Publications by authors named "Eng-Huat Tan"

97 Publications

A phase II study of nimotuzumab (TheraCim-hR3) concurrent with cisplatin/radiotherapy in patients with locally advanced head and neck squamous cell carcinoma.

Authors:
Mei-Kim Ang Jose Enrique Montoya Ekkasit Tharavichitkul Cindy Lim Terence Tan Lan Ying Wang Joseph Wee Yoke-Lim Soong Kam-Weng Fong Quan Sing Ng Daniel Shao-Weng Tan Chee-Keong Toh Eng-Huat Tan Wan-Teck Lim

Head Neck 2021 Feb 5. Epub 2021 Feb 5.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore.

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February 2021

Characteristics and Outcomes of Airway Involvement in Esophageal Cancer.

Authors:
Ken Junyang Goh Pyng Lee Andrea Zhi Xin Foo Eng Huat Tan Hock Soo Ong Anne Ann Ling Hsu

Ann Thorac Surg 2020 Nov 5. Epub 2020 Nov 5.

Department of Respiratory and Critical Care Medicine, Singapore General Hospital.

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November 2020

Immune checkpoint inhibitor-associated myositis and myasthenia gravis overlap: Understanding the diversity in a case series.

Authors:
Evelyn Yi Ting Wong Ming Hui Yong Kok Pin Yong Eng Huat Tan Chee Keong Toh Ravindran Kanesvaran Angela Takano Quan Sing Ng

Asia Pac J Clin Oncol 2020 Sep 27. Epub 2020 Sep 27.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore.

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September 2020

Molecular Characterization and Clinical Outcomes in RET-Rearranged NSCLC.

Authors:
Aaron C Tan Amanda O L Seet Gillianne G Y Lai Tse Hui Lim Alvin S T Lim Gek San Tan Angela Takano David W M Tai Tira J Y Tan Justina Y C Lam Matthew C H Ng Wan Ling Tan Mei-Kim Ang Ravindran Kanesvaran Quan Sing Ng Amit Jain Tanujaa Rajasekaran Wan-Teck Lim Eng-Huat Tan Tony Kiat Hon Lim Daniel S W Tan

J Thorac Oncol 2020 12 28;15(12):1928-1934. Epub 2020 Aug 28.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore. Electronic address:

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December 2020

Genomic landscape of lung adenocarcinoma in East Asians.

Authors:
Jianbin Chen Hechuan Yang Audrey Su Min Teo Lidyana Bte Amer Faranak Ghazi Sherbaf Chu Quan Tan Jacob Josiah Santiago Alvarez Bingxin Lu Jia Qi Lim Angela Takano Rahul Nahar Yin Yeng Lee Cheryl Zi Jin Phua Khi Pin Chua Lisda Suteja Pauline Jieqi Chen Mei Mei Chang Tina Puay Theng Koh Boon-Hean Ong Devanand Anantham Anne Ann Ling Hsu Apoorva Gogna Chow Wei Too Zaw Win Aung Yi Fei Lee Lanying Wang Tony Kiat Hon Lim Andreas Wilm Poh Sum Choi Poh Yong Ng Chee Keong Toh Wan-Teck Lim Siming Ma Bing Lim Jin Liu Wai Leong Tam Anders Jacobsen Skanderup Joe Poh Sheng Yeong Eng-Huat Tan Caretha L Creasy Daniel Shao Weng Tan Axel M Hillmer Weiwei Zhai

Nat Genet 2020 02 3;52(2):177-186. Epub 2020 Feb 3.

Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

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February 2020

Utility of incorporating next-generation sequencing (NGS) in an Asian non-small cell lung cancer (NSCLC) population: Incremental yield of actionable alterations and cost-effectiveness analysis.

Authors:
Aaron C Tan Gillianne G Y Lai Gek San Tan Shou Yu Poon Brett Doble Tse Hui Lim Zaw Win Aung Angela Takano Wan Ling Tan Mei-Kim Ang Bien Soo Tan Anantham Devanand Chow Wei Too Apoorva Gogna Boon-Hean Ong Tina P T Koh Ravindran Kanesvaran Quan Sing Ng Amit Jain Tanujaa Rajasekaran Alvin S T Lim Wan Teck Lim Chee Keong Toh Eng-Huat Tan Tony Kiat Hon Lim Daniel S W Tan

Lung Cancer 2020 01 26;139:207-215. Epub 2019 Nov 26.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore. Electronic address:

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January 2020

Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC).

Authors:
Pei Yuan Fong Sze Huey Tan Darren Wan Teck Lim Eng Huat Tan Quan Sing Ng Kiattisa Sommat Daniel Shao Weng Tan Mei Kim Ang

PLoS One 2019 20;14(11):e0224665. Epub 2019 Nov 20.

Division of Medical Oncology, National Cancer Centre, Singapore.

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April 2020

Phase II study of CC-486 (oral azacitidine) in previously treated patients with locally advanced or metastatic nasopharyngeal carcinoma.

Authors:
Ricard Mesia Paolo Bossi Aaron R Hansen Ching-Yun Hsieh Lisa F Licitra Eng-Huat Tan Peng Chen JulieAnn Miller Lilian L Siu Robert I Haddad

Eur J Cancer 2019 12 4;123:138-145. Epub 2019 Nov 4.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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December 2019

Publisher Correction: Methionine is a metabolic dependency of tumor-initiating cells.

Authors:
Zhenxun Wang Lian Yee Yip Jia Hui Jane Lee Zhengwei Wu Hui Yi Chew Pooi Kiat William Chong Chin Chye Teo Heather Yin-Kuan Ang Kai Lay Esther Peh Ju Yuan Siming Ma Li Shi Kimberly Choo Nurhidayah Basri Xia Jiang Qiang Yu Axel M Hillmer Wan Teck Lim Tony Kiat Hon Lim Angela Takano Eng Huat Tan Daniel Shao Weng Tan Ying Swan Ho Bing Lim Wai Leong Tam

Nat Med 2019 Jun;25(6):1022

Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

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June 2019

Sequencing of therapy following first-line afatinib in patients with EGFR mutation-positive non-small cell lung cancer.

Authors:
Keunchil Park Jaafar Bennouna Michael Boyer Toyoaki Hida Vera Hirsh Terufumi Kato Shun Lu Tony Mok Kazuhiko Nakagawa Kenneth O'Byrne Luis Paz-Ares Martin Schuler Denis Moro Sibilot Eng-Huat Tan Hiroshi Tanaka Yi-Long Wu James C-H Yang Li Zhang Caicun Zhou Angela Märten Wenbo Tang Nobuyuki Yamamoto

Lung Cancer 2019 06 10;132:126-131. Epub 2019 Apr 10.

Internal Medicine III, Wakayama Medical University, 811-1 Kimiidera, Wakayama-shi, Wakayama-ken, 641-8509, Japan. Electronic address:

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June 2019

Methionine is a metabolic dependency of tumor-initiating cells.

Authors:
Zhenxun Wang Lian Yee Yip Jia Hui Jane Lee Zhengwei Wu Hui Yi Chew Pooi Kiat William Chong Chin Chye Teo Heather Yin-Kuan Ang Kai Lay Esther Peh Ju Yuan Siming Ma Li Shi Kimberly Choo Nurhidayah Basri Xia Jiang Qiang Yu Axel M Hillmer Wan Teck Lim Tony Kiat Hon Lim Angela Takano Eng Huat Tan Daniel Shao Weng Tan Ying Swan Ho Bing Lim Wai Leong Tam

Nat Med 2019 05 6;25(5):825-837. Epub 2019 May 6.

Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

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May 2019

First-line afatinib vs gefitinib for patients with EGFR mutation-positive NSCLC (LUX-Lung 7): impact of afatinib dose adjustment and analysis of mode of initial progression for patients who continued treatment beyond progression.

Authors:
Martin Schuler Eng-Huat Tan Kenneth O'Byrne Li Zhang Michael Boyer Tony Mok Vera Hirsh James Chih-Hsin Yang Ki Hyeong Lee Shun Lu Yuankai Shi Sang-We Kim Janessa Laskin Dong-Wan Kim Catherine Dubos Arvis Karl Kölbeck Dan Massey Angela Märten Luis Paz-Ares Keunchil Park

J Cancer Res Clin Oncol 2019 Jun 19;145(6):1569-1579. Epub 2019 Feb 19.

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon- dong, Gangnam-gu, Seoul, 135-710, South Korea.

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June 2019

Clonal MET Amplification as a Determinant of Tyrosine Kinase Inhibitor Resistance in Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer.

Authors:
Gillianne G Y Lai Tse Hui Lim John Lim Perry J R Liew Xue Lin Kwang Rahul Nahar Zaw Win Aung Angela Takano Yin Yeng Lee Dawn P X Lau Gek San Tan Sze Huey Tan Wan Ling Tan Mei-Kim Ang Chee Keong Toh Bien Soo Tan Anantham Devanand Chow Wei Too Apoorva Gogna Boon Hean Ong Tina P T Koh Ravindran Kanesvaran Quan Sing Ng Amit Jain Tanujaa Rajasekaran Ju Yuan Tony Kiat Hon Lim Alvin S T Lim Axel M Hillmer Wan Teck Lim N Gopalakrishna Iyer Wai Leong Tam Weiwei Zhai Eng-Huat Tan Daniel S W Tan

J Clin Oncol 2019 04 24;37(11):876-884. Epub 2019 Jan 24.

1 National Cancer Centre Singapore, Singapore.

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April 2019

Impact of afatinib dose modification on safety and effectiveness in patients with EGFR mutation-positive advanced NSCLC: Results from a global real-world study (RealGiDo).

Authors:
Balazs Halmos Eng-Huat Tan Ross A Soo Jacques Cadranel Min Ki Lee Pascal Foucher Te-Chun Hsia Maximilian Hochmair Frank Griesinger Toyoaki Hida Edward Kim Barbara Melosky Angela Märten Enric Carcereny

Lung Cancer 2019 01 2;127:103-111. Epub 2018 Nov 2.

Department of Medical Oncology, Catalan Institute of Oncology Badalona, Hospital Germans Trias i Pujol, Badalona, Spain. Electronic address:

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January 2019

Correction to: Influence of afatinib dose on outcomes of advanced EGFR-mutant NSCLC patients with brain metastases.

Authors:
Wan-Ling Tan Quan Sing Ng Cindy Lim Eng Huat Tan Chee Keong Toh Mei-Kim Ang Ravindran Kanesvaran Amit Jain Daniel S W Tan Darren Wan-Teck Lim

BMC Cancer 2018 12 24;18(1):1288. Epub 2018 Dec 24.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.

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December 2018

Influence of afatinib dose on outcomes of advanced EGFR-mutant NSCLC patients with brain metastases.

Authors:
Wan-Ling Tan Quan Sing Ng Cindy Lim Eng Huat Tan Chee Keong Toh Mei-Kim Ang Ravindran Kanesvaran Amit Jain Daniel S W Tan Darren Wan-Teck Lim

BMC Cancer 2018 Dec 3;18(1):1198. Epub 2018 Dec 3.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.

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December 2018

Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study.

Authors:
Benjamin J Solomon Benjamin Besse Todd M Bauer Enriqueta Felip Ross A Soo D Ross Camidge Rita Chiari Alessandra Bearz Chia-Chi Lin Shirish M Gadgeel Gregory J Riely Eng Huat Tan Takashi Seto Leonard P James Jill S Clancy Antonello Abbattista Jean-François Martini Joseph Chen Gerson Peltz Holger Thurm Sai-Hong Ignatius Ou Alice T Shaw

Lancet Oncol 2018 12 6;19(12):1654-1667. Epub 2018 Nov 6.

Massachusetts General Hospital, Boston, MA, USA.

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December 2018

Concurrent-Adjuvant Chemoradiation Therapy for Stage III-IVB Nasopharyngeal Carcinoma-Exploration for Achieving Optimal 10-Year Therapeutic Ratio.

Authors:
Wai-Tong Ng Stewart Y Tung Victor Lee Roger K C Ngan Horace C W Choi Lucy L K Chan To-Wai Leung Lillian L Siu Tai-Xiang Lu Terence Tan Eng-Huat Tan Henry C K Sze Alice W Y Ng Harry H Y Yiu Brian O'Sullivan Rick Chappell Anne W M Lee

Int J Radiat Oncol Biol Phys 2018 08 2;101(5):1078-1086. Epub 2018 May 2.

Departments of Clinical Oncology, The University of Hong Kong and the University of Hong Kong-Shenzhen Hospital, Hong Kong, China. Electronic address:

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August 2018

Bystander CD8 T cells are abundant and phenotypically distinct in human tumour infiltrates.

Authors:
Yannick Simoni Etienne Becht Michael Fehlings Chiew Yee Loh Si-Lin Koo Karen Wei Weng Teng Joe Poh Sheng Yeong Rahul Nahar Tong Zhang Hassen Kared Kaibo Duan Nicholas Ang Michael Poidinger Yin Yeng Lee Anis Larbi Alexis J Khng Emile Tan Cherylin Fu Ronnie Mathew Melissa Teo Wan Teck Lim Chee Keong Toh Boon-Hean Ong Tina Koh Axel M Hillmer Angela Takano Tony Kiat Hon Lim Eng Huat Tan Weiwei Zhai Daniel S W Tan Iain Beehuat Tan Evan W Newell

Nature 2018 05 16;557(7706):575-579. Epub 2018 May 16.

Agency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore, Singapore.

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May 2018

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency.

Authors:
Yannick Simoni Michael Fehlings Henrik N Kløverpris Naomi McGovern Si-Lin Koo Chiew Yee Loh Shawn Lim Ayako Kurioka Joannah R Fergusson Choong-Leong Tang Ming Hian Kam Koh Dennis Tony Kiat Hon Lim Alexander Chung Yaw Fui Chan Weng Hoong Jerry Kok Yen Chan Maria Curotto de Lafaille Sriram Narayanan Sonia Baig Muhammad Shabeer Sue-Anne Ee Shiow Toh Henry Kun Kiaang Tan Rosslyn Anicete Eng-Huat Tan Angela Takano Paul Klenerman Alasdair Leslie Daniel S W Tan Iain Beehuat Tan Florent Ginhoux Evan W Newell

Immunity 2018 05;48(5):1060

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May 2018

Afatinib as First-line Treatment of Older Patients With EGFR Mutation-Positive Non-Small-Cell Lung Cancer: Subgroup Analyses of the LUX-Lung 3, LUX-Lung 6, and LUX-Lung 7 Trials.

Authors:
Yi-Long Wu Lecia V Sequist Eng-Huat Tan Sarayut L Geater Sergey Orlov Li Zhang Ki Hyeong Lee Chun-Ming Tsai Terufumi Kato Carlos H Barrios Martin Schuler Vera Hirsh Nobuyuki Yamamoto Kenneth O'Byrne Michael Boyer Tony Mok Barbara Peil Angela Märten James Chih-Hsin Yang Luis Paz-Ares Keunchil Park

Clin Lung Cancer 2018 07 17;19(4):e465-e479. Epub 2018 Mar 17.

Division of Hematology/Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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July 2018

A Decade of Never-smokers Among Lung Cancer Patients-Increasing Trend and Improved Survival.

Authors:
Chee-Keong Toh Whee-Sze Ong Wan-Teck Lim Daniel Shao-Weng Tan Quan-Sing Ng Ravindran Kanesvaran Wei-Jie Seow Mei-Kim Ang Eng-Huat Tan

Clin Lung Cancer 2018 09 17;19(5):e539-e550. Epub 2018 Mar 17.

Division of Medical Oncology, National Cancer Centre, Singapore.

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September 2018

Phase 1b Trial of Ficlatuzumab, a Humanized Hepatocyte Growth Factor Inhibitory Monoclonal Antibody, in Combination With Gefitinib in Asian Patients With NSCLC.

Authors:
Eng-Huat Tan Wan-Teck Lim Myung-Ju Ahn Quan-Sing Ng Jin Seok Ahn Daniel Shao-Weng Tan Jong-Mu Sun May Han Francis C Payumo Krista McKee Wei Yin Marc Credi Shefali Agarwal Jaroslaw Jac Keunchil Park

Clin Pharmacol Drug Dev 2018 06 18;7(5):532-542. Epub 2018 Jan 18.

Division of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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June 2018

Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing.

Authors:
Rahul Nahar Weiwei Zhai Tong Zhang Angela Takano Alexis J Khng Yin Yeng Lee Xingliang Liu Chong Hee Lim Tina P T Koh Zaw Win Aung Tony Kiat Hon Lim Lavanya Veeravalli Ju Yuan Audrey S M Teo Cheryl X Chan Huay Mei Poh Ivan M L Chua Audrey Ann Liew Dawn Ping Xi Lau Xue Lin Kwang Chee Keong Toh Wan-Teck Lim Bing Lim Wai Leong Tam Eng-Huat Tan Axel M Hillmer Daniel S W Tan

Nat Commun 2018 01 15;9(1):216. Epub 2018 Jan 15.

Cancer Stem Cell Biology, Genome Institute of Singapore, Singapore, 138672, Singapore.

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January 2018

Improved Survival of Advanced Lung Cancer in Singapore Over the Past Decade.

Authors:
Chee Keong Toh Whee Sze Ong Daniel Sw Tan Quan Sing Ng Ravindran Kanesvaran Kam Weng Fong Mei Kim Ang Eng Huat Tan Wan Teck Lim

Ann Acad Med Singap 2017 Sep;46(9):333-338

Division of Medical Oncology, National Cancer Centre, Singapore, Singapore.

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September 2017

Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma.

Authors:
Daniel S W Tan Fui Teen Chong Hui Sun Leong Shen Yon Toh Dawn P Lau Xue Lin Kwang Xiaoqian Zhang Gopinath M Sundaram Gek San Tan Mei Mei Chang Boon Tin Chua Wan Teck Lim Eng Huat Tan Mei Kim Ang Tony K H Lim Prabha Sampath Balram Chowbay Anders J Skanderup Ramanuj DasGupta N Gopalakrishna Iyer

Nat Med 2017 Oct 18;23(10):1167-1175. Epub 2017 Sep 18.

Cancer Therapeutics Research Laboratory, National Cancer Centre Singapore, Singapore.

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October 2017

Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib.

Authors:
Srinivasaraghavan Kannan Mohan R Pradhan Garima Tiwari Wei-Chong Tan Balram Chowbay Eng Huat Tan Daniel Shao-Weng Tan Chandra Verma

Sci Rep 2017 05 8;7(1):1540. Epub 2017 May 8.

Bioinformatics Institute (A*STAR), 30 Biopolis Street, 07-01 matrix, Singapore, 138671, Singapore.

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May 2017

A systematic review and meta-analysis of individual patient data on the impact of the BIM deletion polymorphism on treatment outcomes in epidermal growth factor receptor mutant lung cancer.

Authors:
Sheila X Soh Fahad J Siddiqui John C Allen Go Woon Kim Jae Cheol Lee Yasushi Yatabe Manabu Soda Hiroyuki Mano Ross A Soo Tan-Min Chin Hiromichi Ebi Seiji Yano Keitaro Matsuo Xiaomin Niu Shun Lu Kazutoshi Isobe Jih-Hsiang Lee James C Yang Mingchuan Zhao Caicun Zhou June-Koo Lee Se-Hoon Lee Ji Yun Lee Myung-Ju Ahn Tira J Tan Daniel S Tan Eng-Huat Tan S Tiong Ong Wan-Teck Lim

Oncotarget 2017 Jun;8(25):41474-41486

Division of Medical Oncology, National Cancer Centre, Singapore.

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June 2017

Management of epidermal growth factor receptor tyrosine kinase inhibitor-related cutaneous and gastrointestinal toxicities.

Authors:
Derrick Chen-Wee Aw Eng Huat Tan Tan Min Chin Hong Liang Lim Haur Yueh Lee Ross A Soo

Asia Pac J Clin Oncol 2018 Feb 2;14(1):23-31. Epub 2017 May 2.

Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore.

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February 2018

Influence of the KDM4A rs586339 polymorphism on overall survival in Asian non-small-cell lung cancer patients.

Authors:
Charlie Marvalim Jing Xiang Gimson Wong Natalia Sutiman Wan Teck Lim Shao Weng Tan Ravindran Kanesvaran Quan Sing Ng Amit Jain Mei Kim Ang Wan Ling Tan Chee Keong Toh Eng Huat Tan Balram Chowbay

Pharmacogenet Genomics 2017 03;27(3):120-123

aLaboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research bNational Cancer Centre, Division of Medical Oncology cClinical Pharmacology, SingHealth dDepartment of Clinical Sciences, Duke-NUS Medical School, Singapore.

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March 2017