Enric Domingo

Enric Domingo

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Enric Domingo

Publications by authors named "Enric Domingo"

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Tumour-infiltrating CD8 lymphocytes and colorectal cancer recurrence by tumour and nodal stage.

Br J Cancer 2019 Sep 7;121(6):474-482. Epub 2019 Aug 7.

Cancer Genomics and Immunology Group, The Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1038/s41416-019-0540-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738075PMC
September 2019

Correction: Tumour-infiltrating CD8 lymphocytes and colorectal cancer recurrence by tumour and nodal stage.

Br J Cancer 2019 Sep 23. Epub 2019 Sep 23.

Cancer Genomics and Immunology Group, The Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1038/s41416-019-0590-7DOI Listing
September 2019

Targeted next generation sequencing reveals a common genetic pathway for colorectal cancers with chromosomal instability and those with microsatellite and chromosome stability.

Pathol Res Pract 2019 Jul 20;215(7):152445. Epub 2019 May 20.

Academic Unit of Pathology and Nottingham Molecular Pathology Node, University of Nottingham, Queen's Medical Centre, UK.

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http://dx.doi.org/10.1016/j.prp.2019.152445DOI Listing
July 2019

Guidelines for using sigQC for systematic evaluation of gene signatures.

Nat Protoc 2019 05 10;14(5):1377-1400. Epub 2019 Apr 10.

Computational Biology and Integrative Genomics Lab, MRC/CRUK Oxford Institute and Department of Oncology, University of Oxford, Oxford, UK.

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http://www.nature.com/articles/s41596-019-0136-8
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http://dx.doi.org/10.1038/s41596-019-0136-8DOI Listing
May 2019

Pulmonary hypertension associated with left heart disease: efforts to improve the meaning of haemodynamic phenotypes.

Eur Respir J 2019 Mar 7;53(3). Epub 2019 Mar 7.

Cardiologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1183/13993003.01894-2018DOI Listing
March 2019

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.

Oncogenesis 2019 Feb 19;8(3):13. Epub 2019 Feb 19.

Cancer Genetics and Stem Cell Group, Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.1038/s41389-019-0125-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381143PMC
February 2019

Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series.

Lancet Gastroenterol Hepatol 2018 09 2;3(9):635-643. Epub 2018 Jul 2.

Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, Oxford, UK; Genomic Medicine Theme, National Institute for Health Research Oxford Biomedical Research Centre, Wellcome Trust Centre for Human Genetics, Oxford, UK; Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham, UK.

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http://dx.doi.org/10.1016/S2468-1253(18)30117-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088509PMC
September 2018

Acute Right Ventricular Dysfunction in Intensive Care Unit.

Biomed Res Int 2017 19;2017:8217105. Epub 2017 Oct 19.

Area del Cor, Hospital Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1155/2017/8217105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671685PMC
July 2018

Pulmonary vascular disease due to left heart disease: how to achieve a more accurate approach beyond the haemodynamic phenotype.

Eur J Heart Fail 2018 05 26;20(5):942-943. Epub 2017 Sep 26.

Area del Cor, Hospital Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1002/ejhf.954DOI Listing
May 2018

Area at risk and collateral circulation in a first acute myocardial infarction with occluded culprit artery. STEMI vs non-STEMI patients.

Int J Cardiol 2018 05 31;259:14-19. Epub 2018 Jan 31.

Unitat Coronària, Servei de Cardiologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.ijcard.2018.01.047DOI Listing
May 2018

Short-term exposure to air pollutants increases the risk of ST elevation myocardial infarction and of infarct-related ventricular arrhythmias and mortality.

Int J Cardiol 2018 Jan 5;250:35-42. Epub 2017 Oct 5.

Department of Cardiology, Vall d'Hebron Hospital, CIBERCV, Autonomous University of Barcelona, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.ijcard.2017.10.004DOI Listing
January 2018

Pulmonary arterial wall disease in COPD and interstitial lung diseases candidates for lung transplantation.

Respir Res 2017 05 6;18(1):85. Epub 2017 May 6.

Department of Neumology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1186/s12931-017-0568-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420403PMC
May 2017

BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer.

Cancer Cell 2017 01;31(1):79-93

Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Translational Cancer Therapeutics Laboratory, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC2E 6DD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225404PMC
January 2017

Is sidedness prognostically important across all stages of colorectal cancer?

Lancet Oncol 2016 11;17(11):1480-1482

Department of Oncology, University of Oxford, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1016/S1470-2045(16)30431-4DOI Listing
November 2016

[Treatment of pulmonary arterial hypertension].

Med Clin (Barc) 2015 Jun 26;144(12):566-70. Epub 2014 Jul 26.

Servicio de Cardiología, Hospital Universitario Vall d'Hebron, Barcelona, España; Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Barcelona, Barcelona, España.

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http://dx.doi.org/10.1016/j.medcli.2014.03.033DOI Listing
June 2015

The emerging role of the contractile and vascular reserves in pulmonary arterial hypertension.

Eur Respir J 2015 Jun;45(6):1756-8

Cardiologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain Dept of Physiology, School of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1183/09031936.00023015DOI Listing
June 2015

Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.

Mol Oncol 2015 Jan 20;9(1):167-78. Epub 2014 Aug 20.

Microvascular Research Laboratories, Veterinary Sciences Building, School of Physiology and Pharmacology, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK; Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Queen's Medical Centre, NG7 2UH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286123PMC
January 2015

'Toxgnostics': an unmet need in cancer medicine.

Nat Rev Cancer 2014 06 15;14(6):440-5. Epub 2014 May 15.

Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1038/nrc3729DOI Listing
June 2014

Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.

J Clin Oncol 2014 Apr 3;32(10):1031-9. Epub 2014 Mar 3.

Dan Rosmarin, Claire Palles, David Church, Enric Domingo, Angela Jones, Ian Tomlinson, Wellcome Trust Centre for Human Genetics, NIHR Comprehensive Biomedical Research Centre, University of Oxford; Dan Rosmarin, David Church, Elaine Johnstone, Haitao Wang, Sharon Love, Patrick Julier, Claire Scudder, George Nicholson, Rachel Midgley, David Kerr, and George Nicholson, University of Oxford, Oxford; Michael Braun, The Christie NHS Foundation Trust, Manchester; Matthew Seymour, St James's University Hospital, Leeds; Lindsay Thompson, Medical Research Council Clinical Trials Unit; Rohini Sharma, Imperial College Healthcare NHS Trust, Hammersmith and Charing Cross Hospitals, London, United Kingdom; Anna Gonzalez-Neira, Spanish National Cancer Research Centre; Miguel Martin, Instituto de Investigacion Sanitaria Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid; Nuria Ribelles, Hospital Universitario Virgen de la Victoria, Málaga; Eva Martinez-Balibrea, Institut Català d'Oncologia, Institut de Recerca Sanitària Germans Trias i Pujol, Barcelona; Jesus Garcia-Foncillas, University Clinic of Navarra, University of Navarra, Pamplona, Spain; Daniel Sargent, Erin Green, Mayo Clinic, Rochester, MN; Howard McLeod, University of North Carolina, Chapel Hill, NC; Ulrich M. Zanger, Matthias Schwab, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Ulrich M. Zanger, Matthias Schwab, University Hospital Tuebingenl, Tuebingen, Germany; Benjamin Lacas, Valérie Boige, Jean-Pierre Pignon, Institut Gustave Roussy, Villejuif; Marie-Christine Etienne-Grimaldi, Gérard Milano, Centre Antoine Lacassagne, Nice; Thierry Lecomte, Pierre Laurent-Puig, Assistance Publique Hopitaux de Paris, Hopital Européen Georges Pompidou, Paris; Alain Morel, Institut National de la Sante et de la Recherche Medicale U564, Centre Paul Papin, Angers, France; Shoaib Afzal, Henrik Enghusen, Laboratory of Clinical Pharmacology, Rigshospitalet, Copenhagen; Sør

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http://dx.doi.org/10.1200/JCO.2013.51.1857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879695PMC
April 2014

Impairment of pulmonary vascular reserve and right ventricular systolic reserve in pulmonary arterial hypertension.

BMC Pulm Med 2014 Apr 24;14:69. Epub 2014 Apr 24.

Pathophysiology Department, School of Medicine, Hospital de Clínicas, Universidad de la República, Avda Italia 2870, PC 11600 Montevideo, Uruguay.

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http://dx.doi.org/10.1186/1471-2466-14-69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007147PMC
April 2014

Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer.

J Clin Oncol 2013 Dec 23;31(34):4297-305. Epub 2013 Sep 23.

Enric Domingo, David N. Church, Rajarajan Ramamoorthy, and Ian P.M. Tomlinson, The Wellcome Trust Centre for Human Genetics, University of Oxford; David N. Church, David J. Kerr, and Rachel Midgley, Oxford Cancer Centre, Churchill Hospital; Yoko Yanagisawa, Elaine Johnstone, David J. Kerr, and Rachel Midgley, University of Oxford, Oxford; Rajarajan Ramamoorthy and Brian Davidson, University College London, Royal Free Hospital, London, United Kingdom; and Oliver Sieber, Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research, Melbourne, Victoria, Australia.

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http://jco.ascopubs.org/content/early/2013/09/18/JCO.2013.50
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2013.50.0322
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http://dx.doi.org/10.1200/JCO.2013.50.0322DOI Listing
December 2013

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations.

Am J Gastroenterol 2013 Nov 17;108(11):1785-93. Epub 2013 Sep 17.

1] Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research, Parkville, Victoria, Australia [2] Faculty of Medicine, Dentistry and Health Sciences, Department of Medical Biology, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1038/ajg.2013.292DOI Listing
November 2013

Typical angina without significant coronary stenosis: comparison of clinical profile, circadian presentation, and long-term follow-up between patients with and patients without vasospastic angina.

Coron Artery Dis 2013 Aug;24(5):374-80

Coronary Care Unit, Cardiology Service, Hospital General Universitari Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1097/MCA.0b013e328362230eDOI Listing
August 2013

Methylated arginines and nitric oxide in end-stage renal disease: impact of inflammation, oxidative stress and haemodialysis.

Biomarkers 2013 Jun 14;18(4):357-64. Epub 2013 May 14.

Cardiology Department, Hospital Universitari Vall d'Hebrón, Barcelona, Spain.

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http://dx.doi.org/10.3109/1354750X.2013.795608DOI Listing
June 2013

Acute absolute vasodilatation is associated with a lower vascular wall stiffness in pulmonary arterial hypertension.

Int J Cardiol 2013 Apr 23;164(2):227-31. Epub 2011 Jul 23.

Depto de Fisiopatología, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay.

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http://dx.doi.org/10.1016/j.ijcard.2011.07.020DOI Listing
April 2013

Pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension: How can patients be better selected?

World J Cardiol 2013 Mar;5(3):18-21

Juan C Grignola, Department of Pathophysiology, Faculty of Medicine, University of the Republic, Montevideo 11600, Uruguay.

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http://dx.doi.org/10.4330/wjc.v5.i3.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610002PMC
March 2013

Persistent angina pectoris, cardiac mortality and myocardial infarction during a 12 year follow-up in 273 variant angina patients without significant fixed coronary stenosis.

Am J Cardiol 2012 Nov 25;110(9):1249-55. Epub 2012 Jul 25.

Unitat Coronària, Servei de Cardiologia, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.amjcard.2012.06.026DOI Listing
November 2012

Activation of polymorphonuclear leukocytes and increased plasma vasoconstrictors in vasospastic and nonvasospastic angina.

Can J Cardiol 2011 Sep-Oct;27(5):601-5. Epub 2011 Jun 25.

Unitat Coronària and Laboratorio de Cardiología Experimental, Servei de Cardiologia, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.cjca.2011.01.004DOI Listing
December 2011

Assessment of right ventricular afterload by pressure waveform analysis in acute pulmonary hypertension.

World J Cardiol 2011 Oct;3(10):322-8

Juan C Grignola, Lucía Devera, Fernando Ginés, Department of Pathophysiology. Hospital de Clínicas, Facultad de Medicina. Universidad de la República, 11600 Montevideo, Uruguay.

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http://dx.doi.org/10.4330/wjc.v3.i10.322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206970PMC
October 2011

Prothrombotic profile in patients with vasospastic or non vasospastic angina and non significant coronary stenosis.

Thromb J 2011 May 27;9:10. Epub 2011 May 27.

Unitat Coronària, Àrea del Cor, Laboratori d'Hemostàsia*, Hospital General Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1186/1477-9560-9-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115835PMC
May 2011

Recurrent severe acute pulmonary edema caused by transient left ventricular insufficiency with mitral regurgitation related to severe coronary artery spasm.

Circ Heart Fail 2010 Mar;3(2):332-5

Department of Cardiology, Hospital General Universitari Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.109.921957DOI Listing
March 2010

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.

Nat Genet 2008 May 30;40(5):623-30. Epub 2008 Mar 30.

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK.

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http://dx.doi.org/10.1038/ng.111DOI Listing
May 2008

[Long-term outcomes of treatment with bosentan in pulmonary hypertension].

Arch Bronconeumol 2006 Dec;42(12):616-20

Servei de Pneumologia, Hospital Universitari Vall d'Hebron, Barcelona, España.

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http://dx.doi.org/10.1016/s1579-2129(07)60002-0DOI Listing
December 2006

Comparison of clinical and angiographic features and longterm follow-up events between patients with variant angina and patients with ST elevation myocardial infarction.

Int J Cardiol 2006 Aug 22;111(2):256-62. Epub 2005 Nov 22.

Unitat Coronària, Servei de Cardiologia, Hospital General Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.ijcard.2005.08.024DOI Listing
August 2006

E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients.

J Hum Genet 2005 10;50(11):604-6. Epub 2005 Sep 10.

Unitat d'Antropologia, Departament de Biologia Animal, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1007/s10038-005-0298-9DOI Listing
June 2006

Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer.

Oncogene 2005 Nov;24(51):7630-4

Institute of Molecular Pathology and Immunology of the University of Porto, Rua Roberto Frias S/N, Porto 4200-465, Portugal.

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http://dx.doi.org/10.1038/sj.onc.1208906DOI Listing
November 2005

Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors.

Cancer Res 2005 Nov;65(22):10170-3

Molecular Oncology and Aging Group, Molecular Biology and Biochemistry Research Center (CIBBIM), Valle Hebron Hospital Research Institute, Barcelona, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2580DOI Listing
November 2005

Early negative T waves and viable myocardium in patients with a first ST-elevation acute coronary syndrome.

J Electrocardiol 2005 Jul;38(3):171-8

Unitat Coronària-Secció d'Hemodinàmica, Servei de Cardiologia, Hospital General Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona 08035, Spain.

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http://dx.doi.org/10.1016/j.jelectrocard.2005.01.010DOI Listing
July 2005

Comparison of plasma serotonin levels in patients with variant angina pectoris versus healed myocardial infarction.

Am J Cardiol 2005 Jul;96(2):204-7

Unitat Coronària, Servei de Cardiologia, Hospital General Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.amjcard.2005.03.044DOI Listing
July 2005

BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes.

Oncogene 2005 Jun;24(24):3995-8

Molecular Oncology and Aging Research, Centre d'Investigacions en Bioquímica i Biologia Molecular (CIBBIM), Hospital Universitari Vall d'Hebron, Passeig Vall d'Hebron 119-129, Barcelona 08035, Spain.

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http://dx.doi.org/10.1038/sj.onc.1208569DOI Listing
June 2005

Low levels of microsatellite instability characterize MLH1 and MSH2 HNPCC carriers before tumor diagnosis.

Hum Mol Genet 2005 Jan 24;14(2):235-9. Epub 2004 Nov 24.

Molecular Oncology and Aging Research, Centre d'Investigacions en Bioquímica i Biologia Molecular (CIBBIM), Hospital Universitari Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1093/hmg/ddi021DOI Listing
January 2005

Long-term prognosis of clinical variables, coronary reserve and extent of coronary disease in patients with a first episode of unstable angina.

Int J Cardiol 2005 Jan;98(1):27-34

Unitat Coronària i Secció d' Hemodinàmica, Servei de Cardiologia, Hospital General Vall d'Hebron, P. Vall d'Hebron 119-129, 08035 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.ijcard.2003.08.005DOI Listing
January 2005

Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation.

Genes Chromosomes Cancer 2004 Feb;39(2):138-42

Molecular Pathology Program, Centre d'Investigacions en Bioquímica i Biologia Molecular, Barcelona, Spain.

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http://dx.doi.org/10.1002/gcc.10310DOI Listing
February 2004

BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency.

Oncogene 2003 Dec;22(57):9192-6

Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto 4200-465, Portugal.

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http://dx.doi.org/10.1038/sj.onc.1207061DOI Listing
December 2003