Publications by authors named "Emma Nally"

6 Publications

  • Page 1 of 1

Successful Use of Electroconvulsive Therapy for Catatonia After Hypoxic-Ischemic Brain Injury.

J Acad Consult Liaison Psychiatry 2021 Jan-Feb;62(1):123-130. Epub 2020 Sep 2.

Departments of Psychiatry, Neurology, and Rehabilitation Medicine, NYU Grossman School of Medicine, New York, NY.

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http://dx.doi.org/10.1016/j.psym.2020.08.009DOI Listing
September 2020

Identification of in the urine of an individual with spinal cord injury and augmentation cystoplasty using 16S sequencing: copathogen or innocent bystander?

Spinal Cord Ser Cases 2018 21;4:85. Epub 2018 Sep 21.

7Division of Urology, Children's National Health System, Washington, DC USA.

Introduction: People with neuropathic bladder (NB) secondary to spinal cord injury (SCI) are at risk for multiple genitourinary complications, the most frequent of which is urinary tract infection (UTI). Despite the high frequency with which UTI occurs, our understanding of the role of urinary microbes in health and disease is limited. In this paper, we present the first prospective case study integrating symptom reporting, urinalysis, urine cultivation, and 16S ribosomal ribonucleic acid (rRNA) sequencing of the urine microbiome.

Case Presentation: A 55-year-old male with NB secondary to SCI contributed 12 urine samples over an 8-month period during asymptomatic, symptomatic, and postantibiotic periods. All bacteria identified on culture were present on 16S rRNA sequencing, however, 16S rRNA sequencing revealed the presence of bacteria not isolated on culture. In particular, was present in three samples during both asymptomatic and symptomatic periods. White blood cells of ≥5-10/high power field and leukocyte esterase ≥2 on urinalysis was associated with the presence of symptoms.

Discussion: In this patient, there was a predominance of pathogenic bacteria and a lack of putative probiotic bacteria during both symptomatic and asymptomatic states. Urinalysis-defined inflammatory markers were present to a greater extent during symptomatic periods compared to the asymptomatic state, which may underscore a role for urinalysis or other inflammatory markers in differentiating asymptomatic bacteriuria from UTI in patients with NB. The finding of potentially pathogenic bacteria identified by sequencing but not cultivation, suggests a need for greater understanding of the relationships amongst bacterial species in the bacteriuric neuropathic bladder.
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http://dx.doi.org/10.1038/s41394-018-0115-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155001PMC
September 2018

Quadriparesis Caused by Lead Poisoning Nine Years After a Gunshot Wound With Retained Bullet Fragments: A Case Report.

PM R 2017 Apr 6;9(4):411-414. Epub 2016 Oct 6.

Musculoskelal Rehabilitation Program and Inpatient Services, MedStar National Rehabilitation Hospital, 102 Irving Street, NW, Washington, DC 20010(‡). Electronic address:

Lead toxicity in adults is characterized by nonspecific symptoms of abdominal pain, vomiting, constipation, fatigue, and weight loss. We present a case of severe lead toxicity that developed subacutely, causing quadriparesis 9 years after a gunshot wound with retained bullet fragments. The onset of symptoms may have been related to the development of a pseudocyst. The long interval between the gunshot wound and the onset of symptoms contributed to a delay in suspecting that the retained bullet was a source of lead toxicity. The patient's symptoms gradually improved after chelation therapy, removal of the bullet fragment, and an extended program of acute inpatient rehabilitation.

Level Of Evidence: V.
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http://dx.doi.org/10.1016/j.pmrj.2016.09.012DOI Listing
April 2017

Poster 231 Hemiballismus as the Presenting Symptom of Polycythemia Vera: A Case Report.

PM R 2016 Sep 24;8(9S):S235-S236. Epub 2016 Sep 24.

Georgetown University Hospital, Washington, District of Columbia, United States.

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http://dx.doi.org/10.1016/j.pmrj.2016.07.265DOI Listing
September 2016

Poster 59 Acute Diffuse Tendinopathy Causing Systemic Weakness and Pain Secondary to Ciprofloxacin Use: A Case Report.

PM R 2016 Sep 24;8(9S):S180. Epub 2016 Sep 24.

Georgetown University Hospital, Washington, District of Columbia, United States.

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http://dx.doi.org/10.1016/j.pmrj.2016.07.102DOI Listing
September 2016

Nuclear receptor DHR96 acts as a sentinel for low cholesterol concentrations in Drosophila melanogaster.

Mol Cell Biol 2010 Feb 23;30(3):793-805. Epub 2009 Nov 23.

Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.

All eukaryotic cells have to maintain cholesterol concentrations within defined margins in order to function normally. Perturbing cholesterol homeostasis can result in a wide range of cellular and systemic defects, including cardiovascular diseases, as well as Niemann-Pick and Tangier diseases. Here, we show that DHR96 is indispensable for mediating the transcriptional response to dietary cholesterol and that it acts as a key regulator of the Niemann-Pick type C gene family, as well as of other genes involved in cholesterol uptake, metabolism, and transport. DHR96 mutants are viable and phenotypically normal on a standard medium but fail to survive on diets that are low in cholesterol. DHR96 mutants have aberrant cholesterol levels, demonstrating a defect in maintaining cholesterol homeostasis. Remarkably, we found that a high-cholesterol diet phenocopied the genomic profile of the DHR96 mutation, indicating that DHR96 resides at the top of a genetic hierarchy controlling cholesterol homeostasis in insects. We propose a model whereby DHR96 is activated when cellular cholesterol concentrations drop below a critical threshold in order to protect cells from severe cholesterol deprivation.
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http://dx.doi.org/10.1128/MCB.01327-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812236PMC
February 2010