Emile R Chimusa

Emile R Chimusa

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Emile R Chimusa

Emile R Chimusa

Publications by authors named "Emile R Chimusa"

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30Publications

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Population Structure and Implications on the Genetic Architecture of HIV-1 Phenotypes Within Southern Africa.

Front Genet 2019 27;10:905. Epub 2019 Sep 27.

Division of Human Genetics, Department of Pathology, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fgene.2019.00905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777512PMC
September 2019

Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects.

BMC Med Genomics 2019 08 14;12(1):120. Epub 2019 Aug 14.

Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Private Bag, Rondebosch, Cape Town, 7700, South Africa.

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http://dx.doi.org/10.1186/s12920-019-0564-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693204PMC
August 2019

Dissecting Mutation Prediction of Variants in African Genomes: Challenges and Perspectives.

Front Genet 2019 25;10:601. Epub 2019 Jun 25.

Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fgene.2019.00601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603221PMC
June 2019

Hydroxyurea-Induced miRNA Expression in Sickle Cell Disease Patients in Africa.

Front Genet 2019 28;10:509. Epub 2019 May 28.

Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fgene.2019.00509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568309PMC
May 2019

Detecting genetic modifiers of spondyloepimetaphyseal dysplasia with joint laxity in the Caucasian Afrikaner community.

Hum Mol Genet 2019 04;28(7):1053-1063

Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
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http://dx.doi.org/10.1093/hmg/ddy373DOI Listing
April 2019

Post genome-wide association analysis: dissecting computational pathway/network-based approaches.

Brief Bioinform 2019 03;20(2):690-700

Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Private Bag, Rondebosch, 7700, Cape Town, South Africa; African Institute for Mathematical Sciences, 7945 Muizenberg, Cape Town, South Africa and Computational Biology Division, Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Anzio Road, Observatory, 7925, Cape Town, South Africa.

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http://dx.doi.org/10.1093/bib/bby035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556901PMC
March 2019

Host and Microbiome Genome-Wide Association Studies: Current State and Challenges.

Front Genet 2018 22;9:637. Epub 2019 Jan 22.

Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fgene.2018.00637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349833PMC
January 2019

Large-scale data-driven integrative framework for extracting essential targets and processes from disease-associated gene data sets.

Brief Bioinform 2018 11;19(6):1141-1152

Department of Integrative Biomedical Sciences and the Head of the Computational Biology Division, UCT.

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http://dx.doi.org/10.1093/bib/bbx052DOI Listing
November 2018

Dating admixture events is unsolved problem in multi-way admixed populations.

Brief Bioinform 2018 Nov 19. Epub 2018 Nov 19.

Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine,Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa.

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/bib/bby112DOI Listing
November 2018

Tantalizing dilemma in risk prediction from disease scoring statistics.

Brief Funct Genomics 2018 07;18(4):211-219

Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.

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http://dx.doi.org/10.1093/bfgp/ely040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609536PMC
July 2018

Clinical and genetic factors are associated with pain and hospitalisation rates in sickle cell anaemia in Cameroon.

Br J Haematol 2018 01 3;180(1):134-146. Epub 2017 Dec 3.

Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa.

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http://dx.doi.org/10.1111/bjh.15011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847561PMC
January 2018

A multi-scenario genome-wide medical population genetics simulation framework.

Bioinformatics 2017 Oct;33(19):2995-3002

Department of Pathology, Division of Human Genetics, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa.

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http://dx.doi.org/10.1093/bioinformatics/btx369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870573PMC
October 2017

Clinical and genetic predictors of renal dysfunctions in sickle cell anaemia in Cameroon.

Br J Haematol 2017 08 3;178(4):629-639. Epub 2017 May 3.

Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1111/bjh.14724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660286PMC
August 2017

A Genomic and Protein-Protein Interaction Analyses of Nonsyndromic Hearing Impairment in Cameroon Using Targeted Genomic Enrichment and Massively Parallel Sequencing.

OMICS 2017 02 11;21(2):90-99. Epub 2017 Jan 11.

1 Division of Human Genetics, Department of Pathology, Faculty of Health Sciences - University of Cape Town , Cap Town, South Africa .

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http://dx.doi.org/10.1089/omi.2016.0171DOI Listing
February 2017

Minimum information required for a DMET experiment reporting.

Pharmacogenomics 2016 09 22;17(14):1533-45. Epub 2016 Aug 22.

Laboratory of Pharmacogenomics, Section of Neuroscience & Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, sp 8 Sestu-Monserrato, Km 0.700, 09042 Cagliari, Italy.

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http://dx.doi.org/10.2217/pgs-2016-0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123892PMC
September 2016

A-DaGO-Fun: an adaptable Gene Ontology semantic similarity-based functional analysis tool.

Bioinformatics 2016 Feb 17;32(3):477-9. Epub 2015 Oct 17.

Computational Biology Group, Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa and.

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http://dx.doi.org/10.1093/bioinformatics/btv590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006308PMC
February 2016

ancGWAS: a post genome-wide association study method for interaction, pathway and ancestry analysis in homogeneous and admixed populations.

Bioinformatics 2016 Feb 27;32(4):549-56. Epub 2015 Oct 27.

Computational Biology Group, Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, 7925, Observatory, South Africa and.

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http://dx.doi.org/10.1093/bioinformatics/btv619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939890PMC
February 2016

A panel of ancestry informative markers for the complex five-way admixed South African coloured population.

PLoS One 2013 20;8(12):e82224. Epub 2013 Dec 20.

Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology and the DST/NRF Centre of Excellence for Biomedical TB Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082224PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869660PMC
March 2015

A genomic portrait of haplotype diversity and signatures of selection in indigenous southern African populations.

PLoS Genet 2015 Mar 26;11(3):e1005052. Epub 2015 Mar 26.

MRC Human Genetics Research Unit, Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1371/journal.pgen.1005052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374865PMC
March 2015

Determining ancestry proportions in complex admixture scenarios in South Africa using a novel proxy ancestry selection method.

PLoS One 2013 16;8(9):e73971. Epub 2013 Sep 16.

Computational Biology Group, Department of Clinical Laboratory Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Cape Town, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073971PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774743PMC
May 2014

Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.

Hum Mol Genet 2014 Feb 20;23(3):796-809. Epub 2013 Sep 20.

Department of Clinical Laboratory Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1093/hmg/ddt462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888262PMC
February 2014