Emmanuel J Wiertz

Emmanuel J Wiertz

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Emmanuel J Wiertz

Emmanuel J Wiertz

Publications by authors named "Emmanuel J Wiertz"

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Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking.

J Gen Virol 2019 Mar 29;100(3):497-510. Epub 2019 Jan 29.

1​Laboratory of Virus Molecular Biology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland.

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http://dx.doi.org/10.1099/jgv.0.001224DOI Listing
March 2019

RNA accessibility impacts potency of Tough Decoy microRNA inhibitors.

RNA Biol 2018 7;15(11):1410-1419. Epub 2018 Nov 7.

a Department of Medical Microbiology , University Medical Center Utrecht , Utrecht , The Netherlands.

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https://www.tandfonline.com/doi/full/10.1080/15476286.2018.1
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http://dx.doi.org/10.1080/15476286.2018.1537746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284568PMC
January 2019

Mutagenic repair of double-stranded DNA breaks in vaccinia virus genomes requires cellular DNA ligase IV activity in the cytosol.

J Gen Virol 2018 06 20;99(6):790-804. Epub 2018 Apr 20.

1​Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://www.microbiologyresearch.org/content/journal/jgv/10.1
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http://dx.doi.org/10.1099/jgv.0.001034DOI Listing
June 2018

New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins.

Mol Immunol 2018 Mar 29. Epub 2018 Mar 29.

Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2018.03.020DOI Listing
March 2018

Endocytosed soluble cowpox virus protein CPXV012 inhibits antigen cross-presentation in human monocyte-derived dendritic cells.

Immunol Cell Biol 2018 02 1;96(2):137-148. Epub 2018 Feb 1.

Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 EA, The Netherlands.

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http://dx.doi.org/10.1111/imcb.1024DOI Listing
February 2018

EBV MicroRNA BART16 Suppresses Type I IFN Signaling.

J Immunol 2017 05 17;198(10):4062-4073. Epub 2017 Apr 17.

Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1501605
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http://dx.doi.org/10.4049/jimmunol.1501605DOI Listing
May 2017

A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape.

Sci Rep 2017 02 8;7:41968. Epub 2017 Feb 8.

Department of Medical Microbiology, Virology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/srep41968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296774PMC
February 2017

The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein.

Viruses 2016 11 15;8(11). Epub 2016 Nov 15.

Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.

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http://dx.doi.org/10.3390/v8110309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127023PMC
November 2016

Comprehensive profiling of functional Epstein-Barr virus miRNA expression in human cell lines.

BMC Genomics 2016 08 17;17:644. Epub 2016 Aug 17.

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/s12864-016-2978-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987988PMC
August 2016

Exploiting the exploiter: a viral inhibitor stabilizes TAP for cryo-EM.

Nat Struct Mol Biol 2016 Feb;23(2):95-7

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/nsmb.3168DOI Listing
February 2016

Immune Evasion by Epstein-Barr Virus.

Curr Top Microbiol Immunol 2015 ;391:355-81

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/978-3-319-22834-1_12DOI Listing
December 2015

Suppression of a Natural Killer Cell Response by Simian Immunodeficiency Virus Peptides.

PLoS Pathog 2015 Sep 2;11(9):e1005145. Epub 2015 Sep 2.

Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America.

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http://search.proquest.com/openview/1b90cce4fca1aec7111a3b70
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http://dx.plos.org/10.1371/journal.ppat.1005145
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http://dx.doi.org/10.1371/journal.ppat.1005145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557930PMC
September 2015

Pathogenicity of Bovine Neonatal Pancytopenia-associated vaccine-induced alloantibodies correlates with Major Histocompatibility Complex class I expression.

Sci Rep 2015 Aug 3;5:12748. Epub 2015 Aug 3.

1] Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands [2] Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/srep12748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522679PMC
August 2015

Silencing the shutoff protein of Epstein-Barr virus in productively infected B cells points to (innate) targets for immune evasion.

J Gen Virol 2015 Apr 12;96(Pt 4):858-65. Epub 2014 Dec 12.

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands

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http://dx.doi.org/10.1099/jgv.0.000021DOI Listing
April 2015

Viral immune evasion: Lessons in MHC class I antigen presentation.

Semin Immunol 2015 Mar 15;27(2):125-37. Epub 2015 Apr 15.

Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2015.03.010DOI Listing
March 2015

TAP mediates import of Mycobacterium tuberculosis-derived peptides into phagosomes and facilitates loading onto HLA-I.

PLoS One 2013 11;8(11):e79571. Epub 2013 Nov 11.

Portland VA Medical Center, Portland, Oregon, United States of America ; Department of Pulmonary and Critical Care Medicine, Oregon Health & Sciences University, Portland, Oregon, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079571PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823705PMC
November 2014

Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.

PLoS Pathog 2014 Feb 20;10(2):e1003960. Epub 2014 Feb 20.

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands ; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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https://dx.plos.org/10.1371/journal.ppat.1003960
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http://dx.doi.org/10.1371/journal.ppat.1003960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930590PMC
February 2014

Viral interference with antigen presentation: trapping TAP.

Mol Immunol 2013 Sep 8;55(2):139-42. Epub 2012 Nov 8.

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2012.10.009DOI Listing
September 2013

MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation.

Proc Natl Acad Sci U S A 2013 Aug 8;110(35):14290-5. Epub 2013 Aug 8.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1303380110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761574PMC
August 2013

Evaluation of viral interference with MHC class I-restricted antigen processing and presentation using a flow cytometry-based approach.

Methods Mol Biol 2013 ;960:127-136

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/978-1-62703-218-6_10DOI Listing
June 2013

Structural and functional analysis of the TAP-inhibiting UL49.5 proteins of varicelloviruses.

Mol Immunol 2011 Sep 20;48(15-16):2038-51. Epub 2011 Jul 20.

Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2011.06.438DOI Listing
September 2011

Inhibition of mouse TAP by immune evasion molecules encoded by non-murine herpesviruses.

Mol Immunol 2011 Mar 2;48(6-7):835-45. Epub 2011 Feb 2.

Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2010.12.008DOI Listing
March 2011

Exploiting human herpesvirus immune evasion for therapeutic gain: potential and pitfalls.

Immunol Cell Biol 2011 Mar 8;89(3):359-66. Epub 2011 Feb 8.

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/icb.2010.129DOI Listing
March 2011

Viral evasion of T cell immunity: ancient mechanisms offering new applications.

Curr Opin Immunol 2011 Feb 9;23(1):96-103. Epub 2010 Dec 9.

Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.coi.2010.11.005DOI Listing
February 2011

CD8+ T cell responses against TAP-inhibited cells are readily detected in the human population.

J Immunol 2010 Dec 27;185(11):6508-17. Epub 2010 Oct 27.

Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1001774DOI Listing
December 2010

Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71.

J Immunol 2010 Dec 8;185(12):7605-13. Epub 2010 Nov 8.

Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1001503DOI Listing
December 2010

Herpesviruses and immunity: the art of evasion.

Vet Microbiol 2010 Jun 25;143(1):89-100. Epub 2010 Feb 25.

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.vetmic.2010.02.017DOI Listing
June 2010

The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocation.

Mol Biol Cell 2010 Jan 28;21(1):140-51. Epub 2009 Oct 28.

Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1091/mbc.e09-07-0586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801707PMC
January 2010

Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cells.

Cell Host Microbe 2009 Nov;6(5):422-32

Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S193131280900350
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http://dx.doi.org/10.1016/j.chom.2009.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791900PMC
November 2009

Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates.

J Cell Biol 2009 Nov;187(5):655-68

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1083/jcb.200908036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806592PMC
November 2009

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.

J Cell Biol 2009 Sep 31;186(5):685-92. Epub 2009 Aug 31.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB20XY, England, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742190PMC
http://dx.doi.org/10.1083/jcb.200906110DOI Listing
September 2009

Synthesis and biological evaluation of a chitobiose-based peptide N-glycanase inhibitor library.

J Org Chem 2009 Jan;74(2):605-16

Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1021/jo801906sDOI Listing
January 2009

The Epstein-Barr virus G-protein-coupled receptor contributes to immune evasion by targeting MHC class I molecules for degradation.

PLoS Pathog 2009 Jan 2;5(1):e1000255. Epub 2009 Jan 2.

Cancer Research-UK Institute for Cancer Studies, School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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https://dx.plos.org/10.1371/journal.ppat.1000255
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http://dx.doi.org/10.1371/journal.ppat.1000255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603334PMC
January 2009

Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.

Semin Cancer Biol 2008 Dec 25;18(6):397-408. Epub 2008 Oct 25.

Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center (LUMC), Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.semcancer.2008.10.008DOI Listing
December 2008

Signaling of a varicelloviral factor across the endoplasmic reticulum membrane induces destruction of the peptide-loading complex and immune evasion.

J Biol Chem 2008 May 5;283(19):13428-36. Epub 2008 Mar 5.

Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, D-60438, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1074/jbc.M800226200DOI Listing
May 2008

The DNase of gammaherpesviruses impairs recognition by virus-specific CD8+ T cells through an additional host shutoff function.

J Virol 2008 Mar 19;82(5):2385-93. Epub 2007 Dec 19.

Division of Cancer Studies, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, United Kingdom.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01946-07
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http://dx.doi.org/10.1128/JVI.01946-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258936PMC
March 2008

TAP-inhibiting proteins US6, ICP47 and UL49.5 differentially affect minor and major histocompatibility antigen-specific recognition by cytotoxic T lymphocytes.

Int Immunol 2007 Sep;19(9):1115-22

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2300RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/intimm/dxm082DOI Listing
September 2007

A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates.

J Exp Med 2007 Aug 9;204(8):1863-73. Epub 2007 Jul 9.

Cancer Research UK Institute for Cancer Studies and MRC Centre for Immune Regulation, University of Birmingham, Edgbaston, Birmingham, B15 2TT, England, UK.

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http://www.jem.org/lookup/doi/10.1084/jem.20070256
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http://dx.doi.org/10.1084/jem.20070256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118677PMC
August 2007

The nested open reading frame in the Epstein-Barr virus nuclear antigen-1 mRNA encodes a protein capable of inhibiting antigen presentation in cis.

Mol Immunol 2007 Jul 20;44(14):3588-96. Epub 2007 Apr 20.

Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2007.03.005DOI Listing
July 2007

Herpesvirus interference with major histocompatibility complex class II-restricted T-cell activation.

J Virol 2007 May 1;81(9):4389-96. Epub 2006 Nov 1.

Department of Medical Microbiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1128/JVI.01525-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900142PMC
May 2007

Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3.

J Cell Biol 2007 May 14;177(4):613-24. Epub 2007 May 14.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1083/jcb.200611063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064207PMC
May 2007

In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virus.

Mol Immunol 2007 Feb 7;44(6):1352-60. Epub 2006 Jul 7.

Department of Molecular Cell Biology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2006.05.012DOI Listing
February 2007

Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion.

Proc Natl Acad Sci U S A 2007 Feb 21;104(9):3366-71. Epub 2007 Feb 21.

Division of Cancer Studies, University of Birmingham Medical School, Vincent Drive, Edgbaston, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0611128104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805610PMC
February 2007

The varicellovirus-encoded TAP inhibitor UL49.5 regulates the presentation of CTL epitopes by Qa-1b1.

J Immunol 2007 Jan;178(2):657-62

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.178.2.657DOI Listing
January 2007

Ubiquitination of MHC class I heavy chains is essential for dislocation by human cytomegalovirus-encoded US2 but not US11.

J Biol Chem 2006 Oct 29;281(40):30063-71. Epub 2006 Jul 29.

Department of Medical Microbiology, Leiden University Medical Center, Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M602248200DOI Listing
October 2006

Human cytomegalovirus-encoded US2 and US11 target unassembled MHC class I heavy chains for degradation.

Mol Immunol 2006 Mar 10;43(8):1258-66. Epub 2005 Aug 10.

Department of Medical Microbiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2005.07.005DOI Listing
March 2006

Subtle sequence variation among MHC class I locus products greatly influences sensitivity to HCMV US2- and US11-mediated degradation.

Int Immunol 2006 Jan 16;18(1):173-82. Epub 2005 Dec 16.

Department of Medical Microbiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1093/intimm/dxh362DOI Listing
January 2006

Viral immune evasion: a masterpiece of evolution.

Immunogenetics 2002 Nov 24;54(8):527-42. Epub 2002 Oct 24.

Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00251-002-0493-1DOI Listing
November 2002