Enrico Gratton

Enrico Gratton

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Enrico Gratton

Publications by authors named "Enrico Gratton"

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Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice.

Cell Metab 2019 Jun 28;29(6):1258-1273.e11. Epub 2019 Mar 28.

Division of Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583797PMC
June 2019

StarD5: an ER stress protein regulates plasma membrane and intracellular cholesterol homeostasis.

J Lipid Res 2019 Jun 23;60(6):1087-1098. Epub 2019 Apr 23.

Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298

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http://dx.doi.org/10.1194/jlr.M091967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547630PMC
June 2019

Mechanisms of phosphate transport.

Nat Rev Nephrol 2019 Jun 5. Epub 2019 Jun 5.

Institute of Physiology, University of Zurich, Zurich, Switzerland, and Swiss National Centres of Competence in Research, NCCR Kidney.CH, Zurich, Switzerland.

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http://dx.doi.org/10.1038/s41581-019-0159-yDOI Listing
June 2019

Determination of the metabolic index using the fluorescence lifetime of free and bound NADH in the phasor approach.

J Biophotonics 2019 Jun 13:e201900156. Epub 2019 Jun 13.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, California.

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http://dx.doi.org/10.1002/jbio.201900156DOI Listing
June 2019

The DIVER Microscope for Imaging in Scattering Media.

Methods Protoc 2019 Jun 21;2(2). Epub 2019 Jun 21.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.3390/mps2020053DOI Listing
June 2019

Widefield multifrequency fluorescence lifetime imaging using a two-tap complementary metal-oxide semiconductor camera with lateral electric field charge modulators.

J Biophotonics 2019 May 14;12(5):e201800223. Epub 2019 Feb 14.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, California.

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http://doi.wiley.com/10.1002/jbio.201800223
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http://dx.doi.org/10.1002/jbio.201800223DOI Listing
May 2019

Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT and the endothelin-1 ET receptors: Influence of ligand binding.

Biochim Biophys Acta Gen Subj 2019 May 6;1863(5):917-924. Epub 2019 Mar 6.

Center of Innovation and Technology Transfer, Institute of Scientific Research and High Technology Services (INDICASAT AIP) Panama, Panama. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03044165193005
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http://dx.doi.org/10.1016/j.bbagen.2019.03.004DOI Listing
May 2019

Visualizing the regulation of SLC34 proteins at the apical membrane.

Pflugers Arch 2019 Apr 6;471(4):533-542. Epub 2019 Jan 6.

Department of Biomedical Engineering, Laboratory for Fluorescence Dynamics, University of California at Irvine, Irvine, CA, USA.

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http://dx.doi.org/10.1007/s00424-018-02249-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436987PMC
April 2019

Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response.

Proc Natl Acad Sci U S A 2019 04 27;116(15):7323-7332. Epub 2019 Mar 27.

Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Melbourne, VIC 3010, Australia;

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http://dx.doi.org/10.1073/pnas.1814965116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462080PMC
April 2019

Fluorescence lifetime detection with particle counting devices.

Biomed Opt Express 2019 Mar 12;10(3):1223-1233. Epub 2019 Feb 12.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California Irvine, Irvine, CA, USA.

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http://dx.doi.org/10.1364/BOE.10.001223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420272PMC
March 2019

LAURDAN fluorescence and phasor plots reveal the effects of a HO bolus in NIH-3T3 fibroblast membranes dynamics and hydration.

Free Radic Biol Med 2018 11 6;128:144-156. Epub 2018 Jun 6.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, 3208 Natural Sciences II, Irvine, CA 92697‑2715, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175669PMC
November 2018

Selective plane illumination microscopy with a light sheet of uniform thickness formed by an electrically tunable lens.

Microsc Res Tech 2018 Sep 24;81(9):924-928. Epub 2016 Jun 24.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, California, USA.

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http://dx.doi.org/10.1002/jemt.22707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479743PMC
September 2018

Fit-free analysis of fluorescence lifetime imaging data using the phasor approach.

Nat Protoc 2018 09;13(9):1979-2004

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California at Irvine, Irvine, CA, USA.

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http://dx.doi.org/10.1038/s41596-018-0026-5DOI Listing
September 2018

Differences between FLIM phasor analyses for data collected with the Becker and Hickl SPC830 card and with the FLIMbox card.

Microsc Res Tech 2018 Sep 8;81(9):980-989. Epub 2018 Oct 8.

Laboratory for Fluorescence Dynamics, University of California, Irvine, Irvine, California.

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http://dx.doi.org/10.1002/jemt.23061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240382PMC
September 2018

Hyperspectral imaging in highly scattering media by the spectral phasor approach using two filters.

Biomed Opt Express 2018 Aug 3;9(8):3503-3511. Epub 2018 Jul 3.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1364/BOE.9.003503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191637PMC
August 2018

Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer.

J Biol Chem 2018 07 31;293(29):11374-11387. Epub 2018 May 31.

From the Programa de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Centro Nacional de Ressonância Magnética Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-901, Brazil,

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http://dx.doi.org/10.1074/jbc.RA118.003285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065177PMC
July 2018

Quantitative image mean squared displacement (iMSD) analysis of the dynamics of profilin 1 at the membrane of live cells.

Methods 2018 05 11;140-141:119-125. Epub 2017 Dec 11.

Centre for Bioactive Discovery in Health and Ageing, School of Science and Technology, University of New England, Armidale, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2017.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995621PMC
May 2018

Comparison between iMSD and 2D-pCF analysis for molecular motion studies on in vivo cells: The case of the epidermal growth factor receptor.

Methods 2018 05 1;140-141:74-84. Epub 2018 Mar 1.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2018.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999564PMC
May 2018

Viral highway to nucleus exposed by image correlation analyses.

Sci Rep 2018 01 18;8(1):1152. Epub 2018 Jan 18.

Department of Biological and Environmental Science and Nanoscience Center, University of Jyvaskyla, Jyvaskyla, Finland.

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http://dx.doi.org/10.1038/s41598-018-19582-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773500PMC
January 2018

Visualization of barriers and obstacles to molecular diffusion in live cells by spatial pair-cross-correlation in two dimensions.

Biomed Opt Express 2018 01 20;9(1):303-321. Epub 2017 Dec 20.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, USA.

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http://dx.doi.org/10.1364/BOE.9.000303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772584PMC
January 2018

Cholesterol modulates the cellular localization of Orai1 channels and its disposition among membrane domains.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Dec 13;1862(12):1481-1490. Epub 2017 Sep 13.

Departamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902182PMC
December 2017

Human immunodeficiency virus type-1 (HIV-1) evades antibody-dependent phagocytosis.

PLoS Pathog 2017 12 27;13(12):e1006793. Epub 2017 Dec 27.

Department of Medicine, Division of Infectious Diseases, University of California, Irvine School of Medicine, Irvine, California, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760106PMC
December 2017

New insight into the interaction of TRAF2 C-terminal domain with lipid raft microdomains.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Sep 9;1862(9):813-822. Epub 2017 May 9.

Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy; Center NAST, Nanoscience, Nanotechnology, Innovative Instrumentation, University of Rome Tor Vergata, 00133 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562040PMC
September 2017

sideSPIM - selective plane illumination based on a conventional inverted microscope.

Biomed Opt Express 2017 Sep 1;8(9):3918-3937. Epub 2017 Aug 1.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California Irvine, Irvine, CA, USA.

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http://dx.doi.org/10.1364/BOE.8.003918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611913PMC
September 2017

A multidimensional phasor approach reveals LAURDAN photophysics in NIH-3T3 cell membranes.

Sci Rep 2017 08 23;7(1):9215. Epub 2017 Aug 23.

Laboratory for Fluorescence Dynamics, Biomedical Engineering Department, University of California at Irvine, Irvine, California, USA.

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http://dx.doi.org/10.1038/s41598-017-08564-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569084PMC
August 2017

Assessment of Membrane Fluidity Fluctuations during Cellular Development Reveals Time and Cell Type Specificity.

PLoS One 2016 30;11(6):e0158313. Epub 2016 Jun 30.

Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Engineering, Thuwal, KSA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158313PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928918PMC
July 2017

Spatial analysis of Cdc42 activity reveals a role for plasma membrane-associated Cdc42 in centrosome regulation.

Mol Biol Cell 2017 Jul 24;28(15):2135-2145. Epub 2017 May 24.

Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697

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http://dx.doi.org/10.1091/mbc.E16-09-0665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509425PMC
July 2017

Measuring the effect of a Western diet on liver tissue architecture by FLIM autofluorescence and harmonic generation microscopy.

Biomed Opt Express 2017 Jul 1;8(7):3143-3154. Epub 2017 Jun 1.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, CA, USA.

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http://dx.doi.org/10.1364/BOE.8.003143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508820PMC
July 2017

Erratum: Measuring the effect of Western diet on liver tissue architecture by FLIM autofluorescence and harmonic generation microscopy: erratum.

Biomed Opt Express 2017 07 29;8(7):3501. Epub 2017 Jun 29.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, CA, USA.

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http://dx.doi.org/10.1364/BOE.8.003501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508846PMC
July 2017

Mapping the Dynamics of the Glucocorticoid Receptor within the Nuclear Landscape.

Sci Rep 2017 07 24;7(1):6219. Epub 2017 Jul 24.

Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Buenos Aires, Argentina.

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http://dx.doi.org/10.1038/s41598-017-06676-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524710PMC
July 2017

Metabolic fingerprinting of bacteria by fluorescence lifetime imaging microscopy.

Sci Rep 2017 06 16;7(1):3743. Epub 2017 Jun 16.

Department of Chemical Engineering and Materials Science, University of California, Irvine, Irvine, CA, 92697, USA.

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http://dx.doi.org/10.1038/s41598-017-04032-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473825PMC
June 2017

Spatial Characterization of Bioenergetics and Metabolism of Primordial to Preovulatory Follicles in Whole Ex Vivo Murine Ovary.

Biol Reprod 2016 12 28;95(6):129. Epub 2016 Sep 28.

Department of Developmental and Cell Biology, University of California Irvine, Irvine, California

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http://dx.doi.org/10.1095/biolreprod.116.142141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315427PMC
December 2016

Spectral phasor analysis of LAURDAN fluorescence in live A549 lung cells to study the hydration and time evolution of intracellular lamellar body-like structures.

Biochim Biophys Acta 2016 11 30;1858(11):2625-2635. Epub 2016 Jul 30.

MEMPHYS - Center for Biomembrane Physics, University of Southern Denmark, Odense M, Denmark. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045802PMC
http://dx.doi.org/10.1016/j.bbamem.2016.07.017DOI Listing
November 2016

Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species.

Proc Natl Acad Sci U S A 2016 Nov 24;113(45):12715-12720. Epub 2016 Oct 24.

Center for Epigenetics and Metabolism, U904 INSERM, Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA 92697;

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http://dx.doi.org/10.1073/pnas.1609227113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111721PMC
November 2016

Development of an image Mean Square Displacement (iMSD)-based method as a novel approach to study the intracellular trafficking of nanoparticles.

Acta Biomater 2016 09 20;42:189-198. Epub 2016 Jul 20.

Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2016.07.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483853PMC
September 2016

Persistent nuclear actin filaments inhibit transcription by RNA polymerase II.

J Cell Sci 2016 09 2;129(18):3412-25. Epub 2016 Aug 2.

Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047679PMC
http://dx.doi.org/10.1242/jcs.195867DOI Listing
September 2016

Characterizing fibrosis in UUO mice model using multiparametric analysis of phasor distribution from FLIM images.

Biomed Opt Express 2016 Sep 17;7(9):3519-3530. Epub 2016 Aug 17.

Laboratory Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, CA, USA.

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http://dx.doi.org/10.1364/BOE.7.003519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030029PMC
September 2016

Imaging in turbid media: a transmission detector gives 2-3 order of magnitude enhanced sensitivity compared to epi-detection schemes.

Biomed Opt Express 2016 Sep 30;7(9):3747-3755. Epub 2016 Aug 30.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1364/BOE.7.003747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030047PMC
September 2016

Self-assisted optothermal trapping of gold nanorods under two-photon excitation.

Methods Appl Fluoresc 2016 09 6;4(3):035003. Epub 2016 Sep 6.

Department of Biomedical Engineering, Laboratory for Fluorescence Dynamics, University of California, Irvine, CA, USA.

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http://dx.doi.org/10.1088/2050-6120/4/3/035003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497913PMC
September 2016

Automated detection and analysis of depolarization events in human cardiomyocytes using MaDEC.

Comput Biol Med 2016 08 26;75:109-17. Epub 2016 May 26.

Department of Biomedical Engineering, University of California Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1016/j.compbiomed.2016.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938768PMC
August 2016

Phasor Analysis of Local ICS Detects Heterogeneity in Size and Number of Intracellular Vesicles.

Biophys J 2016 Aug;111(3):619-629

Nanoscopy, Nanophysics, Istituto Italiano di Tecnologia, Genoa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982927PMC
August 2016

Spatiotemporal Fluctuation Analysis: A Powerful Tool for the Future Nanoscopy of Molecular Processes.

Biophys J 2016 Aug;111(4):679-685

Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002078PMC
August 2016

Diffusion Tensor Analysis by Two-Dimensional Pair Correlation of Fluorescence Fluctuations in Cells.

Biophys J 2016 Aug;111(4):841-851

Department of Biomedical Engineering, University of California, Irvine, Irvine, California. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002073PMC
August 2016

Measurements of absolute concentrations of NADH in cells using the phasor FLIM method.

Biomed Opt Express 2016 Jul 1;7(7):2441-52. Epub 2016 Jun 1.

Laboratory for Fluorescence Dynamics, Biomedical Engineering Department,University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1364/BOE.7.002441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948605PMC
July 2016

Spatio-Temporal Regulation of Rac1 Mobility by Actin Islands.

PLoS One 2015 25;10(11):e0143753. Epub 2015 Nov 25.

Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143753PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659588PMC
June 2016

Multi-scale silica structures for improved HIV-1 Capsid (p24) antigen detection.

Analyst 2016 Jun;141(13):4181-8

Department of Chemical Engineering and Materials Science, University of California, Irvine, Irvine, CA 92697, USA. and Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1039/c6an00519eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924925PMC
June 2016

Label-free imaging of metabolism and oxidative stress in human induced pluripotent stem cell-derived cardiomyocytes.

Biomed Opt Express 2016 May 5;7(5):1690-701. Epub 2016 Apr 5.

Laboratory for Fluorescence Dynamic, University of California, Biomedical Engineering, Irvine, California 92617, USA.

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http://dx.doi.org/10.1364/BOE.7.001690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871074PMC
May 2016

Noise modulation in retinoic acid signaling sharpens segmental boundaries of gene expression in the embryonic zebrafish hindbrain.

Elife 2016 Apr 12;5:e14034. Epub 2016 Apr 12.

Department of Developmental and Cell Biology, University of California, Irvine, Irvine, United States.

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http://dx.doi.org/10.7554/eLife.14034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829421PMC
April 2016

Label-free identification of macrophage phenotype by fluorescence lifetime imaging microscopy.

J Biomed Opt 2016 Apr;21(4):46005

University of California Irvine, Department of Biomedical Engineering, 2412 Engineering Hall, Irvine, California 92697, United States.

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http://dx.doi.org/10.1117/1.JBO.21.4.046005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833856PMC
April 2016

Spider Silk Peptide Is a Compact, Linear Nanospring Ideal for Intracellular Tension Sensing.

Nano Lett 2016 Mar 3;16(3):2096-102. Epub 2016 Feb 3.

Institute for Genomic Biology, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.

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http://dx.doi.org/10.1021/acs.nanolett.6b00305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851340PMC
March 2016

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet.

Cell Metab 2016 Mar 28;23(3):492-504. Epub 2016 Jan 28.

Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785086PMC
March 2016

Quantifying the dynamics of the oligomeric transcription factor STAT3 by pair correlation of molecular brightness.

Nat Commun 2016 Mar 24;7:11047. Epub 2016 Mar 24.

EMBL Australia Node in Single Molecule Science, School of Medical Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.

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http://dx.doi.org/10.1038/ncomms11047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820838PMC
March 2016

Spectral properties of single gold nanoparticles in close proximity to biological fluorophores excited by 2-photon excitation.

PLoS One 2015 24;10(4):e0124975. Epub 2015 Apr 24.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California Irvine, Irvine, California, United States of America; Centre for Bioactive Discovery in Health and Ageing, School of Science & Technology, University of New England, Armidale, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124975PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409109PMC
January 2016

Modulated CMOS camera for fluorescence lifetime microscopy.

Microsc Res Tech 2015 Dec 24;78(12):1075-81. Epub 2015 Oct 24.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering University of California, Irvine, California.

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http://dx.doi.org/10.1002/jemt.22587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770881PMC
December 2015

Model-free methods to study membrane environmental probes: a comparison of the spectral phasor and generalized polarization approaches.

Methods Appl Fluoresc 2015 Dec 12;3(4). Epub 2015 Nov 12.

Department of Cell and Molecular Biology, University of Hawaii at Manoa, 651 Halo St., BSB222, Honolulu, HI 96813, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862737PMC
December 2015

Digital quantification of miRNA directly in plasma using integrated comprehensive droplet digital detection.

Lab Chip 2015 Nov 21;15(21):4217-26. Epub 2015 Sep 21.

Department of Chemistry, Beijing Key Laboratory for Analytical Methods and Instrumentation, Tsinghua University, Beijing, 100084, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631652PMC
November 2015

Model-free methods to study membrane environmental probes: a comparison of the spectral phasor and generalized polarization approaches.

Methods Appl Fluoresc 2015 Nov 12;3(4):047001. Epub 2015 Nov 12.

Área de Investigación Respiratoria, Departamento de Fisiopatología, Hospital de Medicina-Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. Biochemistry and Proteomic Analytical Unit, Institut Pasteur of Montevideo, Montevideo, Uruguay. Present address: Laboratory for Fluorescence Dynamics, Biomedical Engineering Department, University of California at Irvine, Irvine, CA, USA.

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November 2015

Advanced fluorescence microscopy methods for the real-time study of transcription and chromatin dynamics.

Transcription 2014 ;5(2):e28425

a Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, California.

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http://dx.doi.org/10.4161/trns.28425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214231PMC
October 2015

Host Cell Plasma Membrane Phosphatidylserine Regulates the Assembly and Budding of Ebola Virus.

J Virol 2015 Sep 1;89(18):9440-53. Epub 2015 Jul 1.

Department of Chemistry and Biochemistry, the Eck Institute for Global Health, and the Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, Notre Dame, Indiana, USA Department of Biochemistry and Molecular Biology, Indiana University School of Medicine-South Bend, South Bend, Indiana, USA

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http://dx.doi.org/10.1128/JVI.01087-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542376PMC
September 2015

Characterization of exogenous DNA mobility in live cells through fluctuation correlation spectroscopy.

Sci Rep 2015 Sep 10;5:13848. Epub 2015 Sep 10.

University of Western Sydney, School of Science and Health, Hawkesbury Campus, Locked Bag 1797, Penrith NSW 2751, Australia.

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http://dx.doi.org/10.1038/srep13848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564760PMC
September 2015

Spatiotemporal regulation of Heterochromatin Protein 1-alpha oligomerization and dynamics in live cells.

Sci Rep 2015 Aug 4;5:12001. Epub 2015 Aug 4.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523856PMC
August 2015

Live-cell observation of cytosolic HIV-1 assembly onset reveals RNA-interacting Gag oligomers.

J Cell Biol 2015 Aug;210(4):629-46

Physical Chemistry, Department of Chemistry, Ludwig Maximilian University of Munich, D-81377 Munich, Germany NanoSystems Initiative Munich (NIM), Ludwig Maximilian University of Munich, D-81377 Munich, Germany Munich Center for Integrated Protein Science (CiPSM), Ludwig Maximilian University of Munich, D-81377 Munich, Germany Center for Nanoscience (CeNS), Ludwig Maximilian University of Munich, D-81377 Munich, Germany

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http://dx.doi.org/10.1083/jcb.201504006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539982PMC
August 2015

Imaging Fibrosis and Separating Collagens using Second Harmonic Generation and Phasor Approach to Fluorescence Lifetime Imaging.

Sci Rep 2015 Aug 21;5:13378. Epub 2015 Aug 21.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California Irvine, California.

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http://dx.doi.org/10.1038/srep13378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543938PMC
August 2015

Number and brightness analysis of sFRP4 domains in live cells demonstrates vesicle association signal of the NLD domain and dynamic intracellular responses to Wnt3a.

Int J Biochem Cell Biol 2015 Jul 21;64:91-6. Epub 2015 Mar 21.

Molecular Pharmacology Laboratory, School of Pharmacy, CHIRI Biosciences Research Precinct, Curtin University, Western Australia, Australia. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464842PMC
July 2015

NADH fluorescence lifetime is an endogenous reporter of α-synuclein aggregation in live cells.

FASEB J 2015 Jun 24;29(6):2484-94. Epub 2015 Feb 24.

*Department of Biology, University of Padua, Padua, Italy; Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, Irvine, California, USA; and Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, Genoa, Italy

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http://dx.doi.org/10.1096/fj.14-260281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447231PMC
June 2015

Electrically tunable lens speeds up 3D orbital tracking.

Biomed Opt Express 2015 Jun 21;6(6):2181-90. Epub 2015 May 21.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473752PMC
June 2015

Fluorescence lifetime imaging of endogenous biomarker of oxidative stress.

Sci Rep 2015 May 20;5:9848. Epub 2015 May 20.

Laboratory of Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine.

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http://dx.doi.org/10.1038/srep09848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438616PMC
May 2015

Live Cell Characterization of DNA Aggregation Delivered through Lipofection.

Sci Rep 2015 May 27;5:10528. Epub 2015 May 27.

University of Western Sydney, School of Science and Health, Hawkesbury Campus, Locked Bag 1797, Penrith NSW 2751, Australia.

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http://www.nature.com/articles/srep10528
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444954PMC
May 2015

Spectral properties and dynamics of gold nanorods revealed by EMCCD-based spectral phasor method.

Microsc Res Tech 2015 Apr 13;78(4):283-93. Epub 2015 Feb 13.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine.

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http://dx.doi.org/10.1002/jemt.22473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404027PMC
April 2015

Encoding and decoding spatio-temporal information for super-resolution microscopy.

Nat Commun 2015 Apr 2;6:6701. Epub 2015 Apr 2.

Nanoscopy, Nanophysics Istituto Italiano di Tecnologia, via Morego 30, Genoa 16163, Italy.

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http://dx.doi.org/10.1038/ncomms7701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384168PMC
April 2015

Eisosomes are dynamic plasma membrane domains showing pil1-lsp1 heteroligomer binding equilibrium.

Biophys J 2015 Apr;108(7):1633-1644

Laboratorio de Biología Celular de Membranas, Institut Pasteur de Montevideo, Montevideo, Uruguay. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390835PMC
April 2015

Single cell visualization of transcription kinetics variance of highly mobile identical genes using 3D nanoimaging.

Sci Rep 2015 Mar 19;5:9258. Epub 2015 Mar 19.

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California Irvine.

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http://dx.doi.org/10.1038/srep09258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365385PMC
March 2015

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion.

Elife 2015 Mar 25;4. Epub 2015 Mar 25.

Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, United States.

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http://dx.doi.org/10.7554/eLife.06557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400582PMC
March 2015

Modes of diffusion of cholera toxin bound to GM1 on live cell membrane by image mean square displacement analysis.

Biophys J 2015 Mar;108(6):1448-1458

Centre for Bioactive Discovery in Health and Ageing, School of Science and Technology, University of New England, Armidale, Australia; Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, Irvine, California.

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http://dx.doi.org/10.1016/j.bpj.2015.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375681PMC
March 2015

In vivo single-cell detection of metabolic oscillations in stem cells.

Cell Rep 2015 Jan 24;10(1):1-7. Epub 2014 Dec 24.

Laboratory of Fluorescence Dynamics, Biomedical Engineering Department, University of California, Irvine, Irvine, CA 92037, USA; Center for Complex Biological System, University of California, Irvine, Irvine, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340841PMC
January 2015

Application of three-photon excitation FCS to the study of protein oligomerization.

J Phys Chem B 2014 Dec 8;118(50):14627-31. Epub 2014 Dec 8.

Laboratory for Fluorescence Dynamics, Biomedical Engineering, University of California, Irvine , Irvine, California 92697, United States.

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http://dx.doi.org/10.1021/jp511126xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275161PMC
December 2014

Mapping diffusion in a living cell via the phasor approach.

Biophys J 2014 Dec;107(12):2775-2785

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California Irvine, Irvine, California. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.08.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269802PMC
December 2014

Probing short-range protein Brownian motion in the cytoplasm of living cells.

Nat Commun 2014 Dec 23;5:5891. Epub 2014 Dec 23.

Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy.

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http://dx.doi.org/10.1038/ncomms6891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281647PMC
December 2014

Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection.

Nat Commun 2014 Nov 13;5:5427. Epub 2014 Nov 13.

1] Department of Pharmaceutical Sciences, University of California-Irvine, 845 Health Sciences Road, Irvine, California 92697, USA [2] Sue and Bill Gross Stem Cell Research Center, University of California-Irvine, 845 Health Sciences Road, Irvine, California 92697, USA [3] Chao Family Comprehensive Cancer Center, University of California-Irvine, 845 Health Sciences Road, Irvine, California 92697, USA [4] Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California-Irvine, 845 Health Sciences Road, Irvine, California 92697, USA [5] Department of Biomedical Engineering, University of California-Irvine, 845 Health Sciences Road, Irvine, California 92697, USA.

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http://dx.doi.org/10.1038/ncomms6427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243214PMC
November 2014

Rapid measurement of molecular transport and interaction inside living cells using single plane illumination.

Sci Rep 2014 Nov 14;4:7048. Epub 2014 Nov 14.

Laboratory of Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, CA, USA.

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http://www.nature.com/articles/srep07048
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231332PMC
November 2014

Evaluation of BiesseBioscreen as a new methodology for bacteriuria screening.

New Microbiol 2014 Oct 1;37(4):495-501. Epub 2014 Oct 1.

Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273739PMC
October 2014

Orbital Single Particle Tracking on a commercial confocal microscope using piezoelectric stage feedback.

Methods Appl Fluoresc 2014 Jun;2(2)

Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, CA 92697, United States.

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http://dx.doi.org/10.1088/2050-6120/2/2/024010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235585PMC
June 2014

Enhanced emission of fluorophores on shrink-induced wrinkled composite structures.

Opt Mater Express 2014 ;4(4):753-763

Deparment of Chemical Engineering & Materials Science, University of California, Irvine, California 92697, USA ; Department of Biomedical Engineering, University of California, Irvine, California 92697, USA.

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http://dx.doi.org/10.1364/OME.4.000753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220269PMC
January 2014