Emily H Cheng

Emily H Cheng

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Emily H Cheng

Emily H Cheng

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Chromosome 3p Loss-Orchestrated VHL, HIF, and Epigenetic Deregulation in Clear Cell Renal Cell Carcinoma.

J Clin Oncol 2018 Oct 29:JCO2018792549. Epub 2018 Oct 29.

James J. Hsieh, Valerie H. Le, and Toshinao Oyama, Washington University, St Louis, MO; Christopher J. Ricketts, National Institutes of Health, Bethesda, MA; Thai Huu Ho, Mayo Clinic, Phoenix, AZ; and Emily H. Cheng, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://ascopubs.org/doi/10.1200/JCO.2018.79.2549
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http://dx.doi.org/10.1200/JCO.2018.79.2549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299341PMC
October 2018

Chromosome 3p Loss-Orchestrated VHL, HIF, and Epigenetic Deregulation in Clear Cell Renal Cell Carcinoma.

J Clin Oncol 2018 Oct 29:JCO2018792549. Epub 2018 Oct 29.

James J. Hsieh, Valerie H. Le, and Toshinao Oyama, Washington University, St Louis, MO; Christopher J. Ricketts, National Institutes of Health, Bethesda, MA; Thai Huu Ho, Mayo Clinic, Phoenix, AZ; and Emily H. Cheng, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://ascopubs.org/doi/10.1200/JCO.2018.79.2549
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http://dx.doi.org/10.1200/JCO.2018.79.2549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299341PMC
October 2018

Genomic classifications of renal cell carcinoma: a critical step towards the future application of personalized kidney cancer care with pan-omics precision.

J Pathol 2018 04 14;244(5):525-537. Epub 2018 Feb 14.

Human Genome Sequencing Center, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1002/path.5022DOI Listing
April 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

ΔNp63 Inhibits Oxidative Stress-Induced Cell Death, Including Ferroptosis, and Cooperates with the BCL-2 Family to Promote Clonogenic Survival.

Cell Rep 2017 Dec;21(10):2926-2939

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173166
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http://dx.doi.org/10.1016/j.celrep.2017.11.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915869PMC
December 2017

Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy.

Nat Commun 2017 07 17;8:16078. Epub 2017 Jul 17.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncomms16078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520052PMC
July 2017

SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer.

Mol Cell Oncol 2017 19;4(4):e1342747. Epub 2017 Jun 19.

Molecular Oncology, Department of Medicine, Siteman Cancer Center, Washington University, St. Louis, MO, USA.

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http://dx.doi.org/10.1080/23723556.2017.1342747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540208PMC
June 2017

Overcome tumor heterogeneity-imposed therapeutic barriers through convergent genomic biomarker discovery: A braided cancer river model of kidney cancer.

Semin Cell Dev Biol 2017 04 8;64:98-106. Epub 2016 Sep 8.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States.

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http://dx.doi.org/10.1016/j.semcdb.2016.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522717PMC
April 2017

The VDAC2-BAK axis regulates peroxisomal membrane permeability.

J Cell Biol 2017 03 7;216(3):709-722. Epub 2017 Feb 7.

Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan

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http://dx.doi.org/10.1083/jcb.201605002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350511PMC
March 2017

BAK regulates catalase release from peroxisomes.

Mol Cell Oncol 2017 17;4(3):e1306610. Epub 2017 Mar 17.

Human Oncology and Pathogenesis Program and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1080/23723556.2017.1306610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462519PMC
March 2017

A braided cancer river connects tumor heterogeneity and precision medicine.

Clin Transl Med 2016 Dec 20;5(1):42. Epub 2016 Oct 20.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

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http://dx.doi.org/10.1186/s40169-016-0123-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073086PMC
December 2016

The panoramic view of clear cell renal cell carcinoma metabolism: values of integrated global cancer metabolomics.

Transl Androl Urol 2016 Dec;5(6):984-986

Department of Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.21037/tau.2016.11.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182233PMC
December 2016

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.

Mol Cell 2016 08 14;63(3):485-97. Epub 2016 Jul 14.

Department of Biochemistry and Department of Medicine, Albert Einstein Cancer Center, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975667PMC
August 2016

Assembly of Bak homodimers into higher order homooligomers in the mitochondrial apoptotic pore.

Sci Rep 2016 08 4;6:30763. Epub 2016 Aug 4.

Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA.

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http://dx.doi.org/10.1038/srep30763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973285PMC
August 2016

Taspase 1: A protease with many biological surprises.

Mol Cell Oncol 2015 Oct-Dec;2(4):e999513. Epub 2015 Jan 23.

Human Oncology & Pathogenesis Program; Memorial Sloan-Kettering Cancer Center; New York, NY, USA; Department of Medicine; Memorial Sloan-Kettering Cancer Center; New York, NY, USA; Department of Medicine; Weill Medical College of Cornell University; New York, NY, USA.

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http://dx.doi.org/10.1080/23723556.2014.999513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905357PMC
June 2016

Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis.

Cell Res 2014 Nov 30;24(11):1354-66. Epub 2014 Sep 30.

1] Human Oncology & Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA [2] Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA [3] Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.

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http://dx.doi.org/10.1038/cr.2014.129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220155PMC
November 2014

Tumor genetic analyses of patients with metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy.

Clin Cancer Res 2014 Apr 12;20(7):1955-64. Epub 2014 Mar 12.

Authors' Affiliations: Departments of Medicine, Surgery, Pathology, Radiology, and Computational Biology; Human Oncology and Pathogenesis Program; Genomics Core Laboratory, Memorial Sloan-Kettering Cancer Center; and Department of Medicine, Weill Medical College of Cornell University, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140619PMC
April 2014

Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4.

Cancer Cell 2014 Apr;25(4):530-42

Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097146PMC
April 2014

Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.

Dev Cell 2013 Oct;27(2):188-200

Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2013.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947863PMC
October 2013

HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.

J Clin Invest 2013 Jul 24;123(7):3154-65. Epub 2013 Jun 24.

Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1172/JCI65566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696564PMC
July 2013

Cancer therapeutics: Pulling the plug on BCL-X(L).

Nat Chem Biol 2013 Jun;9(6):351-2

Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nchembio.1256DOI Listing
June 2013

In cancer drug resistance, germline matters too.

Nat Med 2012 Apr 5;18(4):494-6. Epub 2012 Apr 5.

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http://www.nature.com/articles/nm.2725
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http://dx.doi.org/10.1038/nm.2725DOI Listing
April 2012

MLL fusions: pathways to leukemia.

Cancer Biol Ther 2009 Jul;8(13):1204-11

Molecular Oncology, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289713PMC
http://dx.doi.org/10.4161/cbt.8.13.8924DOI Listing
July 2009

VDAC2 inhibits BAK activation and mitochondrial apoptosis.

Science 2003 Jul;301(5632):513-7

Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1083995
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http://dx.doi.org/10.1126/science.1083995DOI Listing
July 2003

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis.

Science 2003 Apr 6;300(5616):135-9. Epub 2003 Mar 6.

Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Department of Pathology and Medicine, Harvard Medical School, Boston, MA 02115, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1081208
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http://dx.doi.org/10.1126/science.1081208DOI Listing
April 2003