI Listing
February 2014

Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia.

Authors:
Chiea Chuen Khor Masahiro Miyake Li Jia Chen Yi Shi Veluchamy A Barathi Fan Qiao Isao Nakata Kenji Yamashiro Xin Zhou Pancy O S Tam Ching-Yu Cheng E Shyong Tai Eranga N Vithana Tin Aung Yik-Ying Teo Tien-Yin Wong Muka Moriyama Kyoko Ohno-Matsui Manabu Mochizuki Fumihiko Matsuda Rita Y Y Yong Eric P H Yap Zhenglin Yang Chi Pui Pang Seang-Mei Saw Nagahisa Yoshimura

Hum Mol Genet 2013 Dec 9;22(25):5288-94. Epub 2013 Aug 9.

Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1093/hmg/ddt385DOI Listing
December 2013

Transmembrane water-flux through SLC4A11: a route defective in genetic corneal diseases.

Authors:
Gonzalo L Vilas Sampath K Loganathan Jun Liu Andri K Riau James D Young Jodhbir S Mehta Eranga N Vithana Joseph R Casey

Hum Mol Genet 2013 Nov 27;22(22):4579-90. Epub 2013 Jun 27.

Membrane Protein Disease Research Group, Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.

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http://dx.doi.org/10.1093/hmg/ddt307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889808PMC
November 2013

SLC4A11 is an EIPA-sensitive Na(+) permeable pHi regulator.

Authors:
Diego G Ogando Supriya S Jalimarada Wenlin Zhang Eranga N Vithana Joseph A Bonanno

Am J Physiol Cell Physiol 2013 Oct 17;305(7):C716-27. Epub 2013 Jul 17.

School of Optometry, Indiana University, Bloomington, Indiana;

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http://dx.doi.org/10.1152/ajpcell.00056.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798668PMC
October 2013

Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice.

Authors:
Veluchamy A Barathi Jia Lin Kwan Queenie S W Tan Sung Rhan Weon Li Fong Seet Liang Kee Goh Eranga N Vithana Roger W Beuerman

Dis Model Mech 2013 Sep 2;6(5):1146-58. Epub 2013 May 2.

Singapore Eye Research Institute, 11 Third Hospital Avenue, 168751 Singapore, Singapore.

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http://dx.doi.org/10.1242/dmm.010967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759334PMC
September 2013

Differential expression of the Slc4 bicarbonate transporter family in murine corneal endothelium and cell culture.

Authors:
William Shei Jun Liu Hla M Htoon Tin Aung Eranga N Vithana

Mol Vis 2013 24;19:1096-106. Epub 2013 May 24.

Singapore Eye Research Institute, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668641PMC
September 2013

Mice with a targeted disruption of Slc4a11 model the progressive corneal changes of congenital hereditary endothelial dystrophy.

Authors:
Sang Beom Han Heng-Pei Ang Rebekah Poh Shyam S Chaurasia Gary Peh Jun Liu Donald T H Tan Eranga N Vithana Jodhbir S Mehta

Invest Ophthalmol Vis Sci 2013 Sep 27;54(9):6179-89. Epub 2013 Sep 27.

Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1167/iovs.13-12089DOI Listing
September 2013

Lack of association between primary angle-closure glaucoma susceptibility loci and the ocular biometric parameters anterior chamber depth and axial length.

Authors:
Monisha E Nongpiur Xin Wei Liang Xu Shamira A Perera Ren-Yi Wu Yingfeng Zheng Yang Li Ya-Xing Wang Ching-Yu Cheng Jost B Jonas Tien-Yin Wong Eranga N Vithana Tin Aung Chiea-Chuen Khor

Invest Ophthalmol Vis Sci 2013 Aug 27;54(8):5824-8. Epub 2013 Aug 27.

Singapore Eye Research Institute, Singapore.

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August 2013

Ion transport function of SLC4A11 in corneal endothelium.

Authors:
Supriya S Jalimarada Diego G Ogando Eranga N Vithana Joseph A Bonanno

Invest Ophthalmol Vis Sci 2013 Jun 21;54(6):4330-40. Epub 2013 Jun 21.

School of Optometry, Indiana University, Bloomington, Indiana, USA.

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http://dx.doi.org/10.1167/iovs.13-11929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691053PMC
June 2013

Seven new loci associated with age-related macular degeneration.

Authors:
Lars G Fritsche Wei Chen Matthew Schu Brian L Yaspan Yi Yu Gudmar Thorleifsson Donald J Zack Satoshi Arakawa Valentina Cipriani Stephan Ripke Robert P Igo Gabriëlle H S Buitendijk Xueling Sim Daniel E Weeks Robyn H Guymer Joanna E Merriam Peter J Francis Gregory Hannum Anita Agarwal Ana Maria Armbrecht Isabelle Audo Tin Aung Gaetano R Barile Mustapha Benchaboune Alan C Bird Paul N Bishop Kari E Branham Matthew Brooks Alexander J Brucker William H Cade Melinda S Cain Peter A Campochiaro Chi-Chao Chan Ching-Yu Cheng Emily Y Chew Kimberly A Chin Itay Chowers David G Clayton Radu Cojocaru Yvette P Conley Belinda K Cornes Mark J Daly Baljean Dhillon Albert O Edwards Evangelos Evangelou Jesen Fagerness Henry A Ferreyra James S Friedman Asbjorg Geirsdottir Ronnie J George Christian Gieger Neel Gupta Stephanie A Hagstrom Simon P Harding Christos Haritoglou John R Heckenlively Frank G Holz Guy Hughes John P A Ioannidis Tatsuro Ishibashi Peronne Joseph Gyungah Jun Yoichiro Kamatani Nicholas Katsanis Claudia N Keilhauer Jane C Khan Ivana K Kim Yutaka Kiyohara Barbara E K Klein Ronald Klein Jaclyn L Kovach Igor Kozak Clara J Lee Kristine E Lee Peter Lichtner Andrew J Lotery Thomas Meitinger Paul Mitchell Saddek Mohand-Saïd Anthony T Moore Denise J Morgan Margaux A Morrison Chelsea E Myers Adam C Naj Yusuke Nakamura Yukinori Okada Anton Orlin M Carolina Ortube Mohammad I Othman Chris Pappas Kyu Hyung Park Gayle J T Pauer Neal S Peachey Olivier Poch Rinki Ratna Priya Robyn Reynolds Andrea J Richardson Raymond Ripp Guenther Rudolph Euijung Ryu José-Alain Sahel Debra A Schaumberg Hendrik P N Scholl Stephen G Schwartz William K Scott Humma Shahid Haraldur Sigurdsson Giuliana Silvestri Theru A Sivakumaran R Theodore Smith Lucia Sobrin Eric H Souied Dwight E Stambolian Hreinn Stefansson Gwen M Sturgill-Short Atsushi Takahashi Nirubol Tosakulwong Barbara J Truitt Evangelia E Tsironi André G Uitterlinden Cornelia M van Duijn Lingam Vijaya Johannes R Vingerling Eranga N Vithana Andrew R Webster H-Erich Wichmann Thomas W Winkler Tien Y Wong Alan F Wright Diana Zelenika Ming Zhang Ling Zhao Kang Zhang Michael L Klein Gregory S Hageman G Mark Lathrop Kari Stefansson Rando Allikmets Paul N Baird Michael B Gorin Jie Jin Wang Caroline C W Klaver Johanna M Seddon Margaret A Pericak-Vance Sudha K Iyengar John R W Yates Anand Swaroop Bernhard H F Weber Michiaki Kubo Margaret M Deangelis Thierry Léveillard Unnur Thorsteinsdottir Jonathan L Haines Lindsay A Farrer Iris M Heid Gonçalo R Abecasis

Nat Genet 2013 Apr 3;45(4):433-9, 439e1-2. Epub 2013 Mar 3.

Institute of Human Genetics, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1038/ng.2578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739472PMC
April 2013

Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.

Authors:
Yi Lu Veronique Vitart Kathryn P Burdon Chiea Chuen Khor Yelena Bykhovskaya Alireza Mirshahi Alex W Hewitt Demelza Koehn Pirro G Hysi Wishal D Ramdas Tanja Zeller Eranga N Vithana Belinda K Cornes Wan-Ting Tay E Shyong Tai Ching-Yu Cheng Jianjun Liu Jia-Nee Foo Seang Mei Saw Gudmar Thorleifsson Kari Stefansson David P Dimasi Richard A Mills Jenny Mountain Wei Ang René Hoehn Virginie J M Verhoeven Franz Grus Roger Wolfs Raphaële Castagne Karl J Lackner Henriët Springelkamp Jian Yang Fridbert Jonasson Dexter Y L Leung Li J Chen Clement C Y Tham Igor Rudan Zoran Vatavuk Caroline Hayward Jane Gibson Angela J Cree Alex MacLeod Sarah Ennis Ozren Polasek Harry Campbell James F Wilson Ananth C Viswanathan Brian Fleck Xiaohui Li David Siscovick Kent D Taylor Jerome I Rotter Seyhan Yazar Megan Ulmer Jun Li Brian L Yaspan Ayse B Ozel Julia E Richards Sayoko E Moroi Jonathan L Haines Jae H Kang Louis R Pasquale R Rand Allingham Allison Ashley-Koch Paul Mitchell Jie Jin Wang Alan F Wright Craig Pennell Timothy D Spector Terri L Young Caroline C W Klaver Nicholas G Martin Grant W Montgomery Michael G Anderson Tin Aung Colin E Willoughby Janey L Wiggs Chi P Pang Unnur Thorsteinsdottir Andrew J Lotery Christopher J Hammond Cornelia M van Duijn Michael A Hauser Yaron S Rabinowitz Norbert Pfeiffer David A Mackey Jamie E Craig Stuart Macgregor Tien Y Wong

Nat Genet 2013 Feb 6;45(2):155-63. Epub 2013 Jan 6.

Queensland Institute of Medical Research, Statistical Genetics, Herston, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1038/ng.2506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720123PMC
February 2013

Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.

Authors:
Eranga N Vithana Chiea-Chuen Khor Chunyan Qiao Monisha E Nongpiur Ronnie George Li-Jia Chen Tan Do Khaled Abu-Amero Chor Kai Huang Sancy Low Liza-Sharmini A Tajudin Shamira A Perera Ching-Yu Cheng Liang Xu Hongyan Jia Ching-Lin Ho Kar Seng Sim Ren-Yi Wu Clement C Y Tham Paul T K Chew Daniel H Su Francis T Oen Sripriya Sarangapani Nagaswamy Soumittra Essam A Osman Hon-Tym Wong Guangxian Tang Sujie Fan Hailin Meng Dao T L Huong Hua Wang Bo Feng Mani Baskaran Balekudaru Shantha Vedam L Ramprasad Govindasamy Kumaramanickavel Sudha K Iyengar Alicia C How Kelvin Y Lee Theru A Sivakumaran Victor H K Yong Serena M L Ting Yang Li Ya-Xing Wang Wan-Ting Tay Xueling Sim Raghavan Lavanya Belinda K Cornes Ying-Feng Zheng Tina T Wong Seng-Chee Loon Vernon K Y Yong Naushin Waseem Azhany Yaakub Kee-Seng Chia R Rand Allingham Michael A Hauser Dennis S C Lam Martin L Hibberd Shomi S Bhattacharya Mingzhi Zhang Yik Ying Teo Donald T Tan Jost B Jonas E-Shyong Tai Seang-Mei Saw Do Nhu Hon Saleh A Al-Obeidan Jianjun Liu Tran Nguyen Bich Chau Cameron P Simmons Jin-Xin Bei Yi-Xin Zeng Paul J Foster Lingam Vijaya Tien-Yin Wong Chi-Pui Pang Ningli Wang Tin Aung

Nat Genet 2012 Oct 26;44(10):1142-1146. Epub 2012 Aug 26.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1038/ng.2390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333205PMC
October 2012

Association of genetic variants on 8p21 and 4q12 with age-related macular degeneration in Asian populations.

Authors:
Isao Nakata Kenji Yamashiro Yumiko Akagi-Kurashige Masahiro Miyake Kyoko Kumagai Akitaka Tsujikawa Ke Liu Li Jia Chen David T L Liu Timothy Y Y Lai Yoichi Sakurada Seigo Yoneyama Ching-Yu Cheng Peter Cackett Ian Y Yeo Wan Ting Tay Belinda K Cornes Eranga N Vithana Tin Aung Keitaro Matsuo Fumihiko Matsuda Tien-Yin Wong Hiroyuki Iijima Chi Pui Pang Nagahisa Yoshimura

Invest Ophthalmol Vis Sci 2012 Sep 25;53(10):6576-81. Epub 2012 Sep 25.

Department of Ophthalmology and the Center for Genomic Medicine/INSERM U.852, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1167/iovs.12-10219DOI Listing
September 2012

Depletion of SLC4A11 causes cell death by apoptosis in an immortalized human corneal endothelial cell line.

Authors:
Jun Liu Li-Fong Seet Li Wei Koh Anandalakshmi Venkatraman Divya Venkataraman Rajiv R Mohan Jeppe Praetorius Joseph A Bonanno Tin Aung Eranga N Vithana

Invest Ophthalmol Vis Sci 2012 Jun 5;53(7):3270-9. Epub 2012 Jun 5.

Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.1167/iovs.11-8724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007482PMC
June 2012

Oligomerization of SLC4A11 protein and the severity of FECD and CHED2 corneal dystrophies caused by SLC4A11 mutations.

Authors:
Gonzalo L Vilas Sampath K Loganathan Anita Quon Periasamy Sundaresan Eranga N Vithana Joseph Casey

Hum Mutat 2012 Feb 20;33(2):419-28. Epub 2011 Dec 20.

Membrane Protein Disease Research Group, Department of Physiology, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1002/humu.21655DOI Listing
February 2012

Identification of four novel variants that influence central corneal thickness in multi-ethnic Asian populations.

Authors:
Belinda K Cornes Chiea Chuen Khor Monisha E Nongpiur Liang Xu Wan-Ting Tay Yingfeng Zheng Raghavan Lavanya Yang Li Renyi Wu Xueling Sim Ya-Xing Wang Peng Chen Yik Ying Teo Kee-Seng Chia Mark Seielstad Jianjun Liu Martin L Hibberd Ching-Yu Cheng Seang-Mei Saw E-Shyong Tai Jost B Jonas Eranga N Vithana Tien Y Wong Tin Aung

Hum Mol Genet 2012 Jan 7;21(2):437-45. Epub 2011 Oct 7.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.

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http://dx.doi.org/10.1093/hmg/ddr463DOI Listing
January 2012

A novel mutation in transforming growth factor-beta induced protein (TGFβIp) reveals secondary structure perturbation in lattice corneal dystrophy.

Authors:
Rajamani Lakshminarayanan Eranga N Vithana Shu-Ming Chai Shyam S Chaurasia Padhmanaban Saraswathi Anandalaksmi Venkatraman Camille Rojare Divya Venkataraman Donald Tan Tin Aung Roger W Beuerman Jodhbir S Mehta

Br J Ophthalmol 2011 Oct 10;95(10):1457-62. Epub 2011 Aug 10.

Singapore National Eye Centre, Singapore 168751, Singapore.

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http://dx.doi.org/10.1136/bjophthalmol-2011-300651DOI Listing
October 2011

Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascularization or polypoidal choroidal vasculopathy in Chinese subjects.

Authors:
Chelvin C A Sng Peter D Cackett Ian Y Yeo Anbupalam Thalamuthu Anandalakshmi Venkatraman Divya Venkataraman Adrian H Koh E-Shyong Tai Tien Y Wong Tin Aung Eranga N Vithana

Ophthalmic Res 2011 16;45(4):191-6. Epub 2010 Nov 16.

Singapore Eye Research Institute, National University of Singapore, Singapore.

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http://dx.doi.org/10.1159/000321387DOI Listing
August 2011

Association of TCF4 gene polymorphisms with Fuchs' corneal dystrophy in the Chinese.

Authors:
Anbupalam Thalamuthu Chiea Chuen Khor Divya Venkataraman Li Wei Koh Donald T H Tan Tin Aung Jodhbir S Mehta Eranga N Vithana

Invest Ophthalmol Vis Sci 2011 Jul 29;52(8):5573-8. Epub 2011 Jul 29.

Genome Institute of Singapore, Singapore.

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http://dx.doi.org/10.1167/iovs.11-7568DOI Listing
July 2011

Relationship of smoking and cardiovascular risk factors with polypoidal choroidal vasculopathy and age-related macular degeneration in Chinese persons.

Authors:
Peter Cackett Ian Yeo Chui Ming Gemmy Cheung Eranga N Vithana Doric Wong Wan Ting Tay E Shyong Tai Tin Aung Tien Y Wong

Ophthalmology 2011 May 13;118(5):846-52. Epub 2010 Dec 13.

Singapore Eye Research Institute, Singapore, Republic of Singapore.

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http://dx.doi.org/10.1016/j.ophtha.2010.09.026DOI Listing
May 2011

Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area.

Authors:
Chiea Chuen Khor Wishal D Ramdas Eranga N Vithana Belinda K Cornes Xueling Sim Wan-Ting Tay Seang-Mei Saw Yingfeng Zheng Raghavan Lavanya Renyi Wu Jie Jin Wang Paul Mitchell André G Uitterlinden Fernando Rivadeneira Yik-Ying Teo Kee-Seng Chia Mark Seielstad Martin Hibberd Johannes R Vingerling Caroline C W Klaver Nomdo M Jansonius E-Shyong Tai Tien-Yin Wong Cornelia M van Duijn Tin Aung

Hum Mol Genet 2011 May 9;20(9):1864-72. Epub 2011 Feb 9.

Infectious Diseases, Genome Institute of Singapore, A*STAR, Singapore.

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http://dx.doi.org/10.1093/hmg/ddr060DOI Listing
May 2011

The heritability and sibling risk of angle closure in Asians.

Authors:
Nishani Amerasinghe Jian Zhang Anbupalam Thalamuthu Mingguang He Eranga N Vithana Ananth Viswanathan Tien Y Wong Paul J Foster Tin Aung

Ophthalmology 2011 Mar 29;118(3):480-5. Epub 2010 Oct 29.

Singapore National Eye Centre, Singapore, Republic of Singapore.

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http://dx.doi.org/10.1016/j.ophtha.2010.06.043DOI Listing
March 2011

Collagen-related genes influence the glaucoma risk factor, central corneal thickness.

Authors:
Eranga N Vithana Tin Aung Chiea Chuen Khor Belinda K Cornes Wan-Ting Tay Xueling Sim Raghavan Lavanya Renyi Wu Yingfeng Zheng Martin L Hibberd Kee Seng Chia Mark Seielstad Liang Kee Goh Seang-Mei Saw E Shyong Tai Tien Y Wong

Hum Mol Genet 2011 Feb 23;20(4):649-58. Epub 2010 Nov 23.

Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.1093/hmg/ddq511DOI Listing
February 2011

Missense mutations in the sodium borate cotransporter SLC4A11 cause late-onset Fuchs corneal dystrophy.

Authors:
S Amer Riazuddin Eranga N Vithana Li-Fong Seet Yangjian Liu Amr Al-Saif Li Wei Koh Yee Meng Heng Tin Aung Danielle N Meadows Allen O Eghrari John D Gottsch Nicholas Katsanis

Hum Mutat 2010 Nov 14;31(11):1261-8. Epub 2010 Oct 14.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/humu.21356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970683PMC
November 2010

Identification of a novel mutation in the NTF4 gene that causes primary open-angle glaucoma in a Chinese population.

Authors:
Eranga N Vithana Monisha E Nongpiur Divya Venkataraman Stephanie H Chan Jagadeesh Mavinahalli Tin Aung

Mol Vis 2010 Aug 15;16:1640-5. Epub 2010 Aug 15.

Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore.

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http://www.molvis.org/molvis/v16/a176/mv-v16-a176-vithana.pd
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927376PMC
August 2010

Absence of phenotype-genotype correlation of patients expressing mutations in the SLC4A11 gene.

Authors:
Jodhbir Singh Mehta Boomiraj Hemadevi Eranga N Vithana Jambulingam Arunkumar Muthaiah Srinivasan Venkatesh Prajna Donald T Tan Tin Aung Periasamy Sundaresan

Cornea 2010 Mar;29(3):302-6

Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1097/ICO.0b013e3181ae9038DOI Listing
March 2010

SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery.

Authors:
Li-Fong Seet Roseline Su V A Barathi Wing Sum Lee Rebekah Poh Yee Meng Heng Ed Manser Eranga N Vithana Tin Aung Matt Weaver E Helene Sage Tina T Wong

PLoS One 2010 Feb 25;5(2):e9415. Epub 2010 Feb 25.

Ocular Wound Healing and Therapeutics Group, Singapore Eye Research Institute, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009415PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828474PMC
February 2010

Polypoidal choroidal vasculopathy and neovascular age-related macular degeneration: same or different disease?

Authors:
Augustinus Laude Peter D Cackett Eranga N Vithana Ian Y Yeo Doric Wong Adrian H Koh Tien Y Wong Tin Aung

Prog Retin Eye Res 2010 Jan 23;29(1):19-29. Epub 2009 Oct 23.

Princess Alexandra Eye Pavilion, NHS Lothian, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S135094620900069
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http://dx.doi.org/10.1016/j.preteyeres.2009.10.001DOI Listing
January 2010

Novel human pathological mutations. Gene symbol: SLC4A11. Disease: Corneal endothelial dystrophy 2.

Authors:
Shu Ming Chai Eranga N Vithana Divya Venkataraman Huda Saleh Najeeb P P Chekkalichintavida Fathi al-Sayyed Tin Aung

Hum Genet 2010 Jan;127(1):110

Third Hospital Avenue, 11, 168751, Singapore, Singapore.

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January 2010

Association of LOXL1 polymorphisms with pseudoexfoliation in the Chinese.

Authors:
Kelvin Y C Lee Su Ling Ho Anbupalam Thalamuthu Anandalakshmi Venkatraman Divya Venkataraman Don C K Pek Tin Aung Eranga N Vithana

Mol Vis 2009 Jun 4;15:1120-6. Epub 2009 Jun 4.

Singapore National Eye Centre, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690963PMC
June 2009

Exploring the basis of sex bias in primary congenital glaucoma.

Authors:
Eranga N Vithana Tin Aung

J Ophthalmic Vis Res 2009 Apr;4(2):73-4

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498551PMC
April 2009

Association of LOXL1 gene polymorphisms with pseudoexfoliation in the Japanese.

Authors:
Mineo Ozaki Kelvin Y C Lee Eranga N Vithana Victor H Yong Anbupalam Thalamuthu Takanori Mizoguchi Anandalakshmi Venkatraman Tin Aung

Invest Ophthalmol Vis Sci 2008 Sep 30;49(9):3976-80. Epub 2008 Apr 30.

Ozaki Eye Hospital and Dept of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

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http://dx.doi.org/10.1167/iovs.08-1805DOI Listing
September 2008

Lack of association between the rs2664538 polymorphism in the MMP-9 gene and primary angle closure glaucoma in Singaporean subjects.

Authors:
Tin Aung Victor H K Yong Marcus C C Lim Divya Venkataraman Ju-Yuan Toh Paul T K Chew Eranga N Vithana

J Glaucoma 2008 Jun-Jul;17(4):257-8

Singapore National Eye Centre, National University Hospital, Singapore.

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http://dx.doi.org/10.1097/IJG.0b013e31815c3aa5DOI Listing
July 2008

Analysis of conjunctival fibroblasts from a proband with Schnyder corneal dystrophy.

Authors:
Jodhbir S Mehta Eranga N Vithana Divya Venkataraman Anandalakshmi Venkatraman Rebekah Poh Roger W Beuerman Tin Aung Donald T H Tan

Mol Vis 2008 Jul 9;14:1277-81. Epub 2008 Jul 9.

Singapore Eye Research Institute, Singapore; 2Singapore National Eye Centre, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447815PMC
July 2008

Molecular analysis of CHX10 and MFRP in Chinese subjects with primary angle closure glaucoma and short axial length eyes.

Authors:
Tin Aung Marcus C C Lim Tina T L Wong Anbupalam Thalamuthu Victor H K Yong Divya Venkataraman Anandalakshmi Venkatraman Paul T K Chew Eranga N Vithana

Mol Vis 2008 Jul 17;14:1313-8. Epub 2008 Jul 17.

Singapore National Eye Centre, Singapore; 2Singapore Eye Research Institute, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2480479PMC
July 2008

Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy.

Authors:
Kelvin Y Lee Eranga N Vithana Ranjana Mathur Victor H Yong Ian Y Yeo Anbupalam Thalamuthu Mun-Wai Lee Adrian H Koh Marcus C Lim Alicia C How Doric W Wong Tin Aung

Invest Ophthalmol Vis Sci 2008 Jun;49(6):2613-9

Singapore National Eye Centre, Singapore.

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.0
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http://dx.doi.org/10.1167/iovs.07-0860DOI Listing
June 2008

SLC4A11 mutations in Fuchs endothelial corneal dystrophy.

Authors:
Eranga N Vithana Patricio E Morgan Vedam Ramprasad Donald T H Tan Victor H K Yong Divya Venkataraman Anandalakshmi Venkatraman Gary H F Yam Soumittra Nagasamy Ricky W K Law Rama Rajagopal Chi P Pang Govindsamy Kumaramanickevel Joseph R Casey Tin Aung

Hum Mol Genet 2008 Mar 16;17(5):656-66. Epub 2007 Nov 16.

Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751, Singapore.

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http://dx.doi.org/10.1093/hmg/ddm337DOI Listing
March 2008

Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset Fuchs endothelial corneal dystrophy.

Authors:
Jodhbir S Mehta Eranga N Vithana Donald T H Tan Victor H K Yong Gary H F Yam Ricky W K Law Wesley G W Chong Calvin P Pang Tin Aung

Invest Ophthalmol Vis Sci 2008 Jan;49(1):184-8

Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore.

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http://dx.doi.org/10.1167/iovs.07-0847DOI Listing
January 2008

Identification and characterization of a novel mutation in the carbonic anhydrase IV gene that causes retinitis pigmentosa.

Authors:
Bernardo V Alvarez Eranga N Vithana Zhenglin Yang Adrian H Koh Kit Yeung Victor Yong Haley J Shandro Yali Chen Prasanna Kolatkar Paaventhan Palasingam Kang Zhang Tin Aung Joseph R Casey

Invest Ophthalmol Vis Sci 2007 Aug;48(8):3459-68

Membrane Protein Research Group, Department of Physiology, University of Alberta, Edmonton Alberta, Canada.

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http://dx.doi.org/10.1167/iovs.06-1515DOI Listing
August 2007

Bradyopsia in an Asian man.

Authors:
Jacob Y C Cheng Chi D Luu Victor H K Yong Ranjana Mathur Tin Aung Eranga N Vithana

Arch Ophthalmol 2007 Aug;125(8):1138-40

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http://dx.doi.org/10.1001/archopht.125.8.1138DOI Listing
August 2007

Novel SLC4A11 mutations in patients with recessive congenital hereditary endothelial dystrophy (CHED2). Mutation in brief #958. Online.

Authors:
Vedam L Ramprasad Neil D Ebenezer Tin Aung Rama Rajagopal Victor H K Yong Stephen J Tuft Deepa Viswanathan Mohamed F El-Ashry Petra Liskova Donald T H Tan Shomi S Bhattacharya Govindasamy Kumaramanickavel Eranga N Vithana

Hum Mutat 2007 May;28(5):522-3

ONGC Department of Genetics & Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.

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http://dx.doi.org/10.1002/humu.9487DOI Listing
May 2007

Lack of association between interleukin-1 gene cluster polymorphisms and glaucoma in Chinese subjects.

Authors:
Alicia C S How Tin Aung Xinyi Chew Victor H K Yong Marcus C C Lim Kelvin Y C Lee Ju-Yuan Toh Yuqing Li Jianjun Liu Eranga N Vithana

Invest Ophthalmol Vis Sci 2007 May;48(5):2123-6

Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1167/iovs.06-1213DOI Listing
May 2007

Mutations in sodium-borate cotransporter SLC4A11 cause recessive congenital hereditary endothelial dystrophy (CHED2).

Authors:
Eranga N Vithana Patricio Morgan Periasamy Sundaresan Neil D Ebenezer Donald T H Tan Moin D Mohamed Seema Anand Khin O Khine Divya Venkataraman Victor H K Yong Manuel Salto-Tellez Anandalakshmi Venkatraman Ke Guo Boomiraj Hemadevi Muthiah Srinivasan Venkatesh Prajna Myint Khine Joseph R Casey Chris F Inglehearn Tin Aung

Nat Genet 2006 Jul 11;38(7):755-7. Epub 2006 Jun 11.

Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751.

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http://dx.doi.org/10.1038/ng1824DOI Listing
July 2006

A large deletion in the adRP gene PRPF31: evidence that haploinsufficiency is the cause of disease.

Authors:
Leen Abu-Safieh Eranga N Vithana Irmela Mantel Graham E Holder Lucia Pelosini Alan C Bird Shomi S Bhattacharya

Mol Vis 2006 Apr 18;12:384-8. Epub 2006 Apr 18.

Institute of Ophthalmology, University College London, London, UK.

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April 2006

Characterization of Bietti crystalline dystrophy patients with CYP4V2 mutations.

Authors:
Kelvin Y C Lee Adrian H C Koh Tin Aung Victor H K Yong Kit Yeung Chong-Lye Ang Eranga N Vithana

Invest Ophthalmol Vis Sci 2005 Oct;46(10):3812-6

Singapore National Eye Centre.

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http://dx.doi.org/10.1167/iovs.05-0378DOI Listing
October 2005

Molecular analysis of the myocilin gene in Chinese subjects with chronic primary-angle closure glaucoma.

Authors:
Tin Aung Victor H K Yong Paul T K Chew Steve K L Seah Gus Gazzard Paul J Foster Eranga N Vithana

Invest Ophthalmol Vis Sci 2005 Apr;46(4):1303-6

Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1167/iovs.04-1163DOI Listing
April 2005

Expression of PRPF31 mRNA in patients with autosomal dominant retinitis pigmentosa: a molecular clue for incomplete penetrance?

Authors:
Eranga N Vithana Leen Abu-Safieh Lucia Pelosini Elizabeth Winchester Dan Hornan Alan C Bird David M Hunt Stephen A Bustin Shomi S Bhattacharya

Invest Ophthalmol Vis Sci 2003 Oct;44(10):4204-9

Division of Molecular Genetics, Institute of Ophthalmology, University College London, London, UK.

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http://dx.doi.org/10.1167/iovs.03-0253DOI Listing
October 2003

Disease mechanism for retinitis pigmentosa (RP11) caused by mutations in the splicing factor gene PRPF31.

Authors:
Evelyne C Deery Eranga N Vithana Richard J Newbold Victoria A Gallon Shomi S Bhattacharya Martin J Warren David M Hunt Susan E Wilkie

Hum Mol Genet 2002 Dec;11(25):3209-19

School of Biological Sciences, Queen Mary, University of London, London E1 4NS, UK.

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http://dx.doi.org/10.1093/hmg/11.25.3209DOI Listing
December 2002

Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa.

Authors:
Christina F Chakarova Matthew M Hims Hanno Bolz Leen Abu-Safieh Reshma J Patel Myrto G Papaioannou Chris F Inglehearn T Jeffrey Keen Catherine Willis Anthony T Moore Thomas Rosenberg Andrew R Webster Alan C Bird Andreas Gal David Hunt Eranga N Vithana Shomi S Bhattacharya

Hum Mol Genet 2002 Jan;11(1):87-92

Department of Molecular Genetics, Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EV, UK.

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http://dx.doi.org/10.1093/hmg/11.1.87DOI Listing
January 2002