Publications by authors named "Emma Shanks"

24Publications

Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment.

Br J Cancer 2020 02 17;122(4):517-527. Epub 2019 Dec 17.

Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden, Glasgow, G61 1QH, UK.

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http://dx.doi.org/10.1038/s41416-019-0681-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028732PMC
February 2020

The phospholipid PI(3,4)P is an apical identity determinant.

Nat Commun 2018 11 28;9(1):5041. Epub 2018 Nov 28.

Institute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.1038/s41467-018-07464-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262019PMC
November 2018

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines.

Cell Chem Biol 2017 Aug 3;24(8):981-992.e4. Epub 2017 Aug 3.

Centre for Gene Regulation & Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563080PMC
August 2017

3q26-29 Amplification in head and neck squamous cell carcinoma: a review of established and prospective oncogenes.

FEBS J 2017 09 3;284(17):2705-2731. Epub 2017 May 3.

Cancer Research UK Beatson Institute, Glasgow, UK.

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http://dx.doi.org/10.1111/febs.14061DOI Listing
September 2017

Academic drug discovery within the United Kingdom: a reassessment.

Nat Rev Drug Discov 2015 Jul 19;14(7):510. Epub 2015 Jun 19.

Target Discovery Institute, Oxford OX3 7FZ, UK.

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http://dx.doi.org/10.1038/nrd4661DOI Listing
July 2015

Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality.

Cell 2014 Aug;158(5):1199-1209

The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 6997801, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.07.027DOI Listing
August 2014

Strategic siRNA screening approaches to target cancer at the Cancer Research UK Beatson Institute.

Authors:
Emma J Shanks

Comb Chem High Throughput Screen 2014 May;17(4):328-32

Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.2174/1386207317666140323133249DOI Listing
May 2014

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

ChemMedChem 2011 Feb 29;6(2):302-8. Epub 2010 Dec 29.

Drug Discovery Unit, Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, Scotland, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.201000450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047710PMC
February 2011

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei.

ChemMedChem 2009 Dec;4(12):2060-9

Drug Discovery Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.200900262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855869PMC
December 2009

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase.

Anal Biochem 2010 Jan 11;396(2):194-203. Epub 2009 Sep 11.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD15EH, UK.

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http://dx.doi.org/10.1016/j.ab.2009.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789237PMC
January 2010

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.

ChemMedChem 2009 Aug;4(8):1341-53

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.200900098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929374PMC
August 2009