Ennio Ongini

Ennio Ongini

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Ennio Ongini

Ennio Ongini

Publications by authors named "Ennio Ongini"

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Naproxcinod shows significant advantages over naproxen in the mdx model of Duchenne Muscular Dystrophy.

Orphanet J Rare Dis 2015 Aug 22;10:101. Epub 2015 Aug 22.

Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, Consiglio Nazionale delle Ricerche Institute of Neuroscience, University Hospital "Luigi Sacco", University of Milan, 20157, Milan, Italy.

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http://dx.doi.org/10.1186/s13023-015-0311-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546261PMC
August 2015

Nitric oxide (NO): an emerging target for the treatment of glaucoma.

Invest Ophthalmol Vis Sci 2014 Aug 14;55(8):5005-15. Epub 2014 Aug 14.

Nicox Research Institute, Bresso, Milan, Italy.

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http://dx.doi.org/10.1167/iovs.14-14515DOI Listing
August 2014

Long-term treatment with naproxcinod significantly improves skeletal and cardiac disease phenotype in the mdx mouse model of dystrophy.

Hum Mol Genet 2014 Jun 23;23(12):3239-49. Epub 2014 Jan 23.

Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC, USA Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA

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http://dx.doi.org/10.1093/hmg/ddu033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030778PMC
June 2014

Nitric oxide prevents atorvastatin-induced skeletal muscle dysfunction and alterations in mice.

Muscle Nerve 2013 Jan 5;47(1):72-80. Epub 2012 Oct 5.

Department of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100 Pavia, Italy.

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http://dx.doi.org/10.1002/mus.23465DOI Listing
January 2013

Gastrointestinal-sparing effects of novel NSAIDs in rats with compromised mucosal defence.

PLoS One 2012 9;7(4):e35196. Epub 2012 Apr 9.

Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035196PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322164PMC
August 2012

Nitric oxide enhances the anti-inflammatory and anti-atherogenic activity of atorvastatin in a mouse model of accelerated atherosclerosis.

Cardiovasc Res 2012 Jun 23;94(3):428-38. Epub 2012 Feb 23.

Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Via E. dal Pozzo, 06126 Perugia, Italy.

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1093/cvr/cvs100DOI Listing
June 2012

Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis.

Gastroenterology 2011 Oct 13;141(4):1314-22, 1322.e1-5. Epub 2011 Jul 13.

Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1053/j.gastro.2011.06.075DOI Listing
October 2011

The nitric oxide-donating pravastatin, NCX 6550, inhibits cytokine release and NF-κB activation while enhancing PPARγ expression in human monocyte/macrophages.

Pharmacol Res 2010 Nov 27;62(5):391-9. Epub 2010 Jul 27.

Department of Medical Sciences, School of Medicine, University A. Avogadro, Via Solaroli 17, 28100 Novara, Italy.

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http://dx.doi.org/10.1016/j.phrs.2010.07.006DOI Listing
November 2010

The cardio-protective properties of Ncx-6550, a nitric oxide donating pravastatin, in the mouse.

Microcirculation 2010 Aug;17(6):417-26

Department of Experimental Medicine, Section of Pharmacology, 2nd University of Naples, Italy.

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http://dx.doi.org/10.1111/j.1549-8719.2010.00040.xDOI Listing
August 2010

(Nitrooxyacyloxy)methyl esters of aspirin as novel nitric oxide releasing aspirins.

J Med Chem 2009 Aug;52(16):5058-68

Dipartimento di Scienza e Tecnologia del Farmaco, Universita degli Studi di Torino, Via Pietro Giuria 9, 10125 Torino, Italy.

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http://dx.doi.org/10.1021/jm900587hDOI Listing
August 2009

Searching for new NO-donor aspirin-like molecules: a new class of nitrooxy-acyl derivatives of salicylic acid.

J Med Chem 2008 Mar 23;51(6):1894-903. Epub 2008 Feb 23.

Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, Turin, Italy.

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http://dx.doi.org/10.1021/jm701104fDOI Listing
March 2008

An Aging Interventions Testing Program: study design and interim report.

Aging Cell 2007 Aug 18;6(4):565-75. Epub 2007 Jun 18.

Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor VA Medical Center, Ann Arbor, MI 48109-2200, USA.

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http://kaeberleinlab.org/501/miller2.pdf
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http://doi.wiley.com/10.1111/j.1474-9726.2007.00311.x
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http://dx.doi.org/10.1111/j.1474-9726.2007.00311.xDOI Listing
August 2007

3H-[1,2,4]-Triazolo[5,1-i]purin-5-amine derivatives as adenosine A2A antagonists.

Bioorg Med Chem Lett 2007 Mar 8;17(6):1659-62. Epub 2007 Jan 8.

CV & CNS Departments of Chemical Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0700025
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http://dx.doi.org/10.1016/j.bmcl.2006.12.104DOI Listing
March 2007

Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases.

Neurobiol Dis 2006 Apr 22;22(1):25-32. Epub 2005 Nov 22.

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S096999610500268
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http://dx.doi.org/10.1016/j.nbd.2005.09.012DOI Listing
April 2006

The nitrosteroid NCX 1015, a prednisolone derivative, improves recovery of function in rats after spinal cord injury.

Brain Res 2005 Nov 2;1062(1-2):16-25. Epub 2005 Nov 2.

Department of Neuroscience, Georgetown University Medical Center, Research Building, Room EP04, Box 571464 Washington, DC 20057, USA.

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http://dx.doi.org/10.1016/j.brainres.2005.08.057DOI Listing
November 2005

Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease.

Brain Res Brain Res Rev 2005 Apr 28;48(2):400-8. Epub 2005 Jan 28.

Nicox Research Institute, Bresso, Milan, Italy.

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http://dx.doi.org/10.1016/j.brainresrev.2004.12.029DOI Listing
April 2005

Nitric oxide-releasing aspirin derivative, NCX 4016, promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia.

Arterioscler Thromb Vasc Biol 2004 Nov 2;24(11):2082-7. Epub 2004 Sep 2.

Molecular and Cellular Medicine, National Institute of Biostructures and Biosystems, Alghero, Italy.

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http://dx.doi.org/10.1161/01.ATV.0000144030.39087.3bDOI Listing
November 2004

Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action.

J Neurochem 2004 Nov;91(3):521-36

Nicox Research Institute, 20091 Bresso, Milan, Italy.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02743.xDOI Listing
November 2004

Glutamate efflux from human cerebrocortical slices during ischemia: vesicular-like mode of glutamate release and sensitivity to A(2A) adenosine receptor blockade.

Neuropharmacology 2004 Nov;47(6):884-91

Dipartimento di Medicina Sperimentale, Sezione di Farmacologia e Tossicologia, Università di Genova, Viale Cembrano 4, 16148 Genoa, Italy.

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http://dx.doi.org/10.1016/j.neuropharm.2004.06.022DOI Listing
November 2004

The distinct alterations produced in cardiovascular functions by prednisolone and nitro-prednisolone (NCX-1015) in the rat highlight a causal role for endothelin-1.

J Pharmacol Exp Ther 2004 Sep 27;310(3):1133-41. Epub 2004 Apr 27.

The William Harvey Research Institute, Queen Mary School of Medicine and Dentistry, University of London, Charterhouse Square, EC1M 6BQ London, UK.

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http://dx.doi.org/10.1124/jpet.104.068726DOI Listing
September 2004

A nitric oxide releasing derivative of flurbiprofen inhibits experimental autoimmune encephalomyelitis.

J Neuroimmunol 2004 May;150(1-2):10-9

Neuroimmunology Unit, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.

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http://dx.doi.org/10.1016/j.jneuroim.2004.01.004DOI Listing
May 2004

A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure.

FASEB J 2004 Mar 20;18(3):587-8. Epub 2004 Jan 20.

Institute of Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1096/fj.03-0872fjeDOI Listing
March 2004

Adenosine A(2A) receptors in nonlocomotor features of Parkinson's disease: introduction.

Authors:
Ennio Ongini

Neurology 2003 Dec;61(11 Suppl 6):S72-3

Nicox Research Institute, Bresso, Milan, Italy.

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http://dx.doi.org/10.1212/01.wnl.0000095217.17071.b6DOI Listing
December 2003

Adenosine A2A receptors in neuroadaptation to repeated dopaminergic stimulation: implications for the treatment of dyskinesias in Parkinson's disease.

Neurology 2003 Dec;61(11 Suppl 6):S74-81

Molecular Neurobiology Laboratory, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02118, USA.

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http://dx.doi.org/10.1212/01.wnl.0000095218.26363.7bDOI Listing
December 2003

Sensitivity to selective adenosine A1 and A2A receptor antagonists of the release of glutamate induced by ischemia in rat cerebrocortical slices.

Neuropharmacology 2003 Aug;45(2):201-10

Department of Experimental Medicine, Pharmacology and Toxicology Section, University of Genoa, Viale Cembrano 4, Genoa, Italy.

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http://dx.doi.org/10.1016/s0028-3908(03)00156-4DOI Listing
August 2003

Intracellular release of nitric oxide by NCX 972, an NO-releasing metronidazole, enhances in vitro killing of Entamoeba histolytica.

Antimicrob Agents Chemother 2003 Jul;47(7):2303-6

Laboratory of Parasitology, Istituto Superiore di Sanità, University of Rome "Roma Tre," Milan, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC161880PMC
http://dx.doi.org/10.1128/aac.47.7.2303-2306.2003DOI Listing
July 2003

Nitric oxide-donating non-steroidal anti-inflammatory drugs: the case of nitroderivatives of aspirin.

Eur J Med Chem 2003 Apr;38(4):441-6

Nicox Research Institute, Via Ariosto 21, 20091 Bresso, Milan, Italy.

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April 2003

Lack of the nociceptin receptor does not affect acute or chronic nociception in mice.

Peptides 2002 Sep;23(9):1589-96

Schering-Plough Research Institute, San Raffaele Science Park, Via Olgettina 58, Milan, Italy.

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http://dx.doi.org/10.1016/s0196-9781(02)00102-xDOI Listing
September 2002

Effects of adenosine A1 and A2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes.

Br J Pharmacol 2002 Jun;136(3):434-40

Dipartimento di Medicina Sperimentale, Sezione di Farmacologia e Tossicologia, Università di Genova, Viale Cembrano 4, 16148 Genova, Italy.

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http://dx.doi.org/10.1038/sj.bjp.0704712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573357PMC
June 2002

Up-regulation of ORL-1 receptors in spinal tissue of allodynic rats after sciatic nerve injury.

Eur J Pharmacol 2002 Jun;447(1):59-65

Schering-Plough Research Institute, San Raffaele Science Park, Via Olgettina, 58, 20132-, Milan, Italy.

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http://dx.doi.org/10.1016/s0014-2999(02)01833-2DOI Listing
June 2002

Nitric oxide-releasing drugs: a novel class of effective and safe therapeutic agents.

Ann N Y Acad Sci 2002 May;962:360-71

NicOx SA, Espace Gaia II - Bâtiment I BP 313, Sophia Antipolis, France.

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http://dx.doi.org/10.1111/j.1749-6632.2002.tb04080.xDOI Listing
May 2002

Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors.

J Neurosci 2002 Feb;22(3):1054-62

Molecular Neurobiology Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02129, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758487PMC
February 2002