Emmett V Schmidt

Emmett V Schmidt

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Emmett V Schmidt

Emmett V Schmidt

Publications by authors named "Emmett V Schmidt"

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Developing combination strategies using PD-1 checkpoint inhibitors to treat cancer.

Authors:
Emmett V Schmidt

Semin Immunopathol 2019 01 29;41(1):21-30. Epub 2018 Oct 29.

Merck & Co., Inc., Kenilworth, NJ, USA.

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http://link.springer.com/10.1007/s00281-018-0714-9
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http://dx.doi.org/10.1007/s00281-018-0714-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323091PMC
January 2019

Epacadostat Plus Pembrolizumab in Patients With Advanced Solid Tumors: Phase I Results From a Multicenter, Open-Label Phase I/II Trial (ECHO-202/KEYNOTE-037).

J Clin Oncol 2018 Sep 28:JCO2018789602. Epub 2018 Sep 28.

Tara C. Mitchell, University of Pennsylvania; Anthony J. Olszanski, Fox Chase Cancer Center, Philadelphia, PA; Omid Hamid and Ani S. Balmanoukian, The Angeles Clinic and Research Institute, Los Angeles, CA; David C. Smith, University of Michigan, Ann Arbor, MI; Todd M. Bauer, Tennessee Oncology, Nashville, TN; Jeffrey S. Wasser, University of Connecticut School of Medicine, Farmington, CT; Jason J. Luke and Thomas F. Gajewski, University of Chicago Medicine, Chicago, IL; Emmett V. Schmidt, Merck & Co, Kenilworth, NJ; and Yufan Zhao, Xiaohua Gong, Janet Maleski, and Lance Leopold, Incyte Corporation, Wilmington, DE.

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http://dx.doi.org/10.1200/JCO.2018.78.9602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225502PMC
September 2018

Transposon activation mutagenesis as a screening tool for identifying resistance to cancer therapeutics.

BMC Cancer 2013 Feb 27;13:93. Epub 2013 Feb 27.

Center for Molecular Therapeutics, Center for Cancer Research, Massachusetts General Hospital, and Harvard Medical School, CNY 149-Rm7308, Thirteenth St. Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1186/1471-2407-13-93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598783PMC
February 2013

Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin.

Biochem Pharmacol 2011 Feb 28;81(3):388-95. Epub 2010 Oct 28.

Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.bcp.2010.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053085PMC
February 2011

High-dose mannose-binding lectin therapy for Ebola virus infection.

J Infect Dis 2011 Jan;203(2):175-9

Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1093/infdis/jiq025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071052PMC
January 2011

Genome-wide analysis of YY2 versus YY1 target genes.

Nucleic Acids Res 2010 Jul 9;38(12):4011-26. Epub 2010 Mar 9.

Cancer Research Center at Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1093/nar/gkq112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896514PMC
July 2010

Cyclin D1 enhances the response to estrogen and progesterone by regulating progesterone receptor expression.

Mol Cell Biol 2010 Jun 19;30(12):3111-25. Epub 2010 Apr 19.

Cancer Research Center at Massachusetts General Hospital, 55 Fruit Street, GRJ 9th floor, Boston, MA 02114, USA.

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http://dx.doi.org/10.1128/MCB.01398-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876668PMC
June 2010

Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway.

Cell Cycle 2009 May 18;8(9):1344-51. Epub 2009 May 18.

Cancer Research Center at Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865178PMC
http://dx.doi.org/10.4161/cc.8.9.8215DOI Listing
May 2009

c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation.

Cancer Res 2007 Dec;67(23):11209-17

Cancer Research Center at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022657PMC
December 2007

Heat shock protein B8, a cyclin-dependent kinase-independent cyclin D1 target gene, contributes to its effects on radiation sensitivity.

Cancer Res 2007 Nov;67(22):10774-81

Oxford Cancer Centre, Department of Radiotherapy, Churchill Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1475DOI Listing
November 2007

Identification of cyclin D1- and estrogen-regulated genes contributing to breast carcinogenesis and progression.

Cancer Res 2006 Dec;66(24):11649-58

Massachusetts General Hospital Cancer Research Center, Massachusetts General Hospital Cancer Center--Harvard University, 55 Fruit Street, GRJ 904, Boston, MA 02114, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1645DOI Listing
December 2006

Cell-based models of sustained, interferon-sensitive hepatitis C virus genotype 1 replication.

J Virol Methods 2006 Mar 28;132(1-2):195-203. Epub 2005 Nov 28.

Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, GRJ 816, 55 Fruit Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.jviromet.2005.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865175PMC
March 2006

Apoptosis of activated CD4+ and CD8+ T cells is enhanced by co-culture with hepatocytes expressing hepatitis C virus (HCV) structural proteins through FasL induction.

Virology 2006 Mar 5;346(2):363-72. Epub 2005 Dec 5.

Division of Infectious Disease, Beth Israel Deaconess Hospital, HIM 223a, 330 Brookline Ave., Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.virol.2005.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865190PMC
March 2006

Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant.

Cancer Res 2006 Feb;66(4):1923-8

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865171PMC
February 2006

Hepatitis C virus expression suppresses interferon signaling by degrading STAT1.

Gastroenterology 2005 Apr;128(4):1034-41

Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1053/j.gastro.2005.02.006DOI Listing
April 2005

Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis.

Hepatology 2005 Mar;41(3):660-7

Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/hep.20621DOI Listing
March 2005

The role of c-myc in regulation of translation initiation.

Authors:
Emmett V Schmidt

Oncogene 2004 Apr;23(18):3217-21

Cancer Research Center at Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/sj.onc.1207548DOI Listing
April 2004

The role of the cyclin D1-dependent kinases in ErbB2-mediated breast cancer.

Am J Pathol 2004 Mar;164(3):1031-8

Massachusetts General Hospital (MGH) Cancer Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1614725PMC
http://dx.doi.org/10.1016/S0002-9440(10)63190-2DOI Listing
March 2004

Activated eIF4E-binding protein slows G1 progression and blocks transformation by c-myc without inhibiting cell growth.

J Biol Chem 2004 Jan 7;279(5):3327-39. Epub 2003 Nov 7.

Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M310872200
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http://dx.doi.org/10.1074/jbc.M310872200DOI Listing
January 2004

Protein kinase R is increased and is functional in hepatitis C virus-related hepatocellular carcinoma.

Am J Gastroenterol 2003 Nov;98(11):2528-34

Gastrointestinal Unit, Cancer Center and Hospital for Children, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1111/j.1572-0241.2003.08663.xDOI Listing
November 2003

Forced expression of cyclin D1 does not compensate for Id2 deficiency in the mammary gland.

FEBS Lett 2003 Sep;551(1-3):123-7

Department of Biochemistry, Fukui Medical University, 23-3 Shimoaizuki, Matsuoka, 910-1193 Fukui, Japan.

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http://dx.doi.org/10.1016/s0014-5793(03)00906-2DOI Listing
September 2003

Epidermal growth factor receptor expression is a candidate target of the synergistic combination of trastuzumab and flavopiridol in breast cancer.

Cancer Res 2003 Jul;63(13):3626-31

Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA.

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July 2003

Genes involved in breast cancer progression: analysis of global changes in gene expression or retroviral tagging?

Authors:
Emmett V Schmidt

Am J Pathol 2002 Dec;161(6):1973-7

Massachusetts General Hospital Cancer Center, Building 149, 7th Floor, 13th Street, Charlestown, MA 02129, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850906PMC
http://dx.doi.org/10.1016/S0002-9440(10)64473-2DOI Listing
December 2002

Viral RNA mutations are region specific and increased by ribavirin in a full-length hepatitis C virus replication system.

J Virol 2002 Sep;76(17):8505-17

Gastrointestinal Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136407PMC
http://dx.doi.org/10.1128/jvi.76.17.8505-8517.2002DOI Listing
September 2002

Activation of different Wnt/beta-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors.

Oncogene 2002 Aug;21(36):5548-56

Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, MD 20892, USA.

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http://dx.doi.org/10.1038/sj.onc.1205686DOI Listing
August 2002

Rate-limiting effects of Cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol.

Cancer Res 2002 Apr;62(8):2267-71

Laboratory of Tumor Biology, Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA.

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April 2002