Dr. Emmanouil Antalis, BSc, MSc, PhD, MD student - National and Kapodistrian University of Athens School of Medicine - Chemist - MSc Clinical Biochemist - PhD in Medicine - MD student

Dr. Emmanouil Antalis

BSc, MSc, PhD, MD student

National and Kapodistrian University of Athens School of Medicine

Chemist - MSc Clinical Biochemist - PhD in Medicine - MD student

Athens, Attica | Greece

Main Specialties: Biology, Chemical Pathology, Chemistry, Clinical & Laboratory Immunology, Epidemiology, Infectious Disease

Additional Specialties: Immunochemistry, Molecular Biology

ORCID logohttps://orcid.org/0000-0001-9011-114X

Dr. Emmanouil Antalis, BSc, MSc, PhD, MD student - National and Kapodistrian University of Athens School of Medicine - Chemist - MSc Clinical Biochemist - PhD in Medicine - MD student

Dr. Emmanouil Antalis

BSc, MSc, PhD, MD student

Introduction

Primary Affiliation: National and Kapodistrian University of Athens School of Medicine - Athens, Attica , Greece

Specialties:

Additional Specialties:

Research Interests:

Publications

7Publications

70Reads

53Profile Views

Th17 serum cytokines in relation to laboratory-confirmed respiratory viral infection: A pilot study.

J Med Virol 2019 06 4;91(6):963-971. Epub 2019 Feb 4.

4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece.

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http://dx.doi.org/10.1002/jmv.25406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166444PMC
June 2019
14 Reads
2.347 Impact Factor

Mixed viral infections of the respiratory tract; an epidemiological study during consecutive winter seasons.

J Med Virol 2018 04 17;90(4):663-670. Epub 2018 Jan 17.

4th Department of Internal Medicine, University Hospital Attikon, National and Kapodistrian University of Athens Medical School, Athens, Greece.

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http://dx.doi.org/10.1002/jmv.25006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167177PMC
April 2018
33 Reads
2.350 Impact Factor

Antiviral susceptibility profile of influenza A viruses; keep an eye on immunocompromised patients under prolonged treatment.

Eur J Clin Microbiol Infect Dis (2016)

European Journal of Clinical Microbiology & Infectious Diseases

There was an increase in severe and fatal influenza cases in Greece during the 2011–2015 post-pandemic period. To investigate causality, we determined neuraminidase (NA) inhibitor susceptibility and resistance-conferring NA and hemagglutinin (HA) mutations in circulating influenza type A viruses during the pandemic (2009–2010) and post-pandemic periods in Greece. One hundred thirty-four influenza A(H1N1)pdm09 and 95 influenza A(H3N2) viruses submitted to the National Influenza Reference Laboratory of Southern Greece were tested for susceptibility to oseltamivir and zanamivir. Antiviral resistance was assessed by neuraminidase sequence analysis, as well as the fluorescence-based 50 % inhibitory concentration (IC50) method. Five influenza A(H1N1)pdm09 viruses (2.2 %) showed significantly reduced inhibition by oseltamivir (average IC50 300.60nM vs. 1.19nM) by Gaussian kernel density plot analysis. These viruses were isolated from immunocompromised patients and harbored the H275Y oseltamivir resistance-conferring NA substitution. All A(H1N1)pdm09 viruses were zanamivir-susceptible, and all A(H3N2) viruses were susceptible to both drugs. Oseltamivir-resistant viruses did not form a distinct cluster by phylogenetic analysis. Permissive mutations were detected in immunogenic and non immunogenic NA regions of both oseltamivir- resistant and susceptible viruses in the post-pandemic seasons. Several amino acid substitutions in the HA1 domain of the HA gene of post-pandemic viruses were identified. This study indicated low resistance to NAIs among tested influenza viruses. Antiviral resistance emerged only in immunocompromised patients under long-term oseltamivir treatment. Sequential sample testing in this vulnerable group of patients is recommended to characterise resistance or reinfection and viral evolution.

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November 2016
383 Reads

Aseptic abscess syndrome associated with traveler's diarrhea after a trip to Malaysia.

IDCases 2016 15;6:23-5. Epub 2016 Sep 15.

4th Department of Internal Medicine, National and Kapodistrian University of Athens School of Medicine, University General Hospital "Attikon", Athens, Greece.

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http://dx.doi.org/10.1016/j.idcr.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035335PMC
September 2016
23 Reads

Top co-authors

Aris Spathis
Aris Spathis

School of Medicine

3
Sotirios Tsiodras
Sotirios Tsiodras

University of Athens Medical School

3
Athanasios Kossyvakis
Athanasios Kossyvakis

Centro Nacional de Microbiología

2
Christine Kottaridi
Christine Kottaridi

University of Thessaly

2
Andreas Mentis
Andreas Mentis

Hellenic Pasteur Institute

2
George Giannopoulos
George Giannopoulos

University of Athens

1
Androula Pavli
Androula Pavli

Hellenic Center for Disease Control and Prevention

1
George Dimitriadis
George Dimitriadis

Research Institute and Diabetes Center

1
Dimitrios Boumpas
Dimitrios Boumpas

University of Crete

1