Publications by authors named "Emiel F M Wouters"

100Publications

Effect of Sustained-Release Morphine for Refractory Breathlessness in Chronic Obstructive Pulmonary Disease on Health Status: A Randomized Clinical Trial.

JAMA Intern Med 2020 Oct;180(10):1306-1314

Department of Health Services Research, Care and Public Health Research Institute, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.

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http://dx.doi.org/10.1001/jamainternmed.2020.3134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432282PMC
October 2020

Predictors for long-term mortality in COPD patients requiring non-invasive positive pressure ventilation for the treatment of acute respiratory failure.

Clin Respir J 2020 Aug 11. Epub 2020 Aug 11.

Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1111/crj.13251DOI Listing
August 2020

Skin auto-fluorescence as a measure of advanced glycation end-products is associated with microvascular health in patients with COPD.

Microvasc Res 2020 Nov 5;132:104053. Epub 2020 Aug 5.

Health Unit, Flemish Institute for Technological Research (VITO), Mol, Belgium; Department of Biology, University of Antwerp, Wilrijk, Belgium; Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.

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http://dx.doi.org/10.1016/j.mvr.2020.104053DOI Listing
November 2020

Incorporating Comprehensive Assessment Parameters to Better Characterize and Plan Rehabilitation for Persons with Chronic Obstructive Pulmonary Disease.

J Am Med Dir Assoc 2020 Jul 25. Epub 2020 Jul 25.

CIRO+, Department of Research & Development, Horn, the Netherlands; NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, the Netherlands; Ludwig Boltzman Institute for Lung Health, Vienna, Austria.

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http://dx.doi.org/10.1016/j.jamda.2020.05.026DOI Listing
July 2020

Skin autofluorescence: early sign of lung function deterioration?

ERJ Open Res 2020 Apr 20;6(2). Epub 2020 Jul 20.

Dept of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1183/23120541.00368-2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369460PMC
April 2020

Phenotypic Characteristics of Patients With Chronic Obstructive Pulmonary Disease After Stratification for the Short Physical Performance Battery Summary Score.

Arch Phys Med Rehabil 2020 Jun 1. Epub 2020 Jun 1.

Department of Research and Development, CIRO, Horn, the Netherlands; Reval Rehabilitation Research, Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium; Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.apmr.2020.05.011DOI Listing
June 2020

Clustering of patients with end-stage chronic diseases by symptoms: a new approach to identify health needs.

Aging Clin Exp Res 2020 Apr 11. Epub 2020 Apr 11.

Department of Research and Education, CIRO Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands.

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http://dx.doi.org/10.1007/s40520-020-01549-5DOI Listing
April 2020

The Transient Receptor Potential Channel Vanilloid 1 Is Critical in Innate Airway Epithelial Responses to Protease Allergens.

Am J Respir Cell Mol Biol 2020 08;63(2):198-208

Department of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, Vermont; and.

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http://dx.doi.org/10.1165/rcmb.2019-0170OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397771PMC
August 2020

Blood eosinophil count in the general population: typical values and potential confounders.

Eur Respir J 2020 May 14;55(5). Epub 2020 May 14.

Second Dept of Respiratory and Critical Care Medicine and Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Otto Wagner Hospital, Vienna, Austria.

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http://dx.doi.org/10.1183/13993003.01874-2019DOI Listing
May 2020

Impact of mild-to-moderate exacerbations on outcomes of neuromuscular electrical stimulation (NMES) in patients with COPD.

Respir Med 2020 01 28;161:105851. Epub 2019 Nov 28.

Department of Research and Development, CIRO, Horn, the Netherlands; Department of Respiratory Medicine, Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, the Netherlands; Reval Rehabilitation Research, Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium.

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http://dx.doi.org/10.1016/j.rmed.2019.105851DOI Listing
January 2020

Loss of Alveolar Attachments as a Pathomechanistic Link between Small Airway Disease and Emphysema.

Am J Respir Crit Care Med 2020 04;201(7):878-879

Maastricht University Medical Center+Maastricht, the Netherlands.

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http://dx.doi.org/10.1164/rccm.201910-1981LEDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124717PMC
April 2020

C-reactive protein as a biomarker of response to inhaled corticosteroids among patients with COPD.

Pulm Pharmacol Ther 2020 02 27;60:101870. Epub 2019 Nov 27.

Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre, Maastricht, the Netherlands; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, the Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.pupt.2019.101870DOI Listing
February 2020

Attitudes of patients with chronic breathlessness towards treatment with opioids.

Eur Respir J 2020 02 20;55(2). Epub 2020 Feb 20.

Dept of Health Services Research, CAPHRI School for Public Health and Primary Care, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1183/13993003.01752-2019DOI Listing
February 2020

Cell Type- and Exposure-Specific Modulation of CD63/CD81-Positive and Tissue Factor-Positive Extracellular Vesicle Release in response to Respiratory Toxicants.

Oxid Med Cell Longev 2019 14;2019:5204218. Epub 2019 Aug 14.

Department of Medical Microbiology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, PO box 5800, 6202AZ Maastricht, Netherlands.

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http://dx.doi.org/10.1155/2019/5204218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710792PMC
January 2020

The Medusa faces of dyspnoea in COPD.

Eur Respir J 2019 Apr 18;53(4). Epub 2019 Apr 18.

Dept Respiratory Diseases, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands. CIRO+, Center of Expertise for Organ Failure, Horn, The Netherlands

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00487
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http://dx.doi.org/10.1183/13993003.00487-2019DOI Listing
April 2019

Risk stratification for short-term mortality at hospital admission for acute exacerbations of COPD.

Respirology 2019 08 21;24(8):765-776. Epub 2019 Mar 21.

Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1111/resp.13538DOI Listing
August 2019

Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles.

J Extracell Vesicles 2019 5;8(1):1585163. Epub 2019 Mar 5.

Department of Medical Microbiology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1080/20013078.2019.1585163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407597PMC
March 2019

Organizational aspects of pulmonary rehabilitation in chronic respiratory diseases.

Respirology 2019 09 27;24(9):838-843. Epub 2019 Feb 27.

Department of Research and Education, CIRO, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands.

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http://dx.doi.org/10.1111/resp.13512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849848PMC
September 2019

Emphysema: looking beyond alpha-1 antitrypsin deficiency.

Expert Rev Respir Med 2019 04 22;13(4):381-397. Epub 2019 Feb 22.

b Department of Respiratory Medicine , Maastricht University Medical Center , Maastricht , The Netherlands.

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http://dx.doi.org/10.1080/17476348.2019.1580575DOI Listing
April 2019

Contribution of individual COPD assessment test (CAT) items to CAT total score and effects of pulmonary rehabilitation on CAT scores.

Health Qual Life Outcomes 2018 Oct 30;16(1):205. Epub 2018 Oct 30.

Department of Research and Education, CIRO, Hornerheide 1, Horn, 6085, NM, The Netherlands.

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http://dx.doi.org/10.1186/s12955-018-1034-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208036PMC
October 2018

Trends in moderate and severe exacerbations among COPD patients in the UK from 2005 to 2013.

Respir Med 2018 11 17;144:1-6. Epub 2018 Sep 17.

CIRO+, Centre for Specialised Treatments Chronic Respiratory Diseases, Horn, the Netherlands; Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S09546111183029
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http://dx.doi.org/10.1016/j.rmed.2018.09.010DOI Listing
November 2018

Chronic Obstructive Pulmonary Disease: Shifting the Paradigm to the Vasculature.

Am J Respir Crit Care Med 2019 02;199(3):258-259

1 Department of Respiratory Diseases Maastricht University Medical Center Maastricht, the Netherlands and.

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https://www.atsjournals.org/doi/10.1164/rccm.201808-1542ED
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http://dx.doi.org/10.1164/rccm.201808-1542EDDOI Listing
February 2019

Blood eosinophilia, use of inhaled corticosteroids, and risk of COPD exacerbations and mortality.

Pharmacoepidemiol Drug Saf 2018 11 28;27(11):1191-1199. Epub 2018 Sep 28.

Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre, Maastricht, the Netherlands.

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http://dx.doi.org/10.1002/pds.4655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282838PMC
November 2018

Copper as the most likely pathogenic divergence factor between lung fibrosis and emphysema.

Med Hypotheses 2018 Nov 14;120:49-54. Epub 2018 Aug 14.

Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.mehy.2018.08.003DOI Listing
November 2018

Peripheral endothelial function is positively associated with maximal aerobic capacity in patients with chronic obstructive pulmonary disease.

Respir Med 2018 09 21;142:41-47. Epub 2018 Jul 21.

Environmental Risk and Health Unit, Flemish Institute for Technological Research (VITO), Mol, Belgium; Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.

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http://dx.doi.org/10.1016/j.rmed.2018.07.013DOI Listing
September 2018

Adverse respiratory effects of opioids for chronic breathlessness: to what extent can we learn lessons from chronic pain?

Eur Respir J 2018 07 19;52(1). Epub 2018 Jul 19.

Centre of Expertise for Palliative Care, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands.

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http://dx.doi.org/10.1183/13993003.00882-2018DOI Listing
July 2018

COPD patient education and support - Achieving patient-centredness.

Patient Educ Couns 2018 11 1;101(11):2031-2036. Epub 2018 Jun 1.

Bournemouth University, Bournemouth, UK; BHR Limited, UK.

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http://dx.doi.org/10.1016/j.pec.2018.05.024DOI Listing
November 2018

Looking into the eye of patients with chronic obstructive pulmonary disease: an opportunity for better microvascular profiling of these complex patients.

Acta Ophthalmol 2018 Sep 16;96(6):539-549. Epub 2018 May 16.

Environmental Risk and Health Unit, Flemish Institute for Technological Research (VITO), Mol, Belgium.

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http://doi.wiley.com/10.1111/aos.13765
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http://dx.doi.org/10.1111/aos.13765DOI Listing
September 2018

Determinants of functional, peak and endurance exercise capacity in people with chronic obstructive pulmonary disease.

Respir Med 2018 05 29;138:81-87. Epub 2018 Mar 29.

Department of Research and Education, CIRO, Horn, The Netherlands; Department of Respiratory Medicine, Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2018.03.032DOI Listing
May 2018

Extracellular vesicles released in response to respiratory exposures: implications for chronic disease.

J Toxicol Environ Health B Crit Rev 2018 1;21(3):142-160. Epub 2018 May 1.

a Department of Medical Microbiology , NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center , Maastricht , The Netherlands.

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http://dx.doi.org/10.1080/10937404.2018.1466380DOI Listing
August 2019

Crystalline silica alters Sulfatase-1 expression in rat lungs which influences hyper-proliferative and fibrogenic effects in human lung epithelial cells.

Toxicol Appl Pharmacol 2018 06 17;348:43-53. Epub 2018 Apr 17.

Department of Respiratory Medicine, Maastricht University, Medical Centre, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2018.04.011DOI Listing
June 2018

Left ventricular volume and wall stress are linked to lung function impairment in COPD.

Int J Cardiol 2018 06;261:172-178

Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg, Member of the German Centre for Lung Research (DZL), Marburg, Germany.

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http://dx.doi.org/10.1016/j.ijcard.2018.02.074DOI Listing
June 2018

Redox-dependent thiol modifications: implications for the release of extracellular vesicles.

Cell Mol Life Sci 2018 Jul 28;75(13):2321-2337. Epub 2018 Mar 28.

Department of Medical Microbiology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.

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http://dx.doi.org/10.1007/s00018-018-2806-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986851PMC
July 2018

Personalised pulmonary rehabilitation in COPD.

Eur Respir Rev 2018 Mar 28;27(147). Epub 2018 Mar 28.

Maastricht University Medical Center, Dept of Respiratory Diseases, Maastricht, The Netherlands.

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http://dx.doi.org/10.1183/16000617.0125-2017DOI Listing
March 2018

Increased Small Intestinal Permeability during Severe Acute Exacerbations of COPD.

Respiration 2018;95(5):334-342. Epub 2018 Jan 25.

Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, the Netherlands.

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http://dx.doi.org/10.1159/000485935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985742PMC
October 2018

Spatiotemporal gait characteristics in patients with COPD during the Gait Real-time Analysis Interactive Lab-based 6-minute walk test.

PLoS One 2017 28;12(12):e0190099. Epub 2017 Dec 28.

Department of Human Movement Science, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190099PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746246PMC
February 2018

Oxygen saturation measurements in telemonitoring of patients with COPD: a systematic review.

Expert Rev Respir Med 2018 02 20;12(2):113-123. Epub 2017 Dec 20.

a Environmental Risk and Health unit , Flemish Institute for Technological Research (VITO) , Mol , Belgium.

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http://dx.doi.org/10.1080/17476348.2018.1417842DOI Listing
February 2018

Redefining Cut-Points for High Symptom Burden of the Global Initiative for Chronic Obstructive Lung Disease Classification in 18,577 Patients With Chronic Obstructive Pulmonary Disease.

J Am Med Dir Assoc 2017 Dec;18(12):1097.e11-1097.e24

Department of Research and Education, CIRO, Horn, The Netherlands; REVAL, Rehabilitation Research Center, BIOMED, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium; Department of Respiratory Medicine, Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jamda.2017.09.003DOI Listing
December 2017

Respiratory adverse effects of opioids for breathlessness: a systematic review and meta-analysis.

Eur Respir J 2017 11 22;50(5). Epub 2017 Nov 22.

Centre of Expertise for Palliative Care, Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands.

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http://dx.doi.org/10.1183/13993003.01153-2017DOI Listing
November 2017

Obesity and Metabolic Abnormalities in Chronic Obstructive Pulmonary Disease.

Ann Am Thorac Soc 2017 Nov;14(Supplement_5):S389-S394

Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, the Netherlands.

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http://dx.doi.org/10.1513/AnnalsATS.201705-371AWDOI Listing
November 2017

Vitamin K deficiency: the linking pin between COPD and cardiovascular diseases?

Respir Res 2017 11 13;18(1):189. Epub 2017 Nov 13.

Department of Pulmonary Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s12931-017-0673-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683584PMC
November 2017

Endothelial function in patients with chronic obstructive pulmonary disease: a systematic review of studies using flow mediated dilatation.

Expert Rev Respir Med 2017 12 12;11(12):1021-1031. Epub 2017 Oct 12.

b Environmental Risk and Health Unit , Flemish Institute for Technological Research (VITO) , Mol , Belgium.

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http://dx.doi.org/10.1080/17476348.2017.1389277DOI Listing
December 2017

Airflow Obstruction and Use of Solid Fuels for Cooking or Heating: BOLD Results.

Am J Respir Crit Care Med 2018 03 12;197(5):595-610. Epub 2017 Sep 12.

Imperial College, Respiratory Epidemiology and Public Health, London, United Kingdom of Great Britain and Northern Ireland ;

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http://dx.doi.org/10.1164/rccm.201701-0205OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005234PMC
March 2018

Increased exercise tolerance using daytime mouthpiece ventilation for patients with diaphragm paralysis.

Breathe (Sheff) 2017 Sep;13(3):225-229

Dept of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands.

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http://dx.doi.org/10.1183/20734735.005817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584713PMC
September 2017

A randomized clinical trial investigating the efficacy of targeted nutrition as adjunct to exercise training in COPD.

J Cachexia Sarcopenia Muscle 2017 Oct 12;8(5):748-758. Epub 2017 Jun 12.

Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/jcsm.12219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659064PMC
October 2017

Cognitive impairment and clinical characteristics in patients with chronic obstructive pulmonary disease.

Chron Respir Dis 2018 05 29;15(2):91-102. Epub 2017 May 29.

1 Department of Research and Education, CIRO, Centre of expertise for chronic organ failure, Horn, the Netherlands.

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http://dx.doi.org/10.1177/1479972317709651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958463PMC
May 2018

Response.

Chest 2017 05;151(5):1182-1183

Department of Research and Education, CIRO, Horn, the Netherlands; Department of Respiratory Medicine and the Centre of Expertise for Palliative Care, Maastricht UMC+, Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.chest.2017.01.014DOI Listing
May 2017

Fatigue in COPD: an important yet ignored symptom.

Lancet Respir Med 2017 07 21;5(7):542-544. Epub 2017 Apr 21.

Department of Research and Education, CIRO+, Center of Expertise for Chronic Organ Failure, 6085 NM Horn, Netherlands; Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S22132600173015
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http://dx.doi.org/10.1016/S2213-2600(17)30158-3DOI Listing
July 2017

Changes in physical activity and sedentary behaviour following pulmonary rehabilitation in patients with COPD.

Respir Med 2017 05 31;126:122-129. Epub 2017 Mar 31.

Department of Research & Education, CIRO, Center of Expertise for Chronic Organ Failure, Horn, The Netherlands; Department of Respiratory Medicine, Maastricht University Medical Center+ (MUMC+), NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.rmed.2017.03.029DOI Listing
May 2017

Reliability, construct validity and determinants of 6-minute walk test performance in patients with chronic heart failure.

Int J Cardiol 2017 Aug 28;240:285-290. Epub 2017 Feb 28.

Department of Research & Education, CIRO, Center of Expertise for Chronic Organ Failure, Horn, The Netherlands.

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http://dx.doi.org/10.1016/j.ijcard.2017.02.109DOI Listing
August 2017

Lower-limb muscle function is a determinant of exercise tolerance after lung resection surgery in patients with lung cancer.

Respirology 2017 08 30;22(6):1185-1189. Epub 2017 Mar 30.

Faculty of Medicine and Life Sciences, Rehabilitation Research Centre, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.

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http://dx.doi.org/10.1111/resp.13041DOI Listing
August 2017

Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol-antioxidants.

Free Radic Biol Med 2017 07 28;108:334-344. Epub 2017 Mar 28.

Department of Medical Microbiology, Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.03.026DOI Listing
July 2017