Enrico Petretto

Enrico Petretto

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Enrico Petretto

Publications by authors named "Enrico Petretto"

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Broad regulation of gene isoform expression by Wnt signaling in cancer.

RNA 2019 Dec 10;25(12):1696-1713. Epub 2019 Sep 10.

Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, 169857.

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http://dx.doi.org/10.1261/rna.071506.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859862PMC
December 2019

Transcriptional Networks of Microglia in Alzheimer's Disease and Insights into Pathogenesis.

Genes (Basel) 2019 10 12;10(10). Epub 2019 Oct 12.

Programme in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, 8 College Road, 69857 Singapore, Singapore.

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http://dx.doi.org/10.3390/genes10100798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826883PMC
October 2019

Response to: 'M-CSF and GM-CSF monocyte-derived macrophages in systemic sclerosis: the two sides of the same coin?' by Lescoat .

Ann Rheum Dis 2019 03 9;78(3):e20. Epub 2018 Mar 9.

Faculty of Medicine, Medical Research Council (MRC) London Institute of Medical Sciences, Imperial College London, London, UK.

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http://dx.doi.org/10.1136/annrheumdis-2018-213121DOI Listing
March 2019

In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors.

Cell Rep 2019 Mar;26(12):3231-3245.e9

Cardiovascular & Metabolic Disorders Program, Duke-NUS Medical School, National University of Singapore, Singapore 169857, Singapore; Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.02.083DOI Listing
March 2019

Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects.

Cell Rep 2019 02;26(9):2494-2508.e7

Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A(∗)STAR), Singapore 138648, Singapore; Department of Medicine, National University of Singapore (NUS), Singapore 117597, Singapore; Department of Physiology, National University of Singapore (NUS), Singapore 117597, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.02.008DOI Listing
February 2019

Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis.

J Clin Invest 2018 12 12;128(12):5620-5633. Epub 2018 Nov 12.

Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.

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http://www.jci.org/articles/view/122383
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http://dx.doi.org/10.1172/JCI122383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264740PMC
December 2018

Culturing functional pancreatic islets on α5-laminins and curative transplantation to diabetic mice.

Matrix Biol 2018 09 27;70:5-19. Epub 2018 Mar 27.

Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore; Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2018.03.018DOI Listing
September 2018

Common signalling pathways in macrophage and osteoclast multinucleation.

J Cell Sci 2018 06 5;131(11). Epub 2018 Jun 5.

Centre for Inflammatory Disease, Imperial College London, London W12 0NN, UK

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http://dx.doi.org/10.1242/jcs.216267DOI Listing
June 2018

Expression QTLs Mapping and Analysis: A Bayesian Perspective.

Methods Mol Biol 2017 ;1488:189-215

Department of Medical Genetics, University of Cambridge, Box 238, Lv 6 Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1007/978-1-4939-6427-7_8DOI Listing
January 2018

Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease.

Methods Mol Biol 2017 ;1488:337-362

Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.

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http://dx.doi.org/10.1007/978-1-4939-6427-7_16DOI Listing
January 2018

Cell Type of Origin Dictates the Route to Pluripotency.

Cell Rep 2017 Dec;21(10):2649-2660

Department of Anatomy and Developmental Biology, Monash University, Wellington Road, Clayton, VIC 3800, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Wellington Road, Clayton, VIC 3800, Australia; Australian Regenerative Medicine Institute, Monash University, Wellington Road, Clayton, VIC 3800, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.029DOI Listing
December 2017

Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants.

Nat Commun 2017 09 5;8(1):428. Epub 2017 Sep 5.

Centre for the Developing Brain, Department of Perinatal Imaging and Health, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, SE1 7EH, UK.

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http://dx.doi.org/10.1038/s41467-017-00422-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585205PMC
September 2017

An embryonic system to assess direct and indirect Wnt transcriptional targets.

Sci Rep 2017 09 11;7(1):11092. Epub 2017 Sep 11.

Yale-NUS College, 12 College Ave West, #01- 201, Singapore, 138610, Republic of Singapore.

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http://dx.doi.org/10.1038/s41598-017-11519-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593962PMC
September 2017

Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat.

Dis Model Mech 2017 03 26;10(3):297-306. Epub 2017 Jan 26.

Centre for Genomic and Experimental Medicine & Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1242/dmm.026716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374317PMC
March 2017

Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis.

Mol Ther 2017 03 1;25(3):679-693. Epub 2017 Feb 1.

Bristol Heart Institute, University of Bristol, Bristol BS2 8HW, UK; National Heart and Lung Institute, Imperial College London, London SW3 6NP, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016173000
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http://dx.doi.org/10.1016/j.ymthe.2016.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363195PMC
March 2017

Computational methods for direct cell conversion.

Cell Cycle 2016 Dec 13;15(24):3343-3354. Epub 2016 Oct 13.

a Cardiovascular and Metabolic Disorders, Duke-NUS Medical School , Singapore.

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http://dx.doi.org/10.1080/15384101.2016.1238119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224461PMC
December 2016

Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet.

Dis Model Mech 2016 10 13;9(10):1231-1239. Epub 2016 Jul 13.

Mobiofood Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43003 Tarragona, Spain

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http://dmm.biologists.org/lookup/doi/10.1242/dmm.025528
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http://dx.doi.org/10.1242/dmm.025528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087837PMC
October 2016

From integrative genomics to systems genetics in the rat to link genotypes to phenotypes.

Dis Model Mech 2016 10;9(10):1097-1110

Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore (NUS) Medical School, Singapore

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http://dx.doi.org/10.1242/dmm.026104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087832PMC
October 2016

Web-based Gene Pathogenicity Analysis (WGPA): a web platform to interpret gene pathogenicity from personal genome data.

Bioinformatics 2016 Feb 21;32(4):635-7. Epub 2015 Oct 21.

Duke-NUS Graduate Medical School Singapore, Singapore, 169857 Singapore.

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http://dx.doi.org/10.1093/bioinformatics/btv598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743624PMC
February 2016

Unique regulatory properties of mesangial cells are genetically determined in the rat.

PLoS One 2014 24;9(10):e111452. Epub 2014 Oct 24.

Centre for Complement and Inflammation Research (CCIR), Hammersmith Hospital, Imperial College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111452PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208843PMC
December 2015

Use of Quantitative Real Time Polymerase Chain Reaction to Assess Gene Transcripts Associated With Antibody-Mediated Rejection of Kidney Transplants.

Transplantation 2015 Sep;99(9):1981-8

1 Centre for Complement and Inflammation Research, Division of Immunology and Inflammation, Department of Medicine, Imperial College, London, United Kingdom. 2 Department of Cellular Pathology, Hammersmith Hospital, London, United Kingdom. 3 Imperial College Kidney and Transplant Institute, Hammersmith Hospital, London, United Kingdom. 4 Histocompatibility and Immunogenetics Laboratory, Imperial College Healthcare NHS Trust, London, United Kingdom. 5 Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/TP.0000000000000621DOI Listing
September 2015

Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs.

Circulation 2015 Sep 15;132(11):1003-12. Epub 2015 Jul 15.

From Department of Bioengineering, Imperial College London, United Kingdom (R.M.P., V.V.M., A.L.P., R.K.); Institute of Clinical Medicine, Aarhus University Hospital, Denmark (C.B.P., N.R.H., M.M.B., N.P.A., A.K.G., J.F.B., E.F.); Department of Cardiology, Aarhus University Hospital, Denmark (C.B.P., N.R.H., M.M.B., N.P.A., A.K.G., J.F.B., H.E.B., E.F.); NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom (I.D.K., W.A.S.B., G.D.'A., A.M., C.D.M., R.d.S.); Graduate Medical School, Duke-National University of Singapore, Singapore (E.P.); National Heart Centre, NHRIS, Singapore (N.F.); National Heart and Lung Institute, Imperial College London, United Kingdom (C.D.M., R.d.S.); and Institute of Cardiovascular Medicine and Science, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom (C.D.M., R.d.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.016270DOI Listing
September 2015

EvoTol: a protein-sequence based evolutionary intolerance framework for disease-gene prioritization.

Nucleic Acids Res 2015 Mar 29;43(5):e33. Epub 2014 Dec 29.

Medical Research Council (MRC) Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore

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http://dx.doi.org/10.1093/nar/gku1322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357693PMC
March 2015

Genetic influences on brain gene expression in rats selected for tameness and aggression.

Genetics 2014 Nov 3;198(3):1277-90. Epub 2014 Sep 3.

Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany Department of Human Genetics, Gonda Center, University of California, Los Angeles, California 90095

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http://dx.doi.org/10.1534/genetics.114.168948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224166PMC
November 2014

Thin-cap fibroatheroma rupture is associated with a fine interplay of shear and wall stress.

Arterioscler Thromb Vasc Biol 2014 Oct 24;34(10):2224-31. Epub 2014 Jul 24.

From the Department of Bioengineering, Imperial College London, London, United Kingdom (R.M.P., S.M.B., V.V.M., R.K.); NHLI, Imperial College London and NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom (R.d.S.); and MRC-Clinical Sciences Centre, Imperial College London, London, United Kingdom (E.P.).

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http://dx.doi.org/10.1161/ATVBAHA.114.303426DOI Listing
October 2014

Single cell expression quantitative trait loci and complex traits.

Authors:
Enrico Petretto

Genome Med 2013 20;5(8):72. Epub 2013 Aug 20.

Medical Research Council (MRC) Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1186/gm476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978606PMC
May 2014

Leveraging gene co-expression networks to pinpoint the regulation of complex traits and disease, with a focus on cardiovascular traits.

Brief Funct Genomics 2014 Jan 19;13(1):66-78. Epub 2013 Aug 19.

MRC-Clinical Sciences Centre, Hammersmith Hospital Campus, Imperial College Centre for Translational and Experimental Medicine (ICTEM Building), Du Cane Road, London, W12 0NN UK. Tel.: + 44-020-8383-1468; Fax: +44-208-383-8577;

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http://dx.doi.org/10.1093/bfgp/elt030DOI Listing
January 2014

Multi-tissue analysis of co-expression networks by higher-order generalized singular value decomposition identifies functionally coherent transcriptional modules.

PLoS Genet 2014 Jan 2;10(1):e1004006. Epub 2014 Jan 2.

Medical Research Council (MRC) Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom.

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http://dx.plos.org/10.1371/journal.pgen.1004006
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http://dx.doi.org/10.1371/journal.pgen.1004006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879165PMC
January 2014

Transcriptional network analysis for the regulation of left ventricular hypertrophy and microvascular remodeling.

J Cardiovasc Transl Res 2013 Dec 9;6(6):931-44. Epub 2013 Aug 9.

Medical Research Council (MRC) Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Imperial Centre for Translational and Experimental Medicine (ICTEM) Building, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1007/s12265-013-9504-xDOI Listing
December 2013

JunD/AP1 regulatory network analysis during macrophage activation in a rat model of crescentic glomerulonephritis.

BMC Syst Biol 2013 Sep 22;7:93. Epub 2013 Sep 22.

MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1186/1752-0509-7-93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849178PMC
September 2013

Integrative genomics in cardiovascular medicine.

Cardiovasc Res 2013 Mar 27;97(4):623-30. Epub 2012 Sep 27.

MRC Clinical Sciences Centre, Imperial Centre for Translational and Experimental Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1093/cvr/cvs303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583255PMC
March 2013

Mapping genetic determinants of coronary microvascular remodeling in the spontaneously hypertensive rat.

Basic Res Cardiol 2013 Jan 30;108(1):316. Epub 2012 Nov 30.

Department of Radiology, Oncology and Pathology, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1007/s00395-012-0316-yDOI Listing
January 2013

Bayesian detection of expression quantitative trait loci hot spots.

Genetics 2011 Dec 16;189(4):1449-59. Epub 2011 Sep 16.

MRC Clinical Sciences Centre, Imperial College, London W12 0NN UK.

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http://dx.doi.org/10.1534/genetics.111.131425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241411PMC
December 2011

Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat.

Physiol Genomics 2011 Nov 16;43(21):1207-18. Epub 2011 Aug 16.

Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College, London, United Kingdom.

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http://physiolgenomics.physiology.org/content/physiolgenomic
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http://physiolgenomics.physiology.org/cgi/doi/10.1152/physio
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http://dx.doi.org/10.1152/physiolgenomics.00210.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217321PMC
November 2011

FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans.

Rheumatology (Oxford) 2011 Jul 4;50(7):1206-10. Epub 2011 Feb 4.

Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

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http://dx.doi.org/10.1093/rheumatology/keq456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670581PMC
July 2011

New insights into the genetic control of gene expression using a Bayesian multi-tissue approach.

PLoS Comput Biol 2010 Apr 8;6(4):e1000737. Epub 2010 Apr 8.

Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1000737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851562PMC
April 2010

Genetic mapping and positional cloning.

Methods Mol Biol 2010 ;597:13-32

Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Section of Molecular Genetics and Rheumatology, Imperial College, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1007/978-1-60327-389-3_2DOI Listing
February 2010

Repeatability of published microarray gene expression analyses.

Nat Genet 2009 Feb 28;41(2):149-55. Epub 2008 Jan 28.

Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece.

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http://dx.doi.org/10.1038/ng.295DOI Listing
February 2009

Insight into the genetics of hypertension, a core component of the metabolic syndrome.

Curr Opin Clin Nutr Metab Care 2008 Jul;11(4):393-7

aInstitute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.

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https://insights.ovid.com/crossref?an=00075197-200807000-000
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http://dx.doi.org/10.1097/MCO.0b013e32830366f6DOI Listing
July 2008

Adrenal gland tumorigenesis after gonadectomy in mice is a complex genetic trait driven by epistatic loci.

Endocrinology 2008 Feb 15;149(2):651-61. Epub 2007 Nov 15.

Department of Reproductive Biology, Physiological Genomics and Medicine Group, Medical Research Council, Clinical Sciences Center, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1210/en.2007-0925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556873PMC
February 2008

A gene harvest revealing the archeology and complexity of human disease.

Nat Genet 2007 Nov;39(11):1299-301

Faculty of Medicine, Imperial College, London W12 0NN, UK.

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http://dx.doi.org/10.1038/ng1107-1299DOI Listing
November 2007

Heritability and tissue specificity of expression quantitative trait loci.

PLoS Genet 2006 Oct 28;2(10):e172. Epub 2006 Aug 28.

Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.0020172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617131PMC
October 2006