Ephraim J Fuchs

Ephraim J Fuchs

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Ephraim J Fuchs

Ephraim J Fuchs

Publications by authors named "Ephraim J Fuchs"

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85Publications

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Post-transplantation cyclophosphamide to facilitate HLA-haploidentical hematopoietic cell transplantation: Mechanisms and results.

Semin Hematol 2019 Jul 20;56(3):183-189. Epub 2018 Sep 20.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2018.09.002DOI Listing
July 2019

Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a prospective clinical trial.

Lancet Haematol 2019 Apr 14;6(4):e183-e193. Epub 2019 Mar 14.

Hematologic Malignancies and Bone Marrow Transplantation Program, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/S2352-3026(19)30031-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506220PMC
April 2019

Major Histocompatibility Mismatch and Donor Choice for Second Allogeneic Bone Marrow Transplantation.

Biol Blood Marrow Transplant 2017 Nov 25;23(11):1887-1894. Epub 2017 Jul 25.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Division of Hematologic Malignancies, Bunting Blaustein Cancer Research Bldg., 1650 Orleans Street, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2017.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881910PMC
November 2017

Haplotype Counting for Sensitive Chimerism Testing: Potential for Early Leukemia Relapse Detection.

J Mol Diagn 2017 05;19(3):427-436

Department of Pathology, Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, Maryland; Department of Oncology, Johns Hopkins University, Johns Hopkins Medical Institutions, Baltimore, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15251578173010
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http://dx.doi.org/10.1016/j.jmoldx.2017.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707182PMC
May 2017

Allogeneic stem cell transplantation for sickle cell disease.

Curr Opin Hematol 2016 11;23(6):524-529

Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130409PMC
November 2016

Selecting the best haploidentical donor.

Semin Hematol 2016 Oct 15;53(4):246-251. Epub 2016 Aug 15.

Johns Hopkins University, Baltimore, MD.

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http://dx.doi.org/10.1053/j.seminhematol.2016.08.001DOI Listing
October 2016

Recent developments in HLA-haploidentical transplantations.

Best Pract Res Clin Haematol 2015 Jun-Sep;28(2-3):141-6. Epub 2015 Oct 22.

Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 289 Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2015.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013658PMC
September 2016

Haploidentical bone marrow and stem cell transplantation: experience with post-transplantation cyclophosphamide.

Semin Hematol 2016 Apr 15;53(2):90-7. Epub 2016 Jan 15.

Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Department of Oncology; Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2016.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806368PMC
April 2016

How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation?

J Hematol Oncol 2016 Apr 12;9:35. Epub 2016 Apr 12.

Peking University People's Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 South Street of Xizhimen, Beijing, Xicheng District, 100044, China.

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http://dx.doi.org/10.1186/s13045-016-0265-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830035PMC
April 2016

Modern approaches to HLA-haploidentical blood or marrow transplantation.

Nat Rev Clin Oncol 2016 Feb 31;13(2):132. Epub 2015 Dec 31.

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http://dx.doi.org/10.1038/nrclinonc.2015.234DOI Listing
February 2016

Modern approaches to HLA-haploidentical blood or marrow transplantation.

Nat Rev Clin Oncol 2016 Jan 25;13(1):10-24. Epub 2015 Aug 25.

Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans Street, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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https://www.nature.com/articles/nrclinonc.2015.128.pdf
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http://www.nature.com/articles/nrclinonc.2015.128
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http://dx.doi.org/10.1038/nrclinonc.2015.128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695979PMC
January 2016

Anti-CD45 radioimmunotherapy without TBI before transplantation facilitates persistent haploidentical donor engraftment.

Blood 2016 Jan 17;127(3):352-9. Epub 2015 Nov 17.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Medical Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA; and.

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http://dx.doi.org/10.1182/blood-2014-12-617019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722286PMC
January 2016

Comparable Outcomes for Hematologic Malignancies after HLA-Haploidentical Transplantation with Posttransplantation Cyclophosphamide and HLA-Matched Transplantation.

Adv Hematol 2015 2;2015:431923. Epub 2015 Dec 2.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1155/2015/431923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680052PMC
December 2015

Haplo graft engineering: sculpting to a T.

Authors:
Ephraim J Fuchs

Blood 2015 Apr;125(15):2315-6

SIDNEY KIMMEL COMPREHENSIVE CANCER CENTER AT JOHNS HOPKINS.

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http://dx.doi.org/10.1182/blood-2015-02-625269DOI Listing
April 2015

Mismatched related and unrelated donors for allogeneic hematopoietic cell transplantation for adults with hematologic malignancies.

Biol Blood Marrow Transplant 2014 Oct 23;20(10):1485-92. Epub 2014 May 23.

Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.bbmt.2014.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163123PMC
October 2014

HLA-haploidentical donor lymphocyte infusions for patients with relapsed hematologic malignancies after related HLA-haploidentical bone marrow transplantation.

Biol Blood Marrow Transplant 2014 Mar 1;20(3):314-8. Epub 2013 Dec 1.

The Sidney Kimmel Comprehensive Cancer Center, Department of Oncology at the Johns Hopkins University, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2013.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010132PMC
March 2014

Transplantation tolerance: from theory to clinic.

Authors:
Ephraim J Fuchs

Immunol Rev 2014 Mar;258(1):64-79

Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/imr.12154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142800PMC
March 2014

Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide.

Sci Transl Med 2013 Nov;5(211):211ra157

The Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1126/scitranslmed.3006960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155575PMC
November 2013

Haploidentical transplantation for hematologic malignancies: where do we stand?

Authors:
Ephraim J Fuchs

Hematology Am Soc Hematol Educ Program 2012 ;2012:230-6

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1182/asheducation-2012.1.230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657706PMC
June 2013

Partially mismatched transplantation and human leukocyte antigen donor-specific antibodies.

Biol Blood Marrow Transplant 2013 Apr 22;19(4):647-52. Epub 2013 Jan 22.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.bbmt.2013.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768172PMC
April 2013

Human leukocyte antigen-haploidentical stem cell transplantation using T-cell-replete bone marrow grafts.

Authors:
Ephraim J Fuchs

Curr Opin Hematol 2012 Nov;19(6):440-7

Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1097/MOH.0b013e32835822dcDOI Listing
November 2012

HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease.

Blood 2012 Nov 6;120(22):4285-91. Epub 2012 Sep 6.

Hematologic Malignancies and Bone Marrow Transplantation Program, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and Johns Hopkins University School of Medicine, Baltimore, MD 21231-1000, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-07-43
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http://dx.doi.org/10.1182/blood-2012-07-438408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507140PMC
November 2012

Treatment of hematological malignancies with nonmyeloablative, HLA-haploidentical bone marrow transplantation and high dose, post-transplantation cyclophosphamide.

Best Pract Res Clin Haematol 2011 Sep 13;24(3):359-68. Epub 2011 Jul 13.

Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.beha.2011.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204344PMC
September 2011

5-azacytidine as salvage treatment in relapsed myeloid tumors after allogeneic bone marrow transplantation.

Biol Blood Marrow Transplant 2011 May 15;17(5):754-8. Epub 2010 Oct 15.

George W. Santos Bone Marrow Transplant Service, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1016/j.bbmt.2010.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090635PMC
May 2011

High-dose cyclophosphamide for graft-versus-host disease prevention.

Curr Opin Hematol 2010 Nov;17(6):493-9

Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1097/MOH.0b013e32833eaf1bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138214PMC
November 2010

High-dose, post-transplantation cyclophosphamide to promote graft-host tolerance after allogeneic hematopoietic stem cell transplantation.

Immunol Res 2010 Jul;47(1-3):65-77

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 288 Bunting-Blaustein Cancer Research Building, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1007/s12026-009-8139-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892158PMC
July 2010

Cryoimmunotherapy in urologic oncology.

Urology 2010 May 16;75(5):1009-14. Epub 2009 Sep 16.

James Buchanan Brady Urology Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287-2101, USA.

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http://dx.doi.org/10.1016/j.urology.2009.06.020DOI Listing
May 2010

Improved survival with inhibitory killer immunoglobulin receptor (KIR) gene mismatches and KIR haplotype B donors after nonmyeloablative, HLA-haploidentical bone marrow transplantation.

Biol Blood Marrow Transplant 2010 Apr 2;16(4):533-42. Epub 2009 Dec 2.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University,1650 Orleans Street, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1016/j.bbmt.2009.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848533PMC
April 2010

High-dose cyclophosphamide for severe aplastic anemia: long-term follow-up.

Blood 2010 Mar 16;115(11):2136-41. Epub 2009 Dec 16.

Division of Hematology,Department of Medicine, Johns Hopkins University School ofMedicine, 720 Rutland Ave, Ross Bldg, Rm 1025, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1182/blood-2009-06-225375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844020PMC
March 2010

HLA-haploidentical stem cell transplantation for hematologic malignancies.

Biol Blood Marrow Transplant 2010 Jan 3;16(1 Suppl):S57-63. Epub 2009 Nov 3.

Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1016/j.bbmt.2009.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832726PMC
January 2010

Cyclophosphamide unmasks an antimetastatic effect of local tumor cryoablation.

J Pharmacol Exp Ther 2009 Aug 30;330(2):596-601. Epub 2009 Apr 30.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.109.15260
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http://dx.doi.org/10.1124/jpet.109.152603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713091PMC
August 2009

The allogeneic effect revisited: exogenous help for endogenous, tumor-specific T cells.

Biol Blood Marrow Transplant 2008 May;14(5):499-509

Division of Cancer Immunology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/j.bbmt.2008.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377414PMC
May 2008

Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse.

Blood 2007 May 16;109(10):4564-74. Epub 2007 Jan 16.

Divisions of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.

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http://dx.doi.org/10.1182/blood-2006-09-048124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885486PMC
May 2007

Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions.

J Immunol 2006 Oct;177(7):4414-25

Divisions of Hematologic Malignancies and Cancer Immunology and Hematopoiesis, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.4049/jimmunol.177.7.4414DOI Listing
October 2006

Graft-versus-host reactions and the effectiveness of donor lymphocyte infusions.

Biol Blood Marrow Transplant 2006 Apr;12(4):414-21

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1016/j.bbmt.2005.11.520DOI Listing
April 2006

Bone marrow transplantation for sickle cell anemia: progress and prospects.

Pediatr Blood Cancer 2005 May;44(5):436-40

The Children's Hospital of Philadelphia, Division of Oncology, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1002/pbc.20169DOI Listing
May 2005

Hematopoietic stem cell transplant as a platform for tumor immunotherapy.

Curr Opin Mol Ther 2004 Feb;6(1):48-53

Division of Immunology and Hematopoiesis, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.

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February 2004

Results of minimally toxic nonmyeloablative transplantation in patients with sickle cell anemia and beta-thalassemia.

Biol Blood Marrow Transplant 2003 Aug;9(8):519-28

Department of Pediatrics, Johns Hopkins Hospital and Oncology Center, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/s1083-8791(03)00192-7DOI Listing
August 2003

Nonmyeloablative alternative donor transplants.

Curr Opin Oncol 2003 Mar;15(2):121-6

Divisions of Hematologic Malignancies and Immunology/Hematopoiesis, Johns Hopkins Oncology Center, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1097/00001622-200303000-00001DOI Listing
March 2003

Successful therapy of metastatic cancer using tumor vaccines in mixed allogeneic bone marrow chimeras.

Blood 2003 Feb 24;101(4):1645-52. Epub 2002 Oct 24.

Divisions of Hematopoiesis/Immunology and Hematologic Malignancies, Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, MD, USA.

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http://dx.doi.org/10.1182/blood-2002-07-2233DOI Listing
February 2003

Donor lymphocyte infusions to treat hematologic malignancies in relapse after allogeneic blood or marrow transplantation.

Cancer Control 2002 Mar-Apr;9(2):123-37

Divisions of Hematologic Malignancies and Immunology/Hematopoiesis, Johns Hopkins Oncology Center, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1177/107327480200900205DOI Listing
June 2002