Publications by authors named "Emilian Damian Popovici"

4 Publications

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Prospects of COVID-19 Vaccination in Romania: Challenges and Potential Solutions.

Front Public Health 2021 10;9:644538. Epub 2021 Feb 10.

Department of Epidemiology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.

The rapid advancement in vaccine development represents a critical milestone that will help humanity tackle the COVID-19 pandemic. However, the success of these efforts is not guaranteed, as it relies on the outcomes of national and international vaccination strategies. In this article, we highlight some of the challenges that Romania will face and propose a set of solutions to overcome them. With this in mind, we discuss issues such as the infrastructure of vaccine storage and delivery, the deployment and administration of immunisations, and the public acceptance of vaccines. The ways in which Romanian society will respond to a national COVID-19 vaccination campaign will be contingent on appropriate and timely actions. As many of the problems encountered in Romania are not unique, the proposed recommendations could be adapted and implemented in other countries that face similar issues, thereby informing better practices in the management of the COVID-19 pandemic.
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http://dx.doi.org/10.3389/fpubh.2021.644538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902778PMC
March 2021

Application of the susceptible-infected-recovered deterministic model in a GII.P17 emergent norovirus strain outbreak in Romania in 2015.

Infect Drug Resist 2019 16;12:2543-2551. Epub 2019 Aug 16.

Epidemiology Department, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania.

Purpose: This study shows the epidemiological profile of the first gastroenteritis outbreak of GII.P17 in the Romanian territory. An outbreak with such large amplitude in a European territory was previously undocumented.

Patients And Methods: Using a cross-sectional design, with the susceptible-infected-recovered (SIR) deterministic compartmental model for a fixed population, and the cluster method for establishing the high-incidence zones, we carried out our investigation by means of questionnaires containing personal data, affected collectivities, disease onset and duration, symptoms displayed, medical assistance provided, previous antibiotic intake where applicable, food consumption and water sources, and sanitation conditions. The confirmation of cases was done based on the typical norovirus gastroenteritis symptomatology and using three laboratory confirmations (by molecular diagnosis) for GII.P17-GII.17 genotype noroviruses from three patients.

Results: A gastroenteritis outbreak occurred in October-November 2015, affecting 328 people in Arad, a county in Western Romania, covering 44 neighbouring localities with a total population of 35,440 people. The study detected an inter-human transmission of the infection, with an intrafamilial risk of disease of 2.26 (95% CI 1.76 to 2.90) compared with the community transmission (in school collectivity). The basic reproduction number dropped from 1.26 to 0.18 during weeks 43:44, after controlling the transmission by decontamination and isolation.

Conclusion: SIR made it possible to highlight the expansion of the emerging norovirus strain infection from community to family collectivities. This study provides practical solutions to limit disease cases, even in the absence of etiology, and shows the importance of sometimes underestimated traditional control methods.
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http://dx.doi.org/10.2147/IDR.S204175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701636PMC
August 2019

Molecular identification of emergent GII.P17-GII.17 norovirus genotype, Romania, 2015.

Euro Surveill 2016 ;21(7):pii=30141

Molecular Epidemiology Laboratory, Cantacuzino National Institute of Research, Bucharest, Romania.

The novel GII.P17-GII.17 norovirus genotype has been reported as cause of gastroenteritis outbreaks in China and Japan since the winter season 2014/15, replacing the pandemic strain GII.4 Sydney 2012. These emergent strains have also been sporadically reported on other continents than Asia. GII.P17-GII.17 isolates, similar to Kawasaki308 2015, were identified in three patients during a large outbreak of acute gastroenteritis affecting 328 people in Romania, in neighbouring localities, in 2015.
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http://dx.doi.org/10.2807/1560-7917.ES.2016.21.7.30141DOI Listing
August 2016

Clostridium difficile in western Romania: unfavourable outcome predictors in a hospital for infectious diseases.

BMC Infect Dis 2015 Mar 21;15:141. Epub 2015 Mar 21.

Department 13, Epidemiology Department, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania.

Background: The recent emergence of Clostridium difficile infections has included this condition among top nosocomial infections, due to its incidence, complications and important fatality, as well as to significant economic costs.

Methods: A prospective surveillance study of Clostridium difficile enterocolitis cases was performed in "Victor Babeş" Infectious Diseases Hospital in Timişoara (Romania) between 01.01.2013 - 30.06.2014, to estimate the incidence and to investigate the risk factors for unfavourable outcome and relapse. Dichotomous variables were compared by the chi-square test or Fisher exact test and the Mann-Whitney U test was used for continuous variables. Risk factors for unfavourable outcome/recurrence were investigated by logistic regression.

Results: 210 patients who experienced 219 episodes of infection with Clostridium difficile were identified, which gives an incidence per hospital of 20.57/15.70 to 1,000 discharged patients in 2013/2014 or 17.73/14.04 to 10,000 patient-days. In 162 patients (77.14%) the evolution was favourable while in 48 (22.86%) the outcome was unfavourable. In 42 patients (20.00%) recurrence of symptoms was identified. The multivariate analysis by logistic regression identified the ATLAS score (OR = 4.97, 95% CI = 2.12 to 11.66, p <0.001), age (OR = 1.12, 95% CI = 1.00 to 1.25, p = 0.046), and the number of antibiotics after episode onset (OR = 2.692, 95% CI = 1.01 to 7.17, p = 0.047) as predictors of an unfavourable evolution, while the number of hospitalization days (OR = 1.10, 95% CI = 1.03 to 1.16, p = 0.0015) was associated with recurrence of symptoms.

Conclusions: The high incidence identified in our study is explained by the endemic character of these infections in some hospitals in Timişoara, released in late 2012, and the fact that "Victor Babeş" Hospital is the only one in our area that provides treatment in all suspected or confirmed cases of this condition requiring hospitalization. The study identified the ATLAS score, age, and the number of antibiotics after episode onset as predictors of unfavourable evolution, while the number of days of hospitalization was associated with the recurrence of symptoms.
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http://dx.doi.org/10.1186/s12879-015-0895-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372176PMC
March 2015