Publications

A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity.
Exp Neurol 2016 Dec 15;286:1-11. Epub 2016 Sep 15.
Institute of Neuroscience, Université catholique de Louvain, Av. Hippocrate 54, Brussels, Belgium. Electronic address:

Early ALS-type gait abnormalities in AMP-dependent protein kinase-deficient mice suggest a role for this metabolic sensor in early stages of the disease.
Metab Brain Dis 2015 Dec 9;30(6):1369-77. Epub 2015 Jul 9.
Group of Neuropharmacology, Université catholique de Louvain, B1.54.10, Av. Hippocrate 54, 1200, Brussels, Belgium.

Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling.
Br J Pharmacol 2015 Nov 25;172(22):5333-46. Epub 2015 Oct 25.
Neuropharmacology Group, Institute of Neuroscience, Université catholique de Louvain, Brussels, Belgium.

Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor.
Prog Neuropsychopharmacol Biol Psychiatry 2015 Oct 17;62:1-6. Epub 2015 Apr 17.
Laboratório de Farmacologia Bioquímica e Molecular, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, 373, Sala J1-17, CEP 21941-912 Ilha do Fundão, Rio de Janeiro, Brazil; Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, 373, Sala K2-27, CEP 21941-912 Ilha do Fundão, Rio de Janeiro, Brazil. Electronic address:

The anti-inflammatory peptide stearyl-norleucine-VIP delays disease onset and extends survival in a rat model of inherited amyotrophic lateral sclerosis.
Exp Neurol 2015 Jan 13;263:91-101. Epub 2014 Oct 13.
Group of Neuropharmacology, Institute of Neuroscience, Université catholique de Louvain, B-1200 Brussels, Belgium. Electronic address:

Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells.
Bioorg Med Chem 2013 Nov 13;21(22):7107-17. Epub 2013 Sep 13.
UCL/SSS/IREC/FATH, Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Avenue E. Mounier 53, B1.53.09, B-1200 Brussels, Belgium; Molecules, Solids and Reactivity (MOST), Institute of Condensed Matter and Nanosciences (IMCN), UCLouvain, Place Louis Pasteur 1, 1348 Louvain-la-Neuve, Belgium.

Up-regulation of spinal microglial Iba-1 expression persists after resolution of neuropathic pain hypersensitivity.
Neurosci Lett 2013 Oct 8;554:146-50. Epub 2013 Sep 8.
Institute of Neuroscience, Group of Neuropharmacology, Université catholique de Louvain, Avenue Hippocrate B1.54.10, 1200 Brussels, Belgium; Department of Neurology, University of Würzburg, Josef-Schneider-Straße 11, 97080 Würzburg, Germany.

Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo.
Neuropharmacology 2012 Jun 13;62(7):2328-36. Epub 2012 Feb 13.
Neuropharmacology Group, Institute of Neuroscience, Université catholique de Louvain, 54.10, Av. Hippocrate 54, B-1200 Brussels, Belgium.

Increasing the density of the D2L receptor and manipulating the receptor environment are required to evidence the partial agonist properties of aripiprazole.
Prog Neuropsychopharmacol Biol Psychiatry 2012 Jan 17;36(1):60-70. Epub 2011 Aug 17.
Institute of Neuroscience (Ions), Group of Neuropharmacology, Université Catholique de Louvain, Avenue Mounier 53, bte B1.53.02, B-1200 Brussels, Belgium.


Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line.
J Neurochem 2007 Sep 1;102(6):1996-2007. Epub 2007 Jun 1.
Unité de Chimie Pharmaceutique et de Radiopharmacie (UCL 7340), Université catholique de Louvain, Brussels, BelgiumLaboratoire de Pharmacologie expérimentale (UCL 5410), Université catholique de Louvain, Brussels, Belgium.

Unilateral induction of progenitors in the spinal cord of hSOD1(G93A) transgenic rats correlates with an asymmetrical hind limb paralysis.
Neurosci Lett 2006 Jun 15;401(1-2):25-9. Epub 2006 Mar 15.
Laboratoire de Pharmacologie Expérimentale, Université catholique de Louvain, Av. Hippocrate 54.10, B-1200 Brussels, Belgium.


Distinct regions of C-terminus of the high affinity neurotensin receptor mediate the functional coupling with pertussis toxin sensitive and insensitive G-proteins.
FEBS Lett 2002 Feb;512(1-3):329-33
Laboratoire de Pharmacologie Exprimentale (FARL), Département de Physiologie et de Pharmacologie, Université catholique de Louvain 54.10, Avenue Hippocrate 54, B-1200, Brussels, Belgium.

Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes.
Mol Metab 2013 9;2(4):393-404. Epub 2013 Aug 9.
INSERM, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862, F-33000 Bordeaux, France ; University of Bordeaux, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862, F-33000 Bordeaux, France ; Neuropharmacology, Institute of Neurosciences, Université Catholique de Louvain, Av. Hippocrate 54, B1.54.10-10, 1200 Bruxelles, Belgium.


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