Publications by authors named "Emma J Murphy"

19 Publications

  • Page 1 of 1

β-Glucan Metabolic and Immunomodulatory Properties and Potential for Clinical Application.

Authors:
Emma J Murphy Emanuele Rezoagli Ian Major Neil J Rowan John G Laffey

J Fungi (Basel) 2020 Dec 10;6(4). Epub 2020 Dec 10.

Lung Biology Group, Regenerative Medicine Institute at CURAM Centre for Medical Devices, School of Medicine, National University of Ireland Galway, H91 CF50 Galway, Ireland.

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December 2020

A Bilayer Vaginal Tablet for the Localized Delivery of Disulfiram and 5-Fluorouracil to the Cervix.

Authors:
Ismin Zainol Abidin Emanuele Rezoagli Bianca Simonassi-Paiva Gustavo Waltzer Fehrenbach Kevin Masterson Robert Pogue Zhi Cao Neil Rowan Emma J Murphy Ian Major

Pharmaceutics 2020 Dec 6;12(12). Epub 2020 Dec 6.

Materials Research Institute, Athlone Institute of Technology, Dublin Road, N37 HD68 Athlone, Ireland.

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December 2020

β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects - Implications for coronavirus disease (COVID-19) immunotherapies.

Authors:
Emma J Murphy Claire Masterson Emanuele Rezoagli Daniel O'Toole Ian Major Gary D Stack Mark Lynch John G Laffey Neil J Rowan

Sci Total Environ 2020 Aug 11;732:139330. Epub 2020 May 11.

Bioscience Research Institute, Athlone Institute of Technology, Athlone, Ireland; Centre for Disinfection, Sterilization and Biosecurity, Athlone Institute of Technology, Athlone, Ireland.

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August 2020

Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail.

Authors:
Jing Wang Emma J Murphy Jay C Nix David N M Jones

Sci Rep 2020 02 24;10(1):3300. Epub 2020 Feb 24.

Dept. of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12801 East 17th Ave, Aurora, CO, 80045, USA.

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February 2020

Correction to: Complete NMR chemical shift assignments of odorant binding protein 22 from the yellow fever mosquito, Aedes aegypti, bound to arachidonic acid.

Authors:
David N M Jones Jing Wang Emma J Murphy

Biomol NMR Assign 2019 10;13(2):279

Department of Pharmacology, University of Colorado School of Medicine, 12801 East 17th Ave, Aurora, CO, 80045, USA.

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October 2019

Complete NMR chemical shift assignments of odorant binding protein 22 from the yellow fever mosquito, Aedes aegypti, bound to arachidonic acid.

Authors:
David N M Jones Jing Wang Emma J Murphy

Biomol NMR Assign 2019 04 25;13(1):187-193. Epub 2019 Jan 25.

Department of Pharmacology, University of Colorado School of Medicine, 12801 East 17th Ave, Aurora, CO, 80045, USA.

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April 2019

A novel high-content imaging-based technique for measuring binding of Dickkopf-1 to low-density lipoprotein receptor-related protein 6.

Authors:
Richard S Priestley Jonathan Cheung Emma J Murphy Matthias T Ehebauer John B Davis Elena Di Daniel

J Pharmacol Toxicol Methods 2019 Jan - Feb;95:47-55. Epub 2018 Nov 23.

Alzheimer's Research UK Oxford Drug Discovery Institute, University of Oxford, NDM Research Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, UK. Electronic address:

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March 2019

Discovery of a PCAF Bromodomain Chemical Probe.

Authors:
Moses Moustakim Peter G K Clark Laura Trulli Angel L Fuentes de Arriba Matthias T Ehebauer Apirat Chaikuad Emma J Murphy Jacqui Mendez-Johnson Danette Daniels Chun-Feng D Hou Yu-Hui Lin John R Walker Raymond Hui Hongbing Yang Lucy Dorrell Catherine M Rogers Octovia P Monteiro Oleg Fedorov Kilian V M Huber Stefan Knapp Jag Heer Darren J Dixon Paul E Brennan

Angew Chem Int Ed Engl 2017 01 14;56(3):827-831. Epub 2016 Dec 14.

Structural Genomics Consortium & Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7DQ and OX3 7FZ, UK.

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January 2017

Heme enzymes. Neutron cryo-crystallography captures the protonation state of ferryl heme in a peroxidase.

Authors:
Cecilia M Casadei Andrea Gumiero Clive L Metcalfe Emma J Murphy Jaswir Basran Maria Grazia Concilio Susana C M Teixeira Tobias E Schrader Alistair J Fielding Andreas Ostermann Matthew P Blakeley Emma L Raven Peter C E Moody

Science 2014 Jul 10;345(6193):193-7. Epub 2014 Jul 10.

Department of Biochemistry and Henry Wellcome Laboratories for Structural Biology, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

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July 2014

Interactions of Anopheles gambiae odorant-binding proteins with a human-derived repellent: implications for the mode of action of n,n-diethyl-3-methylbenzamide (DEET).

Authors:
Emma J Murphy Jamie C Booth Foteini Davrazou Alex M Port David N M Jones

J Biol Chem 2013 Feb 23;288(6):4475-85. Epub 2012 Dec 23.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.

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February 2013

A novel mechanism of ligand binding and release in the odorant binding protein 20 from the malaria mosquito Anopheles gambiae.

Authors:
Brian P Ziemba Emma J Murphy Hannah T Edlin David N M Jones

Protein Sci 2013 Jan 29;22(1):11-21. Epub 2012 Nov 29.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.

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January 2013

Crystal structure of guaiacol and phenol bound to a heme peroxidase.

Authors:
Emma J Murphy Clive L Metcalfe Chukwudi Nnamchi Peter C E Moody Emma L Raven

FEBS J 2012 May 5;279(9):1632-9. Epub 2011 Dec 5.

Department of Chemistry, University of Leicester, Leicester, UK.

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May 2012

New insights into the mechanism of odorant detection by the malaria-transmitting mosquito Anopheles gambiae.

Authors:
Foteini Davrazou Emily Dong Emma J Murphy Hannah T Johnson David N M Jones

J Biol Chem 2011 Sep 4;286(39):34175-83. Epub 2011 Aug 4.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.

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September 2011

G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction.

Authors:
Bu'hussain Hayee Aristotelis Antonopoulos Emma J Murphy Farooq Z Rahman Gavin Sewell Bradley N Smith Sara McCartney Mark Furman Georgina Hall Stuart L Bloom Stuart M Haslam Howard R Morris Kaan Boztug Christoph Klein Bryan Winchester Edgar Pick David C Linch Rosemary E Gale Andrew M Smith Anne Dell Anthony W Segal

Glycobiology 2011 Jul 8;21(7):914-24. Epub 2011 Mar 8.

Department of Molecular Medicine, University College London, UK.

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July 2011

An analysis of substrate binding interactions in the heme peroxidase enzymes: a structural perspective.

Authors:
Andrea Gumiero Emma J Murphy Clive L Metcalfe Peter C E Moody Emma Lloyd Raven

Arch Biochem Biophys 2010 Aug 4;500(1):13-20. Epub 2010 Mar 4.

Department of Chemistry, University of Leicester, England, UK.

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August 2010

CO binding and ligand discrimination in human myeloperoxidase.

Authors:
Emma J Murphy Amandine Maréchal Anthony W Segal Peter R Rich

Biochemistry 2010 Mar;49(10):2150-8

Centre for Molecular Medicine, Division of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK.

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March 2010

Peroxide-dependent formation of a covalent link between Trp51 and the heme in cytochrome c peroxidase.

Authors:
Zoi Pipirou Victor Guallar Jaswir Basran Clive L Metcalfe Emma J Murphy Andrew R Bottrill Sharad C Mistry Emma Lloyd Raven

Biochemistry 2009 Apr;48(16):3593-9

Department of Chemistry, University of Leicester, England, UK.

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April 2009

Engineering the substrate specificity and reactivity of a heme protein: creation of an ascorbate binding site in cytochrome c peroxidase.

Authors:
Emma J Murphy Clive L Metcalfe Jaswir Basran Peter C E Moody Emma Lloyd Raven

Biochemistry 2008 Dec;47(52):13933-41

Department of Chemistry, Henry Wellcome Building, University of Leicester, University Road, Leicester, LE1 9HN, England U.K.

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December 2008

The tuberculosis prodrug isoniazid bound to activating peroxidases.

Authors:
Clive Metcalfe Isabel K Macdonald Emma J Murphy Katherine A Brown Emma Lloyd Raven Peter C E Moody

J Biol Chem 2008 Mar 5;283(10):6193-200. Epub 2007 Dec 5.

Department of Chemistry, University of Leicester, Lancaster Road, Leicester, United Kingdom.

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March 2008