Emma Guttman-Yassky

Emma Guttman-Yassky

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Emma Guttman-Yassky

Publications by authors named "Emma Guttman-Yassky"

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The proteomic skin profile of moderate-to-severe atopic dermatitis patients shows an inflammatory signature.

J Am Acad Dermatol 2020 Mar 25;82(3):690-699. Epub 2019 Oct 25.

Department of Dermatology and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.10.039DOI Listing
March 2020

Upadacitinib in adults with moderate to severe atopic dermatitis: 16-week results from a randomized, placebo-controlled trial.

J Allergy Clin Immunol 2020 Mar 29;145(3):877-884. Epub 2019 Nov 29.

Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC.

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http://dx.doi.org/10.1016/j.jaci.2019.11.025DOI Listing
March 2020

Chronic Hand Eczema Understanding Has Ramifications On Clinical Management.

J Eur Acad Dermatol Venereol 2020 Mar 16. Epub 2020 Mar 16.

Department of Dermatology, and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1111/jdv.16375DOI Listing
March 2020

Efficacy of biologics in atopic dermatitis.

Expert Opin Biol Ther 2020 Feb 3:1-14. Epub 2020 Feb 3.

Department of Dermatology, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, USA.

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http://dx.doi.org/10.1080/14712598.2020.1722998DOI Listing
February 2020

Alopecia Areata Is Associated with Atopic Diathesis: Results from a Population-Based Study of 51,561 Patients.

J Allergy Clin Immunol Pract 2020 Feb 6. Epub 2020 Feb 6.

Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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http://dx.doi.org/10.1016/j.jaip.2020.01.052DOI Listing
February 2020

Increased cardiovascular and atherosclerosis markers in blood of older patients with atopic dermatitis.

Ann Allergy Asthma Immunol 2020 Jan 14;124(1):70-78. Epub 2019 Oct 14.

Department of Dermatology, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.10.013DOI Listing
January 2020

New treatments for atopic dermatitis targeting beyond IL-4/IL-13 cytokines.

Ann Allergy Asthma Immunol 2020 Jan 14;124(1):28-35. Epub 2019 Oct 14.

Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.10.005DOI Listing
January 2020

Evolution of pathologic T-cell subsets in patients with atopic dermatitis from infancy to adulthood.

J Allergy Clin Immunol 2020 Jan 15;145(1):215-228. Epub 2019 Oct 15.

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.09.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957229PMC
January 2020

Comparing cutaneous molecular improvement with different treatments in atopic dermatitis patients.

J Allergy Clin Immunol 2020 Jan 16. Epub 2020 Jan 16.

Department of Dermatology and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2020.01.005DOI Listing
January 2020

Granuloma annulare skin profile shows activation of T-helper cell type 1, T-helper cell type 2, and Janus kinase pathways.

J Am Acad Dermatol 2019 Dec 20. Epub 2019 Dec 20.

Department of Dermatology and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, New York; Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.12.028DOI Listing
December 2019

Kallikrein 7 Promotes Atopic Dermatitis-Associated Itch Independently of Skin Inflammation.

J Invest Dermatol 2019 Dec 26. Epub 2019 Dec 26.

Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA; Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.10.022DOI Listing
December 2019

Crisaborole and atopic dermatitis skin biomarkers: An intrapatient randomized trial.

J Allergy Clin Immunol 2019 Nov 13;144(5):1274-1289. Epub 2019 Aug 13.

Department of Dermatology and Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.06.047DOI Listing
November 2019

Major Differences in Expression of Inflammatory Pathways in Skin from Different Body Sites of Healthy Individuals.

J Invest Dermatol 2019 Oct 3;139(10):2228-2232.e10. Epub 2019 May 3.

Department of Dermatology and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.04.008DOI Listing
October 2019

Oral Janus kinase/SYK inhibition (ASN002) suppresses inflammation and improves epidermal barrier markers in patients with atopic dermatitis.

J Allergy Clin Immunol 2019 Oct 26;144(4):1011-1024. Epub 2019 Jul 26.

Department of Dermatology, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.07.013DOI Listing
October 2019

Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis.

J Allergy Clin Immunol 2019 Oct 1;144(4):1036-1049. Epub 2019 Aug 1.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.06.019DOI Listing
October 2019

The skin as an immune organ: Tolerance versus effector responses and applications to food allergy and hypersensitivity reactions.

J Allergy Clin Immunol 2019 Aug 5;144(2):362-374. Epub 2019 Apr 5.

Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY.

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http://dx.doi.org/10.1016/j.jaci.2019.03.021DOI Listing
August 2019

Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis.

J Allergy Clin Immunol 2019 Jul 24;144(1):144-156. Epub 2019 Jan 24.

Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.01.015DOI Listing
July 2019

Understanding the immune landscape in atopic dermatitis: The era of biologics and emerging therapeutic approaches.

Exp Dermatol 2019 Jul 15;28(7):756-768. Epub 2019 Apr 15.

Icahn School of Medicine at Mount Sinai, New York City, New York.

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http://dx.doi.org/10.1111/exd.13911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850480PMC
July 2019

Blood endotyping distinguishes the profile of vitiligo from that of other inflammatory and autoimmune skin diseases.

J Allergy Clin Immunol 2019 Jun 18;143(6):2095-2107. Epub 2018 Dec 18.

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.11.031DOI Listing
June 2019

Racial differences in atopic dermatitis.

Ann Allergy Asthma Immunol 2019 May 20;122(5):449-455. Epub 2018 Nov 20.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2018.11.015DOI Listing
May 2019

JAK Inhibitors for Atopic Dermatitis: An Update.

Am J Clin Dermatol 2019 Apr;20(2):181-192

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, 5 E. 98th Street, New York, NY, 10029, USA.

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http://dx.doi.org/10.1007/s40257-018-0413-2DOI Listing
April 2019

Topical agents for the treatment of atopic dermatitis.

Expert Rev Clin Immunol 2019 04 8;15(4):369-382. Epub 2019 Jan 8.

a Department of Dermatology , Icahn School of Medicine , New York , NY , USA.

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http://dx.doi.org/10.1080/1744666X.2019.1564038DOI Listing
April 2019

Correction to: JAK Inhibitors for Atopic Dermatitis: An Update.

Am J Clin Dermatol 2019 04;20(2):193

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, 5 E. 98th Street, New York, NY, 10029, USA.

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http://dx.doi.org/10.1007/s40257-019-00421-1DOI Listing
April 2019

Current and emerging biologic and small molecule therapies for atopic dermatitis.

Expert Opin Biol Ther 2019 04 7;19(4):367-380. Epub 2019 Feb 7.

a Department of Dermatology, Laboratory of Inflammatory Skin Diseases , Icahn School of Medicine at Mount Sinai , New York , NY , USA.

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https://www.tandfonline.com/doi/full/10.1080/14712598.2019.1
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http://dx.doi.org/10.1080/14712598.2019.1573422DOI Listing
April 2019

What's New in Atopic Dermatitis.

Dermatol Clin 2019 Apr 16;37(2):205-213. Epub 2019 Feb 16.

Department of Dermatology, Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, 5 East 98th Street, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.det.2018.12.007DOI Listing
April 2019

Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients.

Ann Allergy Asthma Immunol 2019 03 1;122(3):318-330.e3. Epub 2018 Dec 1.

The Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York; Department of Dermatology, the Laboratory for Inflammatory Skin Diseases, and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2018.11.025DOI Listing
March 2019

The Unique Molecular Signatures of Contact Dermatitis and Implications for Treatment.

Clin Rev Allergy Immunol 2019 Feb;56(1):1-8

Department of Dermatology and the Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai Medical Center, 5 E. 98th Street, New York, NY, 10029, USA.

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http://dx.doi.org/10.1007/s12016-018-8685-0DOI Listing
February 2019

Ichthyosis molecular fingerprinting shows profound T17 skewing and a unique barrier genomic signature.

J Allergy Clin Immunol 2019 02 24;143(2):604-618. Epub 2018 May 24.

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Laboratory for Investigative Dermatology, Rockefeller University, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.03.021DOI Listing
February 2019

Treatment of atopic dermatitis with tralokinumab, an anti-IL-13 mAb.

J Allergy Clin Immunol 2019 01 12;143(1):135-141. Epub 2018 Jun 12.

Clinical Respiratory Management, MedImmune, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2018.05.029DOI Listing
January 2019

Atopic dermatitis in African American patients is T2/T22-skewed with T1/T17 attenuation.

Ann Allergy Asthma Immunol 2019 01 14;122(1):99-110.e6. Epub 2018 Sep 14.

Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2018.08.024DOI Listing
January 2019

Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council.

J Allergy Clin Immunol 2019 01 7;143(1):36-45. Epub 2018 Nov 7.

Dermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183157
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http://dx.doi.org/10.1016/j.jaci.2018.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626639PMC
January 2019

Atopic dermatitis endotypes and implications for targeted therapeutics.

J Allergy Clin Immunol 2019 01;143(1):1-11

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Laboratory for Investigative Dermatology, Rockefeller University, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.10.032DOI Listing
January 2019

An integrated model of alopecia areata biomarkers highlights both T1 and T2 upregulation.

J Allergy Clin Immunol 2018 11 5;142(5):1631-1634.e13. Epub 2018 Jul 5.

Department of Dermatology, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.06.029DOI Listing
November 2018

The Major Orphan Forms of Ichthyosis Are Characterized by Systemic T-Cell Activation and Th-17/Tc-17/Th-22/Tc-22 Polarization in Blood.

J Invest Dermatol 2018 10 14;138(10):2157-2167. Epub 2018 Apr 14.

Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Illinois, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.03.1523DOI Listing
October 2018

Efficacy and safety of secukinumab treatment in adults with extensive alopecia areata.

Arch Dermatol Res 2018 Oct 18;310(8):607-614. Epub 2018 Aug 18.

Department of Dermatology, Icahn School of Medicine at Mount Sinai Medical Center, New York, NY, USA.

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http://link.springer.com/10.1007/s00403-018-1853-5
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http://dx.doi.org/10.1007/s00403-018-1853-5DOI Listing
October 2018

Atopic dermatitis in Chinese patients shows T2/T17 skewing with psoriasiform features.

J Allergy Clin Immunol 2018 09 28;142(3):1013-1017. Epub 2018 Jun 28.

Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.06.016DOI Listing
September 2018

Monoclonal antibodies for the treatment of atopic dermatitis.

Curr Opin Allergy Clin Immunol 2018 08;18(4):356-364

Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai.

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http://Insights.ovid.com/crossref?an=00130832-201808000-0001
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http://dx.doi.org/10.1097/ACI.0000000000000455DOI Listing
August 2018

Response to "Comment on: 'When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council'".

J Am Acad Dermatol 2018 08;79(2):e25-e26

Trinity College Dublin, National Children's Research Centre, Paediatric Dermatology, Our Lady's Children's Hospital, Dublin, Republic of Ireland.

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http://dx.doi.org/10.1016/j.jaad.2018.03.048DOI Listing
August 2018

Serum from Asian patients with atopic dermatitis is characterized by T2/T22 activation, which is highly correlated with nonlesional skin measures.

J Allergy Clin Immunol 2018 07 11;142(1):324-328.e11. Epub 2018 Apr 11.

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Laboratory for Investigative Dermatology, Rockefeller University, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.02.047DOI Listing
July 2018

IL-17C: A Unique Epithelial Cytokine with Potential for Targeting across the Spectrum of Atopic Dermatitis and Psoriasis.

J Invest Dermatol 2018 07;138(7):1467-1469

Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA.

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http://dx.doi.org/10.1016/j.jid.2018.02.037DOI Listing
July 2018

Effect of short-term liver X receptor activation on epidermal barrier features in mild to moderate atopic dermatitis: A randomized controlled trial.

Ann Allergy Asthma Immunol 2018 06 19;120(6):631-640.e11. Epub 2018 Mar 19.

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10811206183021
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http://dx.doi.org/10.1016/j.anai.2018.03.013DOI Listing
June 2018

Early-onset pediatric atopic dermatitis is characterized by T2/T17/T22-centered inflammation and lipid alterations.

J Allergy Clin Immunol 2018 06 3;141(6):2094-2106. Epub 2018 May 3.

Laboratory for Investigative Dermatology, Rockefeller University, New York, NY; Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183039
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http://dx.doi.org/10.1016/j.jaci.2018.02.040DOI Listing
June 2018

Systemic immune mechanisms in atopic dermatitis and psoriasis with implications for treatment.

Exp Dermatol 2018 04 9;27(4):409-417. Epub 2017 May 9.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1111/exd.13336DOI Listing
April 2018

Atopic dermatitis in diverse racial and ethnic groups-Variations in epidemiology, genetics, clinical presentation and treatment.

Exp Dermatol 2018 04;27(4):340-357

Department of Dermatology, Mount Sinai St. Luke's and Mount Sinai West, New York, NY, USA.

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http://doi.wiley.com/10.1111/exd.13514
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http://dx.doi.org/10.1111/exd.13514DOI Listing
April 2018

Successful treatment of juvenile pityriasis rubra pilaris with ustekinumab in a 7-year-old girl.

JAAD Case Rep 2018 Mar 9;4(2):206-210. Epub 2018 Feb 9.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.

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https://linkinghub.elsevier.com/retrieve/pii/S23525126173021
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http://dx.doi.org/10.1016/j.jdcr.2017.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993550PMC
March 2018

Prostaglandin E stimulates adaptive IL-22 production and promotes allergic contact dermatitis.

J Allergy Clin Immunol 2018 01 3;141(1):152-162. Epub 2017 Jun 3.

Medical Research Council (MRC) Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.04.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626002PMC
January 2018

Immunologic, microbial, and epithelial interactions in atopic dermatitis.

Ann Allergy Asthma Immunol 2018 01 7;120(1):34-41. Epub 2017 Nov 7.

Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2017.09.055DOI Listing
January 2018

Cytokine Targeted Therapeutics for Alopecia Areata: Lessons from Atopic Dermatitis and Other Inflammatory Skin Diseases.

J Investig Dermatol Symp Proc 2018 01;19(1):S62-S64

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA; Department of Genetics and Genomics Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA; The Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jisp.2017.10.005DOI Listing
January 2018

Systemic therapies in atopic dermatitis: The pipeline.

Clin Dermatol 2017 Jul - Aug;35(4):387-397. Epub 2017 Mar 23.

Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.clindermatol.2017.03.012DOI Listing
November 2017

Effective use of ustekinumab in a patient with concomitant psoriasis, vitiligo, and alopecia areata.

JAAD Case Rep 2017 Nov 23;3(6):477-479. Epub 2017 Sep 23.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1016/j.jdcr.2017.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614637PMC
November 2017

When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.

J Am Acad Dermatol 2017 Oct 10;77(4):623-633. Epub 2017 Aug 10.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2017.06.042DOI Listing
October 2017

Atopic dermatitis and psoriasis: two different immune diseases or one spectrum?

Curr Opin Immunol 2017 Oct 1;48:68-73. Epub 2017 Sep 1.

Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1016/j.coi.2017.08.008DOI Listing
October 2017

Atopic dermatitis: pathogenesis.

Semin Cutan Med Surg 2017 Sep;36(3):100-103

Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, California, USA.

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http://dx.doi.org/10.12788/j.sder.2017.036DOI Listing
September 2017

The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm.

Adv Ther 2017 07 23;34(7):1594-1609. Epub 2017 Jun 23.

Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1007/s12325-017-0542-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504208PMC
July 2017

Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march.

J Allergy Clin Immunol 2017 Jun;139(6):1723-1734

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Laboratory for Investigative Dermatology, Rockefeller University, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.04.004DOI Listing
June 2017

Assessing the current treatment of atopic dermatitis: Unmet needs.

J Allergy Clin Immunol 2017 04;139(4S):S47-S48

Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY.

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http://dx.doi.org/10.1016/j.jaci.2017.01.010DOI Listing
April 2017

The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies.

J Allergy Clin Immunol 2017 Apr;139(4S):S65-S76

Department of Pediatrics, National Jewish Health, Denver, Colo. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405702PMC
April 2017

Patch testing of food allergens promotes Th17 and Th2 responses with increased IL-33: a pilot study.

Exp Dermatol 2017 03 10;26(3):272-275. Epub 2017 Jan 10.

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1111/exd.13148DOI Listing
March 2017

An Integrated Model of Atopic Dermatitis Biomarkers Highlights the Systemic Nature of the Disease.

J Invest Dermatol 2017 03 4;137(3):603-613. Epub 2016 Nov 4.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA; Department of Immunology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.09.037DOI Listing
March 2017

Major differences between human atopic dermatitis and murine models, as determined by using global transcriptomic profiling.

J Allergy Clin Immunol 2017 02 1;139(2):562-571. Epub 2016 Oct 1.

Laboratory for Investigative Dermatology, Rockefeller University, New York, NY; Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.08.029DOI Listing
February 2017

An IL-17-dominant immune profile is shared across the major orphan forms of ichthyosis.

J Allergy Clin Immunol 2017 01 20;139(1):152-165. Epub 2016 Aug 20.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY; Laboratory for Investigative Dermatology, Rockefeller University, New York, NY.

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http://dx.doi.org/10.1016/j.jaci.2016.07.019DOI Listing
January 2017

Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder.

J Invest Dermatol 2017 01 20;137(1):18-25. Epub 2016 Oct 20.

Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1016/j.jid.2016.08.022DOI Listing
January 2017

Early-onset pediatric atopic dermatitis is T2 but also T17 polarized in skin.

J Allergy Clin Immunol 2016 12 23;138(6):1639-1651. Epub 2016 Sep 23.

Department of Dermatology and Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY; Laboratory for Investigative Dermatology, Rockefeller University, New York, NY. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749163079
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http://dx.doi.org/10.1016/j.jaci.2016.07.013DOI Listing
December 2016

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis.

N Engl J Med 2016 12 30;375(24):2335-2348. Epub 2016 Sep 30.

From the Department of Dermatology, Oregon Health and Science University (E.L.S.), and Oregon Medical Research Center (A.B.) - both in Portland; the Department of Dermatology and Allergy, University of Bonn, Bonn (T.B.), the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M.W.), and the Department of Dermatology and Allergy, Ludwig-Maximilian University, Munich (A.W.) - all in Germany; the Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York (E.G.-Y.), the Department of Dermatology, University of Rochester Medical Center, Rochester (L.A.B.), and Regeneron Pharmaceuticals, Tarrytown (Y.S., N.M.H.G., B.A., V.M., A.G., N.S., G.D.Y., M.A.) - all in New York; the Dermatology Research Unit, University of Sheffield Medical School, Sheffield, United Kingdom (M.J.C.); the Department of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago (J.I.S.); the Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark (M.D.); the Department of Dermatology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino, Osaka, Japan (Y.K.); the Department of Dermatology, University Hospital of Nice, Nice (J.-P.L.), and Sanofi, Chilly-Mazarin (L.E.) - both in France; the Clinic of Dermatology, Tartu University Hospital, Tartu, Estonia (K.K.); the Department of Medicine, Université Laval, Hôpital Hôtel-Dieu de Québec, Quebec, QC, Canada (Y.P.); and Sanofi, Bridgewater, NJ (G.P., H.S.).

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http://dx.doi.org/10.1056/NEJMoa1610020DOI Listing
December 2016

Accelerated T-cell activation and differentiation of polar subsets characterizes early atopic dermatitis development.

J Allergy Clin Immunol 2016 11 16;138(5):1473-1477.e5. Epub 2016 Jun 16.

Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.04.052DOI Listing
November 2016

The 'omics' revolution: redefining the understanding and treatment of allergic skin diseases.

Curr Opin Allergy Clin Immunol 2016 10;16(5):469-76

aDepartment of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA bDepartment of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel cLaboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA *Margeaux Oliva and Yael Renert-Yuval contributed equally to the article.

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http://dx.doi.org/10.1097/ACI.0000000000000306DOI Listing
October 2016

The translational revolution in atopic dermatitis, and how it also translates to other inflammatory skin diseases.

Cutis 2016 Sep;98(3):145-146

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, and the Laboratory for Investigative Dermatology, The Rockefeller University, New York, USA.

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September 2016

Cellular and molecular immunologic mechanisms in patients with atopic dermatitis.

J Allergy Clin Immunol 2016 08;138(2):336-49

Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland; Swiss Institute for Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

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http://dx.doi.org/10.1016/j.jaci.2016.06.010DOI Listing
August 2016