Publications by authors named "Emma L Rawlins"

33Publications

Distal lung epithelial progenitor cell function declines with age.

Sci Rep 2020 06 26;10(1):10490. Epub 2020 Jun 26.

Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.

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http://dx.doi.org/10.1038/s41598-020-66966-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319976PMC
June 2020

A Subpopulation of Foxj1-Expressing, Nonmyelinating Schwann Cells of the Peripheral Nervous System Contribute to Schwann Cell Remyelination in the Central Nervous System.

J Neurosci 2018 10 18;38(43):9228-9239. Epub 2018 Sep 18.

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0AH, United Kingdom,

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http://dx.doi.org/10.1523/JNEUROSCI.0585-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199410PMC
October 2018

Human lung development: recent progress and new challenges.

Development 2018 08 15;145(16). Epub 2018 Aug 15.

Wellcome Trust/CRUK Gurdon Institute, Wellcome Trust/MRC Stem Cell Institute, Department of Pathology, University of Cambridge, Cambridge CB2 1QN, UK

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http://dx.doi.org/10.1242/dev.163485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124546PMC
August 2018

Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium.

Biol Open 2018 Apr 16;7(4). Epub 2018 Apr 16.

Wellcome Trust/CRUK Gurdon Institute, Wellcome Trust/MRC Stem Cell Institute, Department of Pathology, University of Cambridge, Cambridge, CB2 1QN, UK

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http://bio.biologists.org/lookup/doi/10.1242/bio.033944
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http://dx.doi.org/10.1242/bio.033944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936064PMC
April 2018

Developmental mechanisms and adult stem cells for therapeutic lung regeneration.

Dev Biol 2018 01 25;433(2):166-176. Epub 2017 Dec 25.

Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, UK; Department of Pathology, University of Cambridge, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2017.09.016DOI Listing
January 2018

Lung Organoids and Their Use To Study Cell-Cell Interaction.

Curr Pathobiol Rep 2017 24;5(2):223-231. Epub 2017 Apr 24.

Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN UK.

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http://dx.doi.org/10.1007/s40139-017-0137-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446548PMC
April 2017

Cancer: Tumours build their niche.

Nature 2017 05 10;545(7654):292-293. Epub 2017 May 10.

Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK. Both are also at the Wellcome Trust - Medical Research Council Stem Cell Institute, Cambridge.

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http://dx.doi.org/10.1038/nature22494DOI Listing
May 2017

FGFR2 is required for airway basal cell self-renewal and terminal differentiation.

Development 2017 05 27;144(9):1600-1606. Epub 2017 Mar 27.

Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, CB2 1QN, UK

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http://dx.doi.org/10.1242/dev.135681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450841PMC
May 2017

Synthetic scaffolds help airway cells reach maturity.

Elife 2016 11 1;5. Epub 2016 Nov 1.

Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.7554/eLife.21786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089856PMC
November 2016

Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate.

Development 2016 10 30;143(20):3686-3699. Epub 2016 Aug 30.

Wellcome Trust/CRUK Gurdon Institute, Wellcome Trust/MRC Stem Cell Institute, Department of Pathology, University of Cambridge, Cambridge CB2 1QN, UK

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http://dx.doi.org/10.1242/dev.134023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087639PMC
October 2016

Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.

Development 2016 07 10;143(14):2522-35. Epub 2016 Jun 10.

King's College London Centre for Stem Cells and Regenerative Medicine, 28th Floor, Tower Wing, Guy's Hospital Campus, Great Maze Pond, London SE1 9RT, UK

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http://dev.biologists.org/lookup/doi/10.1242/dev.131797
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http://dx.doi.org/10.1242/dev.131797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958333PMC
July 2016

Mechanical cell competition kills cells via induction of lethal p53 levels.

Nat Commun 2016 04 25;7:11373. Epub 2016 Apr 25.

The Wellcome Trust/Cancer Research UK Gurdon Institute and Zoology Department, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1038/ncomms11373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848481PMC
April 2016

An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium.

Dev Cell 2016 Apr;37(1):85-97

Wellcome Trust/CRUK Gurdon Institute, Wellcome Trust/MRC Stem Cell Institute, Department of Pathology, University of Cambridge, Cambridge CB2 1QN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2016.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825408PMC
April 2016

Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium.

Cell Rep 2015 Jul 25;12(1):90-101. Epub 2015 Jun 25.

Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK; Wellcome Trust-MRC Stem Cell Institute University of Cambridge, Cambridge CB2 3EG, UK; Department of Pathology, University of Cambridge, Cambridge CB2 3EG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518462PMC
July 2015

Stem cells: Emergency back-up for lung repair.

Authors:
Emma L Rawlins

Nature 2015 Jan;517(7536):556-7

Wellcome Trust/Cancer Research UK Gurdon Institute, the Wellcome Trust/MRC Stem Cell Institute and in the Department of Pathology, University of Cambridge, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1038/517556aDOI Listing
January 2015

The best laid schemes of airway repair.

Eur Respir J 2014 Aug;44(2):299-301

Lungs for Living Research Centre, University College London, London, UK

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http://dx.doi.org/10.1183/09031936.00088014DOI Listing
August 2014

The a"MAZE"ing world of lung-specific transgenic mice.

Am J Respir Cell Mol Biol 2012 Mar 28;46(3):269-82. Epub 2011 Dec 28.

Children's Hospital Medical Center, Divisions of Neonatology and Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1165/rcmb.2011-0372PSDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785140PMC
March 2012

A 10-gene progenitor cell signature predicts poor prognosis in lung adenocarcinoma.

Ann Thorac Surg 2011 Apr 25;91(4):1046-50; discussion 1050. Epub 2011 Feb 25.

Department of Surgery, Duke University, Durham, North Carolina, USA.

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http://dx.doi.org/10.1016/j.athoracsur.2010.12.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376444PMC
April 2011

The building blocks of mammalian lung development.

Authors:
Emma L Rawlins

Dev Dyn 2011 Mar 18;240(3):463-76. Epub 2010 Nov 18.

Gurdon Institute and Department of Pathology, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/dvdy.22482DOI Listing
March 2011

The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells.

Development 2009 Nov;136(22):3741-5

Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1242/dev.037317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766341PMC
November 2009

Basal cells as stem cells of the mouse trachea and human airway epithelium.

Proc Natl Acad Sci U S A 2009 Aug 22;106(31):12771-5. Epub 2009 Jul 22.

Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.0906850106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714281PMC
August 2009

Lung epithelial progenitor cells: lessons from development.

Authors:
Emma L Rawlins

Proc Am Thorac Soc 2008 Aug;5(6):675-81

Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1513/pats.200801-006AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645259PMC
August 2008

Ciliated epithelial cell lifespan in the mouse trachea and lung.

Am J Physiol Lung Cell Mol Physiol 2008 Jul 16;295(1):L231-4. Epub 2008 May 16.

Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1152/ajplung.90209.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494792PMC
July 2008

Lung development and repair: contribution of the ciliated lineage.

Proc Natl Acad Sci U S A 2007 Jan 28;104(2):410-7. Epub 2006 Dec 28.

Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.0610770104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1752191PMC
January 2007

Epithelial stem cells of the lung: privileged few or opportunities for many?

Development 2006 Jul 30;133(13):2455-65. Epub 2006 May 30.

Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.02407
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http://dx.doi.org/10.1242/dev.02407DOI Listing
July 2006

Intercellular growth factor signaling and the development of mouse tracheal submucosal glands.

Dev Dyn 2005 Aug;233(4):1378-85

Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1002/dvdy.20461DOI Listing
August 2005

Echinoid facilitates Notch pathway signalling during Drosophila neurogenesis through functional interaction with Delta.

Development 2003 Dec 19;130(26):6475-84. Epub 2003 Nov 19.

The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3JR, UK.

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http://dx.doi.org/10.1242/dev.00882DOI Listing
December 2003

Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups.

Development 2003 Aug;130(16):3715-24

Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3JR, Scotland, UK.

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http://dx.doi.org/10.1242/dev.00602DOI Listing
August 2003