Publications by authors named "Emilio Perucca"

100Publications

The Interplay Between Liver First-Pass Effect and Lymphatic Absorption of Cannabidiol and Its Implications for Cannabidiol Oral Formulations.

Clin Pharmacokinet 2020 Aug 12. Epub 2020 Aug 12.

Institute of Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

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http://dx.doi.org/10.1007/s40262-020-00931-wDOI Listing
August 2020

A pragmatic algorithm to select appropriate antiseizure medications in patients with epilepsy.

Epilepsia 2020 Jul 22. Epub 2020 Jul 22.

Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1111/epi.16610DOI Listing
July 2020

Response: Cannabidiol antiseizure activity and its interactions with clobazam: "It's déjà vu all over again" Yogi Berra.

Epilepsia 2020 Jul 5. Epub 2020 Jul 5.

Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1111/epi.16601DOI Listing
July 2020

Does screening for adverse effects improve health outcomes in epilepsy? A randomized trial.

Neurology 2020 07 29;95(3):e239-e246. Epub 2020 Jun 29.

From the Clinical Pharmacology Unit (V.F., G.G., E.P.), University of Pavia; IRCCS Mondino Foundation (V.F., C.F., C.A.G., E.P.), Pavia; Epilepsy Center (M.P.C.), San Paolo Hospital, Milan; Magna Graecia University (G.D.S.), Catanzaro; School of Hospital Pharmacy (G.F.), University of Milan; Epilepsy Center (A.L.N.), Neurology Hospital "Amaducci," University of Bari; Unit of Neurology (E.R.), Usl Centro Toscana Health Authority, Prato; University of Foggia (L.M.S.); Epilepsy Center (S.S.), Federico II University, Naples; and IRCCS (P.T.), Institute of Neurological Sciences of Bologna and Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000009880DOI Listing
July 2020

Relationship between saliva and plasma rufinamide concentrations in patients with epilepsy.

Epilepsia 2020 Jul 20;61(7):e79-e84. Epub 2020 Jun 20.

Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1111/epi.16584DOI Listing
July 2020

Critical Aspects Affecting Cannabidiol Oral Bioavailability and Metabolic Elimination, and Related Clinical Implications.

CNS Drugs 2020 Aug;34(8):795-800

School of Pharmacy, Faculty of Medicine, Institute of Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.

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http://dx.doi.org/10.1007/s40263-020-00741-5DOI Listing
August 2020

Does cannabidiol have antiseizure activity independent of its interactions with clobazam? An appraisal of the evidence from randomized controlled trials.

Epilepsia 2020 Jun 26;61(6):1082-1089. Epub 2020 May 26.

Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1111/epi.16542DOI Listing
June 2020

Keeping people with epilepsy safe during the COVID-19 pandemic.

Neurology 2020 06 23;94(23):1032-1037. Epub 2020 Apr 23.

From the Department Neurology (J.A.F.), NYU Grossman School of Medicine New York University, NY; Epilepsy Unit (M.J.B.), International Bureau for Epilepsy, Scottish Epilepsy Initiative, Glasgow, Scotland; Neurology (R.C.), Hospital J P Garrahan, Buenos Aires, AR; Department Neurology (O.D.), NYU Grossman School of Medicine, NY; Institute of Neurology (D.D.), Huashan Hospital, Fudan University, Shanghai, China; Cleveland Clinic Epilepsy Center (L.J.), Cleveland, OH; Department of Neurology (N.J.), Icahn School of Medicine at Mount Sinai, New York, NY; Division of Epilepsy (A.K.), Department of Neurology, Miller School of Medicine, University of Miami, FL; Cincinnati Children's Hospital Medical Center (A.C.M.), School of Medicine, University of Cincinnati, OH; KEMRI-Wellcome Programme (C.R.N.), Kilifi, Kenya and Department of Psychiatry (C.R.N.), University of Oxford, United Kingdom; Division of Epilepsy and Clinical Neurophysiology (A.A.P.), Department of Neurology, Harvard Medical School, Boston Children's Hospital, MA; Harvard Medical School (P.B.P.), Brigham and Women's Hospital, Boston, MA; Department of Internal Medicine and Therapeutics (E.P.), University of Pavia and IRCCS Mondino Foundation, Member of the ERN EpiCARE, Pavia, Italy; UCL Queen Square Institute of Neurology (J.W.S.), London, United Kingdom and Stichting Epilepsie Instelligen Nederland (SEIN) (J.W.S.), Heemstede, Netherlands; University of Melbourne (I.E.S.), Austin and Royal Children's Hospitals, Florey and Murdoch Children's Research Institutes, Melbourne, Australia; Dayanand Medical College (G.S.), Ludhiana, India; Matthew's Friends-Ketogenic Dietary Therapies (E.W.), London, United Kingdom; Department of Paediatric Neurology (J.W.), Red Cross War Memorial Children's Hospital, Neuroscience Institute, Cape Town, South Africa; and UCL NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, London, United Kingdom and Member of the ERN EpiCARE (J.H.C.), Young Epilepsy, Lingfield, United Kingdom.

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http://dx.doi.org/10.1212/WNL.0000000000009632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455365PMC
June 2020

30 years of second-generation antiseizure medications: impact and future perspectives.

Lancet Neurol 2020 06 25;19(6):544-556. Epub 2020 Feb 25.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/S1474-4422(20)30035-1DOI Listing
June 2020

Time to Start Calling Things by Their Own Names? The Case for Antiseizure Medicines.

Epilepsy Curr 2020 Mar 20;20(2):69-72. Epub 2020 Feb 20.

Unit of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Italy.

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http://dx.doi.org/10.1177/1535759720905516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160876PMC
March 2020

Pyridoxine supplementation for levetiracetam-related neuropsychiatric adverse events: A systematic review.

Epilepsy Behav 2020 02 6;103(Pt A):106861. Epub 2020 Jan 6.

Oxford Epilepsy Research Group, Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.yebeh.2019.106861DOI Listing
February 2020

Antiepileptic drugs: evolution of our knowledge and changes in drug trials.

Authors:
Emilio Perucca

Epileptic Disord 2019 Aug;21(4):319-329

Past President of the International League Against Epilepsy Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia and IRCCS Mondino Foundation, Pavia, Italy.

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http://dx.doi.org/10.1684/epd.2019.1083DOI Listing
August 2019

Declining malformation rates with changed antiepileptic drug prescribing: An observational study.

Neurology 2019 08 7;93(9):e831-e840. Epub 2019 Aug 7.

From the Department of Clinical Neuroscience (T.T.), Karolinska Institutet; Department of Neurology (T.T.), Karolinska University Hospital, Stockholm, Sweden; Epilepsy Center, Department of Neurophysiology and Experimental Epileptology (D.B.), Fondazione IRCCS Istituto Neurologico Carlo Besta; Department of Clinical Science and Community (E.B.), Section of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro," Faculty of Medicine and Surgery, University of Milan, Italy; Belfast Health and Social Care Trust (J.C.), Belfast, UK; Department of Genetics (D.L.), University Medical Center Utrecht; Stichting Epilepsie Instellingen Nederland (SEIN) (D.L.), Heemstede, the Netherlands; Department of Internal Medicine and Therapeutics (E.P.), University of Pavia; Clinical Trial Center (E.P.), IRCCS Mondino Foundation, Pavia, Italy; The Epilepsy Clinic, Department of Neurology (A.S.), Rigshospitalet-Blegdamsvej, University State Hospital, Copenhagen, Denmark; Department of Neurology (S.V.T.), Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, Kerala State, India; Departments of Medicine and Neurology (F.V.), University of Melbourne and Monash University; and Royal Melbourne Hospital (F.V.), Australia.

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http://dx.doi.org/10.1212/WNL.0000000000008001DOI Listing
August 2019

Pharmacological and Therapeutic Properties of Cannabidiol for Epilepsy.

Drugs 2019 Sep;79(13):1435-1454

Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Via Ferrata 9, 27100, Pavia, Italy.

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http://dx.doi.org/10.1007/s40265-019-01171-4DOI Listing
September 2019

Novel therapies for epilepsy in the pipeline.

Epilepsy Behav 2019 08 6;97:282-290. Epub 2019 Jul 6.

Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran; Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yebeh.2019.04.042DOI Listing
August 2019

Neurovascular Drug Biotransformation Machinery in Focal Human Epilepsies: Brain CYP3A4 Correlates with Seizure Frequency and Antiepileptic Drug Therapy.

Mol Neurobiol 2019 Dec 26;56(12):8392-8407. Epub 2019 Jun 26.

Cerebrovascular Research Laboratory, Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.

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http://dx.doi.org/10.1007/s12035-019-01673-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854685PMC
December 2019

The ILAE at 110-Reflections on the last decade.

Epilepsia Open 2019 Jun 25;4(2):247-253. Epub 2019 May 25.

Saul R. Korey Department of Neurology Isabelle Rapin Division of Child Neurology Dominick P. Purpura Department of Neuroscience Laboratory of Developmental Epilepsy Albert Einstein College of Medicine Einstein/Montefiore Epilepsy Center Montefiore Medical Center Bronx New York.

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http://dx.doi.org/10.1002/epi4.12340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546007PMC
June 2019

A summary of data presented at the XIV conference on new antiepileptic drug and devices (EILAT XIV).

Epilepsy Res 2019 07 11;153:66-67. Epub 2019 Mar 11.

Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.002DOI Listing
July 2019

Seizure-alerting behavior in dogs owned by people experiencing seizures.

Epilepsy Behav 2019 05 18;94:104-111. Epub 2019 Mar 18.

Laboratory for Ethology, Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183100
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http://dx.doi.org/10.1016/j.yebeh.2019.02.001DOI Listing
May 2019

Identifying mutations in epilepsy genes: Impact on treatment selection.

Epilepsy Res 2019 05 4;152:18-30. Epub 2019 Mar 4.

Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; Clinical Trial Center, IRCCS Mondino Foundation, Pavia, Italy.

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.001DOI Listing
May 2019

Validated outcome of treatment changes according to International League Against Epilepsy criteria in adults with drug-resistant focal epilepsy.

Epilepsia 2019 06 13;60(6):1114-1123. Epub 2019 Mar 13.

Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia and Clinical Trial Center, IRCCS Mondino Foundation, Pavia, Italy.

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http://dx.doi.org/10.1111/epi.14685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850288PMC
June 2019

Teratogenicity of antiepileptic drugs.

Curr Opin Neurol 2019 04;32(2):246-252

Department of Internal Medicine and Therapeutics, University of Pavia, Clinical Trial Center, IRCCS Mondino Foundation, Pavia, Italy.

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http://dx.doi.org/10.1097/WCO.0000000000000659DOI Listing
April 2019

Do neurologists agree in diagnosing drug resistance in adults with focal epilepsy?

Epilepsia 2019 01 25;60(1):175-183. Epub 2018 Dec 25.

Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia and Clinical Trial Center, IRCCS Mondino Foundation, Pavia, Italy.

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http://doi.wiley.com/10.1111/epi.14622
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http://dx.doi.org/10.1111/epi.14622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379205PMC
January 2019

From clinical trials of antiepileptic drugs to treatment.

Authors:
Emilio Perucca

Epilepsia Open 2018 Dec 10;3(Suppl Suppl 2):220-230. Epub 2018 Jul 10.

Division of Clinical and Experimental Pharmacology Department of Internal Medicine and Therapeutics University of Pavia Pavia Italy.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/epi4.12239
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http://dx.doi.org/10.1002/epi4.12239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293126PMC
December 2018

Drug interactions with carbamazepine: An ever expanding list?

Authors:
Emilio Perucca

Epilepsy Res 2018 11 6;147:119-120. Epub 2018 Aug 6.

Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, and Clinical Trial Center, IRCCS Mondino Foundation, Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.eplepsyres.2018.08.001DOI Listing
November 2018

EURAP registry: inadequate monitoring of prescribed drugs in pregnancy - Authors' reply.

Lancet Neurol 2018 09;17(9):741-742

Department of Medicine and Department of Neurology, University of Melbourne, Royal Melbourne Hospital, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1016/S1474-4422(18)30281-3DOI Listing
September 2018

No Evidence of a Causal Role of Antiepileptic Drug Treatment with Regard to the Development of Dementia.

J Am Geriatr Soc 2018 09 9;66(9):1850-1852. Epub 2018 Aug 9.

Department of Epileptology, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1111/jgs.15467DOI Listing
September 2018

Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.

Lancet Neurol 2018 06 18;17(6):530-538. Epub 2018 Apr 18.

Department of Medicine and Department of Neurology, University of Melbourne, Royal Melbourne Hospital, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1016/S1474-4422(18)30107-8DOI Listing
June 2018

Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?

Authors:
Emilio Perucca

J Epilepsy Res 2017 Dec 31;7(2):61-76. Epub 2017 Dec 31.

Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.14581/jer.17012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767492PMC
December 2017

Genetic testing to prevent adverse reactions to antiepileptic drugs: Primum non nocere.

Neurology 2018 01 29;90(4):155-156. Epub 2017 Dec 29.

From the Pediatric Neurology Unit and Laboratories (R.G.), Children's Hospital A. Meyer-University of Florence; IRCCS Stella Maris (R.G.), Pisa; Department of Internal Medicine and Therapeutics (E.P.), University of Pavia; and Clinical Trial Center (E.P.), C. Mondino National Neurological Institute, Pavia, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000004869DOI Listing
January 2018

A simple and rapid HPLC-UV method for the determination of retigabine in human plasma.

Biomed Chromatogr 2018 May 24;32(5):e4168. Epub 2018 Jan 24.

Clinical and Experimental Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1002/bmc.4168DOI Listing
May 2018

Maternal and fetal outcomes associated with vagus nerve stimulation during pregnancy.

Epilepsy Res 2017 11;137:159-162

Departments of Medicine and Neurology, University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.eplepsyres.2017.05.013DOI Listing
November 2017

A new classification is born.

Epilepsia 2017 04 8;58(4):511. Epub 2017 Mar 8.

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http://dx.doi.org/10.1111/epi.13694DOI Listing
April 2017

Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII).

Epilepsia 2017 02 23;58(2):181-221. Epub 2017 Jan 23.

Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, Washington, U.S.A.

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http://dx.doi.org/10.1111/epi.13634DOI Listing
February 2017

Perampanel effects in the WAG/Rij rat model of epileptogenesis, absence epilepsy, and comorbid depressive-like behavior.

Epilepsia 2017 02 18;58(2):231-238. Epub 2016 Dec 18.

Department of Science of Health, School of Medicine and Surgery, University of Catanzaro, Catanzaro, Italy.

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http://dx.doi.org/10.1111/epi.13629DOI Listing
February 2017

Development and Validation of an HPLC-UV Assay for the Therapeutic Monitoring of the New Antiepileptic Drug Perampanel in Human Plasma.

Ther Drug Monit 2016 12;38(6):744-750

*Genomic and post-Genomic Center, C. Mondino National Neurological Institute; †Division of Clinical and Experimental Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; and ‡Department of Health Science, School of Medicine, University of Catanzaro, Catanzaro, Italy.

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http://dx.doi.org/10.1097/FTD.0000000000000350DOI Listing
December 2016

A Tribute to Steve White.

Authors:
Emilio Perucca

Neurochem Res 2017 07 1;42(7):1867-1868. Epub 2016 Oct 1.

International League against Epilepsy (ILAE), Department of Internal Medicine, University of Pavia and C. Mondino National Neurological Institute, Pavia, Italy.

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http://dx.doi.org/10.1007/s11064-016-2071-1DOI Listing
July 2017

Not all that glitters is gold: A guide to the critical interpretation of drug trials in epilepsy.

Epilepsia Open 2016 09 27;1(1-2):9-21. Epub 2016 Jul 27.

Department of Clinical Neurosciences and Hotchkiss Brain Institute Cumming School of Medicine University of Calgary Calgary Alberta Canada.

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http://dx.doi.org/10.1002/epi4.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867835PMC
September 2016

Commentary: Message from the ILAE president.

Authors:
Emilio Perucca

Epilepsia Open 2016 Sep 21;1(1-2). Epub 2016 Jul 21.

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http://dx.doi.org/10.1002/epi4.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867838PMC
September 2016

Withdrawal of valproic acid treatment during pregnancy and seizure outcome: Observations from EURAP.

Epilepsia 2016 08 20;57(8):e173-7. Epub 2016 Jun 20.

Departments of Medicine and Neurology, University of Melbourne, Royal Melbourne Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/epi.13437DOI Listing
August 2016

Reflections on monotherapy trials for epilepsy - Authors' reply.

Lancet Neurol 2016 06 9;15(7):657-658. Epub 2016 May 9.

Department of Neurology, Hôpital Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1016/S1474-4422(16)00119-8DOI Listing
June 2016

The safety of generic substitution in epilepsy.

Authors:
Emilio Perucca

Lancet Neurol 2016 Apr 12;15(4):344-5. Epub 2016 Feb 12.

Department of Internal Medicine and Therapeutics, University of Pavia and C. Mondino National Neurological Institute, Via Ferrata 9, 27100 Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(16)00042-9DOI Listing
April 2016

The remarkable story of valproic acid.

Lancet Neurol 2016 02 12;15(2):141. Epub 2016 Jan 12.

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http://dx.doi.org/10.1016/S1474-4422(15)00398-1DOI Listing
February 2016

In Memoriam: Hanneke De Boer (1946-2015).

Epilepsia 2016 Jan;57(1):162-3

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http://dx.doi.org/10.1111/epi.13293DOI Listing
January 2016

Epilepsy, seizures, physical exercise, and sports: A report from the ILAE Task Force on Sports and Epilepsy.

Epilepsia 2016 Jan 10;57(1):6-12. Epub 2015 Dec 10.

Department of Physiology, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil.

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http://dx.doi.org/10.1111/epi.13261DOI Listing
January 2016

The current state of epilepsy guidelines: A systematic review.

Epilepsia 2016 Jan 10;57(1):13-23. Epub 2015 Dec 10.

Department of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1111/epi.13273DOI Listing
January 2016

Antiepileptic drug use and epileptic seizures in nursing home residents in the Province of Pavia, Italy: A reappraisal 12 years after a first survey.

Epilepsy Res 2016 Jan 1;119:41-8. Epub 2015 Dec 1.

Epilepsy Centre, IRCCS C. Mondino National Neurological Institute, Pavia, Italy; Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1016/j.eplepsyres.2015.11.009DOI Listing
January 2016

Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug.

Lancet Neurol 2016 02 5;15(2):210-218. Epub 2015 Dec 5.

Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; C Mondino National Neurological Institute, Pavia, Italy.

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http://www.thelancet.com/pdfs/journals/laneur/PIIS1474-4422(
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http://linkinghub.elsevier.com/retrieve/pii/S147444221500314
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http://dx.doi.org/10.1016/S1474-4422(15)00314-2DOI Listing
February 2016

Challenges in the clinical development of new antiepileptic drugs.

Pharmacol Res 2016 Jan 2;103:95-104. Epub 2015 Dec 2.

C. Mondino National Neurological Institute, Pavia, Italy; Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

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http://pdfs.journals.lww.com/drug-monitoring/2002/02000/Chal
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http://linkinghub.elsevier.com/retrieve/pii/S104366181500268
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http://dx.doi.org/10.1016/j.phrs.2015.11.007DOI Listing
January 2016

Is a separate monotherapy indication warranted for antiepileptic drugs?

Lancet Neurol 2015 Dec;14(12):1229-40

Department of Neurology, Hôpital Pitié-Salpêtriére, Paris, France.

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http://dx.doi.org/10.1016/S1474-4422(15)00229-XDOI Listing
December 2015

Developing clinical practice guidelines for epilepsy: A report from the ILAE Epilepsy Guidelines Working Group.

Epilepsia 2015 Dec 30;56(12):1859-69. Epub 2015 Oct 30.

Department of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1111/epi.13217DOI Listing
December 2015

Availability of antiepileptic drugs across Europe.

Epilepsia 2015 Dec 19;56(12):e191-7. Epub 2015 Oct 19.

Department on Internal Medicine and Therapeutics, University of Pavia, and C. Mondino National Neurological Institute, Pavia, Italy.

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http://dx.doi.org/10.1111/epi.13210DOI Listing
December 2015

From global campaign to global commitment: The World Health Assembly's Resolution on epilepsy.

Epilepsia 2015 Nov 22;56(11):1651-7. Epub 2015 Sep 22.

University of Pavia and C. Mondino National Neurological Hospital, Pavia, Italy.

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http://dx.doi.org/10.1111/epi.13192DOI Listing
November 2015

The pharmacogenomics of epilepsy.

Expert Rev Neurother 2015 Oct 1;15(10):1161-70. Epub 2015 Sep 1.

a 1 C. Mondino National Neurological Institute, Pavia, Italy.

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http://dx.doi.org/10.1586/14737175.2015.1083424DOI Listing
October 2015

Antiepileptic drugs and intrauterine death: A prospective observational study from EURAP.

Neurology 2015 Aug 17;85(7):580-8. Epub 2015 Jul 17.

From the Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm, Sweden; Epilepsy Center (D.B.), Department of Neurophysiology and Experimental Epileptology, IRCCS Neurological Institute Carlo Besta Foundation, Milan; Department of Clinical Science and Community (E.B.), Section of Medical Statistics and Biometry G.A. Maccacaro, Faculty of Medicine and Surgery, University of Milan, Italy; Belfast Health and Social Care Trust (J.J.C.), Belfast, Ireland; Department of Medical Genetics (D.L.), University Medical Center Utrecht; SEIN-Epilepsy Institute in the Netherlands Foundation (D.L.), Hoofddorp, the Netherlands; Department of Internal Medicine and Therapeutics (E.P.), University of Pavia, and Clinical Trial Center, C. Mondino National Neurological Institute, Pavia, Italy; The Epilepsy Clinic (A.S.), Department of Neurology, Rigshospitalet University State Hospital, Copenhagen, Denmark; Department of Neurology (S.V.T.), Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, Kerala, India; and Departments of Medicine and Neurology (F.V.), University of Melbourne, Royal Melbourne Hospital, Australia.

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August 2015

Extending the phenotypic spectrum of RBFOX1 deletions: Sporadic focal epilepsy.

Epilepsia 2015 Sep 15;56(9):e129-33. Epub 2015 Jul 15.

Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1111/epi.13076DOI Listing
September 2015

Dose-dependent teratogenicity of valproate in mono- and polytherapy: an observational study.

Neurology 2015 Sep 17;85(10):866-72. Epub 2015 Jun 17.

From the Department of Clinical Neuroscience (T.T.), Karolinska Institutet, Stockholm, Sweden; Epilepsy Center (D.B.), Department of Neurophysiology and Experimental Epileptology, IRCCS Neurological Institute Carlo Besta Foundation, Milan; Department of Clinical Science and Community (E.B.), Section of Medical Statistics and Biometry G.A. Maccacaro, Faculty of Medicine and Surgery, University of Milan, Italy; Belfast Health and Social Care Trust (J.C.), Belfast, Ireland; Department of Medical Genetics (D.L.), University Medical Center Utrecht; SEIN-Epilepsy Institute in the Netherlands Foundation (D.L.), Hoofddorp, the Netherlands; Department of Internal Medicine and Therapeutics (E.P.), University of Pavia, and Clinical Trial Center, C. Mondino National Neurological Institute, Pavia, Italy; The Epilepsy Clinic (A.S.), Department of Neurology, Rigshospitalet University State Hospital, Copenhagen, Denmark; Department of Neurology (S.V.T.), Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, Kerala State, India; and Departments of Medicine and Neurology (F.V.), University of Melbourne, Royal Melbourne Hospital, Australia.

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September 2015

CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.

Expert Opin Drug Metab Toxicol 2015 3;11(8):1269-79. Epub 2015 Jun 3.

C. Mondino National Neurological Institute , Pavia , Italy.

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http://dx.doi.org/10.1517/17425255.2015.1053463DOI Listing
March 2016

Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII).

Epilepsy Res 2015 Mar 19;111:85-141. Epub 2015 Jan 19.

Anticonvulsant Drug Development Program and Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1016/j.eplepsyres.2015.01.001DOI Listing
March 2015

Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: an in vitro study.

Epilepsia 2015 Mar 5;56(3):439-49. Epub 2015 Feb 5.

Cerebrovascular Research, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, U.S.A; Department of Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, U.S.A; Department of Bio-medical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, U.S.A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413932PMC
March 2015

Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs.

Epileptic Disord 2014 Dec;16(4):409-31

Department of Internal Medicine and Therapeutics, University of Pavia, and C. Mondino National Neurological Institute, Pavia, Italy.

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http://dx.doi.org/10.1684/epd.2014.0714DOI Listing
December 2014

Commentary: why an international epilepsy day?

Authors:
Emilio Perucca

Epilepsia 2015 Feb 17;56(2):170-1. Epub 2014 Nov 17.

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http://dx.doi.org/10.1111/epi.12813DOI Listing
February 2015

Epilepsy: new advances.

Lancet 2015 Mar 24;385(9971):884-98. Epub 2014 Sep 24.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/S0140-6736(14)60456-6DOI Listing
March 2015

Commentary: Epilepsy is a Global Problem.

Epilepsia 2014 Sep 4;55(9):1326-8. Epub 2014 Aug 4.

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http://dx.doi.org/10.1111/epi.12725DOI Listing
September 2014

Gender issues in antiepileptic drug treatment.

Neurobiol Dis 2014 Dec 20;72 Pt B:217-23. Epub 2014 May 20.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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December 2014

Introduction to the clinical definition of epilepsy by the ILAE president.

Authors:
Emilio Perucca

Epilepsia 2014 Apr 14;55(4):473-4. Epub 2014 Apr 14.

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April 2014

In memoriam: Harry Meinardi (February 20, 1932-December 20, 2013).

Epilepsia 2014 Apr 7;55(4):621-2. Epub 2014 Mar 7.

Department of Internal Medicine and Therapeutics, University of Pavia and C Mondino National Neurological Institute, Pavia, Italy.

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April 2014

Perampanel for adjunctive treatment of partial-onset seizures: a pooled dose-response analysis of phase III studies.

Epilepsia 2014 Mar 7;55(3):423-31. Epub 2014 Mar 7.

Eisai Neuroscience and General Medicine Product Creation Unit, Eisai Inc, Woodcliff Lake, New Jersey, U.S.A.

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http://doi.wiley.com/10.1111/epi.12527
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March 2014

Optimizing antiepileptic drug treatment in tumoral epilepsy.

Authors:
Emilio Perucca

Epilepsia 2013 Dec;54 Suppl 9:97-104

Department of Internal Medicine and Therapeutics, University of Pavia and C Mondino National Neurological Institute, Pavia, Italy.

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December 2013

Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry.

Epilepsia 2013 Sep 12;54(9):1621-7. Epub 2013 Jul 12.

Epilepsy Center, Department of Neurophysiology and Experimental Epileptology, I.R.C.C.S. Neurological Institute "Carlo Besta" Foundation, Milan, Italy.

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September 2013

Epileptic Disorders to become the educational journal of the ILAE.

Epileptic Disord 2013 Jun;15(2):99

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June 2013

Novel frontiers in epilepsy treatments: preventing epileptogenesis by targeting inflammation.

Expert Rev Neurother 2013 Jun;13(6):615-25

Department of Neurological Surgery, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1586/ern.13.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264793PMC
June 2013

Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age: an update.

Clin Pharmacokinet 2013 Aug;52(8):627-45

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

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http://dx.doi.org/10.1007/s40262-013-0067-4DOI Listing
August 2013

Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes.

Epilepsia 2013 Mar 25;54(3):551-63. Epub 2013 Jan 25.

Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.

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March 2013