Dr. Emilio Hirsch, PhD - University of Torino - Professor

Dr. Emilio Hirsch

PhD

University of Torino

Professor

Torino | Italy

ORCID logohttps://orcid.org/0000-0002-9073-6024

Dr. Emilio Hirsch, PhD - University of Torino - Professor

Dr. Emilio Hirsch

PhD

Introduction

Primary Affiliation: University of Torino - Torino , Italy

Education

Jan 1994
University of Torino
PhD

Experience

Jan 2005
University of Torino
Full Professor of Experimental Biology
Biotecnologie Molecolari e Sciene della Salute

Publications

153Publications

2818Reads

967Profile Views

2205PubMed Central Citations

Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting.

Oxid Med Cell Longev 2018 26;2018:6419805. Epub 2018 Feb 26.

Department of Molecular Biotechnology and Health Science, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1155/2018/6419805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846462PMC
September 2018
8 Reads

Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes.

Nat Chem Biol 2018 08 18;14(8):801-810. Epub 2018 Jun 18.

Department of Molecular Biotechnology and Health Sciences. Molecular Biotechnology Center, University of Turin, Torino, Italy.

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http://dx.doi.org/10.1038/s41589-018-0086-4DOI Listing
August 2018
9 Reads
1 Citation
13.000 Impact Factor

Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities.

Int J Mol Sci 2018 Jun 20;19(6). Epub 2018 Jun 20.

Department Molecular Biotechnology and Health Science, University of Torino, Via Nizza 52, 10126 Turin, Italy.

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http://dx.doi.org/10.3390/ijms19061821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032284PMC
June 2018
3 Reads
1 Citation
2.862 Impact Factor

Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits.

Food Chem 2018 May 7;247:56-65. Epub 2017 Dec 7.

Department of Clinical Analysis, Centre of Health Sciences, Federal University of Santa Catarina, Campus Universitário - Trindade, 88040-970 Florianopolis, SC, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.foodchem.2017.12.015DOI Listing
May 2018
8 Reads
3.391 Impact Factor

p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation.

PLoS One 2016 21;11(7):e0159310. Epub 2016 Jul 21.

Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA, University of Tuebingen, 72074 Tuebingen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159310PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956235PMC
July 2017
30 Reads
2 Citations
3.234 Impact Factor

Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection.

J Leukoc Biol 2017 02 28;101(2):367-376. Epub 2016 Jul 28.

Institute of Molecular Health Sciences, Department of Biology, ETH Zurich, Zurich, Switzerland;

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http://dx.doi.org/10.1189/jlb.4HI0316-157RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610570PMC
February 2017
16 Reads
1 Citation
4.290 Impact Factor

PI3Kγ Inhibition Protects Against Diabetic Cardiomyopathy in Mice.

Rev Esp Cardiol (Engl Ed) 2017 Jan 13;70(1):16-24. Epub 2016 Jul 13.

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Istituto Neurologico Mediterraneo, Pozzilli, Isernia, Italy; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.rec.2016.04.034DOI Listing
January 2017
2 Reads
1 Citation

Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking.

Adv Biol Regul 2017 Jan 14;63:132-139. Epub 2016 Sep 14.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center (MBC), University of Torino, Via Nizza 52, 10126 Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2016.09.002DOI Listing
January 2017
4 Reads
5 Citations

Rac signal adaptation controls neutrophil mobilization from the bone marrow.

Sci Signal 2016 12 20;9(459):ra124. Epub 2016 Dec 20.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1126/scisignal.aah5882DOI Listing
December 2016
12 Reads
1 Citation
6.280 Impact Factor

Phosphoinositide 3-Kinase γ Restrains Neurotoxic Effects of Microglia After Focal Brain Ischemia.

Mol Neurobiol 2016 10 9;53(8):5468-79. Epub 2015 Oct 9.

Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Friedrich Schiller University, Hans-Knöll-Strasse 2, D-07745, Jena, Germany.

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http://dx.doi.org/10.1007/s12035-015-9472-zDOI Listing
October 2016
3 Reads
3 Citations
5.140 Impact Factor

Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression.

Cancer Discov 2016 08 13;6(8):870-85. Epub 2016 May 13.

Moores Cancer Center, University of California, San Diego, La Jolla, California. Department of Pathology, University of California, San Diego, La Jolla, California.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091937PMC
August 2016
43 Reads
21 Citations
15.930 Impact Factor

New signal transduction paradigms in anthracycline-induced cardiotoxicity.

Biochim Biophys Acta 2016 Jul 29;1863(7 Pt B):1916-25. Epub 2016 Jan 29.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2016.01.021DOI Listing
July 2016
21 Reads
20 Citations

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis.

Nat Cell Biol 2016 05 18;18(5):549-60. Epub 2016 Apr 18.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Ashton Street, Liverpool L69 3GE, UK.

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http://dx.doi.org/10.1038/ncb3340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894551PMC
May 2016
32 Reads
33 Citations
19.680 Impact Factor

Genetic Deletion and Pharmacological Inhibition of PI3K γ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease.

Mediators Inflamm 2015 21;2015:545417. Epub 2015 Jun 21.

Department of Clinical and Biological Sciences, University of Torino, A.O.U. S.Luigi Gonzaga, Regione Gonzole 10, Orbassano, 10043 Turin, Italy.

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http://dx.doi.org/10.1155/2015/545417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491401PMC
May 2016
12 Reads
5 Citations
3.240 Impact Factor

Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation.

J Am Soc Nephrol 2016 Apr 13;27(4):1135-44. Epub 2015 Aug 13.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy;

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http://dx.doi.org/10.1681/ASN.2014100967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814170PMC
April 2016
24 Reads
6 Citations
9.343 Impact Factor

Crossroads of PI3K and Rac pathways.

Small GTPases 2015 5;6(2):71-80. Epub 2015 May 5.

a Molecular Biotechnology Center; Department of Molecular Biotechnology and Health Sciences; University of Torino ; Torino , Italy.

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http://dx.doi.org/10.4161/21541248.2014.989789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601376PMC
April 2016
30 Reads
11 Citations

Phosphoinositide 3-kinase gamma controls inflammation-induced myocardial depression via sequential cAMP and iNOS signalling.

Cardiovasc Res 2015 Nov 2;108(2):243-53. Epub 2015 Sep 2.

Institute of Molecular Cell Biology, Jena University Hospital, Friedrich Schiller University, Hans-Knöll-Straße 2, D-07745 Jena, Germany Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany

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http://dx.doi.org/10.1093/cvr/cvv217DOI Listing
November 2015
5 Reads
3 Citations
5.940 Impact Factor

PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development.

Immunity 2015 Oct 6;43(4):674-89. Epub 2015 Oct 6.

Institute of Molecular Health Sciences, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.09.006DOI Listing
October 2015
21 Reads
9 Citations
21.561 Impact Factor

How PI3K-derived lipids control cell division.

Front Cell Dev Biol 2015 30;3:61. Epub 2015 Sep 30.

Department of Molecular Biotechnology and Health Sciences, University of Turin Torino, Italy.

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http://dx.doi.org/10.3389/fcell.2015.00061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588110PMC
October 2015
1 Read
3 Citations

The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors.

Molecules 2015 Sep 18;20(9):17275-87. Epub 2015 Sep 18.

Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale "A. Avogadro", Largo Donegani 2, Novara 28100, Italy.

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http://dx.doi.org/10.3390/molecules200917275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332036PMC
September 2015
2 Reads
2.420 Impact Factor

Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl.

Biochim Biophys Acta 2015 Aug 8;1853(8):1879-88. Epub 2015 May 8.

Department of Biology and Biotechnology, Division of Biochemistry, University of Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2015.05.004DOI Listing
August 2015
3 Reads
4 Citations

Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling.

EMBO Mol Med 2015 Jul;7(7):904-17

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli (IS), Italy Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy

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http://dx.doi.org/10.15252/emmm.201404697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520656PMC
July 2015
4 Reads
8 Citations
8.665 Impact Factor

Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease.

Haematologica 2015 Jul 1;100(7):870-80. Epub 2015 May 1.

Department of Medicine, University of Verona-AOUI Verona, Policlinico GB Rossi, Verona, Italy.

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http://dx.doi.org/10.3324/haematol.2015.124586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486221PMC
July 2015
15 Reads
7 Citations
5.870 Impact Factor

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

Biochem J 2015 Jul;469(1):59-69

Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Centre of Pharmacogenomics and Pharmaceutical Research, University of Tübingen, 72074 Tübingen, Germany

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http://biochemj.org/lookup/doi/10.1042/BJ20150099
Publisher Site
http://dx.doi.org/10.1042/BJ20150099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655608PMC
July 2015
16 Reads
2 Citations
4.400 Impact Factor

In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.

Cancer Discov 2015 Jul 16;5(7):740-51. Epub 2015 Apr 16.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497843PMC
July 2015
39 Reads
14 Citations
15.930 Impact Factor

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling.

Nat Commun 2015 Jun 23;6:7400. Epub 2015 Jun 23.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino 10126, Italy.

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http://dx.doi.org/10.1038/ncomms8400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479417PMC
June 2015
29 Reads
21 Citations
10.742 Impact Factor

PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction.

FEBS Lett 2015 Jun 12;589(14):1552-8. Epub 2015 May 12.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2015.05.001DOI Listing
June 2015
2 Reads
11 Citations
3.170 Impact Factor

PI3K signaling in the pathogenesis of obesity: The cause and the cure.

Adv Biol Regul 2015 May 4;58:1-15. Epub 2014 Dec 4.

Molecular Biotechnology Center, University of Torino, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2014.11.004DOI Listing
May 2015
2 Reads
7 Citations

CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration.

J Pharmacol Exp Ther 2015 Mar 9;352(3):559-67. Epub 2015 Jan 9.

Corporate Pre-Clinical R & D, Chiesi Farmaceutici S.p.A., Parma, Italy (N.M., P.C., R.B., G.M., F.P., E.A., G.A., A.R., E.G., R.D.F., Ca.C., L.C., Ch.C., R.P. M.D., M.C., G.V., F.F.); Molecular Biotechnology Center, University of Turin, Turin, Italy (E.H.); and Dipartimento di Scienze Farmacologiche e Biomolecolari, Milan, Italy (C.B., A.S.)

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http://dx.doi.org/10.1124/jpet.114.220541DOI Listing
March 2015
20 Reads
8 Citations
3.972 Impact Factor

Akt activation by PHLPP1 ablation prevents pathological hypertrophy by promoting angiogenesis.

Cardiovasc Res 2015 Feb 23;105(2):129-30. Epub 2014 Dec 23.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino 10126, Italy

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http://dx.doi.org/10.1093/cvr/cvu261DOI Listing
February 2015
3 Reads
1 Citation
5.940 Impact Factor

Methods to measure the enzymatic activity of PI3Ks.

Methods Enzymol 2014 ;543:115-40

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-801329-8.00006-4DOI Listing
February 2015
3 Reads
1 Citation
2.090 Impact Factor

The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.

Chem Biol 2014 Dec 4;21(12):1680-9. Epub 2014 Dec 4.

Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272670PMC
December 2014
75 Reads
7 Citations
6.645 Impact Factor

Phosphoinositide 3-kinase γ affects LPS-induced disturbance of blood-brain barrier via lipid kinase-independent control of cAMP in microglial cells.

Neuromolecular Med 2014 Dec 18;16(4):704-13. Epub 2014 Jul 18.

Institute of Molecular Cell Biology, Jena University Hospital, Friedrich Schiller University, 07745, Jena, Germany.

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http://dx.doi.org/10.1007/s12017-014-8320-zDOI Listing
December 2014
29 Reads
6 Citations
3.680 Impact Factor

Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis.

World J Gastroenterol 2014 Nov;20(41):15190-9

Enrico Lupia, Luca Pigozzi, Giuseppe Montrucchio, Department of Medical Sciences, University of Torino, 10126 Torino, Italy.

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http://dx.doi.org/10.3748/wjg.v20.i41.15190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223253PMC
November 2014
7 Reads
5 Citations
2.370 Impact Factor

Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice.

Kidney Int 2014 Nov 14;86(5):979-90. Epub 2014 May 14.

Diabetic Nephropathy Laboratory, Department of Medical Sciences, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1038/ki.2014.165DOI Listing
November 2014
17 Reads
5 Citations
8.563 Impact Factor

Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive.

Sci Signal 2014 Nov 18;7(352):ra110. Epub 2014 Nov 18.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy.

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http://dx.doi.org/10.1126/scisignal.2005485DOI Listing
November 2014
24 Reads
14 Citations
6.280 Impact Factor

PI3K/AKT signaling pathway and cancer: an updated review.

Ann Med 2014 Sep 5;46(6):372-83. Epub 2014 Jun 5.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin , Italy.

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http://dx.doi.org/10.3109/07853890.2014.912836DOI Listing
September 2014
9 Reads
120 Citations
3.890 Impact Factor

Phosphoinositide 3-kinases in health and disease.

Subcell Biochem 2012 ;58:183-213

Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1007/978-94-007-3012-0_6DOI Listing
August 2014
8 Reads
5 Citations

Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.

J Exp Med 2014 Aug 29;211(9):1779-92. Epub 2014 Jul 29.

INSERM, UMR1048, F-31300 Toulouse, France Université Toulouse III, Institut de Maladies Métaboliques et Cardiovasculaires, F-31300 Toulouse, France

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http://dx.doi.org/10.1084/jem.20131276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144742PMC
August 2014
30 Reads
6 Citations
12.520 Impact Factor

PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor.

Br J Pharmacol 2014 Jul;171(13):3328-37

Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Jena, Germany.

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http://dx.doi.org/10.1111/bph.12698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080984PMC
July 2014
40 Reads
3 Citations
4.842 Impact Factor

Cancer: natural-born killers unleashed.

Nature 2014 Jun 11;510(7505):342-3. Epub 2014 Jun 11.

Center for Experimental Research and Medical Studies, Department of Molecular Biotechnology and Health Sciences, University of Turin.

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http://dx.doi.org/10.1038/nature13503DOI Listing
June 2014
4 Reads
1 Citation
42.351 Impact Factor

PI3K p110γ deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions.

PLoS One 2013 22;8(8):e72674. Epub 2013 Aug 22.

Department of Immunology and Oncology, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CNB-CSIC), Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072674PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750002PMC
June 2014
47 Reads
4 Citations
3.234 Impact Factor

Myocyte signalling in leucocyte recruitment to the heart.

Cardiovasc Res 2014 May 5;102(2):270-80. Epub 2014 Feb 5.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, Italy.

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http://dx.doi.org/10.1093/cvr/cvu030DOI Listing
May 2014
7 Reads
11 Citations
5.940 Impact Factor

ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models.

Eur J Heart Fail 2014 May 23;16(5):509-18. Epub 2014 Feb 23.

Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Al. Prof. Hernani Monteiro, 4200 319, Porto, Portugal.

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http://dx.doi.org/10.1002/ejhf.66DOI Listing
May 2014
34 Reads
3 Citations
6.530 Impact Factor

Elastin degradation and ensuing inflammation as emerging keys to atherosclerosis.

Cardiovasc Res 2014 Apr 11;102(1):1-2. Epub 2014 Feb 11.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1093/cvr/cvu038DOI Listing
April 2014
23 Reads
5.940 Impact Factor

Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy.

J Allergy Clin Immunol 2013 Oct 14;132(4):959-68. Epub 2013 May 14.

Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.jaci.2013.03.008DOI Listing
October 2013
47 Reads
7 Citations
11.480 Impact Factor

PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth.

PLoS One 2013 2;8(4):e60226. Epub 2013 Apr 2.

Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060226PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614555PMC
October 2013
28 Reads
18 Citations
3.234 Impact Factor

PI3Ks and small GTPases in neutrophil migration: two sides of the same coin.

Mol Immunol 2013 Aug 5;55(1):83-6. Epub 2012 Nov 5.

Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1016/j.molimm.2012.10.004DOI Listing
August 2013
3 Reads
6 Citations
2.973 Impact Factor

Editorial to the SI Leukocyte Adhesion and Migration.

Mol Immunol 2013 Aug 11;55(1):48. Epub 2013 Jan 11.

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http://dx.doi.org/10.1016/j.molimm.2012.12.016DOI Listing
August 2013
5 Reads
2.973 Impact Factor

Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate.

Nature 2013 Jul 3;499(7457):233-7. Epub 2013 Jul 3.

Leibniz Institut für Molekulare Pharmakologie & Freie Universität Berlin, Robert-Roessle-Straße 10, 13125 Berlin, Germany.

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http://dx.doi.org/10.1038/nature12360DOI Listing
July 2013
40 Reads
85 Citations
42.351 Impact Factor

Targeting PI3K in Cancer: Any Good News?

Front Oncol 2013 8;3:108. Epub 2013 May 8.

Molecular Biotechnology Center, University of Turin Turin, Italy.

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http://dx.doi.org/10.3389/fonc.2013.00108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647219PMC
May 2013
4 Reads
37 Citations

Phosphoinositides and cardiovascular diseases.

Curr Top Microbiol Immunol 2012 ;362:43-60

Department of Genetics, Biology and Biochemistry, University of Torino, Molecular Biotechnology Center, Italy.

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http://dx.doi.org/10.1007/978-94-007-5025-8_2DOI Listing
April 2013
6 Reads
1 Citation
4.100 Impact Factor

Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation.

J Immunol 2013 Apr 27;190(7):3648-60. Epub 2013 Feb 27.

Section of General Pathology, Department of Pathology and Diagnostics, University of Verona, Verona 37134, Italy.

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http://dx.doi.org/10.4049/jimmunol.1201951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280093PMC
April 2013
3 Reads
9 Citations
4.922 Impact Factor

NADPH oxidases in heart failure: poachers or gamekeepers?

Antioxid Redox Signal 2013 Mar 27;18(9):1024-41. Epub 2012 Aug 27.

Cardiovascular Division, James Black Centre, King's College London British Heart Foundation Centre of Excellence, London, UK.

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http://dx.doi.org/10.1089/ars.2012.4550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567780PMC
March 2013
10 Reads
47 Citations
7.410 Impact Factor

Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases.

Circulation 2013 Mar 27;127(12):1317-29. Epub 2013 Feb 27.

Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.130179DOI Listing
March 2013
26 Reads
58 Citations
14.430 Impact Factor

Therapeutic applications of PI3K inhibitors in cardiovascular diseases.

Future Med Chem 2013 Mar;5(4):479-92

University of Torino, Molecular Biotechnology Center, Department of Molecular Biotechnology & Health Sciences, Via Nizza 52, 10126, Torino, Italy.

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http://dx.doi.org/10.4155/fmc.13.11DOI Listing
March 2013
16 Reads
1 Citation
4.000 Impact Factor

Two signalling hands for uPAR.

Authors:
Emilio Hirsch

Thromb Haemost 2013 Feb 10;109(2):179. Epub 2013 Jan 10.

Molecular Biotechnology Center, Departments of Genetics, Biology and Biochemistry, School of Medicine, University of Torino, Via Nizza 52, 10126, Torino, Italy.

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http://dx.doi.org/10.1160/TH13-01-0001DOI Listing
February 2013
3 Reads
4.984 Impact Factor

Blockade of phosphatidylinositol 3-kinase PI3Kδ or PI3Kγ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis.

J Immunol 2012 Nov 28;189(9):4612-20. Epub 2012 Sep 28.

Rheumatology Research, Merck Serono S.A., 1211 Geneva, Switzerland.

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http://dx.doi.org/10.4049/jimmunol.1103173DOI Listing
November 2012
26 Reads
13 Citations
4.922 Impact Factor

Inflaming attraction by RNA.

Authors:
Emilio Hirsch

Thromb Haemost 2012 Oct 5;108(4):589. Epub 2012 Sep 5.

Department of Genetics, School of Medicine, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1160/TH12-08-0620DOI Listing
October 2012
5 Reads
4.984 Impact Factor

Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.

Arterioscler Thromb Vasc Biol 2012 Sep 21;32(9):2280-8. Epub 2012 Jun 21.

Institute for Cancer Research and Treatment (IRCC), Candiolo, Italy.

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http://dx.doi.org/10.1161/ATVBAHA.112.250621DOI Listing
September 2012
23 Reads
16 Citations
6.000 Impact Factor

Anchoring proteins as regulators of signaling pathways.

Circ Res 2012 Aug;111(4):482-92

Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1161/CIRCRESAHA.111.262899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508715PMC
August 2012
10 Reads
16 Citations
11.020 Impact Factor

Calming down T cell acute leukemia.

Cancer Cell 2012 Apr;21(4):449-50

Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1016/j.ccr.2012.03.025DOI Listing
April 2012
2 Reads
1 Citation
23.523 Impact Factor

Measuring PI3K lipid kinase activity.

Methods Mol Biol 2012 ;795:55-67

Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1007/978-1-61779-337-0_4DOI Listing
January 2012
3 Reads

Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling.

Blood 2012 Jan 21;119(3):847-56. Epub 2011 Nov 21.

Department of Biochemistry, University of Pavia, Italy.

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http://dx.doi.org/10.1182/blood-2011-07-364992DOI Listing
January 2012
7 Reads
12 Citations
10.452 Impact Factor

Phosphoinositide 3-kinase p110γ in immunity.

IUBMB Life 2011 Sep 28;63(9):707-13. Epub 2011 Jul 28.

Department of Genetic, Biology and Biochemistry and Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, Italy.

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http://dx.doi.org/10.1002/iub.516DOI Listing
September 2011
4 Reads
7 Citations
3.143 Impact Factor

Specific PI3K isoform modulation in heart failure: lessons from transgenic mice.

Curr Heart Fail Rep 2011 Sep;8(3):168-75

Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126, Torino, Italy.

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http://dx.doi.org/10.1007/s11897-011-0059-3DOI Listing
September 2011
23 Reads
4 Citations

IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.

Cardiovasc Res 2011 Aug 14;91(3):456-64. Epub 2011 Apr 14.

Dipartimento di Genetica, Biologia e Biochimica, Molecular Biotechnology Center, Università di Torino, via Nizza 52, Turin, Italy.

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http://dx.doi.org/10.1093/cvr/cvr103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294280PMC
August 2011
25 Reads
30 Citations
5.940 Impact Factor

The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions.

Blood 2011 Jul 6;118(4):1099-108. Epub 2011 May 6.

Department of Genetic, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1182/blood-2010-12-324756DOI Listing
July 2011
10 Reads
15 Citations
10.452 Impact Factor

PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis.

Cancer Cell 2011 Jun;19(6):805-13

Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170773PMC
June 2011
1 Read
26 Citations
23.523 Impact Factor

Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors.

Org Biomol Chem 2011 Jun 14;9(11):4144-9. Epub 2011 Apr 14.

DiSCAFF, Università degli Studi del Piemonte Orientale, via Bovio 6, 28100, Novara, Italy.

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http://dx.doi.org/10.1039/c1ob05336aDOI Listing
June 2011
6 Reads
3.562 Impact Factor

Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice.

Am J Respir Crit Care Med 2011 Apr 22;183(7):922-31. Epub 2010 Oct 22.

Department of Pharmacology, University of São Paulo, Av. Bandeirantes, Ribeirão Preto, SP, Brazil.

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http://dx.doi.org/10.1164/rccm.201002-0223OCDOI Listing
April 2011
25 Reads
13 Citations
13.000 Impact Factor

Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines.

Appl Microbiol Biotechnol 2011 Mar 1;89(5):1423-33. Epub 2011 Feb 1.

Department of Biological Science and Bioengineering, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, People's Republic of China.

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http://dx.doi.org/10.1007/s00253-011-3101-1DOI Listing
March 2011
32 Reads
5 Citations
3.340 Impact Factor

Regulating neutrophil apoptosis: new players enter the game.

Trends Immunol 2011 Mar 12;32(3):117-24. Epub 2011 Feb 12.

Institut National de la Santé et de la Recherche Médicale Unité 1016, 75014 Paris, France.

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http://dx.doi.org/10.1016/j.it.2011.01.001DOI Listing
March 2011
15 Reads
42 Citations
10.400 Impact Factor

Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure.

Circulation 2011 Feb 17;123(4):391-9. Epub 2011 Jan 17.

Department of Genetics, Biology, and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.950543DOI Listing
February 2011
13 Reads
13 Citations
14.430 Impact Factor

More than just kinases: the scaffolding function of PI3K.

Curr Top Microbiol Immunol 2010 ;346:171-81

Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1007/82_2010_57DOI Listing
January 2011
3 Reads
6 Citations
4.100 Impact Factor

Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.

Circ Res 2010 Nov 16;107(10):1275-89. Epub 2010 Sep 16.

Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.110.229054DOI Listing
November 2010
8 Reads
18 Citations
11.020 Impact Factor

Leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure.

Trends Cardiovasc Med 2010 Nov;20(8):273-6

Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy.

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http://dx.doi.org/10.1016/j.tcm.2011.12.007DOI Listing
November 2010
15 Reads
2.910 Impact Factor

Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema.

Intensive Care Med 2010 Nov 19;36(11):1935-45. Epub 2010 Aug 19.

Department of Anesthesia and Critical Care, Ospedale S. Giovanni Battista-Molinette, University of Torino, Corso Dogliotti 14, 10126, Turin, Italy.

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http://dx.doi.org/10.1007/s00134-010-2018-yDOI Listing
November 2010
22 Reads
9 Citations
7.210 Impact Factor

Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment.

Am J Respir Crit Care Med 2010 Sep 27;182(6):762-73. Epub 2010 May 27.

Department of Anesthesiology and Critical Care, University of Turin, Ospedale S. Giovanni Battista-Molinette, Turin, Italy.

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http://dx.doi.org/10.1164/rccm.201001-0088OCDOI Listing
September 2010
18 Reads
17 Citations
13.000 Impact Factor

Dissection of the interplay between class I PI3Ks and Rac signaling in phagocytic functions.

ScientificWorldJournal 2010 Sep 14;10:1826-39. Epub 2010 Sep 14.

Department of Genetics, Biology, and Biochemistry, Molecular Biotechnology Center, University of Turin, Italy.

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http://dx.doi.org/10.1100/tsw.2010.178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763975PMC
September 2010
3 Reads
6 Citations
1.220 Impact Factor

The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation.

J Leukoc Biol 2010 Jun 3;87(6):1083-95. Epub 2010 Mar 3.

1. Abteilung für Pharmakologie und Experimentelle Therapie, Klinikum der Eberhard-Karls-Universität Tübingen, Wilhelmstrasse 56, D-72074 Tübingen, Germany. Institute of Biochemistry and Molecular Biology II, University of Düsseldorf, Universitätsstrabetae 1, D-40225 Düsseldorf, Germany. E-mail:

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http://dx.doi.org/10.1189/jlb.0809585DOI Listing
June 2010
6 Reads
20 Citations

The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice.

Immunol Lett 2010 Jun 27;131(1):33-9. Epub 2010 Mar 27.

Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.imlet.2010.03.008DOI Listing
June 2010
13 Reads
9 Citations
2.510 Impact Factor

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways.

Blood 2010 Apr 18;115(15):3118-27. Epub 2010 Feb 18.

Department of Anesthesiology and Intensive Care Medicine, University of Münster, 48149 Münster, Germany.

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http://dx.doi.org/10.1182/blood-2009-11-254185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858472PMC
April 2010
69 Reads
52 Citations

Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.

Mol Biol Cell 2010 Mar 6;21(5):704-11. Epub 2010 Jan 6.

Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1091/mbc.e09-08-0744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828958PMC
March 2010
35 Reads
26 Citations

PI3K inhibition in inflammation: Toward tailored therapies for specific diseases.

Bioessays 2010 Mar;32(3):185-96

Molecular Biotechnology Center, University of Torino, Italy.

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http://dx.doi.org/10.1002/bies.200900150DOI Listing
March 2010
11 Reads
19 Citations

Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice.

Circ Res 2010 Mar 7;106(4):757-68. Epub 2010 Jan 7.

Experimental Cardiovascular Medicine, Bristol Heart Institute, University of Bristol, Upper Maudlin Street, Bristol, United Kingdom.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.207449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833289PMC
March 2010
9 Reads
13 Citations

PI3K kinase and scaffold functions in heart.

Ann N Y Acad Sci 2010 Feb;1188:39-45

Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05081.xDOI Listing
February 2010
7 Reads
13 Citations

Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets.

Blood 2009 Sep 10;114(10):2193-6. Epub 2009 Jun 10.

Department of Biochemistry, University of Pavia, via Bassi 21, Pavia, Italy.

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http://dx.doi.org/10.1182/blood-2009-03-208074DOI Listing
September 2009
7 Reads
33 Citations

A pro-inflammatory signature mediates FGF2-induced angiogenesis.

J Cell Mol Med 2009 Aug;13(8B):2083-108

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1111/j.1582-4934.2008.00415.xDOI Listing
August 2009
4 Reads
16 Citations

PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells.

Sci Signal 2009 Jun 9;2(74):ra27. Epub 2009 Jun 9.

Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, Basel, Switzerland.

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http://dx.doi.org/10.1126/scisignal.2000259DOI Listing
June 2009
30 Reads
21 Citations

Phosphoinositide 3-kinase signalling in the vascular system.

Cardiovasc Res 2009 May 26;82(2):261-71. Epub 2008 Nov 26.

Molecular Biotechnology Center, University of Torino, via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1093/cvr/cvn325DOI Listing
May 2009
7 Reads
49 Citations

Twice upon a time: PI3K's secret double life exposed.

Trends Biochem Sci 2009 May 17;34(5):244-8. Epub 2009 Apr 17.

Molecular Biotechnology Center, Torino, Italy.

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http://dx.doi.org/10.1016/j.tibs.2009.02.003DOI Listing
May 2009
5 Reads
16 Citations

Tissue-specific KO of ECM proteins.

Methods Mol Biol 2009 ;522:15-50

Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1007/978-1-59745-413-1_2DOI Listing
April 2009
3 Reads
1 Citation

Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin.

Eur J Immunol 2009 Apr;39(4):1136-46

Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1002/eji.200838884DOI Listing
April 2009
13 Reads
16 Citations

The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation.

Cancer Res 2008 Nov;68(21):8899-907

Department of Biomedical Sciences and Human Oncology, Center for Experimental Research and Medical Studies, University of Torino, Turin, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596920PMC
November 2008
12 Reads
16 Citations

Phosphoinositide 3-kinases gamma and delta, linkers of coordinate C5a receptor-Fcgamma receptor activation and immune complex-induced inflammation.

J Biol Chem 2008 Nov 11;283(48):33296-303. Epub 2008 Sep 11.

Molecular Immunology Research Unit, Clinic for Immunology and Rheumatology, Hanover Medical School, Hanover, Germany.

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http://dx.doi.org/10.1074/jbc.M804617200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662258PMC
November 2008
32 Reads
14 Citations

Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells.

Cardiovasc Res 2008 Oct 16;80(1):96-105. Epub 2008 Jun 16.

Center for Molecular Biomedicine, Institute of Molecular Cell Biology, Friedrich Schiller University, Jena, Am Leutragraben 3, 07743 Jena, Germany.

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http://dx.doi.org/10.1093/cvr/cvn159DOI Listing
October 2008
59 Reads
11 Citations

Taming the PI3K team to hold inflammation and cancer at bay.

Pharmacol Ther 2008 May 5;118(2):192-205. Epub 2008 Mar 5.

Molecular Biotechnology Center, University of Torino, via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1016/j.pharmthera.2008.02.004DOI Listing
May 2008
2 Reads
19 Citations

Targeting phosphoinositide 3-kinase gamma to fight inflammation and more.

Thromb Haemost 2008 Feb;99(2):279-85

Molecular Biotechnology Center and Department of Genetics, Biology and Biochemistry, University of Torino, Via Nizza 52, 10126 Turin, Italy.

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http://dx.doi.org/10.1160/TH07-10-0632DOI Listing
February 2008
4 Reads
14 Citations

Isoform selective phosphoinositide 3-kinase gamma and delta inhibitors and their therapeutic potential.

Recent Pat Inflamm Allergy Drug Discov 2008 Jan;2(1):1-10

Molecular Biotechnology Center, University of Torino, Torino, Italy.

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January 2008
4 Reads
4 Citations

Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition.

J Immunol 2007 Feb;178(4):2549-55

Dipartimento di Scienze e Tecnologie Biomediche, Università di Udine, Udine, Italy.

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February 2007
4 Reads
18 Citations
4.920 Impact Factor

CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells.

J Immunol 2006 Nov;177(9):6143-51

Center for Experimental Research and Medical Studies, San Giovanni Battista Hospital, Turin, Italy.

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November 2006
3 Reads
3 Citations
4.920 Impact Factor

Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion.

J Immunol 2006 Jan;176(1):589-93

Department of Immunology and Oncology, and Animal Facility, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Cientificas, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.

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January 2006
54 Reads
26 Citations
4.920 Impact Factor

Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing.

Thromb Haemost 2006 Jan;95(1):29-35

Dipartimento di Genetica, Biologia e Biochimica, University of Torino, Via Santena 5bis, 10126 Torino, Italy.

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January 2006
2 Reads
14 Citations
4.980 Impact Factor

Signal transduction in inflammation. Perspective clues from the leukocyte-endothelium interface.

Authors:
Emilio Hirsch

Thromb Haemost 2006 Jan;95(1):3-4

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January 2006
1 Citation
4.980 Impact Factor

Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy.

Biochem Soc Trans 2003 Feb;31(Pt 1):275-80

Department of Medicine, University of Fribourg, Rue du Musée 5, CH-1700 Fribourg, Switzerland.

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http://dx.doi.org/10.1042/DOI Listing
February 2003
1 Read
34 Citations
3.190 Impact Factor

Resistance to thromboembolism in PI3Kgamma-deficient mice.

FASEB J 2001 Sep 9;15(11):2019-21. Epub 2001 Jul 9.

Dipartimento di Genetica, Biologia e Biochimica, Università di Torino, Via Santina 5 bis, 10126 Turin, Italy.

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http://dx.doi.org/10.1096/fj.00-0810fjeDOI Listing
September 2001
1 Read
38 Citations
5.040 Impact Factor

Integrin function and regulation in development.

Int J Dev Biol 2000 ;44(6):725-31

Department of Genetics, Biology and Biochemistry, University of Torino, Italy.

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March 2001
1 Read
23 Citations
1.900 Impact Factor

Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice.

Blood 1999 Dec;94(11):3906-14

Department of Genetics, Biology and Biochemistry, University of Turin, Italy.

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December 1999
1 Read
48 Citations
10.450 Impact Factor

Determination of positive and negative regulatory elements.

Methods Mol Biol 1999 ;129:189-208

Dipartimento di Genetica, Biologia e Biochimica, Torino, Italy.

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http://dx.doi.org/10.1385/1-59259-249-X:189DOI Listing
October 1999

Mouse myoblasts can fuse and form a normal sarcomere in the absence of beta1 integrin expression.

J Cell Sci 1998 Aug;111 ( Pt 16):2397-409

Max Planck Institute for Biochemistry, Germany.

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August 1998
10 Citations
5.430 Impact Factor

Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules.

J Cell Sci 1997 Dec;110 ( Pt 23):2895-904

Max-Planck-Institute of Biochemistry, 82152 Martinsried, Germany.

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December 1997
1 Read
24 Citations
5.430 Impact Factor

Analysis of regulatory regions of the ciliary neutrophic factor gene in transgenic mice.

Neuroreport 1995 Dec;7(1):57-60

Dipartimento di Genetica, Biologia e Chimica Medica, Università di Torino, Italy.

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December 1995
1.640 Impact Factor

The beta 1 integrin distal promoter is developmentally regulated in transgenic mice.

Cell Adhes Commun 1993 Dec;1(3):203-12

Dipartimento di Biologia, Genetica e Chimica Medica, Università di Torino, Italy.

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December 1993
1 Citation

Expression of beta 1 integrin complexes on the surface of unfertilized mouse oocyte.

Development 1993 Apr;117(4):1369-75

Dipartimento di Genetica, Biologia e Chimica Medica, Università di Torino, Italy.

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April 1993
11 Citations
6.460 Impact Factor

Top co-authors

Alessandra Ghigo
Alessandra Ghigo

Molecular Biotechnology Center

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Elisa Ciraolo
Elisa Ciraolo

Molecular Biotechnology Center

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Alessia Perino
Alessia Perino

Molecular Biotechnology Center

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Irene Franco
Irene Franco

University of Torino

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Reinhard Wetzker
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Jena University Hospital

8
Fulvio Morello
Fulvio Morello

University of Torino

8
Federico Gulluni
Federico Gulluni

University of Turin Turin

7
Giulia Germena
Giulia Germena

University of Torino

7
Guido Tarone
Guido Tarone

University of Torino

6
Carlo C Campa
Carlo C Campa

Molecular Biotechnology Center

6