Publications by authors named "Enrico De Smaele"

57Publications

Che-1/AATF binds to RNA polymerase I machinery and sustains ribosomal RNA gene transcription.

Nucleic Acids Res 2020 06;48(11):5891-5906

SAFU Laboratory, Department of Research, Advanced Diagnostics and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.

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http://dx.doi.org/10.1093/nar/gkaa344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293028PMC
June 2020

From single gene analysis to single cell profiling: a new era for precision medicine.

J Exp Clin Cancer Res 2020 Mar 5;39(1):48. Epub 2020 Mar 5.

Department of Precision Medicine, University of Campania "L. Vanvitelli", Naples and Biogem Scarl, Institute of Genetic Research, Laboratory of Precision and Molecular Oncology, Ariano Irpino, Italy.

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http://dx.doi.org/10.1186/s13046-020-01549-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059661PMC
March 2020

Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module.

Cell Rep 2020 02;30(6):1735-1752.e7

Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy; Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161 Rome, Italy; International Polyamines Foundation-ONLUS, 00159 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.01.024DOI Listing
February 2020

The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.

J Cell Sci 2016 11 12;129(21):4001-4013. Epub 2016 Sep 12.

Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown Street, Liverpool L69 3BX, UK

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http://dx.doi.org/10.1242/jcs.188516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117204PMC
November 2016

Inhibition of ErbB receptors, Hedgehog and NF-kappaB signaling by polyphenols in cancer.

Front Biosci (Landmark Ed) 2013 Jun 1;18:1290-310. Epub 2013 Jun 1.

Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.

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http://dx.doi.org/10.2741/4180DOI Listing
June 2013

Hedgehog/Gli control by ubiquitination/acetylation interplay.

Vitam Horm 2012 ;88:211-27

Department of Molecular Medicine, Sapienza University, Rome, Italy.

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http://dx.doi.org/10.1016/B978-0-12-394622-5.00009-2DOI Listing
August 2012

Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma.

J Exp Pharmacol 2012 14;4:173-85. Epub 2012 Dec 14.

Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.2147/JEP.S28553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863577PMC
May 2016

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration.

Nat Cell Biol 2011 Aug 28;13(10):1272-9. Epub 2011 Aug 28.

Section of Inflammation and Signal Transduction, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1038/ncb2324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462316PMC
August 2011

Vismodegib, a small-molecule inhibitor of the hedgehog pathway for the treatment of advanced cancers.

Curr Opin Investig Drugs 2010 Jun;11(6):707-18

Sapienza University of Rome, Department of Experimental Medicine, Viale Regina Elena 324, 00161 Rome, Italy.

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June 2010

MicroRNAs as biomarkers for CNS cancer and other disorders.

Brain Res 2010 Jun 7;1338:100-11. Epub 2010 Apr 7.

Department of Experimental Medicine, Sapienza University, 324 viale Regina Elena, Rome, Italy.

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http://dx.doi.org/10.1016/j.brainres.2010.03.103DOI Listing
June 2010

Hedgehog signalling in colon cancer and stem cells.

EMBO Mol Med 2009 Sep;1(6-7):300-2

Department of Experimental Medicine, Sapienza University, Rome, Italy.

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http://dx.doi.org/10.1002/emmm.200900042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378148PMC
September 2009

Glucocorticoids and neonatal brain injury: the hedgehog connection.

J Clin Invest 2009 Feb;119(2):243-6

Department of Experimental Medicine, Sapienza University, Rome, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631307PMC
http://dx.doi.org/10.1172/jci38387DOI Listing
February 2009

Hedgehog signaling pathway in neural development and disease.

Psychoneuroendocrinology 2007 Aug 9;32 Suppl 1:S52-6. Epub 2007 Jul 9.

Department of Experimental Medicine and Pathology, University La Sapienza, 324 Viale Regina Elena, 00161 Roma, Italy.

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http://dx.doi.org/10.1016/j.psyneuen.2007.03.017DOI Listing
August 2007

Insights into the structural basis of the GADD45beta-mediated inactivation of the JNK kinase, MKK7/JNKK2.

J Biol Chem 2007 Jun 7;282(26):19029-41. Epub 2007 May 7.

The Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1074/jbc.M703112200DOI Listing
June 2007

Multiple ubiquitin-dependent processing pathways regulate hedgehog/gli signaling: implications for cell development and tumorigenesis.

Cell Cycle 2007 Feb 3;6(4):390-3. Epub 2007 Feb 3.

Department of Experimental Medicine and Pathology, Cenci Bolognetti Foundation, University La Sapienza, Roma, Italy.

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http://dx.doi.org/10.4161/cc.6.4.3809DOI Listing
February 2007

Suppressors of hedgehog signaling: Linking aberrant development of neural progenitors and tumorigenesis.

Mol Neurobiol 2006 Dec;34(3):193-204

Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy.

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http://link.springer.com/10.1385/MN:34:3:193
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http://dx.doi.org/10.1385/MN:34:3:193DOI Listing
December 2006

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.

Nat Cell Biol 2006 Dec 19;8(12):1415-23. Epub 2006 Nov 19.

Department of Experimental Medicine and Pathology, University La Sapienza, Roma, 324 Viale Regina Elena, 00161 Roma, Italy.

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http://dx.doi.org/10.1038/ncb1510DOI Listing
December 2006

Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm.

Trends Mol Med 2005 Dec 14;11(12):537-45. Epub 2005 Nov 14.

Department of Experimental Medicine and Pathology, La Sapienza University, Viale Regina Elena 324, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.molmed.2005.10.005DOI Listing
December 2005

Chromosome 17p deletion in human medulloblastoma: a missing checkpoint in the Hedgehog pathway.

Cell Cycle 2004 Oct 3;3(10):1263-6. Epub 2004 Oct 3.

Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy.

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http://www.tandfonline.com/doi/abs/10.4161/cc.3.10.1200
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http://dx.doi.org/10.4161/cc.3.10.1200DOI Listing
October 2004

Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2.

Nat Cell Biol 2004 Feb 25;6(2):146-53. Epub 2004 Jan 25.

The Gwen Knapp Center for Lupus and Immunology Research, and The Ben May Institute for Cancer Research, The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1038/ncb1093DOI Listing
February 2004

Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis.

Blood 2003 Nov 10;102(9):3270-9. Epub 2003 Jul 10.

Gwen Knapp Center for Lupus and Immunoolgy Research, Ben May Institute, and Committee on Immunology, University of Chicago, IL 60637, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2003-03-06
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http://dx.doi.org/10.1182/blood-2003-03-0689DOI Listing
November 2003

Protection by herpes simplex virus glycoprotein D against Fas-mediated apoptosis: role of nuclear factor kappaB.

J Biol Chem 2003 Sep 4;278(38):36059-67. Epub 2003 Jul 4.

Department of Microbiological, Genetic and Molecular Sciences, Salita Sperone 31, University of Messina, 98166 Messina, Italy.

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http://dx.doi.org/10.1074/jbc.M306198200DOI Listing
September 2003

Regulation of the gadd45beta promoter by NF-kappaB.

DNA Cell Biol 2002 Jul;21(7):491-503

The Gwen Knapp Center for Lupus and Immunology Research, and The Ben May Institute for Cancer Research, Committees on Immunology and Cancer Biology, The University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1089/104454902320219059DOI Listing
July 2002