Dr. Emilio Hirsch, PhD - University of Torino - Professor

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.

Authors:

Meredith L Jenkins Jean Piero Margaria Jordan T B Stariha Reece M Hoffmann Jacob A McPhail David J Hamelin Martin J Boulanger Emilio Hirsch John E Burke

Nat Commun 2018 09 14;9(1):3772. Epub 2018 Sep 14.

Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, V8W 2Y2, Canada.

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http://dx.doi.org/10.1038/s41467-018-06196-z	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138693	PMC

September 2018

19 Reads

10.742 Impact Factor

Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting.

Authors:

Elisabeth Wyart Simone Reano Myriam Y Hsu Dario Livio Longo Mingchuan Li Emilio Hirsch Nicoletta Filigheddu Alessandra Ghigo Chiara Riganti Paolo Ettore Porporato

Oxid Med Cell Longev 2018 26;2018:6419805. Epub 2018 Feb 26.

Department of Molecular Biotechnology and Health Science, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1155/2018/6419805	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846462	PMC

September 2018

6 Reads

Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes.

Authors:

Carlo Cosimo Campa Jean Piero Margaria Abhishek Derle Marco Del Giudice Maria Chiara De Santis Luca Gozzelino Francesca Copperi Carla Bosia Emilio Hirsch

Nat Chem Biol 2018 Aug 18;14(8):801-810. Epub 2018 Jun 18.

Department of Molecular Biotechnology and Health Sciences. Molecular Biotechnology Center, University of Turin, Torino, Italy.

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http://dx.doi.org/10.1038/s41589-018-0086-4	DOI Listing

August 2018

7 Reads

1 Citation

13.000 Impact Factor

Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities.

Authors:

Valentina Zamboni Rebecca Jones Alessandro Umbach Alessandra Ammoni Maria Passafaro Emilio Hirsch Giorgio R Merlo

Int J Mol Sci 2018 Jun 20;19(6). Epub 2018 Jun 20.

Department Molecular Biotechnology and Health Science, University of Torino, Via Nizza 52, 10126 Turin, Italy.

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http://dx.doi.org/10.3390/ijms19061821	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032284	PMC

June 2018

3 Reads

1 Citation

2.862 Impact Factor

Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics.

Authors:

Valentina Zamboni Maria Armentano Gaia Berto Elisa Ciraolo Alessandra Ghigo Donatella Garzotto Alessandro Umbach Ferdinando DiCunto Elena Parmigiani Marina Boido Alessandro Vercelli Nadia El-Assawy Alessandro Mauro Lorenzo Priano Luisa Ponzoni Luca Murru Maria Passafaro Emilio Hirsch Giorgio R Merlo

Sci Rep 2018 May 8;8(1):7254. Epub 2018 May 8.

Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy.

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http://dx.doi.org/10.1038/s41598-018-25354-3	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940682	PMC

May 2018

4 Reads

1 Citation

5.080 Impact Factor

Protumor Steering of Cancer Inflammation by p50 NF-κB Enhances Colorectal Cancer Progression.

Authors:

Chiara Porta Alessandro Ippolito Francesca Maria Consonni Lorenzo Carraro Giuseppe Celesti Carmen Correale Fabio Grizzi Fabio Pasqualini Silvia Tartari Maurizio Rinaldi Paolo Bianchi Fiorella Balzac Stefania Vetrano Emilia Turco Emilio Hirsch Luigi Laghi Antonio Sica

Cancer Immunol Res 2018 05 27;6(5):578-593. Epub 2018 Mar 27.

Department of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale "Amedeo Avogadro," Novara, Italy.

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http://cancerimmunolres.aacrjournals.org/lookup/doi/10.1158/	Publisher Site
http://dx.doi.org/10.1158/2326-6066.CIR-17-0036	DOI Listing

May 2018

8 Reads

2 Citations

Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits.

Authors:

Larissa Jeremias Duarte Vitor Clasen Chaves Marcus Vinicius Pereira Dos Santos Nascimento Eunice Calvete Mingchuan Li Elisa Ciraolo Alessandra Ghigo Emilio Hirsch Claudia Maria Oliveira Simões Flávio Henrique Reginatto Eduardo M Dalmarco

Food Chem 2018 May 7;247:56-65. Epub 2017 Dec 7.

Department of Clinical Analysis, Centre of Health Sciences, Federal University of Santa Catarina, Campus Universitário - Trindade, 88040-970 Florianopolis, SC, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.foodchem.2017.12.015	DOI Listing

May 2018

8 Reads

3.391 Impact Factor

Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis.

Nat Commun 2018 04 17;9(1):1513. Epub 2018 Apr 17.

Department of Pharmacology, Ribeirão Preto Medical School, University of Sao Paulo, Bandeirantes Avenue, 3900, Ribeirão Preto, SP, 14049-900, Brazil.

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http://dx.doi.org/10.1038/s41467-018-03986-3	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904108	PMC

April 2018

12 Reads

10.742 Impact Factor

The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC.

Authors:

Stefan Frantz Ines Falcao-Pires Jean-Luc Balligand Johann Bauersachs Dirk Brutsaert Michele Ciccarelli Dana Dawson Leon J de Windt Mauro Giacca Nazha Hamdani Denise Hilfiker-Kleiner Emilio Hirsch Adelino Leite-Moreira Manuel Mayr Thomas Thum Carlo G Tocchetti Jolanda van der Velden Gilda Varricchi Stephane Heymans

Eur J Heart Fail 2018 03 15;20(3):445-459. Epub 2018 Jan 15.

Department of Cardiology, CARIM School for Cardiovascular Diseases Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/ejhf.1138	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993315	PMC

March 2018

20 Reads

3 Citations

6.530 Impact Factor

p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation.

Authors:

Benedikt Mothes Kirsten Bucher Susanne Ammon-Treiber Matthias Schwab Roland P Piekorz Emilio Hirsch Bernd Nürnberg Sandra Beer-Hammer

PLoS One 2016 21;11(7):e0159310. Epub 2016 Jul 21.

Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA, University of Tuebingen, 72074 Tuebingen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159310	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956235	PMC

July 2017

27 Reads

2 Citations

3.234 Impact Factor

Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection.

Authors:

Christoph Schneider Samuel P Nobs Alex K Heer Emilio Hirsch Josef Penninger Owen M Siggs Manfred Kopf

J Leukoc Biol 2017 02 28;101(2):367-376. Epub 2016 Jul 28.

Institute of Molecular Health Sciences, Department of Biology, ETH Zurich, Zurich, Switzerland;

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http://dx.doi.org/10.1189/jlb.4HI0316-157R	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610570	PMC

February 2017

13 Reads

1 Citation

4.290 Impact Factor

PI3Kγ Inhibition Protects Against Diabetic Cardiomyopathy in Mice.

Authors:

Angelo Maffei Giuseppe Cifelli Raimondo Carnevale Roberta Iacobucci Fabio Pallante Valentina Fardella Stefania Fardella Emilio Hirsch Giuseppe Lembo Daniela Carnevale

Rev Esp Cardiol (Engl Ed) 2017 Jan 13;70(1):16-24. Epub 2016 Jul 13.

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Istituto Neurologico Mediterraneo, Pozzilli, Isernia, Italy; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.rec.2016.04.034	DOI Listing

January 2017

2 Reads

1 Citation

Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking.

Authors:

Carlo Cosimo Campa Emilio Hirsch

Adv Biol Regul 2017 Jan 14;63:132-139. Epub 2016 Sep 14.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center (MBC), University of Torino, Via Nizza 52, 10126 Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2016.09.002	DOI Listing

January 2017

1 Read

5 Citations

Rac signal adaptation controls neutrophil mobilization from the bone marrow.

Authors:

Carlo Cosimo Campa Giulia Germena Elisa Ciraolo Francesca Copperi Anna Sapienza Irene Franco Alessandra Ghigo Annalisa Camporeale Augusta Di Savino Miriam Martini Alessia Perino Remco T A Megens Angela R M Kurz Christoph Scheiermann Markus Sperandio Andrea Gamba Emilio Hirsch

Sci Signal 2016 12 20;9(459):ra124. Epub 2016 Dec 20.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1126/scisignal.aah5882	DOI Listing

December 2016

12 Reads

1 Citation

6.280 Impact Factor

Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.

Sci Rep 2016 10 7;6:34877. Epub 2016 Oct 7.

Department of Molecular Biotechnologies and Health Sciences, University of Torino, Italy.

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http://dx.doi.org/10.1038/srep34877	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054378	PMC

October 2016

23 Reads

8 Citations

5.080 Impact Factor

Phosphoinositide 3-Kinase γ Restrains Neurotoxic Effects of Microglia After Focal Brain Ischemia.

Authors:

Caroline Schmidt Christiane Frahm Nadine Schneble Jörg P Müller Michael Brodhun Irene Franco Otto W Witte Emilio Hirsch Reinhard Wetzker Reinhard Bauer

Mol Neurobiol 2016 10 9;53(8):5468-79. Epub 2015 Oct 9.

Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Friedrich Schiller University, Hans-Knöll-Strasse 2, D-07745, Jena, Germany.

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http://dx.doi.org/10.1007/s12035-015-9472-z	DOI Listing

October 2016

2 Reads

3 Citations

5.140 Impact Factor

Correction: p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation.

Authors:

Benedikt Mothes Kirsten Bucher Susanne Ammon-Treiber Matthias Schwab Roland P Piekorz Emilio Hirsch Bernd Nürnberg Sandra Beer-Hammer

PLoS One 2016;11(9):e0163577. Epub 2016 Sep 19.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163577	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028051	PMC

September 2016

8 Reads

3.234 Impact Factor

Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression.

Authors:

Megan M Kaneda Paola Cappello Abraham V Nguyen Natacha Ralainirina Chanae R Hardamon Philippe Foubert Michael C Schmid Ping Sun Evangeline Mose Michael Bouvet Andrew M Lowy Mark A Valasek Roman Sasik Francesco Novelli Emilio Hirsch Judith A Varner

Cancer Discov 2016 08 13;6(8):870-85. Epub 2016 May 13.

Moores Cancer Center, University of California, San Diego, La Jolla, California. Department of Pathology, University of California, San Diego, La Jolla, California.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1346	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091937	PMC

August 2016

37 Reads

21 Citations

15.930 Impact Factor

Salvage pathways in heart rejuvenation.

Authors:

Emilio Hirsch

Cardiovasc Res 2016 07;111(2):123-4

Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, Torino 10125, Italy

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http://dx.doi.org/10.1093/cvr/cvw158	DOI Listing

July 2016

2 Reads

5.940 Impact Factor

New signal transduction paradigms in anthracycline-induced cardiotoxicity.

Authors:

Alessandra Ghigo Mingchuan Li Emilio Hirsch

Biochim Biophys Acta 2016 Jul 29;1863(7 Pt B):1916-25. Epub 2016 Jan 29.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2016.01.021	DOI Listing

July 2016

21 Reads

20 Citations

Corrigendum: Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis.

Authors:

Sebastian R Nielsen Valeria Quaranta Andrea Linford Perpetua Emeagi Carolyn Rainer Almudena Santos Lucy Ireland Takao Sakai Keiko Sakai Yong-Sam Kim Dannielle Engle Fiona Campbell Daniel Palmer Jeong Heon Ko David A Tuveson Emilio Hirsch Ainhoa Mielgo Michael C Schmid

Nat Cell Biol 2016 06;18(7):822

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http://dx.doi.org/10.1038/ncb3377	DOI Listing

June 2016

25 Reads

1 Citation

19.680 Impact Factor

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis.

Authors:

Sebastian R Nielsen Valeria Quaranta Andrea Linford Perpetua Emeagi Carolyn Rainer Almudena Santos Lucy Ireland Takao Sakai Keiko Sakai Yong-Sam Kim Dannielle Engle Fiona Campbell Daniel Palmer Jeong Heon Ko David A Tuveson Emilio Hirsch Ainhoa Mielgo Michael C Schmid

Nat Cell Biol 2016 05 18;18(5):549-60. Epub 2016 Apr 18.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Ashton Street, Liverpool L69 3GE, UK.

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http://dx.doi.org/10.1038/ncb3340	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894551	PMC

May 2016

21 Reads

33 Citations

19.680 Impact Factor

Genetic Deletion and Pharmacological Inhibition of PI3K γ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease.

Authors:

Maria Galluzzo Elisa Ciraolo Monica Lucattelli Eriola Hoxha Martina Ulrich Carlo Cosimo Campa Giuseppe Lungarella Gerd Doring Zhe Zhou-Suckow Marcus Mall Emilio Hirsch Virginia De Rose

Mediators Inflamm 2015 21;2015:545417. Epub 2015 Jun 21.

Department of Clinical and Biological Sciences, University of Torino, A.O.U. S.Luigi Gonzaga, Regione Gonzole 10, Orbassano, 10043 Turin, Italy.

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http://dx.doi.org/10.1155/2015/545417	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491401	PMC

May 2016

11 Reads

5 Citations

3.240 Impact Factor

Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation.

Authors:

Irene Franco Jean Piero Margaria Maria Chiara De Santis Andrea Ranghino Daniel Monteyne Marco Chiaravalli Monika Pema Carlo Cosimo Campa Edoardo Ratto Federico Gulluni David Perez-Morga Stefan Somlo Giorgio R Merlo Alessandra Boletta Emilio Hirsch

J Am Soc Nephrol 2016 Apr 13;27(4):1135-44. Epub 2015 Aug 13.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy;

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http://dx.doi.org/10.1681/ASN.2014100967	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814170	PMC

April 2016

18 Reads

6 Citations

9.343 Impact Factor

Crossroads of PI3K and Rac pathways.

Authors:

Carlo C Campa Elisa Ciraolo Alessandra Ghigo Giulia Germena Emilio Hirsch

Small GTPases 2015 5;6(2):71-80. Epub 2015 May 5.

a Molecular Biotechnology Center; Department of Molecular Biotechnology and Health Sciences; University of Torino ; Torino , Italy.

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http://dx.doi.org/10.4161/21541248.2014.989789	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601376	PMC

April 2016

21 Reads

11 Citations

Phosphoinositide 3-kinase gamma controls inflammation-induced myocardial depression via sequential cAMP and iNOS signalling.

Authors:

Bernadin Ndongson-Dongmo Regine Heller Dirk Hoyer Michael Brodhun Michael Bauer Johannes Winning Emilio Hirsch Reinhard Wetzker Peter Schlattmann Reinhard Bauer

Cardiovasc Res 2015 Nov 2;108(2):243-53. Epub 2015 Sep 2.

Institute of Molecular Cell Biology, Jena University Hospital, Friedrich Schiller University, Hans-Knöll-Straße 2, D-07745 Jena, Germany Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany

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http://dx.doi.org/10.1093/cvr/cvv217	DOI Listing

November 2015

5 Reads

3 Citations

5.940 Impact Factor

How PI3K-derived lipids control cell division.

Authors:

Carlo C Campa Miriam Martini Maria C De Santis Emilio Hirsch

Front Cell Dev Biol 2015 30;3:61. Epub 2015 Sep 30.

Department of Molecular Biotechnology and Health Sciences, University of Turin Torino, Italy.

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http://dx.doi.org/10.3389/fcell.2015.00061	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588110	PMC

October 2015

1 Read

3 Citations

PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development.

Authors:

Samuel Philip Nobs Christoph Schneider Maren Gil Dietrich Thomas Brocker Antonius Rolink Emilio Hirsch Manfred Kopf

Immunity 2015 Oct 6;43(4):674-89. Epub 2015 Oct 6.

Institute of Molecular Health Sciences, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.09.006	DOI Listing

October 2015

21 Reads

9 Citations

21.561 Impact Factor

The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors.

Authors:

Ubaldina Galli Elisa Ciraolo Alberto Massarotti Jean Piero Margaria Giovanni Sorba Emilio Hirsch Gian Cesare Tron

Molecules 2015 Sep 18;20(9):17275-87. Epub 2015 Sep 18.

Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale "A. Avogadro", Largo Donegani 2, Novara 28100, Italy.

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http://dx.doi.org/10.3390/molecules200917275	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332036	PMC

September 2015

2 Reads

2.420 Impact Factor

Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl.

Authors:

Daria Manganaro Alessandra Consonni Gianni F Guidetti Ilaria Canobbio Caterina Visconte Soochong Kim Mitsuhiko Okigaki Marco Falasca Emilio Hirsch Satya P Kunapuli Mauro Torti

Biochim Biophys Acta 2015 Aug 8;1853(8):1879-88. Epub 2015 May 8.

Department of Biology and Biotechnology, Division of Biochemistry, University of Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2015.05.004	DOI Listing

August 2015

3 Reads

4 Citations

In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.

Authors:

Chen Li Chew Andrea Lunardi Federico Gulluni Daniel T Ruan Ming Chen Leonardo Salmena Michiya Nishino Antonella Papa Christopher Ng Jacqueline Fung John G Clohessy Junko Sasaki Takehiko Sasaki Roderick T Bronson Emilio Hirsch Pier Paolo Pandolfi

Cancer Discov 2015 Jul 16;5(7):740-51. Epub 2015 Apr 16.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1347	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497843	PMC

July 2015

32 Reads

14 Citations

15.930 Impact Factor

Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease.

Authors:

Brian T Kalish Alessandro Matte Immacolata Andolfo Achille Iolascon Olga Weinberg Alessandra Ghigo James Cimino Angela Siciliano Emilio Hirsch Enrica Federti Mark Puder Carlo Brugnara Lucia De Franceschi

Haematologica 2015 Jul 1;100(7):870-80. Epub 2015 May 1.

Department of Medicine, University of Verona-AOUI Verona, Policlinico GB Rossi, Verona, Italy.

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http://dx.doi.org/10.3324/haematol.2015.124586	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486221	PMC

July 2015

10 Reads

7 Citations

5.870 Impact Factor

Guido Tarone (1951-2015).

Authors:

Emilio Hirsch

Cardiovasc Res 2015 Jul 1;107(1):1-2. Epub 2015 Jun 1.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, Torino 10126, Italy

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http://dx.doi.org/10.1093/cvr/cvv164	DOI Listing

July 2015

3 Reads

5.940 Impact Factor

Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling.

Authors:

Ivana D'Andrea Valentina Fardella Stefania Fardella Fabio Pallante Alessandra Ghigo Roberta Iacobucci Angelo Maffei Emilio Hirsch Giuseppe Lembo Daniela Carnevale

EMBO Mol Med 2015 Jul;7(7):904-17

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli (IS), Italy Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy

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http://dx.doi.org/10.15252/emmm.201404697	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520656	PMC

July 2015

4 Reads

8 Citations

8.665 Impact Factor

Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation.

Authors:

Min Zhang Benjamin L Prosser Moradeke A Bamboye Antonio N S Gondim Celio X Santos Daniel Martin Alessandra Ghigo Alessia Perino Alison C Brewer Christopher W Ward Emilio Hirsch W Jonathan Lederer Ajay M Shah

J Am Coll Cardiol 2015 Jul;66(3):261-272

King's College London British Heart Foundation Centre of Excellence, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2015.05.020	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509515	PMC

July 2015

26 Reads

14 Citations

16.503 Impact Factor

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

Authors:

Aliaksei Shymanets Prajwal Oscar Vadas Cornelia Czupalla Jaclyn LoPiccolo Michael Brenowitz Alessandra Ghigo Emilio Hirsch Eberhard Krause Reinhard Wetzker Roger L Williams Christian Harteneck Bernd Nürnberg

Biochem J 2015 Jul;469(1):59-69

Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Centre of Pharmacogenomics and Pharmaceutical Research, University of Tübingen, 72074 Tübingen, Germany

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http://biochemj.org/lookup/doi/10.1042/BJ20150099	Publisher Site
http://dx.doi.org/10.1042/BJ20150099	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655608	PMC

July 2015

15 Reads

2 Citations

4.400 Impact Factor

PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction.

Authors:

Carlo C Campa Irene Franco Emilio Hirsch

FEBS Lett 2015 Jun 12;589(14):1552-8. Epub 2015 May 12.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2015.05.001	DOI Listing

June 2015

2 Reads

11 Citations

3.170 Impact Factor

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling.

Authors:

Laura Braccini Elisa Ciraolo Carlo C Campa Alessia Perino Dario L Longo Gianpaolo Tibolla Marco Pregnolato Yanyan Cao Beatrice Tassone Federico Damilano Muriel Laffargue Enzo Calautti Marco Falasca Giuseppe D Norata Jonathan M Backer Emilio Hirsch

Nat Commun 2015 Jun 23;6:7400. Epub 2015 Jun 23.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino 10126, Italy.

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http://dx.doi.org/10.1038/ncomms8400	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479417	PMC

June 2015

26 Reads

21 Citations

10.742 Impact Factor

PI3K signaling in the pathogenesis of obesity: The cause and the cure.

Authors:

Martina Beretta Michael Bauer Emilio Hirsch

Adv Biol Regul 2015 May 4;58:1-15. Epub 2014 Dec 4.

Molecular Biotechnology Center, University of Torino, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2014.11.004	DOI Listing

May 2015

2 Reads

7 Citations

Morgana acts as an oncosuppressor in chronic myeloid leukemia.

Blood 2015 Apr 12;125(14):2245-53. Epub 2015 Feb 12.

Department of Molecular Biotechnology and Health Sciences, and.

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http://dx.doi.org/10.1182/blood-2014-05-575001	DOI Listing

April 2015

33 Reads

7 Citations

10.452 Impact Factor

CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration.

J Pharmacol Exp Ther 2015 Mar 9;352(3):559-67. Epub 2015 Jan 9.

Corporate Pre-Clinical R & D, Chiesi Farmaceutici S.p.A., Parma, Italy (N.M., P.C., R.B., G.M., F.P., E.A., G.A., A.R., E.G., R.D.F., Ca.C., L.C., Ch.C., R.P. M.D., M.C., G.V., F.F.); Molecular Biotechnology Center, University of Turin, Turin, Italy (E.H.); and Dipartimento di Scienze Farmacologiche e Biomolecolari, Milan, Italy (C.B., A.S.)

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http://dx.doi.org/10.1124/jpet.114.220541	DOI Listing

March 2015

18 Reads

8 Citations

3.972 Impact Factor

Methods to measure the enzymatic activity of PI3Ks.

Authors:

Elisa Ciraolo Federico Gulluni Emilio Hirsch

Methods Enzymol 2014 ;543:115-40

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-801329-8.00006-4	DOI Listing

February 2015

3 Reads

1 Citation

2.090 Impact Factor

Akt activation by PHLPP1 ablation prevents pathological hypertrophy by promoting angiogenesis.

Authors:

Mingchuan Li Emilio Hirsch

Cardiovasc Res 2015 Feb 23;105(2):129-30. Epub 2014 Dec 23.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino 10126, Italy

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http://dx.doi.org/10.1093/cvr/cvu261	DOI Listing

February 2015

3 Reads

1 Citation

5.940 Impact Factor

Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer.

Authors:

Carlotta Costa Hiromichi Ebi Miriam Martini Sean A Beausoleil Anthony C Faber Charles T Jakubik Alan Huang Youzhen Wang Madhuri Nishtala Ben Hall Klarisa Rikova Jean Zhao Emilio Hirsch Cyril H Benes Jeffrey A Engelman

Cancer Cell 2015 Jan 24;27(1):97-108. Epub 2014 Dec 24.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.11.007	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745884	PMC

January 2015

52 Reads

54 Citations

23.523 Impact Factor

Phosphoinositide 3-kinase γ affects LPS-induced disturbance of blood-brain barrier via lipid kinase-independent control of cAMP in microglial cells.

Authors:

Adrian Frister Caroline Schmidt Nadine Schneble Michael Brodhun Falk A Gonnert Michael Bauer Emilio Hirsch Jörg P Müller Reinhard Wetzker Reinhard Bauer

Neuromolecular Med 2014 Dec 18;16(4):704-13. Epub 2014 Jul 18.

Institute of Molecular Cell Biology, Jena University Hospital, Friedrich Schiller University, 07745, Jena, Germany.

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http://dx.doi.org/10.1007/s12017-014-8320-z	DOI Listing

December 2014

23 Reads

6 Citations

3.680 Impact Factor

The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.

Authors:

Chih-Wei Fan Baozhi Chen Irene Franco Jianming Lu Heping Shi Shuguang Wei Changguang Wang Xiaofeng Wu Wei Tang Michael G Roth Noelle S Williams Emilio Hirsch Chuo Chen Lawrence Lum

Chem Biol 2014 Dec 4;21(12):1680-9. Epub 2014 Dec 4.

Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.10.013	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272670	PMC

December 2014

59 Reads

7 Citations

6.645 Impact Factor

Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis.

Authors:

Enrico Lupia Luca Pigozzi Alberto Goffi Emilio Hirsch Giuseppe Montrucchio

World J Gastroenterol 2014 Nov;20(41):15190-9

Enrico Lupia, Luca Pigozzi, Giuseppe Montrucchio, Department of Medical Sciences, University of Torino, 10126 Torino, Italy.

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http://dx.doi.org/10.3748/wjg.v20.i41.15190	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223253	PMC

November 2014

7 Reads

5 Citations

2.370 Impact Factor

Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice.

Authors:

Federica Barutta Serena Grimaldi Irene Franco Stefania Bellini Roberto Gambino Silvia Pinach Alessandro Corbelli Graziella Bruno Maria Pia Rastaldi Teresa Aveta Emilio Hirsch Vincenzo Di Marzo Gabriella Gruden

Kidney Int 2014 Nov 14;86(5):979-90. Epub 2014 May 14.

Diabetic Nephropathy Laboratory, Department of Medical Sciences, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1038/ki.2014.165	DOI Listing

November 2014

14 Reads

5 Citations

8.563 Impact Factor

Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive.

Authors:

Alessia Perino Martina Beretta Ana Kilić Alessandra Ghigo Daniela Carnevale Ivan Enrico Repetto Laura Braccini Dario Longo Michaela Liebig-Gonglach Tania Zaglia Roberta Iacobucci Marco Mongillo Reinhard Wetzker Michael Bauer Silvio Aime Alessandro Vercelli Giuseppe Lembo Alexander Pfeifer Emilio Hirsch

Sci Signal 2014 Nov 18;7(352):ra110. Epub 2014 Nov 18.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy.

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http://dx.doi.org/10.1126/scisignal.2005485	DOI Listing

November 2014

23 Reads

14 Citations

6.280 Impact Factor

PI3K/AKT signaling pathway and cancer: an updated review.

Authors:

Miriam Martini Maria Chiara De Santis Laura Braccini Federico Gulluni Emilio Hirsch

Ann Med 2014 Sep 5;46(6):372-83. Epub 2014 Jun 5.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin , Italy.

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http://dx.doi.org/10.3109/07853890.2014.912836	DOI Listing

September 2014

7 Reads

120 Citations

3.890 Impact Factor

Phosphoinositide 3-kinases in health and disease.

Authors:

Alessandra Ghigo Fulvio Morello Alessia Perino Emilio Hirsch

Subcell Biochem 2012 ;58:183-213

Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1007/978-94-007-3012-0_6	DOI Listing

August 2014

6 Reads

5 Citations

Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.

Authors:

Natalia F Smirnova Stéphanie Gayral Christophe Pedros Gervaise Loirand Nathalie Vaillant Nicole Malet Sahar Kassem Denis Calise Dominique Goudounèche Matthias P Wymann Emilio Hirsch Alain-Pierre Gadeau Laurent O Martinez Abdelhadi Saoudi Muriel Laffargue

J Exp Med 2014 Aug 29;211(9):1779-92. Epub 2014 Jul 29.

INSERM, UMR1048, F-31300 Toulouse, France Université Toulouse III, Institut de Maladies Métaboliques et Cardiovasculaires, F-31300 Toulouse, France

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http://dx.doi.org/10.1084/jem.20131276	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144742	PMC

August 2014

27 Reads

6 Citations

12.520 Impact Factor

PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor.

Authors:

Sreedhar Madishetti Nadine Schneble Christian König Emilio Hirsch Stefan Schulz Jörg P Müller Reinhard Wetzker

Br J Pharmacol 2014 Jul;171(13):3328-37

Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Jena, Germany.

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http://dx.doi.org/10.1111/bph.12698	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080984	PMC

July 2014

33 Reads

3 Citations

4.842 Impact Factor

Cancer: natural-born killers unleashed.

Authors:

Emilio Hirsch Francesco Novelli

Nature 2014 Jun 11;510(7505):342-3. Epub 2014 Jun 11.

Center for Experimental Research and Medical Studies, Department of Molecular Biotechnology and Health Sciences, University of Turin.

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http://dx.doi.org/10.1038/nature13503	DOI Listing

June 2014

4 Reads

1 Citation

42.351 Impact Factor

PI3K p110γ deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions.

Authors:

Teresa M Zotes Cristina F Arias José J Fuster Roberto Spada Sonia Pérez-Yagüe Emilio Hirsch Matthias Wymann Ana C Carrera Vicente Andrés Domingo F Barber

PLoS One 2013 22;8(8):e72674. Epub 2013 Aug 22.

Department of Immunology and Oncology, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CNB-CSIC), Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072674	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750002	PMC

June 2014

44 Reads

4 Citations

3.234 Impact Factor

Myocyte signalling in leucocyte recruitment to the heart.

Authors:

Alessandra Ghigo Irene Franco Fulvio Morello Emilio Hirsch

Cardiovasc Res 2014 May 5;102(2):270-80. Epub 2014 Feb 5.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, Italy.

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http://dx.doi.org/10.1093/cvr/cvu030	DOI Listing

May 2014

5 Reads

11 Citations

5.940 Impact Factor

Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology.

Authors:

Guido Tarone Jean-Luc Balligand Johann Bauersachs Angela Clerk Leon De Windt Stephane Heymans Denise Hilfiker-Kleiner Emilio Hirsch Guido Iaccarino Ralph Knöll Adelino F Leite-Moreira André P Lourenço Manuel Mayr Thomas Thum Carlo G Tocchetti

Eur J Heart Fail 2014 May 17;16(5):494-508. Epub 2014 Mar 17.

Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università di Torino, Torino, Italy.

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http://www.cmcardio.com/upload/092-Tarone-EJHF-2014.pdf	Web Search
http://doi.wiley.com/10.1002/ejhf.62	Publisher Site
http://dx.doi.org/10.1002/ejhf.62	DOI Listing

May 2014

23 Reads

18 Citations

6.530 Impact Factor

Heterocellular signalling and crosstalk in the heart in ischaemia and heart failure.

Authors:

Emilio Hirsch Ryozo Nagai Thomas Thum

Cardiovasc Res 2014 May 8;102(2):191-3. Epub 2014 Apr 8.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino 1026 Italy.

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http://dx.doi.org/10.1093/cvr/cvu073	DOI Listing

May 2014

4 Reads

4 Citations

5.940 Impact Factor

ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models.

Authors:

Adelino F Leite-Moreira André P Lourenço Jean-Luc Balligand Johann Bauersachs Angela Clerk Leon J De Windt Stephane Heymans Denise Hilfiker-Kleiner Emilio Hirsch Guido Iaccarino Karol A Kaminski Ralph Knöll Manuel Mayr Guido Tarone Thomas Thum Carlo G Tocchetti

Eur J Heart Fail 2014 May 23;16(5):509-18. Epub 2014 Feb 23.

Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Al. Prof. Hernani Monteiro, 4200 319, Porto, Portugal.

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http://dx.doi.org/10.1002/ejhf.66	DOI Listing

May 2014

24 Reads

3 Citations

6.530 Impact Factor

Elastin degradation and ensuing inflammation as emerging keys to atherosclerosis.

Authors:

Emilio Hirsch Alessandra Ghigo

Cardiovasc Res 2014 Apr 11;102(1):1-2. Epub 2014 Feb 11.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1093/cvr/cvu038	DOI Listing

April 2014

16 Reads

5.940 Impact Factor

PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.

Authors:

Irene Franco Federico Gulluni Carlo C Campa Carlotta Costa Jean Piero Margaria Elisa Ciraolo Miriam Martini Daniel Monteyne Elisa De Luca Giulia Germena York Posor Tania Maffucci Stefano Marengo Volker Haucke Marco Falasca David Perez-Morga Alessandra Boletta Giorgio R Merlo Emilio Hirsch

Dev Cell 2014 Mar;28(6):647-58

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.01.022	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042153	PMC

March 2014

33 Reads

40 Citations

9.710 Impact Factor

Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction.

Cardiovasc Res 2014 Jan 15;101(1):97-107. Epub 2013 Oct 15.

Department of Cardiology, University of Göttingen, Heart Research Center Göttingen, Göttingen, Germany.

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http://cardiovascres.oxfordjournals.org/content/cardiovascre	Web Search
http://cardiovascres.oxfordjournals.org/cgi/doi/10.1093/cvr/	Publisher Site
http://dx.doi.org/10.1093/cvr/cvt235	DOI Listing

January 2014

39 Reads

11 Citations

5.940 Impact Factor

PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control.

Authors:

Romy Walser John E Burke Elena Gogvadze Thomas Bohnacker Xuxiao Zhang Daniel Hess Peter Küenzi Michael Leitges Emilio Hirsch Roger L Williams Muriel Laffargue Matthias P Wymann

PLoS Biol 2013 25;11(6):e1001587. Epub 2013 Jun 25.

Department of Biomedicine, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1371/journal.pbio.1001587	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692425	PMC

January 2014

26 Reads

8 Citations

PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth.

Authors:

Michael C Schmid Irene Franco Sang Won Kang Emilio Hirsch Lawrence A Quilliam Judith A Varner

PLoS One 2013 2;8(4):e60226. Epub 2013 Apr 2.

Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060226	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614555	PMC

October 2013

20 Reads

18 Citations

3.234 Impact Factor

Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy.

Authors:

Emilie Collmann Thomas Bohnacker Romina Marone Janet Dawson Markus Rehberg Rowan Stringer Fritz Krombach Christoph Burkhart Emilio Hirsch Gregory J Hollingworth Matthew Thomas Matthias P Wymann

J Allergy Clin Immunol 2013 Oct 14;132(4):959-68. Epub 2013 May 14.

Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.jaci.2013.03.008	DOI Listing

October 2013

40 Reads

7 Citations

11.480 Impact Factor

Interaction of the heart and its close and distant neighbours: report of the Meeting of the ESC Working Groups Myocardial Function and Cellular Biology.

Authors:

Emilio Hirsch Denise Hilfiker-Kleiner Jean-Luc Balligand Guido Tarone Leon De Windt Johann Bauersachs Peter Ferdinandy Sean Davidson Derek J Hausenloy Rainer Schulz

Cardiovasc Res 2013 Sep 16;99(4):595-9. Epub 2013 Jul 16.

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http://dx.doi.org/10.1093/cvr/cvt179	DOI Listing

September 2013

17 Reads

7 Citations

5.940 Impact Factor

PI3Ks and small GTPases in neutrophil migration: two sides of the same coin.

Authors:

Giulia Germena Emilio Hirsch

Mol Immunol 2013 Aug 5;55(1):83-6. Epub 2012 Nov 5.

Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1016/j.molimm.2012.10.004	DOI Listing

August 2013

3 Reads

6 Citations

2.973 Impact Factor

Editorial to the SI Leukocyte Adhesion and Migration.

Authors:

Markus Sperandio Emilio Hirsch

Mol Immunol 2013 Aug 11;55(1):48. Epub 2013 Jan 11.

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http://dx.doi.org/10.1016/j.molimm.2012.12.016	DOI Listing

August 2013

5 Reads

2.973 Impact Factor

Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate.

Authors:

York Posor Marielle Eichhorn-Gruenig Dmytro Puchkov Johannes Schöneberg Alexander Ullrich André Lampe Rainer Müller Sirus Zarbakhsh Federico Gulluni Emilio Hirsch Michael Krauss Carsten Schultz Jan Schmoranzer Frank Noé Volker Haucke

Nature 2013 Jul 3;499(7457):233-7. Epub 2013 Jul 3.

Leibniz Institut für Molekulare Pharmakologie & Freie Universität Berlin, Robert-Roessle-Straße 10, 13125 Berlin, Germany.

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http://dx.doi.org/10.1038/nature12360	DOI Listing

July 2013

30 Reads

85 Citations

42.351 Impact Factor

Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception.

PLoS Genet 2012 6;8(12):e1003071. Epub 2012 Dec 6.

Neuroscience Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1371/journal.pgen.1003071	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516557	PMC

May 2013

35 Reads

11 Citations

Targeting PI3K in Cancer: Any Good News?

Authors:

Miriam Martini Elisa Ciraolo Federico Gulluni Emilio Hirsch

Front Oncol 2013 8;3:108. Epub 2013 May 8.

Molecular Biotechnology Center, University of Turin Turin, Italy.

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http://dx.doi.org/10.3389/fonc.2013.00108	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647219	PMC

May 2013

4 Reads

37 Citations

Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation.

Authors:

Laura Fumagalli Carlo C Campa Giulia Germena Clifford A Lowell Emilio Hirsch Giorgio Berton

J Immunol 2013 Apr 27;190(7):3648-60. Epub 2013 Feb 27.

Section of General Pathology, Department of Pathology and Diagnostics, University of Verona, Verona 37134, Italy.

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http://dx.doi.org/10.4049/jimmunol.1201951	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280093	PMC

April 2013

3 Reads

9 Citations

4.922 Impact Factor

Phosphoinositides and cardiovascular diseases.

Authors:

Alessandra Ghigo Alessia Perino Emilio Hirsch

Curr Top Microbiol Immunol 2012 ;362:43-60

Department of Genetics, Biology and Biochemistry, University of Torino, Molecular Biotechnology Center, Italy.

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http://dx.doi.org/10.1007/978-94-007-5025-8_2	DOI Listing

April 2013

5 Reads

1 Citation

4.100 Impact Factor

Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases.

Authors:

Francesca Vinchi Lucia De Franceschi Alessandra Ghigo Tim Townes James Cimino Lorenzo Silengo Emilio Hirsch Fiorella Altruda Emanuela Tolosano

Circulation 2013 Mar 27;127(12):1317-29. Epub 2013 Feb 27.

Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.130179	DOI Listing

March 2013

21 Reads

58 Citations

14.430 Impact Factor

Therapeutic applications of PI3K inhibitors in cardiovascular diseases.

Authors:

Alessandra Ghigo Fulvio Morello Alessia Perino Emilio Hirsch

Future Med Chem 2013 Mar;5(4):479-92

University of Torino, Molecular Biotechnology Center, Department of Molecular Biotechnology & Health Sciences, Via Nizza 52, 10126, Torino, Italy.

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http://dx.doi.org/10.4155/fmc.13.11	DOI Listing

March 2013

13 Reads

1 Citation

4.000 Impact Factor

NADPH oxidases in heart failure: poachers or gamekeepers?

Authors:

Min Zhang Alessia Perino Alessandra Ghigo Emilio Hirsch Ajay M Shah

Antioxid Redox Signal 2013 Mar 27;18(9):1024-41. Epub 2012 Aug 27.

Cardiovascular Division, James Black Centre, King's College London British Heart Foundation Centre of Excellence, London, UK.

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http://dx.doi.org/10.1089/ars.2012.4550	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567780	PMC

March 2013

7 Reads

47 Citations

7.410 Impact Factor

Two signalling hands for uPAR.

Authors:

Emilio Hirsch

Thromb Haemost 2013 Feb 10;109(2):179. Epub 2013 Jan 10.

Molecular Biotechnology Center, Departments of Genetics, Biology and Biochemistry, School of Medicine, University of Torino, Via Nizza 52, 10126, Torino, Italy.

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http://dx.doi.org/10.1160/TH13-01-0001	DOI Listing

February 2013

3 Reads

4.984 Impact Factor

Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.

Authors:

Hee Yun Suk Chen Zhou Teddy T C Yang Hong Zhu Raymond Y L Yu Opeyemi Olabisi XiaoYong Yang Deborah Brancho Ja-Young Kim Philipp E Scherer Philippe G Frank Michael P Lisanti John W Calvert David J Lefer Jeffery D Molkentin Alessandra Ghigo Emilio Hirsch Jianping Jin Chi-Wing Chow

J Biol Chem 2013 Feb 20;288(5):3477-88. Epub 2012 Dec 20.

Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1074/jbc.M112.419150	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561567	PMC

February 2013

10 Reads

6 Citations

4.573 Impact Factor

Rule out of acute aortic dissection with plasma matrix metalloproteinase 8 in the emergency department.

Authors:

Francesca Giachino Marilena Loiacono Manuela Lucchiari Maria Manzo Stefania Battista Elisa Saglio Enrico Lupia Corrado Moiraghi Emilio Hirsch Giulio Mengozzi Fulvio Morello

Crit Care 2013 Feb 25;17(1):R33. Epub 2013 Feb 25.

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http://dx.doi.org/10.1186/cc12536	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057269	PMC

February 2013

12 Reads

5 Citations

Blockade of phosphatidylinositol 3-kinase PI3Kδ or PI3Kγ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis.

Authors:

Anne Roller Alessia Perino Paolo Dapavo Elisabetta Soro Klaus Okkenhaug Emilio Hirsch Hong Ji

J Immunol 2012 Nov 28;189(9):4612-20. Epub 2012 Sep 28.

Rheumatology Research, Merck Serono S.A., 1211 Geneva, Switzerland.

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http://dx.doi.org/10.4049/jimmunol.1103173	DOI Listing

November 2012

22 Reads

13 Citations

4.922 Impact Factor

Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases.

Circulation 2012 Oct 24;126(17):2073-83. Epub 2012 Sep 24.

Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.114074	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913165	PMC

October 2012

267 Reads

19 Citations

14.430 Impact Factor

Inflaming attraction by RNA.

Authors:

Emilio Hirsch

Thromb Haemost 2012 Oct 5;108(4):589. Epub 2012 Sep 5.

Department of Genetics, School of Medicine, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1160/TH12-08-0620	DOI Listing

October 2012

5 Reads

4.984 Impact Factor

Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.

Authors:

Alessio Noghero Alessia Perino Giorgio Seano Elisa Saglio Giuseppe Lo Sasso Franco Veglio Luca Primo Emilio Hirsch Federico Bussolino Fulvio Morello

Arterioscler Thromb Vasc Biol 2012 Sep 21;32(9):2280-8. Epub 2012 Jun 21.

Institute for Cancer Research and Treatment (IRCC), Candiolo, Italy.

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http://dx.doi.org/10.1161/ATVBAHA.112.250621	DOI Listing

September 2012

20 Reads

16 Citations

6.000 Impact Factor

Anchoring proteins as regulators of signaling pathways.

Authors:

Alessia Perino Alessandra Ghigo John D Scott Emilio Hirsch

Circ Res 2012 Aug;111(4):482-92

Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1161/CIRCRESAHA.111.262899	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508715	PMC

August 2012

10 Reads

16 Citations

11.020 Impact Factor

A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.

Nat Chem Biol 2012 Apr 29;8(6):576-82. Epub 2012 Apr 29.

Cellzome AG, Heidelberg, Germany.

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http://dx.doi.org/10.1038/nchembio.957	DOI Listing

April 2012

29 Reads

32 Citations

13.000 Impact Factor

Calming down T cell acute leukemia.

Authors:

Emilio Hirsch Roberto Chiarle

Cancer Cell 2012 Apr;21(4):449-50

Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1016/j.ccr.2012.03.025	DOI Listing

April 2012

2 Reads

1 Citation

23.523 Impact Factor

Measuring PI3K lipid kinase activity.

Authors:

Elisa Ciraolo Alessia Perino Emilio Hirsch

Methods Mol Biol 2012 ;795:55-67

Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1007/978-1-61779-337-0_4	DOI Listing

January 2012

3 Reads

Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling.

Authors:

Alessandra Consonni Lina Cipolla Gianni Guidetti Ilaria Canobbio Elisa Ciraolo Emilio Hirsch Marco Falasca Mitsuhiko Okigaki Cesare Balduini Mauro Torti

Blood 2012 Jan 21;119(3):847-56. Epub 2011 Nov 21.

Department of Biochemistry, University of Pavia, Italy.

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http://dx.doi.org/10.1182/blood-2011-07-364992	DOI Listing

January 2012

4 Reads

12 Citations

10.452 Impact Factor

PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism.

Authors:

Daniela Carnevale Carmine Vecchione Giada Mascio Giovanni Esposito Giuseppe Cifelli Katiuscia Martinello Alessandro Landolfi Giulio Selvetella Paolo Grieco Antonio Damato Elio Franco Hannelore Haase Angelo Maffei Elisa Ciraolo Sergio Fucile Giacomo Frati Orazio Mazzoni Emilio Hirsch Giuseppe Lembo

Cardiovasc Res 2012 Jan 27;93(1):200-9. Epub 2011 Oct 27.

Department of Angiocardioneurology, IRCCS Neuromed, Pozzilli, Isernia, Italy.

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http://dx.doi.org/10.1093/cvr/cvr288	DOI Listing

January 2012

7 Reads

11 Citations

5.940 Impact Factor

Specific PI3K isoform modulation in heart failure: lessons from transgenic mice.

Authors:

Alessandra Ghigo Fulvio Morello Alessia Perino Federico Damilano Emilio Hirsch

Curr Heart Fail Rep 2011 Sep;8(3):168-75

Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126, Torino, Italy.

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http://dx.doi.org/10.1007/s11897-011-0059-3	DOI Listing

September 2011

19 Reads

4 Citations

Phosphoinositide 3-kinase p110γ in immunity.

Authors:

Carlotta Costa Erica L Martin-Conte Emilio Hirsch

IUBMB Life 2011 Sep 28;63(9):707-13. Epub 2011 Jul 28.

Department of Genetic, Biology and Biochemistry and Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, Italy.

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http://dx.doi.org/10.1002/iub.516	DOI Listing

September 2011

4 Reads

7 Citations

3.143 Impact Factor

IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.

Authors:

Mauro Sbroggiò Daniela Carnevale Alessandro Bertero Giuseppe Cifelli Emanuele De Blasio Giada Mascio Emilio Hirsch Wadie F Bahou Emilia Turco Lorenzo Silengo Mara Brancaccio Giuseppe Lembo Guido Tarone

Cardiovasc Res 2011 Aug 14;91(3):456-64. Epub 2011 Apr 14.

Dipartimento di Genetica, Biologia e Biochimica, Molecular Biotechnology Center, Università di Torino, via Nizza 52, Turin, Italy.

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http://dx.doi.org/10.1093/cvr/cvr103	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294280	PMC

August 2011

20 Reads

30 Citations

5.940 Impact Factor

The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions.

Authors:

Carlotta Costa Giulia Germena Erica L Martin-Conte Ivan Molineris Eleonora Bosco Stefano Marengo Ornella Azzolino Fiorella Altruda V Marco Ranieri Emilio Hirsch

Blood 2011 Jul 6;118(4):1099-108. Epub 2011 May 6.

Department of Genetic, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1182/blood-2010-12-324756	DOI Listing

July 2011

9 Reads

15 Citations

10.452 Impact Factor

Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.

Authors:

Michael C Schmid Christie J Avraamides Holly C Dippold Irene Franco Philippe Foubert Lesley G Ellies Lissette M Acevedo Joan R E Manglicmot Xiaodan Song Wolfgang Wrasidlo Sara L Blair Mark H Ginsberg David A Cheresh Emilio Hirsch Seth J Field Judith A Varner

Cancer Cell 2011 Jun;19(6):715-27

Moores UCSD Cancer Center, University of California, San Diego, CA 92093, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.04.016	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144144	PMC

June 2011

16 Reads

80 Citations

23.523 Impact Factor

Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors.

Authors:

Margherita Guasconi Xiaoyun Lu Alberto Massarotti Antonio Caldarelli Elisa Ciraolo Gian Cesare Tron Emilio Hirsch Giovanni Sorba Tracey Pirali

Org Biomol Chem 2011 Jun 14;9(11):4144-9. Epub 2011 Apr 14.

DiSCAFF, Università degli Studi del Piemonte Orientale, via Bovio 6, 28100, Novara, Italy.

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http://dx.doi.org/10.1039/c1ob05336a	DOI Listing

June 2011

4 Reads

3.562 Impact Factor

PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis.

Authors:

Daniel Martin Rebeca Galisteo Alfredo A Molinolo Reinhard Wetzker Emilio Hirsch J Silvio Gutkind

Cancer Cell 2011 Jun;19(6):805-13

Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.05.005	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170773	PMC

June 2011

26 Citations

23.523 Impact Factor

High frequency of development of B cell lymphoproliferation and diffuse large B cell lymphoma in Dbl knock-in mice.

Authors:

Marzia Ognibene Ottavia Barbieri Cristina Vanni Luca Mastracci Simonetta Astigiano Laura Emionite Barbara Salani Manuela Fedele Roberta Resaz Claudya Tenca Franco Fais Federica Sabatini Amleto De Santanna Fiorella Altruda Luigi Varesio Emilio Hirsch Alessandra Eva

J Mol Med (Berl) 2011 May 11;89(5):493-504. Epub 2011 Jan 11.

Laboratory of Molecular Biology, G. Gaslini Institute, Largo Gaslini 5, Genoa, Italy.

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http://dx.doi.org/10.1007/s00109-010-0712-4	DOI Listing

May 2011

14 Reads

2 Citations

5.110 Impact Factor

Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice.

Authors:

Fernando Spiller Carlotta Costa Fabrício O Souto Francesca Vinchi Fabíola L A C Mestriner Helen J Laure José C Alves-Filho Andressa Freitas José C Rosa Sérgio H Ferreira Fiorella Altruda Emilio Hirsch Lewis J Greene Emanuela Tolosano Fernando Q Cunha

Am J Respir Crit Care Med 2011 Apr 22;183(7):922-31. Epub 2010 Oct 22.

Department of Pharmacology, University of São Paulo, Av. Bandeirantes, Ribeirão Preto, SP, Brazil.

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http://dx.doi.org/10.1164/rccm.201002-0223OC	DOI Listing

April 2011

19 Reads

13 Citations

13.000 Impact Factor

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.

Mol Cell 2011 Apr;42(1):84-95

Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Torino 10126, Italy.

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http://dx.doi.org/10.1016/j.molcel.2011.01.030	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265115	PMC

April 2011

25 Reads

56 Citations

14.020 Impact Factor

Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines.

Authors:

Xiao-Yun Lu Elisa Ciraolo Rachele Stefenia Guo-Qiang Chen Yali Zhang Emilio Hirsch

Appl Microbiol Biotechnol 2011 Mar 1;89(5):1423-33. Epub 2011 Feb 1.

Department of Biological Science and Bioengineering, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, People's Republic of China.

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http://dx.doi.org/10.1007/s00253-011-3101-1	DOI Listing

March 2011

24 Reads

5 Citations

3.340 Impact Factor

Regulating neutrophil apoptosis: new players enter the game.

Authors:

Véronique Witko-Sarsat Magali Pederzoli-Ribeil Emilio Hirsch Emilio Hirsh Silvano Sozzani Marco A Cassatella

Trends Immunol 2011 Mar 12;32(3):117-24. Epub 2011 Feb 12.

Institut National de la Santé et de la Recherche Médicale Unité 1016, 75014 Paris, France.

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http://dx.doi.org/10.1016/j.it.2011.01.001	DOI Listing

March 2011

10 Reads

42 Citations

10.400 Impact Factor

Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure.

Authors:

Federico Damilano Irene Franco Cinzia Perrino Katrin Schaefer Ornella Azzolino Daniela Carnevale Giuseppe Cifelli Pierluigi Carullo Riccardo Ragona Alessandra Ghigo Alessia Perino Giuseppe Lembo Emilio Hirsch

Circulation 2011 Feb 17;123(4):391-9. Epub 2011 Jan 17.

Department of Genetics, Biology, and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.950543	DOI Listing

February 2011

11 Reads

13 Citations

14.430 Impact Factor

More than just kinases: the scaffolding function of PI3K.

Authors:

Carlotta Costa Emilio Hirsch

Curr Top Microbiol Immunol 2010 ;346:171-81

Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1007/82_2010_57	DOI Listing

January 2011

3 Reads

6 Citations

4.100 Impact Factor

Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology.

Eur J Heart Fail 2011 Jan;13(1):1-10

Department of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany.

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http://dx.doi.org/10.1093/eurjhf/hfq213	DOI Listing

January 2011

40 Reads

61 Citations

6.530 Impact Factor

Pharmacologic inhibition of phosphoinositide 3-kinase gamma (PI3Kγ) promotes infarct resorption and prevents adverse cardiac remodeling after myocardial infarction in mice.

Authors:

Ignacio M Seropian Antonio Abbate Stefano Toldo Jessica Harrington Lisa Smithson Ramzi Ockaili Eleonora Mezzaroma Federico Damilano Emilio Hirsch Benjamin W Van Tassell

J Cardiovasc Pharmacol 2010 Dec;56(6):651-8

VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.

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https://insights.ovid.com/crossref?an=00005344-201012000-000	Publisher Site
http://dx.doi.org/10.1097/FJC.0b013e3181f9a905	DOI Listing

December 2010

6 Reads

8 Citations

2.130 Impact Factor

Leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure.

Authors:

Alessia Perino Alessandra Ghigo Emilio Hirsch

Trends Cardiovasc Med 2010 Nov;20(8):273-6

Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy.

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http://dx.doi.org/10.1016/j.tcm.2011.12.007	DOI Listing

November 2010

15 Reads

2.910 Impact Factor

Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema.

Authors:

Vito Fanelli Valeria Puntorieri Barbara Assenzio Erica L Martin Vincenzo Elia Martino Bosco Luisa Delsedime Lorenzo Del Sorbo Andrea Ferrari Stefano Italiano Alessandra Ghigo Arthur S Slutsky Emilio Hirsch V Marco Ranieri

Intensive Care Med 2010 Nov 19;36(11):1935-45. Epub 2010 Aug 19.

Department of Anesthesia and Critical Care, Ospedale S. Giovanni Battista-Molinette, University of Torino, Corso Dogliotti 14, 10126, Turin, Italy.

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http://dx.doi.org/10.1007/s00134-010-2018-y	DOI Listing

November 2010

21 Reads

9 Citations

7.210 Impact Factor

Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.

Authors:

Danny Guo Zamaneh Kassiri Ratnadeep Basu Fung L Chow Vijay Kandalam Federico Damilano Wenbin Liang Seigo Izumo Emilio Hirsch Josef M Penninger Peter H Backx Gavin Y Oudit

Circ Res 2010 Nov 16;107(10):1275-89. Epub 2010 Sep 16.

Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.110.229054	DOI Listing

November 2010

6 Reads

18 Citations

11.020 Impact Factor

Nonredundant role of CCRL2 in lung dendritic cell trafficking.

Authors:

Karel Otero Annunciata Vecchi Emilio Hirsch Jennifer Kearley William Vermi Annalisa Del Prete Safiyè Gonzalvo-Feo Cecilia Garlanda Ornella Azzolino Laura Salogni Clare M Lloyd Fabio Facchetti Alberto Mantovani Silvano Sozzani

Blood 2010 Oct 6;116(16):2942-9. Epub 2010 Jul 6.

Istituto Clinico Humanitas, IRCCS, Rozzano, Italy.

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http://dx.doi.org/10.1182/blood-2009-12-259903	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389732	PMC

October 2010

25 Reads

20 Citations

10.450 Impact Factor

Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment.

Am J Respir Crit Care Med 2010 Sep 27;182(6):762-73. Epub 2010 May 27.

Department of Anesthesiology and Critical Care, University of Turin, Ospedale S. Giovanni Battista-Molinette, Turin, Italy.

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http://dx.doi.org/10.1164/rccm.201001-0088OC	DOI Listing

September 2010

16 Reads

17 Citations

13.000 Impact Factor

Dissection of the interplay between class I PI3Ks and Rac signaling in phagocytic functions.

Authors:

Carlotta Costa Giulia Germena Emilio Hirsch

ScientificWorldJournal 2010 Sep 14;10:1826-39. Epub 2010 Sep 14.

Department of Genetics, Biology, and Biochemistry, Molecular Biotechnology Center, University of Turin, Italy.

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http://dx.doi.org/10.1100/tsw.2010.178	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763975	PMC

September 2010

1 Read

6 Citations

1.220 Impact Factor

The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice.

Authors:

Willemijn A van Dop Stefano Marengo Anje A te Velde Elisa Ciraolo Irene Franco Fiebo J ten Kate Guy E Boeckxstaens James C Hardwick Daan W Hommes Emilio Hirsch Gijs R van den Brink

Immunol Lett 2010 Jun 27;131(1):33-9. Epub 2010 Mar 27.

Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.imlet.2010.03.008	DOI Listing

June 2010

12 Reads

9 Citations

2.510 Impact Factor

The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation.

Authors:

Sandra Beer-Hammer Eva Zebedin Max von Holleben Judith Alferink Bernhard Reis Philipp Dresing Daniel Degrandi Stefanie Scheu Emilio Hirsch Veronika Sexl Klaus Pfeffer Bernd Nürnberg Roland P Piekorz

J Leukoc Biol 2010 Jun 3;87(6):1083-95. Epub 2010 Mar 3.

1. Abteilung für Pharmakologie und Experimentelle Therapie, Klinikum der Eberhard-Karls-Universität Tübingen, Wilhelmstrasse 56, D-72074 Tübingen, Germany. Institute of Biochemistry and Molecular Biology II, University of Düsseldorf, Universitätsstrabetae 1, D-40225 Düsseldorf, Germany. E-mail:

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http://dx.doi.org/10.1189/jlb.0809585	DOI Listing

June 2010

4 Reads

20 Citations

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways.

Authors:

Helena Mueller Anika Stadtmann Hugo Van Aken Emilio Hirsch Demin Wang Klaus Ley Alexander Zarbock

Blood 2010 Apr 18;115(15):3118-27. Epub 2010 Feb 18.

Department of Anesthesiology and Intensive Care Medicine, University of Münster, 48149 Münster, Germany.

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http://dx.doi.org/10.1182/blood-2009-11-254185	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858472	PMC

April 2010

57 Reads

52 Citations

Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues.

Authors:

Antonella Roetto Ferdinando Di Cunto Rosa Maria Pellegrino Emilio Hirsch Ornella Azzolino Alessandro Bondi Ilaria Defilippi Sonia Carturan Barbara Miniscalco Fulvio Riondato Daniela Cilloni Lorenzo Silengo Fiorella Altruda Clara Camaschella Giuseppe Saglio

Blood 2010 Apr 23;115(16):3382-9. Epub 2010 Feb 23.

Department of Clinical and Biological Science, University of Torino, Turin, Italy.

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http://dx.doi.org/10.1182/blood-2009-09-240960	DOI Listing

April 2010

10 Reads

18 Citations

PI3K inhibition in inflammation: Toward tailored therapies for specific diseases.

Authors:

Alessandra Ghigo Federico Damilano Laura Braccini Emilio Hirsch

Bioessays 2010 Mar;32(3):185-96

Molecular Biotechnology Center, University of Torino, Italy.

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http://dx.doi.org/10.1002/bies.200900150	DOI Listing

March 2010

10 Reads

19 Citations

Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.

Authors:

Elisa Ciraolo Fulvio Morello Robin M Hobbs Frieder Wolf Romina Marone Manuela Iezzi Xiaoyun Lu Giulio Mengozzi Fiorella Altruda Giovanni Sorba Kaomei Guan Pier Paolo Pandolfi Matthias P Wymann Emilio Hirsch

Mol Biol Cell 2010 Mar 6;21(5):704-11. Epub 2010 Jan 6.

Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1091/mbc.e09-08-0744	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828958	PMC

March 2010

29 Reads

26 Citations

Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.

Authors:

Roberta Ferretti Valeria Palumbo Augusta Di Savino Silvia Velasco Mauro Sbroggiò Paolo Sportoletti Lucia Micale Emilia Turco Lorenzo Silengo Gioacchino Palumbo Emilio Hirsch Julie Teruya-Feldstein Silvia Bonaccorsi Pier Paolo Pandolfi Maurizio Gatti Guido Tarone Mara Brancaccio

Dev Cell 2010 Mar;18(3):486-95

Dipartimento di Genetica, Biologia e Biochimica, Università di Torino, 10126 Torino, Italy.

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http://dx.doi.org/10.1016/j.devcel.2009.12.020	DOI Listing

March 2010

15 Reads

12 Citations

Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice.

Authors:

Mauro Siragusa Rajesh Katare Marco Meloni Federico Damilano Emilio Hirsch Costanza Emanueli Paolo Madeddu

Circ Res 2010 Mar 7;106(4):757-68. Epub 2010 Jan 7.

Experimental Cardiovascular Medicine, Bristol Heart Institute, University of Bristol, Upper Maudlin Street, Bristol, United Kingdom.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.207449	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833289	PMC

March 2010

7 Reads

13 Citations

PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway.

Authors:

Bernhard J Haubner G Gregory Neely Jakob G J Voelkl Federico Damilano Keiji Kuba Yumiko Imai Vukoslav Komnenovic Agnes Mayr Otmar Pachinger Emilio Hirsch Josef M Penninger Bernhard Metzler

PLoS One 2010 Feb 22;5(2):e9350. Epub 2010 Feb 22.

Department of Internal Medicine III (Cardiology), Innsbruck Medical University, Innsbruck, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009350	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825255	PMC

February 2010

19 Reads

11 Citations

PI3K kinase and scaffold functions in heart.

Authors:

Federico Damilano Alessia Perino Emilio Hirsch

Ann N Y Acad Sci 2010 Feb;1188:39-45

Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05081.x	DOI Listing

February 2010

6 Reads

13 Citations

Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets.

Authors:

Ilaria Canobbio Lucia Stefanini Lina Cipolla Elisa Ciraolo Cristian Gruppi Cesare Balduini Emilio Hirsch Mauro Torti

Blood 2009 Sep 10;114(10):2193-6. Epub 2009 Jun 10.

Department of Biochemistry, University of Pavia, via Bassi 21, Pavia, Italy.

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http://dx.doi.org/10.1182/blood-2009-03-208074	DOI Listing

September 2009

6 Reads

33 Citations

A pro-inflammatory signature mediates FGF2-induced angiogenesis.

Authors:

Germán Andrés Daria Leali Stefania Mitola Daniela Coltrini Maura Camozzi Michela Corsini Mirella Belleri Emilio Hirsch Reto A Schwendener Gerhard Christofori Antonio Alcamí Marco Presta

J Cell Mol Med 2009 Aug;13(8B):2083-108

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1111/j.1582-4934.2008.00415.x	DOI Listing

August 2009

4 Reads

16 Citations

PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells.

Authors:

Thomas Bohnacker Romina Marone Emilie Collmann Ronan Calvez Emilio Hirsch Matthias P Wymann

Sci Signal 2009 Jun 9;2(74):ra27. Epub 2009 Jun 9.

Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, Basel, Switzerland.

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http://dx.doi.org/10.1126/scisignal.2000259	DOI Listing

June 2009

25 Reads

21 Citations

Twice upon a time: PI3K's secret double life exposed.

Authors:

Emilio Hirsch Laura Braccini Elisa Ciraolo Fulvio Morello Alessia Perino

Trends Biochem Sci 2009 May 17;34(5):244-8. Epub 2009 Apr 17.

Molecular Biotechnology Center, Torino, Italy.

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http://dx.doi.org/10.1016/j.tibs.2009.02.003	DOI Listing

May 2009

5 Reads

16 Citations

Phosphoinositide 3-kinase signalling in the vascular system.

Authors:

Fulvio Morello Alessia Perino Emilio Hirsch

Cardiovasc Res 2009 May 26;82(2):261-71. Epub 2008 Nov 26.

Molecular Biotechnology Center, University of Torino, via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1093/cvr/cvn325	DOI Listing

May 2009

7 Reads

49 Citations

Tissue-specific KO of ECM proteins.

Authors:

Mara Brancaccio Emila Turco Emilio Hirsch

Methods Mol Biol 2009 ;522:15-50

Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1007/978-1-59745-413-1_2	DOI Listing

April 2009

3 Reads

1 Citation

Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin.

Authors:

Laura Barberis Christian Pasquali Dominique Bertschy-Meier Alessandra Cuccurullo Carlotta Costa Chiara Ambrogio Francis Vilbois Roberto Chiarle Matthias Wymann Fiorella Altruda Christian Rommel Emilio Hirsch

Eur J Immunol 2009 Apr;39(4):1136-46

Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1002/eji.200838884	DOI Listing

April 2009

12 Reads

16 Citations

Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation.

Authors:

Matthew Thomas Matthew J Edwards Elzbieta Sawicka Nicholas Duggan Emilio Hirsch Matthias P Wymann Charles Owen Alexandre Trifilieff Christoph Walker John Westwick Peter Finan

Immunology 2009 Mar 27;126(3):413-22. Epub 2008 Aug 27.

Novartis Institutes for BioMedical Research, Horsham, West Sussex, United Kingdom.

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http://dx.doi.org/10.1111/j.1365-2567.2008.02908.x	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669822	PMC

March 2009

3 Reads

5 Citations

Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.

Eur J Heart Fail 2009 Feb;11(2):119-29

Experimental & Molecular Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.

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http://dx.doi.org/10.1093/eurjhf/hfn043	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639409	PMC

February 2009

23 Reads

1 Citation

The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation.

Authors:

Chiara Ambrogio Claudia Voena Andrea D Manazza Cinzia Martinengo Carlotta Costa Tomas Kirchhausen Emilio Hirsch Giorgio Inghirami Roberto Chiarle

Cancer Res 2008 Nov;68(21):8899-907

Department of Biomedical Sciences and Human Oncology, Center for Experimental Research and Medical Studies, University of Torino, Turin, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2568	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596920	PMC

November 2008

11 Reads

16 Citations

Phosphoinositide 3-kinases gamma and delta, linkers of coordinate C5a receptor-Fcgamma receptor activation and immune complex-induced inflammation.

Authors:

Stephanie Konrad Syed R Ali Kristina Wiege Shahzad N Syed Linda Engling Roland P Piekorz Emilio Hirsch Bernd Nürnberg Reinhold E Schmidt J Engelbert Gessner

J Biol Chem 2008 Nov 11;283(48):33296-303. Epub 2008 Sep 11.

Molecular Immunology Research Unit, Clinic for Immunology and Rheumatology, Hanover Medical School, Hanover, Germany.

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http://dx.doi.org/10.1074/jbc.M804617200	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662258	PMC

November 2008

25 Reads

14 Citations

Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells.

Authors:

Regine Heller Qing Chang Gunter Ehrlich Sherry N Hsieh Simone M Schoenwaelder Peter J Kuhlencordt Klaus T Preissner Emilio Hirsch Reinhard Wetzker

Cardiovasc Res 2008 Oct 16;80(1):96-105. Epub 2008 Jun 16.

Center for Molecular Biomedicine, Institute of Molecular Cell Biology, Friedrich Schiller University, Jena, Am Leutragraben 3, 07743 Jena, Germany.

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http://dx.doi.org/10.1093/cvr/cvn159	DOI Listing

October 2008

45 Reads

11 Citations

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.

Sci Signal 2008 Sep 9;1(36):ra3. Epub 2008 Sep 9.

Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1126/scisignal.1161577	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694958	PMC

September 2008

29 Reads

92 Citations

Taming the PI3K team to hold inflammation and cancer at bay.

Authors:

Emilio Hirsch Elisa Ciraolo Alessandra Ghigo Carlotta Costa

Pharmacol Ther 2008 May 5;118(2):192-205. Epub 2008 Mar 5.

Molecular Biotechnology Center, University of Torino, via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1016/j.pharmthera.2008.02.004	DOI Listing

May 2008

2 Reads

19 Citations

The RhoA-associated protein Citron-N controls dendritic spine maintenance by interacting with spine-associated Golgi compartments.

Authors:

Paola Camera Vanessa Schubert Maurizio Pellegrino Gaia Berto Alessandro Vercelli Patrizia Muzzi Emilio Hirsch Fiorella Altruda Carlos G Dotti Ferdinando Di Cunto

EMBO Rep 2008 Apr 29;9(4):384-92. Epub 2008 Feb 29.

Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino 10126, Italy.

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http://dx.doi.org/10.1038/embor.2008.21	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2288759	PMC

April 2008

9 Reads

6 Citations

Targeting phosphoinositide 3-kinase gamma to fight inflammation and more.

Authors:

Laura Barberis Emilio Hirsch

Thromb Haemost 2008 Feb;99(2):279-85

Molecular Biotechnology Center and Department of Genetics, Biology and Biochemistry, University of Torino, Via Nizza 52, 10126 Turin, Italy.

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http://dx.doi.org/10.1160/TH07-10-0632	DOI Listing

February 2008

3 Reads

14 Citations

Isoform selective phosphoinositide 3-kinase gamma and delta inhibitors and their therapeutic potential.

Authors:

Alessandra Ghigo Emilio Hirsch

Recent Pat Inflamm Allergy Drug Discov 2008 Jan;2(1):1-10

Molecular Biotechnology Center, University of Torino, Torino, Italy.

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January 2008

4 Reads

4 Citations

Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition.

Authors:

Barbara Frossi Juan Rivera Emilio Hirsch Carlo Pucillo

J Immunol 2007 Feb;178(4):2549-55

Dipartimento di Scienze e Tecnologie Biomediche, Università di Udine, Udine, Italy.

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February 2007

4 Reads

18 Citations

4.920 Impact Factor

CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells.

Authors:

Paola Cappello Tiziana Fraone Laura Barberis Carlotta Costa Emilio Hirsch Angela R Elia Cristiana Caorsi Tiziana Musso Francesco Novelli Mirella Giovarelli

J Immunol 2006 Nov;177(9):6143-51

Center for Experimental Research and Medical Studies, San Giovanni Battista Hospital, Turin, Italy.

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November 2006

3 Reads

3 Citations

4.920 Impact Factor

Signal transduction in inflammation. Perspective clues from the leukocyte-endothelium interface.

Authors:

Emilio Hirsch

Thromb Haemost 2006 Jan;95(1):3-4

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January 2006

1 Citation

4.980 Impact Factor

Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing.

Authors:

Emilio Hirsch Giuseppe Lembo Giuseppe Montrucchio Christian Rommel Carlotta Costa Laura Barberis

Thromb Haemost 2006 Jan;95(1):29-35

Dipartimento di Genetica, Biologia e Biochimica, University of Torino, Via Santena 5bis, 10126 Torino, Italy.

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January 2006

1 Read

14 Citations

4.980 Impact Factor

Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion.

Authors:

Domingo F Barber Almira Bartolomé Carmen Hernandez Juana M Flores Cristina Fernandez-Arias Luis Rodríguez-Borlado Emilio Hirsch Matthias Wymann Dimitrios Balomenos Ana C Carrera

J Immunol 2006 Jan;176(1):589-93

Department of Immunology and Oncology, and Animal Facility, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Cientificas, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.

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