Publications by authors named "Emanuele Fabrizi"

3 Publications

  • Page 1 of 1

Efficacy and Safety of a Combined Aerobic, Strength and Flexibility Exercise Training Program in Patients with Implantable Cardiac Devices.

J Cardiovasc Dev Dis 2022 Jun 6;9(6). Epub 2022 Jun 6.

Institute of Sports Medicine, Sport e Salute, 00197 Rome, Italy.

: The "FIDE Project" (Fitness Implantable DEvice) was organized by the Institute of Sports Medicine and Science and the World Society of Arrhythmias with the aim of demonstrating the usefulness of exercise training in improving functional capacity in patients with implantable cardiac devices. : Thirty sedentary patients were selected for the project (25 males and 5 females), with a mean age of 73 ± 5 years (range 44-94 years). Twenty-five were implanted with a Pacemaker (PM) and five with an Implantable Cardioverter Defibrillator (ICD). Atrial fibrillation/atrial flutter was present in ten (34%) patients, post-ischemic dilated cardiomyopathy in five (17.2%), sick sinus syndrome in six (20,7%), complete atrium-ventricular block in six (20.7%), hypertrophic cardiomyopathy in one (3.4%) and recurrent syncope in one (3.4%). The baseline assessment comprised cardiovascular examination, resting and stress ECG, cardiopulmonary exercise testing (V ̇O2peak), strength assessment of different muscle groups, and a flexibility test. The same measurements were repeated after 15-20 consecutive training sessions, over a 2-month period. The exercise prescription was set to 70-80% of HRR (Heart rate reserve) and to 50-70% of 1RM (1-repetition maximum, muscular force). The training protocol consisted of two training sessions per week performed in our institute, 90 min for each (warm-up, aerobic phase, strength phase and stretching) and one or more at home autonomously. : The cardiopulmonary testing after the training period documents a significant improvement in V ̇O2peak (15 ± 4 mL/kg/min vs. 17 ± 4; = 0.001) and in work load (87 ± 30 watts vs. 108 ± 37; = 0.001). Additionally, strength capacity significantly increased after the cardiac rehabilitation program, (quadriceps: 21 ± 18 kg vs. 29 ± 16 kg, = 0.00003). Flexibility tests show a positive trend, but without statistical significance (sit-and-reach test: -19 ± 11 cm vs. -15 ± 11.7 cm; back-scratch test: -19 ± 11.6 cm vs. -15 ± 10 cm; lateral flexibility right -44 ± 1.4 cm vs. -43 ± 9.5 cm; left -43 ± 5 vs. -45 ± 8.7 cm). : A brief period of combined aerobic, strength and flexibility exercise training (FIDE project) proved to be effective and safe in improving functional capacity in patients with cardiac implantable devices.
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June 2022

Hepatic and extra-hepatic sequelae, and prevalence of viral hepatitis C infection estimated from routine data in at-risk groups.

BMC Infect Dis 2010 Apr 19;10:97. Epub 2010 Apr 19.

Department of Epidemiology, Regional Health System - Lazio Region, Via S, Costanza 53, 00198, Rome, Italy.

Background: Concerns about the hepatitis C virus (HCV) are due to the high risk of chronic liver disease and poor treatment efficacy. Synthesizing evidence from multiple data sources is becoming widely used to estimate HCV-infection prevalence. This paper aims to estimate the prevalence of HCV infection, and the hepatic and extrahepatic sequelae in at-risk groups, using routinely collected data in the Lazio region, Italy.

Methods: HCV laboratory surveillance and dialysis, hospital discharge, and drug-user registers were used as information sources to identify at-risk groups and to estimate HCV prevalence and sequelae.Full name and birth date were used as linkage keys for the various health registries. Prevalence was estimated as the percentage of cases within the general population and the at-risk groups, with 95% confidence intervals (95% CI) from 1997 to 2001. The risk of sequelae was estimated through a follow-up of hospital discharges up to December 31, 2004 and calculated as the prevalence ratio in HCV-positive and HCV-negative people, within each at-risk group, with 95% CI.

Results: There were 65,127 HCV-infected people in the study period; the prevalence was 1.24% (95%CI = 1.23%-1.25%) in the whole population, higher in males and older adults. Drug users (35.1%; 95%CI = 34.6-35.7) and dialysis patients (21.1%; 95%CI = 20.2%-22.0%) showed the highest values. Medical procedures with little exposure to blood resulted in higher estimates, ranging between 1.3% and 3.4%, which was not conclusively attributable to the surgical procedures. Cirrhosis, hepatocellular carcinoma and encephalopathy were the most frequent hepatic sequelae; cryoglobulinaemia and non-Hodgkin's lymphoma were the most frequent extrahepatic sequelae.

Conclusions: Synthesising data from multiple routine sources improved estimates of HCV prevalence and sequelae in dialysis patients and drug users, although prevalence validity should be assessed in survey and sequelae need a well-defined longitudinal approach.
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April 2010

[Fatality rates of bacterial meningitis from current health databases suggest a different case definition. Results of a follow-up study of bacterial meningitis in Lazio Region, Italy, 1996-2000].

Epidemiol Prev 2005 May-Aug;29(3-4):188-94

Osservatorio epidemiologico ASL RME, presso il Ministero affari esteri, Roma.

Objectives: To describe mortality and case fatality rate due to bacterial meningitis in the Lazio Region from 1996 to 2000, and to compare these estimates with those from Cause-of-death Registry (CDR) and Hospital Discharge Registry (HDR).

Methods: A follow-up study of mortality was conducted through Registry Offices for bacterial meningitis cases reported to surveillance in 1996-2000 among residents in the Lazio Region. Death due to bacterial meningitis was defined as a patient who died during a hospitalization for meningitis or who died within 30 days after hospitalization and whose underlying cause of death was bacterial meningitis (ICD-9: 036.0, 036.1, 036.2,320.0, 320.1, 320.2, 320.3, 320.7, 320.8, 320.9, 027.0). Case fatality rates estimated from follow-up study were compared with estimates from CDR and HDR of the same period.

Results: 525 bacterial meningitis cases were reported among residents in the whole period; 98 deaths were detected with a case fatality rate (CFR) of 18.7% (CI 95% 15.4-22.5); estimates were higher in patients 64+ year old (44.6%; CI 95% 33.7-55.9) and in meningitis due to Streptococcus pneumoniae (27.5%; CI 95% 20.3-35.6) or Listeria (32.0%; CI 95% 14.9-53.5). The CFR was 10.1% according to the CDR and 10.9% according to the HDR.

Conclusions: CFRs differ according to the database used. Differences may be partially due to a selective lower sensitivity in reporting deceased cases, but the most important factor seems to be the case definition used in follow-up study and other sources of data.
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March 2006