Publications by authors named "Enza Lacivita"

85 Publications

Low Basicity as a Characteristic for Atypical Ligands of Serotonin Receptor 5-HT2.

Int J Mol Sci 2021 Jan 21;22(3). Epub 2021 Jan 21.

Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland.

View Article and Find Full Text PDF
January 2021

International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.

Pharmacol Rev 2021 Jan;73(1):310-520

Neuropharmacology Research Group, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom (N.M.B., A.R.); Department of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia (N.M.B., D.H.); Department of Pharmacology, Georgetown University Medical Center, Washington, DC (G.P.A.); Institut de Génomique Functionnelle, Université Montpellier, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Montpellier, France (C.B., J.B., S.C.-D., S.C., P.M.); Université de Montpellier, Montpellier, France (C.B., J.B., S.C.-D., S.C., P.M.); C.E.N.T.E.R. Division of Gastroenterology and Hepatology Mayo Clinic, Rochester, Minnesota (M.C.); Center for Addiction Research and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas (K.A.C., R.M.H.); School of Life Sciences, Medical School, Queen's Medical Centre, The University of Nottingham, Nottingham, United Kingdom (K.C.F.); Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York (M.G.); Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta (G.D.G.); Department of Physiology, Department of Obstetrics and Gynaecology, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada (N.M.G., E.K.L.); Department of Psychiatry, University of California San Diego, La Jolla, California (A.L.H.); Theranyx, Marseille, France (G.H.); Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, New York (K.H.-D.); Ecole Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, Lausanne, Switzerland (R.H., H.V.); Department of Pharmacy-Drug Science, University of Bari Aldo Moro, Bari, Italy (E.L., M.L.); Department of Pharmacology, Faculty of Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway (F.O.L.); Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom (S.C.R.L.); INSERM UMR-S 1270, Paris, France (L.M., A.R.); Sorbonne Université, Paris, France (L.M., A.R.); Institut du Fer à Moulin, Paris, France (L.M., A.R.); Drug Development, Grunenthal GmbH, Aachen, Germany (A.C.M.); Tucson, Arizona (D.L.N.); Departments of Psychiatry and Behavioral Sciences and Pharmacology, University of Washington, Seattle, Washington (J.F.N.); Neurolixis Inc., Dana Point, California (A.N.-T.); Université Grenoble Alpes, Institut de Biologie Structurale, Grenoble, France (H.N.); CNRS, Institut de Biologie Structurale, Grenoble, France (H.N.); Commissariat à l'Energie Atomique et aux Energies Alternatives, DSV, Institut de Biologie Structurale, Grenoble, France (H.N.); Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina (B.L.R.); Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom (G.J.S.); Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York (M.T.); Department of Pharmacology, University of Oxford, Oxford, United Kingdom (T.S.); Cinvestav-Coapa, Pharmacobiology, Mexico City, Tlalpan, Mexico (C.M.V.); Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan (S.W.W.); The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia (D.H.); and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California (D.H.).

View Article and Find Full Text PDF
January 2021

G-Protein Coupled Receptors Involved in the Resolution of Inflammation: Ligands and Therapeutic Perspectives.

Mini Rev Med Chem 2020 ;20(20):2090-2103

Dipartimento di Farmacia - Scienze del Farmaco, Universita degli Studi di Bari Aldo Moro, via Orabona, 4, 70125 Bari, Italy.

View Article and Find Full Text PDF
January 2020

Privileged scaffold-based design to identify a novel drug-like 5-HT receptor-preferring agonist to target Fragile X syndrome.

Eur J Med Chem 2020 Aug 4;199:112395. Epub 2020 May 4.

Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4, 70125, Bari, Italy. Electronic address:

View Article and Find Full Text PDF
August 2020

Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists.

Medchemcomm 2019 Dec 7;10(12):2078-2088. Epub 2019 Oct 7.

Dipartimento di Farmacia - Scienze del Farmaco , Università degli Studi di Bari Aldo Moro , via Orabona, 4 , 70125 Bari , Italy . Email: ; ; Tel: +39 080 5442750.

View Article and Find Full Text PDF
December 2019

The Contribution of Formyl Peptide Receptor Dysfunction to the Course of Neuroinflammation: A Potential Role in the Brain Pathology.

Curr Neuropharmacol 2020 ;18(3):229-249

Laboratory of Immunoendocrinology, Department of Experimental Neuroendocrinology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna St. 31-343 Krakow, Poland.

View Article and Find Full Text PDF
November 2020

Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate.

Front Behav Neurosci 2019 18;13:208. Epub 2019 Sep 18.

Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.

View Article and Find Full Text PDF
September 2019

Structure-Activity Relationships and Therapeutic Potentials of 5-HT Receptor Ligands: An Update.

J Med Chem 2018 10 5;61(19):8475-8503. Epub 2018 Jun 5.

Dipartimento di Farmacia-Scienze del Farmaco , Università degli Studi di Bari Aldo Moro , Via Orabona 4 , 70125 Bari , Italy.

View Article and Find Full Text PDF
October 2018

Potentiation of capsaicin-induced neurogenic inflammation by 5-HT7 receptors in the rat hind paw: Involvement of calcitonin gen-related peptide.

Peptides 2018 07 3;105:1-6. Epub 2018 May 3.

Departamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Mexico City, Mexico. Electronic address:

View Article and Find Full Text PDF
July 2018

Structural insights into serotonin receptor ligands polypharmacology.

Eur J Med Chem 2018 May 6;151:797-814. Epub 2018 Apr 6.

Institute of Pharmacology, Polish Academy of Sciences, Department of Medicinal Chemistry, 31-343, Kraków, Smętna Street 12, Poland. Electronic address:

View Article and Find Full Text PDF
May 2018

Novel Cu Labeled RGD-BBN Heterotrimers for PET Imaging of Prostate Cancer.

Bioconjug Chem 2018 05 13;29(5):1595-1604. Epub 2018 Apr 13.

Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program , Stanford University , Stanford , California 94305-5344 , United States.

View Article and Find Full Text PDF
May 2018

Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions.

J Med Chem 2017 11 30;60(22):9114-9141. Epub 2017 Oct 30.

Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro , via Orabona 4, 70125, Bari, Italy.

View Article and Find Full Text PDF
November 2017

The brain-penetrant 5-HT receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain.

Neurobiol Dis 2017 Oct 6;106:214-221. Epub 2017 Jul 6.

Department of Physiology, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland; Center for Cognition, Learning and Memory, University of Bern, Bern, Switzerland. Electronic address:

View Article and Find Full Text PDF
October 2017

Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome.

Neuropharmacology 2017 Jul 15;121:79-88. Epub 2017 Apr 15.

Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy. Electronic address:

View Article and Find Full Text PDF
July 2017

Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues.

Curr Top Med Chem 2017 ;17(14):1599-1610

Dipartimento di Farmacia-Scienze del Farmaco, Universita degli Studi di Bari "Aldo Moro", Via Orabona 4, 70125, Bari, Italy.

View Article and Find Full Text PDF
July 2017

Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2.

Bioorg Med Chem 2015 Aug 1;23(15):4824-4830. Epub 2015 Jun 1.

Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'A. Moro', via Orabona, 4, 70125 Bari, Italy. Electronic address:

View Article and Find Full Text PDF
August 2015