Publications by authors named "Enzo Medico"

92Publications

Machine learning for RNA sequencing-based intrinsic subtyping of breast cancer.

Sci Rep 2020 08 21;10(1):14071. Epub 2020 Aug 21.

Candiolo Cancer Institute, FPO-IRCCS, S.P. 142, km 3.95, 10060, Candiolo, TO, Italy.

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http://dx.doi.org/10.1038/s41598-020-70832-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442834PMC
August 2020

Associations between hypovitaminosis D and COVID-19: a narrative review.

Aging Clin Exp Res 2020 Sep 23;32(9):1879-1881. Epub 2020 Jul 23.

University of Torino, Turin, Italy.

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http://dx.doi.org/10.1007/s40520-020-01650-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376522PMC
September 2020

Patient-derived xenografts (PDXs) as model systems for human cancer.

Curr Opin Biotechnol 2020 06 18;63:151-156. Epub 2020 Feb 18.

Candiolo Cancer Institute, FPO-IRCCS, strada Prov. 142, km 3,95, 10060 Candiolo (TO), Italy; University of Torino, Department of Oncology, strada Prov. 142, km 3,95, 10060 Candiolo (TO), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2020.01.003DOI Listing
June 2020

Reverse signaling by semaphorin 4C elicits SMAD1/5- and ID1/3-dependent invasive reprogramming in cancer cells.

Sci Signal 2019 08 20;12(595). Epub 2019 Aug 20.

Istituto di Istologia ed Embriologia, Università Cattolica del Sacro Cuore, Rome 00168, Italy.

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http://dx.doi.org/10.1126/scisignal.aav2041DOI Listing
August 2019

A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology.

Clin Colorectal Cancer 2019 06 7;18(2):91-101.e3. Epub 2019 Mar 7.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO), Italy; University of Turin, Department of Oncology, Candiolo (TO), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2019.02.008DOI Listing
June 2019

Integration of transcriptomic data and metabolic networks in cancer samples reveals highly significant prognostic power.

J Biomed Inform 2018 11 20;87:37-49. Epub 2018 Sep 20.

Department of Informatics, Systems and Communication, University of Milan-Bicocca, Milan, Italy; SYSBIO Centre of Systems Biology, University Milano-Bicocca, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jbi.2018.09.010DOI Listing
November 2018

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies.

Cell Metab 2018 12 30;28(6):848-865.e6. Epub 2018 Aug 30.

Candiolo Cancer Institute - FPO, IRCCS, Strada Provinciale 142, Torino, Candiolo 10060, Italy; University of Torino, Department of Oncology, 10060, Torino, Candiolo, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183050
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http://dx.doi.org/10.1016/j.cmet.2018.08.006DOI Listing
December 2018

Dysregulation of MS risk genes and pathways at distinct stages of disease.

Neurol Neuroimmunol Neuroinflamm 2017 May 16;4(3):e337. Epub 2017 Mar 16.

Institute of Experimental Neurology (INSpe) (S.S., M.D.D., A.R., R.M., E.B., M. Romeo, F.S., G.D.C., M. Rodegher, M. Radaelli, L.M., G.M., R.F., V.M., G.C., C.F.), Division of Neuroscience, San Raffaele Scientific Institute, Milan; University Vita-Salute San Raffaele (S.S., E.B., G.C.), Milan; and Laboratory of Functional Genomics (D.C., E.M.), Institute for Cancer Research and Treatment (IRCC), University of Turin Medical School, Candiolo, Italy.

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http://dx.doi.org/10.1212/NXI.0000000000000337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356498PMC
May 2017

Periodontal disease and women's health.

Curr Med Res Opin 2017 06 24;33(6):1005-1015. Epub 2017 Mar 24.

a IMI (International Microdentistry Institute) , Florence , Italy.

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http://dx.doi.org/10.1080/03007995.2017.1297928DOI Listing
June 2017

Detection of gene communities in multi-networks reveals cancer drivers.

Sci Rep 2015 Dec 7;5:17386. Epub 2015 Dec 7.

Università di Torino, Department of Physics and INFN, Torino, Italy.

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http://dx.doi.org/10.1038/srep17386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671005PMC
December 2015

Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes.

Oncotarget 2015 Jul;6(19):17342-53

Istituto di Endocrinologia ed Oncologia Sperimentale del CNR and Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli "Federico II", 80131, Naples, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627312PMC
http://dx.doi.org/10.18632/oncotarget.3944DOI Listing
July 2015

Stromal contribution to the colorectal cancer transcriptome.

Nat Genet 2015 Apr 23;47(4):312-9. Epub 2015 Feb 23.

1] Candiolo Cancer Institute, Fondazione Piemontese per l'Oncologia'Istituto di Ricovero e Cura a Carattere Scientifico (FRO-IRCCS), Candiolo, Italy. [2] Department of Oncology, University of Torino, Candiolo, Italy.

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http://dx.doi.org/10.1038/ng.3224DOI Listing
April 2015

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.

Sci Transl Med 2015 Jan;7(272):272ra12

Department of Oncology, University of Torino Medical School, 10060 Candiolo, Torino, Italy. Translational Cancer Medicine, Candiolo Cancer Institute-Fondazione del Piemonte per l'Oncologia (FPO) Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 10060 Candiolo, Torino, Italy. National Institute of Biostructures and Biosystems, 00136 Rome, Italy.

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http://dx.doi.org/10.1126/scitranslmed.3010445DOI Listing
January 2015

MicroRNA-mRNA interactions underlying colorectal cancer molecular subtypes.

Nat Commun 2015 11 17;6:8878. Epub 2015 Nov 17.

Department of Oncology, Università degli Studi di Torino, S.P. 142, km 3, 95-10060 Candiolo, Italy.

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http://dx.doi.org/10.1038/ncomms9878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660217PMC
November 2015

Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models.

BMC Cancer 2014 Dec 5;14:918. Epub 2014 Dec 5.

University of Turin Medical School, Department of Oncology, IRCCS-Candiolo, Strada provinciale 142, Km 3,95, Candiolo, 10060 Turin, Italy.

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http://dx.doi.org/10.1186/1471-2407-14-918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289395PMC
December 2014

Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells.

Oncotarget 2015 Jan;6(1):221-33

Candiolo Cancer Institute - FPO IRCCS, Italy. Department of Oncology, University of Torino, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381590PMC
http://dx.doi.org/10.18632/oncotarget.2771DOI Listing
January 2015

BRAF V600E is a determinant of sensitivity to proteasome inhibitors.

Mol Cancer Ther 2013 Dec 9;12(12):2950-61. Epub 2013 Oct 9.

Corresponding Authors: Federica Di Nicolantonio, Department of Oncology, University of Torino, Institute for Cancer Research and Treatment at Candiolo, Strada Provinciale 142 Km 3.95, Candiolo, I-10060, Turin, Italy.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0243DOI Listing
December 2013

Gene expression profiling of HGF/Met activation in neonatal mouse heart.

Transgenic Res 2013 Jun 6;22(3):579-93. Epub 2012 Dec 6.

Department of Oncology, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1007/s11248-012-9667-2DOI Listing
June 2013

The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β.

Biochim Biophys Acta 2012 Oct 31;1823(10):1925-35. Epub 2012 Jul 31.

Institute for Cancer Research and Treatment, Candiolo, Italy.

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http://dx.doi.org/10.1016/j.bbamcr.2012.07.011DOI Listing
October 2012

The MET oncogene is a functional marker of a glioblastoma stem cell subtype.

Cancer Res 2012 Sep 26;72(17):4537-50. Epub 2012 Jun 26.

IRCC-Institute for Cancer Research, Center for Experimental Clinical Molecular Oncology, University of Turin Medical School, Candiolo, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3490DOI Listing
September 2012

Gender-based blood transcriptomes and interactomes in multiple sclerosis: involvement of SP1 dependent gene transcription.

J Autoimmun 2012 May 25;38(2-3):J144-55. Epub 2011 Nov 25.

Institute of Experimental Neurology (INSpe), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1016/j.jaut.2011.11.004DOI Listing
May 2012

Mulcom: a multiple comparison statistical test for microarray data in Bioconductor.

BMC Bioinformatics 2011 Sep 28;12:382. Epub 2011 Sep 28.

Department of Oncological Sciences, University of Torino, Candiolo, Italy.

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http://dx.doi.org/10.1186/1471-2105-12-382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230912PMC
September 2011

Formalin fixation at low temperature better preserves nucleic acid integrity.

PLoS One 2011 15;6(6):e21043. Epub 2011 Jun 15.

Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021043PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115967PMC
November 2011

Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer.

J Natl Cancer Inst 2011 Apr 4;103(8):645-61. Epub 2011 Apr 4.

IRCC-Institute for Cancer Research at Candiolo, University of Turin Medical School, Candiolo, Italy.

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http://dx.doi.org/10.1093/jnci/djr093DOI Listing
April 2011

Human neurotrophin receptor p75NTR defines differentiation-oriented skeletal muscle precursor cells: implications for muscle regeneration.

J Neuropathol Exp Neurol 2011 Feb;70(2):133-42

Neuroimmunology and Neuromuscular Disorders Unit, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy.

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http://dx.doi.org/10.1097/NEN.0b013e3182084391DOI Listing
February 2011

Inhibition of Src impairs the growth of met-addicted gastric tumors.

Clin Cancer Res 2010 Aug 13;16(15):3933-43. Epub 2010 Jul 13.

Division of Molecular Oncology and Laboratory of Functional Genomics, The Oncogenomics Center, Institute for Cancer Research and Treatment, University of Torino Medical School, Strada Provinciale 142, Candiolo, Turin, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0106DOI Listing
August 2010

Generation of functional hepatocytes from mouse germ line cell-derived pluripotent stem cells in vitro.

Stem Cells Dev 2010 Aug;19(8):1183-94

Department of Genetics, Biology and Biochemistry and Molecular Biotechnology Center, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1089/scd.2009.0496DOI Listing
August 2010

Only a subset of Met-activated pathways are required to sustain oncogene addiction.

Sci Signal 2009 ;2(102):er11

Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.

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http://dx.doi.org/10.1126/scisignal.2102er11DOI Listing
March 2011

Only a subset of Met-activated pathways are required to sustain oncogene addiction.

Sci Signal 2009 Dec 8;2(100):ra80. Epub 2009 Dec 8.

Division of Molecular Oncology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, 10060 Candiolo (Torino), Italy.

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http://dx.doi.org/10.1126/scisignal.2000643DOI Listing
December 2009

Individual cell-based models of cell scatter of ARO and MLP-29 cells in response to hepatocyte growth factor.

J Theor Biol 2009 Sep 31;260(1):151-60. Epub 2009 May 31.

Department of Mathematics, Politecnico di Torino, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S002251930900233
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http://dx.doi.org/10.1016/j.jtbi.2009.05.017DOI Listing
September 2009

A molecular signature for Epithelial to Mesenchymal transition in a human colon cancer cell system is revealed by large-scale microarray analysis.

Clin Exp Metastasis 2009 2;26(6):569-87. Epub 2009 Apr 2.

Laboratory of Signal Mediated Gene Expression, Institute of Biological Research and Biotechnology National Hellenic Research Foundation, 116 35 Athens, Greece.

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http://dx.doi.org/10.1007/s10585-009-9256-9DOI Listing
August 2009

Translational and functional oncogenomics. From cancer-oriented genomic screenings to new diagnostic tools and improved cancer treatment.

Authors:
Enzo Medico

Tumori 2008 Mar-Apr;94(2):172-8

Institute for Cancer Research and Treatment, University of Turin Medical School, Turin, Italy.

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July 2008

Exploiting orthologue diversity for systematic detection of gain-of-function phenotypes.

BMC Genomics 2008 May 29;9:254. Epub 2008 May 29.

Laboratory of Functional Genomics, The Oncogenomics Center, Institute for Cancer Research and Treatment (IRCC), University of Turin Medical School, Str. Prov. 142, 10060 Candiolo, Italy.

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http://dx.doi.org/10.1186/1471-2164-9-254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435555PMC
May 2008

Knock-in of oncogenic Kras does not transform mouse somatic cells but triggers a transcriptional response that classifies human cancers.

Cancer Res 2007 Sep;67(18):8468-76

Laboratory of Molecular Genetics and Laboratory of Functional Genomics, The Oncogenomics Center, Institute for Cancer Research and Treatment (IRCC), University of Turin Medical School, Candiolo, Turin, Italy.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-07-1126DOI Listing
September 2007

FLAME, a novel fuzzy clustering method for the analysis of DNA microarray data.

BMC Bioinformatics 2007 Jan 4;8. Epub 2007 Jan 4.

Laboratory of Functional Genomics, The Oncogenomics Center, Institute for Cancer Research and Treatment, University of Torino, School of Medicine, 10060 Candiolo, Italy.

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http://dx.doi.org/10.1186/1471-2105-8-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774579PMC
January 2007

Neural differentiation of human mesenchymal stem cells: Evidence for expression of neural markers and eag K+ channel types.

Exp Hematol 2006 Nov;34(11):1563-72

Department of Pediatrics, Regina Margherita Children's Hospital, The Oncogenomics Center, Institute for Cancer Research and Treatment (IRCC), University of Turin, Turin, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S0301472X0600427
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http://dx.doi.org/10.1016/j.exphem.2006.06.020DOI Listing
November 2006

The MET oncogene drives a genetic programme linking cancer to haemostasis.

Nature 2005 Mar;434(7031):396-400

Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Turin Medical School, Str. Prov. 142, I-10060 Candiolo, Torino, Italy.

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http://www.nature.com/articles/nature03357
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http://dx.doi.org/10.1038/nature03357DOI Listing
March 2005

IGF-II binding to insulin receptor isoform A induces a partially different gene expression profile from insulin binding.

Ann N Y Acad Sci 2004 Dec;1028:450-6

Dipartimento di Medicina Interna e di Medicine Specialistiche, Università di Cantania, Italy.

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http://dx.doi.org/10.1196/annals.1322.053DOI Listing
December 2004

Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cells.

Blood 2005 Mar 12;105(6):2307-15. Epub 2004 Nov 12.

San Raffaele-Telethon Institute for Gene Therapy (HSR-TIGET), via Olgettina 58, 20132, Milan, Italy.

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http://dx.doi.org/10.1182/blood-2004-03-0798DOI Listing
March 2005

Gene trapping: a multi-purpose tool for functional genomics.

Biotechnol Genet Eng Rev 2003 ;20:77-100

Institute for Cancer Research and Treatment, University of Torino Medical School, S.P. 142, km. 3.95, 10060 Candiolo, TO, Italy.

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http://dx.doi.org/10.1080/02648725.2003.10648038DOI Listing
June 2004

Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A.

J Biol Chem 2003 Oct 24;278(43):42178-89. Epub 2003 Jul 24.

Dipartimento di Medicina Interna e di Medicine Specialistiche, Cattedra di Endocrinologia, University of Catania, USL 34, Ospedale Garibaldi, 95123 Catania, Italy.

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http://dx.doi.org/10.1074/jbc.M304980200DOI Listing
October 2003