Publications Authored by Emmanuelle Bouzigon

Genome-wide interaction study of early-life smoking exposure on time-to-asthma onset in childhood.

Authors:

Pierre-Emmanuel Sugier Chloé Sarnowski Raquel Granell Catherine Laprise Markus J Ege Patricia Margaritte-Jeannin Marie-Hélène Dizier Cosetta Minelli Miriam F Moffatt Mark Lathrop William O C M Cookson A John Henderson Erika von Mutius Manolis Kogevinas Florence Demenais Emmanuelle Bouzigon

Clin Exp Allergy 2019 Oct;49(10):1342-1351

Genetic Epidemiology and Functional Genomics of Multifactorial Diseases Team, Inserm, UMRS-1124, Université Paris Descartes, Paris, France.

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http://dx.doi.org/10.1111/cea.13476	DOI Listing

October 2019

Asthma heterogeneity: the increasing genetic evidence.

Authors:

Valérie Siroux Emmanuelle Bouzigon

Lancet Respir Med 2019 Jun 27;7(6):469-471. Epub 2019 Apr 27.

INSERM UMRS 1124, Team of Genetic Epidemiology and Functional Genomics of Multifactorial Diseases, University Paris Descartes, Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S22132600193004	Publisher Site
http://dx.doi.org/10.1016/S2213-2600(19)30047-5	DOI Listing

June 2019

Correction to: Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome.

Genome Biol 2019 05 7;20(1):89. Epub 2019 May 7.

Department of Human Genetics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1186/s13059-019-1702-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503438	PMC

May 2019

Interactive effect between ATPase-related genes and early-life tobacco smoke exposure on bronchial hyper-responsiveness detected in asthma-ascertained families.

Authors:

Marie-Hélène Dizier Patricia Margaritte-Jeannin Lucile Pain Chloé Sarnowski Myriam Brossard Hamida Mohamdi Nolwenn Lavielle Marie-Claude C Babron Jocelyne Just Mark Lathrop Catherine Laprise Emmanuelle Bouzigon Florence Demenais Rachel Nadif

Thorax 2019 03 3;74(3):254-260. Epub 2018 Oct 3.

Aging and Chronic Diseases-Epidemiological and Public Health Approaches (VIMA), Inserm, U1168, Villejuif, France.

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http://dx.doi.org/10.1136/thoraxjnl-2018-211797	DOI Listing

March 2019

A novel role for ciliary function in atopy: ADGRV1 and DNAH5 interactions.

Authors:

Pierre-Emmanuel Sugier Myriam Brossard Chloé Sarnowski Amaury Vaysse Andréanne Morin Lucile Pain Patricia Margaritte-Jeannin Marie-Hélène Dizier William O C M Cookson Mark Lathrop Miriam F Moffatt Catherine Laprise Florence Demenais Emmanuelle Bouzigon

J Allergy Clin Immunol 2018 05 18;141(5):1659-1667.e11. Epub 2017 Sep 18.

Genetic Variation and Human Diseases Unit, INSERM, Université Paris Diderot, Université Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1016/j.jaci.2017.06.050	DOI Listing

May 2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Authors:

Florence Demenais Patricia Margaritte-Jeannin Kathleen C Barnes William O C Cookson Janine Altmüller Wei Ang R Graham Barr Terri H Beaty Allan B Becker John Beilby Hans Bisgaard Unnur Steina Bjornsdottir Eugene Bleecker Klaus Bønnelykke Dorret I Boomsma Emmanuelle Bouzigon Christopher E Brightling Myriam Brossard Guy G Brusselle Esteban Burchard Kristin M Burkart Andrew Bush Moira Chan-Yeung Kian Fan Chung Alexessander Couto Alves John A Curtin Adnan Custovic Denise Daley Johan C de Jongste Blanca E Del-Rio-Navarro Kathleen M Donohue Liesbeth Duijts Celeste Eng Johan G Eriksson Martin Farrall Yuliya Fedorova Bjarke Feenstra Manuel A Ferreira Maxim B Freidin Zofia Gajdos Jim Gauderman Ulrike Gehring Frank Geller Jon Genuneit Sina A Gharib Frank Gilliland Raquel Granell Penelope E Graves Daniel F Gudbjartsson Tari Haahtela Susan R Heckbert Dick Heederik Joachim Heinrich Markku Heliövaara John Henderson Blanca E Himes Hiroshi Hirose Joel N Hirschhorn Albert Hofman Patrick Holt Jouke Hottenga Thomas J Hudson Jennie Hui Medea Imboden Vladimir Ivanov Vincent W V Jaddoe Alan James Christer Janson Marjo-Riitta Jarvelin Deborah Jarvis Graham Jones Ingileif Jonsdottir Pekka Jousilahti Michael Kabesch Mika Kähönen David B Kantor Alexandra S Karunas Elza Khusnutdinova Gerard H Koppelman Anita L Kozyrskyj Eskil Kreiner Michiaki Kubo Rajesh Kumar Ashish Kumar Mikko Kuokkanen Lies Lahousse Tarja Laitinen Catherine Laprise Mark Lathrop Susanne Lau Young-Ae Lee Terho Lehtimäki Sébastien Letort Albert M Levin Guo Li Liming Liang Laura R Loehr Stephanie J London Daan W Loth Ani Manichaikul Ingo Marenholz Fernando J Martinez Melanie C Matheson Rasika A Mathias Kenji Matsumoto Hamdi Mbarek Wendy L McArdle Mads Melbye Erik Melén Deborah Meyers Sven Michel Hamida Mohamdi Arthur W Musk Rachel A Myers Maartje A E Nieuwenhuis Emiko Noguchi George T O'Connor Ludmila M Ogorodova Cameron D Palmer Aarno Palotie Julie E Park Craig E Pennell Göran Pershagen Alexey Polonikov Dirkje S Postma Nicole Probst-Hensch Valery P Puzyrev Benjamin A Raby Olli T Raitakari Adaikalavan Ramasamy Stephen S Rich Colin F Robertson Isabelle Romieu Muhammad T Salam Veikko Salomaa Vivi Schlünssen Robert Scott Polina A Selivanova Torben Sigsgaard Angela Simpson Valérie Siroux Lewis J Smith Maria Solodilova Marie Standl Kari Stefansson David P Strachan Bruno H Stricker Atsushi Takahashi Philip J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Carla M T Tiesler Dara G Torgerson Tatsuhiko Tsunoda André G Uitterlinden Ralf J P van der Valk Amaury Vaysse Sailaja Vedantam Andrea von Berg Erika von Mutius Judith M Vonk Johannes Waage Nick J Wareham Scott T Weiss Wendy B White Magnus Wickman Elisabeth Widén Gonneke Willemsen L Keoki Williams Inge M Wouters James J Yang Jing Hua Zhao Miriam F Moffatt Carole Ober Dan L Nicolae

Nat Genet 2018 01 22;50(1):42-53. Epub 2017 Dec 22.

Departments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.

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http://www.nature.com/articles/s41588-017-0014-7	Publisher Site
http://dx.doi.org/10.1038/s41588-017-0014-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901974	PMC

January 2018

SigMod: an exact and efficient method to identify a strongly interconnected disease-associated module in a gene network.

Authors:

Yuanlong Liu Myriam Brossard Damian Roqueiro Patricia Margaritte-Jeannin Chloé Sarnowski Emmanuelle Bouzigon Florence Demenais

Bioinformatics 2017 May;33(10):1536-1544

INSERM, Genetic Variation and Human Diseases Unit, UMR-946, Paris, France.

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http://dx.doi.org/10.1093/bioinformatics/btx004	DOI Listing

May 2017

Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study.

Authors:

Despoina Manousaki Lavinia Paternoster Marie Standl Miriam F Moffatt Martin Farrall Emmanuelle Bouzigon David P Strachan Florence Demenais Mark Lathrop William O C M Cookson J Brent Richards

PLoS Med 2017 05 9;14(5):e1002294. Epub 2017 May 9.

Centre for Clinical Epidemiology, Department of Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal, Canada.

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http://dx.doi.org/10.1371/journal.pmed.1002294	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423551	PMC

May 2017

Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome.

Genome Biol 2017 03 10;18(1):50. Epub 2017 Mar 10.

Department of Human Genetics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1186/s13059-017-1173-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346261	PMC

March 2017

Genes Interacting with Occupational Exposures to Low Molecular Weight Agents and Irritants on Adult-Onset Asthma in Three European Studies.

Authors:

Marta Rava Ismail Ahmed Manolis Kogevinas Nicole Le Moual Emmanuelle Bouzigon Ivan Curjuric Marie-Hélène Dizier Orianne Dumas Juan R Gonzalez Medea Imboden Amar J Mehta Pascale Tubert-Bitter Jan-Paul Zock Deborah Jarvis Nicole M Probst-Hensch Florence Demenais Rachel Nadif

Environ Health Perspect 2017 02 9;125(2):207-214. Epub 2016 Aug 9.

Inserm, U1168, VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, Villejuif, France.

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http://dx.doi.org/10.1289/EHP376	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289825	PMC

February 2017

Identification of a new locus at 16q12 associated with time to asthma onset.

J Allergy Clin Immunol 2016 10 6;138(4):1071-1080. Epub 2016 Apr 6.

Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.03.018	DOI Listing

October 2016

DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis.

J Allergy Clin Immunol 2016 09 30;138(3):748-753. Epub 2016 Mar 30.

INSERM, UMR946, Genetic Variation and Human Diseases Unit, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.12.1341	DOI Listing

September 2016

Genes Involved in Interleukin-1 Receptor Type II Activities Are Associated With Asthmatic Phenotypes.

Authors:

Anne Marie Madore Vanessa T Vaillancourt Emmanuelle Bouzigon Chloé Sarnowski Florent Monier Marie Hélène Dizier Florence Demenais Catherine Laprise

Allergy Asthma Immunol Res 2016 Sep;8(5):466-70

Département des sciences fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Canada.

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http://dx.doi.org/10.4168/aair.2016.8.5.466	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921702	PMC

September 2016

Association of Forced Vital Capacity with the Developmental Gene NCOR2.

PLoS One 2016 2;11(2):e0147388. Epub 2016 Feb 2.

Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147388	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737618	PMC

July 2016

Interaction between the DNAH9 gene and early smoke exposure in bronchial hyperresponsiveness.

Authors:

Marie-Hélène Dizier Rachel Nadif Patricia Margaritte-Jeannin Sheila J Barton Chloé Sarnowski Valérie Gagné-Ouellet Myriam Brossard Nolwenn Lavielle Jocelyne Just Mark Lathrop John W Holloway Catherine Laprise Emmanuelle Bouzigon Florence Demenais

Eur Respir J 2016 Apr 21;47(4):1072-81. Epub 2016 Jan 21.

INSERM, UMR 946, Genetic Variation and Human Diseases Unit, Paris, France Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.

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http://dx.doi.org/10.1183/13993003.00849-2015	DOI Listing

April 2016

Meta-analysis identifies seven susceptibility loci involved in the atopic march.

Authors:

Ingo Marenholz Jorge Esparza-Gordillo Franz Rüschendorf Anja Bauerfeind David P Strachan Ben D Spycher Hansjörg Baurecht Patricia Margaritte-Jeannin Annika Sääf Marjan Kerkhof Markus Ege Svetlana Baltic Melanie C Matheson Jin Li Sven Michel Wei Q Ang Wendy McArdle Andreas Arnold Georg Homuth Florence Demenais Emmanuelle Bouzigon Cilla Söderhäll Göran Pershagen Johan C de Jongste Dirkje S Postma Charlotte Braun-Fahrländer Elisabeth Horak Ludmila M Ogorodova Valery P Puzyrev Elena Yu Bragina Thomas J Hudson Charles Morin David L Duffy Guy B Marks Colin F Robertson Grant W Montgomery Bill Musk Philip J Thompson Nicholas G Martin Alan James Patrick Sleiman Elina Toskala Elke Rodriguez Regina Fölster-Holst Andre Franke Wolfgang Lieb Christian Gieger Andrea Heinzmann Ernst Rietschel Thomas Keil Sven Cichon Markus M Nöthen Craig E Pennell Peter D Sly Carsten O Schmidt Anja Matanovic Valentin Schneider Matthias Heinig Norbert Hübner Patrick G Holt Susanne Lau Michael Kabesch Stefan Weidinger Hakon Hakonarson Manuel A R Ferreira Catherine Laprise Maxim B Freidin Jon Genuneit Gerard H Koppelman Erik Melén Marie-Hélène Dizier A John Henderson Young Ae Lee

Nat Commun 2015 Nov 6;6:8804. Epub 2015 Nov 6.

Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.1038/ncomms9804	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667629	PMC

November 2015

Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role?

Eur Respir J 2014 Nov 17;44(5):1234-42. Epub 2014 Jul 17.

For the authors' affiliations see the Acknowledgements section.

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http://dx.doi.org/10.1183/09031936.00068014	DOI Listing

November 2014

Understand the allergic diseases biology using human populations by a transdisciplinary approach.

Authors:

Catherine Laprise Emmanuelle Bouzigon

Curr Opin Allergy Clin Immunol 2014 Oct;14(5):379-80

aDépartement des sciences fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Canada bInserm, UMR-946, F-75010 cUniv Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, F-75007, Paris, France.

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http://dx.doi.org/10.1097/ACI.0000000000000103	DOI Listing

October 2014

The nuclear factor I/A (NFIA) gene is associated with the asthma plus rhinitis phenotype.

Authors:

Marie-Hélène Dizier Patricia Margaritte-Jeannin Anne-Marie Madore Miriam Moffatt Myriam Brossard Nolwenn Lavielle Chloé Sarnowski Jocelyne Just William Cookson Mark Lathrop Catherine Laprise Emmanuelle Bouzigon Florence Demenais

J Allergy Clin Immunol 2014 Sep 20;134(3):576-582.e1. Epub 2014 Feb 20.

INSERM U946, Genetic Variation and Human Diseases Unit, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.

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http://dx.doi.org/10.1016/j.jaci.2013.12.1074	DOI Listing

September 2014

Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.

Authors:

Ralf Jp van der Valk Liesbeth Duijts Nicolas J Timpson Muhammad T Salam Marie Standl John A Curtin Jon Genuneit Marjan Kerhof Eskil Kreiner-Møller Alejandro Cáceres Anna Gref Liming L Liang H Rob Taal Emmanuelle Bouzigon Florence Demenais Rachel Nadif Carole Ober Emma E Thompson Karol Estrada Albert Hofman André G Uitterlinden Cornélia van Duijn Fernando Rivadeneira Xia Li Sandrah P Eckel Kiros Berhane W James Gauderman Raquel Granell David M Evans Beate St Pourcain Wendy McArdle John P Kemp George Davey Smith Carla Mt Tiesler Claudia Flexeder Angela Simpson Clare S Murray Oliver Fuchs Dirkje S Postma Klaus Bønnelykke Maties Torrent Martin Andersson Patrick Sleiman Hakon Hakonarson William O Cookson Miriam F Moffatt Lavinia Paternoster Erik Melén Jordi Sunyer Hans Bisgaard Gerard H Koppelman Markus Ege Adnan Custovic Joachim Heinrich Frank D Gilliland Alexander J Henderson Vincent Wv Jaddoe Johan C de Jongste

J Allergy Clin Immunol 2014 Jul 6;134(1):46-55. Epub 2013 Dec 6.

Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jaci.2013.08.053	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334587	PMC

July 2014

Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure.

Authors:

Salome Scholtens Dirkje S Postma Miriam F Moffatt Sviatlana Panasevich Raquel Granell A John Henderson Erik Melén Fredrik Nyberg Göran Pershagen Deborah Jarvis Adaikalavan Ramasamy Matthias Wjst Cecilie Svanes Emmanuelle Bouzigon Florence Demenais Francine Kauffmann Valérie Siroux Erika von Mutius Markus Johannes Ege Charlotte Braun-Fahrländer Jon Genuneit Bert Brunekreef Henriette A Smit Alet H Wijga Marjan Kerkhof Ivan Curjuric Medea Imboden Gian A Thun Nicole Probst-Hensch Maxim B Freidin Elena Iu Bragina I A Deev V P Puzyrev Denise Daley Julie Park Allan Becker Moira Chan-Yeung Anita L Kozyrskyj Peter Pare Ingo Marenholz Susanne Lau Thomas Keil Young-Ae Lee Michael Kabesch Cisca Wijmenga Lude Franke Ilja M Nolte Judith Vonk Ashish Kumar Martin Farrall William O C M Cookson David P Strachan Gerard H Koppelman H Marike Boezen

J Allergy Clin Immunol 2014 Mar 6;133(3):885-8. Epub 2013 Dec 6.

Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.08.049	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969577	PMC

March 2014

A common 16p11.2 inversion underlies the joint susceptibility to asthma and obesity.

Am J Hum Genet 2014 Mar 20;94(3):361-72. Epub 2014 Feb 20.

Hospital del Mar Research Institute (IMIM), Barcelona 08003, Spain; Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona 08003, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.01.015	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951940	PMC

March 2014

Genetic heterogeneity of asthma phenotypes identified by a clustering approach.

Authors:

Valérie Siroux Juan R González Emmanuelle Bouzigon Ivan Curjuric Anne Boudier Medea Imboden Josep Maria Anto Ivo Gut Deborah Jarvis Mark Lathrop Ernst Reidar Omenaas Isabelle Pin Mathias Wjst Florence Demenais Nicole Probst-Hensch Manolis Kogevinas Francine Kauffmann

Eur Respir J 2014 Feb 5;43(2):439-52. Epub 2013 Dec 5.

Inserm, U823, Grenoble.

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http://erj.ersjournals.com/cgi/doi/10.1183/09031936.00032713	Publisher Site
http://dx.doi.org/10.1183/09031936.00032713	DOI Listing

February 2014

The genetics of asthma and allergic diseases: pieces of the puzzle are starting to come together.

Authors:

Catherine Laprise Emmanuelle Bouzigon

Curr Opin Allergy Clin Immunol 2013 Oct;13(5):461-2

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http://dx.doi.org/10.1097/ACI.0b013e328364ebc3	DOI Listing

October 2013

The role of eosinophils and basophils in allergic diseases considering genetic findings.

Authors:

Rachel Nadif Farid Zerimech Emmanuelle Bouzigon Regis Matran

Curr Opin Allergy Clin Immunol 2013 Oct;13(5):507-13

Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, Villejuif, France.

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http://dx.doi.org/10.1097/ACI.0b013e328364e9c0	DOI Listing

October 2013

Using eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma.

Authors:

Lin Li Michael Kabesch Emmanuelle Bouzigon Florence Demenais Martin Farrall Miriam F Moffatt Xihong Lin Liming Liang

Front Genet 2013 31;4:103. Epub 2013 May 31.

Department of Biostatistics, Harvard School of Public Health Boston, MA, USA.

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http://dx.doi.org/10.3389/fgene.2013.00103	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668139	PMC

June 2013

Comprehensive integration of genetic and environmental determinants to increase knowledge of the allergic diseases.

Authors:

Emmanuelle Bouzigon Catherine Laprise

Curr Opin Allergy Clin Immunol 2012 Oct;12(5):447-8

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http://dx.doi.org/10.1097/ACI.0b013e3283583214	DOI Listing

October 2012

Associations between nitric oxide synthase genes and exhaled NO-related phenotypes according to asthma status.

Authors:

Emmanuelle Bouzigon Florent Monier Mekki Boussaha Nicole Le Moual Hélène Huyvaert Régis Matran Sébastien Letort Jean Bousquet Isabelle Pin Mark Lathrop Francine Kauffmann Florence Demenais Rachel Nadif

PLoS One 2012 9;7(5):e36672. Epub 2012 May 9.

Inserm, U946, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036672	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348876	PMC

September 2012

The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma.

J Allergy Clin Immunol 2012 Jun;129(6):1547-53.e3

Genetic Variation and Human Diseases Unit, INSERM, U946, Paris, France; Université Paris, France.

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http://dx.doi.org/10.1016/j.jaci.2012.04.010	DOI Listing

June 2012

Genome-wide association study of lung function decline in adults with and without asthma.

J Allergy Clin Immunol 2012 May 16;129(5):1218-28. Epub 2012 Mar 16.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.jaci.2012.01.074	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340499	PMC

May 2012

Transient receptor potential genes, smoking, occupational exposures and cough in adults.

Authors:

Lidwien A M Smit Manolis Kogevinas Josep M Antó Emmanuelle Bouzigon Juan Ramón González Nicole Le Moual Hans Kromhout Anne-Elie Carsin Isabelle Pin Deborah Jarvis Roel Vermeulen Christer Janson Joachim Heinrich Ivo Gut Mark Lathrop Miguel A Valverde Florence Demenais Francine Kauffmann

Respir Res 2012 Mar 23;13:26. Epub 2012 Mar 23.

INSERM, CESP Centre for research in Epidemiology and Population Health, U1018, Respiratory and environmental epidemiology Team, Villejuif F-94807, France.

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http://respiratory-research.com/content/13/1/26	Publisher Site
http://dx.doi.org/10.1186/1465-9921-13-26	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342106	PMC

March 2012

Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia.

Authors:

Alice Hadchouel Xavier Durrmeyer Emmanuelle Bouzigon Roberto Incitti Johanna Huusko Pierre-Henri Jarreau Richard Lenclen Florence Demenais Marie-Laure Franco-Montoya Inès Layouni Juliana Patkai Jacques Bourbon Mikko Hallman Claude Danan Christophe Delacourt

Am J Respir Crit Care Med 2011 Nov 11;184(10):1164-70. Epub 2011 Aug 11.

Inserm, U955, Créteil, France.

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http://dx.doi.org/10.1164/rccm.201103-0548OC	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826668	PMC

November 2011

To define the biological nature of asthma.

Authors:

Catherine Laprise Emmanuelle Bouzigon

Curr Opin Allergy Clin Immunol 2011 Oct;11(5):391-2

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http://dx.doi.org/10.1097/ACI.0b013e32834ae37e	DOI Listing

October 2011

Mold allergen sensitization in adult asthma according to integrin β3 polymorphisms and Toll-like receptor 2/+596 genotype.

Authors:

Lidwien A M Smit Emmanuelle Bouzigon Jean Bousquet Nicole Le Moual Rachel Nadif Isabelle Pin Mark Lathrop Florence Demenais Francine Kauffmann Valérie Siroux

J Allergy Clin Immunol 2011 Jul 13;128(1):185-191.e7. Epub 2011 May 13.

Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.jaci.2011.04.007	DOI Listing

July 2011

A large-scale, consortium-based genomewide association study of asthma.

Authors:

Miriam F Moffatt Ivo G Gut Florence Demenais David P Strachan Emmanuelle Bouzigon Simon Heath Erika von Mutius Martin Farrall Mark Lathrop William O C M Cookson

N Engl J Med 2010 Sep;363(13):1211-1221

National Heart and Lung Institute, Imperial College (M.F.M., W.O.C.M.C.), the Division of Community Health Sciences, St. George's, University of London (D.P.S.), and Royal Brompton and Harefield NHS Foundation Trust (W.O.C.M.C.) - all in London; Commissariat à l'Energie Atomique, Institut de Génomique, Centre National de Génotypage, Evry, France (I.G.G., S.H., M.L.); INSERM, Unité 946, Fondation Jean-Dausset-Centre d'Etude du Polymorphisme Humain (CEPH) (F.D., E.B.), Fondation Jean Dausset-CEPH (F.D., E.B., M.L.), and Université Paris Diderot Paris 7, Institut Universitaire d'Hématologie (F.D., E.B.) - all in Paris; University Children's Hospital, Asthma and Allergy Department, Ludwig Maximilians University, Munich, Germany (E.M.); and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom (M.F.).

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http://dx.doi.org/10.1056/NEJMoa0906312	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260321	PMC

September 2010

Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy.

Eur J Hum Genet 2010 Jun 13;18(6):700-6. Epub 2010 Jan 13.

INSERM, U946, Paris, France.

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http://www.nature.com/articles/ejhg2009224	Publisher Site
http://dx.doi.org/10.1038/ejhg.2009.224	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987334	PMC

June 2010

CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults.

Authors:

Lidwien A M Smit Valérie Siroux Emmanuelle Bouzigon Marie-Pierre Oryszczyn Mark Lathrop Florence Demenais Francine Kauffmann

Am J Respir Crit Care Med 2009 Mar 18;179(5):363-8. Epub 2008 Dec 18.

INSERM U780, Villejuif, France.

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http://dx.doi.org/10.1164/rccm.200810-1533OC	DOI Listing

March 2009

Meta-analysis of genome-wide linkage studies across autoimmune diseases.

Authors:

Paola Forabosco Emmanuelle Bouzigon Mandy Y Ng Jane Hermanowski Sheila A Fisher Lindsey A Criswell Cathryn M Lewis

Eur J Hum Genet 2009 Feb 10;17(2):236-43. Epub 2008 Sep 10.

King's College London School of Medicine, Department of Medical and Molecular Genetics, London, UK.

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http://www.nature.com/articles/ejhg2008163	Publisher Site
http://dx.doi.org/10.1038/ejhg.2008.163	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2986058	PMC

February 2009

Effect of 17q21 variants and smoking exposure in early-onset asthma.

Authors:

Emmanuelle Bouzigon Eve Corda Hugues Aschard Marie-Hélène Dizier Anne Boland Jean Bousquet Nicolas Chateigner Frédéric Gormand Jocelyne Just Nicole Le Moual Pierre Scheinmann Valérie Siroux Daniel Vervloet Diana Zelenika Isabelle Pin Francine Kauffmann Mark Lathrop Florence Demenais

N Engl J Med 2008 Nov 15;359(19):1985-94. Epub 2008 Oct 15.

INSERM Unité 794, Paris, France.

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http://dx.doi.org/10.1056/NEJMoa0806604	DOI Listing

November 2008

Replication of association between ADAM33 polymorphisms and psoriasis.

Authors:

Valérie Siroux Emmanuelle Bouzigon Marie-Hélène Dizier Isabelle Pin Florence Demenais Francine Kauffmann

PLoS One 2008 Jun 18;3(6):e2448. Epub 2008 Jun 18.

Inserm, U823, Centre de Recherche Albert Bonniot, Epidémiologie des cancers et des affections graves, La Tronche, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002448	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413006	PMC

June 2008

Evidence for linkage of a new region (11p14) to eczema and allergic diseases.

Hum Genet 2008 Jan 18;122(6):605-14. Epub 2007 Oct 18.

INSERM U535, Hôpital Paul Brousse, Bâtiment Leriche, B.P. 1000, 94817, Villejuif Cedex, France.

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http://link.springer.com/content/pdf/10.1007/s00439-007-0439	Web Search
http://link.springer.com/10.1007/s00439-007-0439-7	Publisher Site
http://dx.doi.org/10.1007/s00439-007-0439-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575854	PMC

January 2008

Evidence for gene x smoking exposure interactions in a genome-wide linkage screen of asthma and bronchial hyper-responsiveness in EGEA families.

Authors:

Marie-Hélène Dizier Emmanuelle Bouzigon Michel Guilloud-Bataille Valérie Siroux Arnaud Lemainque Anne Boland Mark Lathrop Florence Demenais

Eur J Hum Genet 2007 Jul 11;15(7):810-5. Epub 2007 Apr 11.

INSERM, U535, Villejuif, France.

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http://dx.doi.org/10.1038/sj.ejhg.5201830	DOI Listing

July 2007

Evidence for a pleiotropic QTL on chromosome 5q13 influencing both time to asthma onset and asthma score in French EGEA families.

Authors:

Emmanuelle Bouzigon Ayse Ulgen Marie-Hélène Dizier Valérie Siroux Mark Lathrop Francine Kauffmann Isabelle Pin Florence Demenais

Hum Genet 2007 Jul 1;121(6):711-9. Epub 2007 May 1.

INSERM, U794, Tour Evry 2, 523 Place des Terrasses de l'Agora, 91034 Evry, France.

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http://dx.doi.org/10.1007/s00439-007-0363-x	DOI Listing

July 2007

Evidence for a locus in 1p31 region specifically linked to the co-morbidity of asthma and allergic rhinitis in the EGEA study.

Authors:

Marie-Hélène Dizier Emmanuelle Bouzigon Michel Guilloud-Bataille Emmanuelle Genin Marie-Pierre Oryszczyn Isabella Annesi-Maesano Florence Demenais

Hum Hered 2007 19;63(3-4):162-7. Epub 2007 Feb 19.

INSERM, U535, Villejuif, France.

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http://dx.doi.org/10.1159/000099828	DOI Listing

June 2007

Meta-analysis of genome-wide linkage studies for multiple sclerosis, using an extended GSMA method.

Authors:

Jane Hermanowski Emmanuelle Bouzigon Paola Forabosco Mandy Y Ng Sheila A Fisher Cathryn M Lewis

Eur J Hum Genet 2007 Jun 21;15(6):703-10. Epub 2007 Mar 21.

Department of Medical and Molecular Genetics, King's College London School of Medicine at Guy's, King's College and St Thomas' Hospitals, London, UK.

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http://dx.doi.org/10.1038/sj.ejhg.5201818	DOI Listing

June 2007

Data acquisition for meta-analysis of genome-wide linkage studies using the genome search meta-analysis method.

Authors:

Paola Forabosco Mandy Y M Ng Emmanuelle Bouzigon Sheila A Fisher Douglas F Levinson Cathryn M Lewis

Hum Hered 2007 27;64(1):74-81. Epub 2007 Apr 27.

Department of Medical and Molecular Genetics, King's College London School of Medicine at Guy's, King's College and St. Thomas' Hospitals, London, UK.

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http://dx.doi.org/10.1159/000101425	DOI Listing

June 2007

Interrelationships of quantitative asthma-related phenotypes in the Epidemiological Study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy.

Authors:

Marie-Pierre Oryszczyn Emmanuelle Bouzigon Jean Maccario Valérie Siroux Rachel Nadif Anne Wright Francine Kauffmann

J Allergy Clin Immunol 2007 Jan 13;119(1):57-63. Epub 2006 Nov 13.

INSERM, U780, Epidemiology and Biostatistics, Villejuif; Univ Paris-Sud, IFR69, Villejuif, France.

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http://dx.doi.org/10.1016/j.jaci.2006.09.026	DOI Listing

January 2007

[Genetics of asthma and atopy: how many genes?].

Authors:

Emmanuelle Bouzigon Florence Demenais Francine Kauffmann

Bull Acad Natl Med 2005 Oct;189(7):1435-48

INSERM-Université d'Evry EMI0006, Tour Evry2, 523 place des Terrasses de l'Agora, 91034 Evry Cedex.

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October 2005

Clustering patterns of LOD scores for asthma-related phenotypes revealed by a genome-wide screen in 295 French EGEA families.

Hum Mol Genet 2004 Dec 27;13(24):3103-13. Epub 2004 Oct 27.

1INSERM EMI0006, Evry, France.

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http://hmg.oxfordjournals.org/content/13/24/3103.full.pdf	Web Search
http://hmg.oxfordjournals.org/content/early/2004/10/27/hmg.d	Web Search
http://www.hmg.oupjournals.org/cgi/doi/10.1093/hmg/ddh340	Publisher Site
http://dx.doi.org/10.1093/hmg/ddh340	DOI Listing

December 2004

Familial correlations and inter-relationships of four asthma-associated quantitative phenotypes in 320 French EGEA families ascertained through asthmatic probands.

Authors:

Emmanuelle Bouzigon Valérie Chaudru Anne-Sophie Carpentier Marie-Hélène Dizier Marie-Pierre Oryszczyn Jean Maccario Francine Kauffmann Florence Demenais

Eur J Hum Genet 2004 Nov;12(11):955-63

INSERM-Université d'Evry EMI0006, Evry, France.

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http://dx.doi.org/10.1038/sj.ejhg.5201241	DOI Listing

November 2004

Emmanuelle Bouzigon

Emmanuelle Bouzigon

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