Publications by authors named "Emanuela Tolosano"

66Publications

Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases.

Cell Rep 2020 Sep;32(12):108181

Department of Surgery, Division of Surgical Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214, USA; Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.108181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551404PMC
September 2020

Liver Sinusoidal Endothelial Cells at the Crossroad of Iron Overload and Liver Fibrosis.

Antioxid Redox Signal 2020 Aug 27. Epub 2020 Aug 27.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1089/ars.2020.8168DOI Listing
August 2020

Hereditary Ataxia: A Focus on Heme Metabolism and Fe-S Cluster Biogenesis.

Int J Mol Sci 2020 May 26;21(11). Epub 2020 May 26.

Molecular Biotechnology Center (MBC), Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy.

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http://dx.doi.org/10.3390/ijms21113760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312568PMC
May 2020

Expression and purification of the heme exporter FLVCR1a.

Protein Expr Purif 2020 08 8;172:105637. Epub 2020 Apr 8.

Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Via Ferrata 9, 27100, Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.pep.2020.105637DOI Listing
August 2020

Evolving Cell-Based and Cell-Free Clinical Strategies for Treating Severe Human Liver Diseases.

Cells 2020 02 7;9(2). Epub 2020 Feb 7.

Institute of Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Center, Via Nizza 52, 10126 Turin, Italy.

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http://dx.doi.org/10.3390/cells9020386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072646PMC
February 2020

The Multifaceted Role of Heme in Cancer.

Front Oncol 2019 15;9:1540. Epub 2020 Jan 15.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Turin, Italy.

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http://dx.doi.org/10.3389/fonc.2019.01540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974621PMC
January 2020

Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells.

Int J Mol Sci 2020 Jan 16;21(2). Epub 2020 Jan 16.

Institute of Biostructure and Bioimaging, CNR c/o Molecular Biotechnology Centre, 10126 Turin, Italy.

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http://dx.doi.org/10.3390/ijms21020575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014300PMC
January 2020

Purinergic Calcium Signals in Tumor-Derived Endothelium.

Cancers (Basel) 2019 Jun 1;11(6). Epub 2019 Jun 1.

Department of Life Sciences and Systems Biology, University of Torino, via Accademia Albertina 13, 10123 Torino, Italy.

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http://dx.doi.org/10.3390/cancers11060766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627696PMC
June 2019

Investigating the Connection Between Endogenous Heme Accumulation and COX2 Activity in Cancer Cells.

Front Oncol 2019 19;9:162. Epub 2019 Mar 19.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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https://www.frontiersin.org/article/10.3389/fonc.2019.00162/
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http://dx.doi.org/10.3389/fonc.2019.00162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433962PMC
March 2019

Temporal and age-dependent effects of haptoglobin deletion on intracerebral hemorrhage-induced brain damage and neurobehavioral outcomes.

Exp Neurol 2019 07 19;317:22-33. Epub 2019 Feb 19.

Department of Anesthesiology, University of Florida, Gainesville, FL, United States of America; Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, FL, United States of America; Departments of Neurology, Psychiatry, and Pharmaceutics, University of Florida, Gainesville, FL, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2019.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936604PMC
July 2019

Unraveling the Role of Heme in Neurodegeneration.

Front Neurosci 2018 9;12:712. Epub 2018 Oct 9.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy.

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https://www.frontiersin.org/article/10.3389/fnins.2018.00712
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http://dx.doi.org/10.3389/fnins.2018.00712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189481PMC
October 2018

Characterization of Human Mesenchymal Stem Cells Isolated from the Testis.

Stem Cells Int 2018 3;2018:4910304. Epub 2018 Sep 3.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Via Nizza 52, 10126 Turin, Italy.

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https://www.hindawi.com/journals/sci/2018/4910304/
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http://dx.doi.org/10.1155/2018/4910304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140008PMC
September 2018

Mitochondrial Targeting in Neurodegeneration: A Heme Perspective.

Pharmaceuticals (Basel) 2018 Sep 18;11(3). Epub 2018 Sep 18.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy.

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http://dx.doi.org/10.3390/ph11030087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161291PMC
September 2018

Targeting Metabolism to Counteract Tumor Angiogenesis: A Review of Patent Literature.

Recent Pat Anticancer Drug Discov 2018 ;13(4):422-427

Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy. Address: via Accademia Albertina 13, Torino, Italy.

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http://dx.doi.org/10.2174/1574892813666180528105023DOI Listing
December 2018

Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis.

Cell Death Differ 2018 03 11;25(3):573-588. Epub 2017 Dec 11.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1038/s41418-017-0001-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864215PMC
March 2018

Posterior column ataxia with retinitis pigmentosa coexisting with sensory-autonomic neuropathy and leukemia due to the homozygous p.Pro221Ser FLVCR1 mutation.

Am J Med Genet B Neuropsychiatr Genet 2017 Oct 2;174(7):732-739. Epub 2017 Aug 2.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1002/ajmg.b.32570DOI Listing
October 2017

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.

Free Radic Biol Med 2017 07 8;108:452-464. Epub 2017 Apr 8.

Dept. Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.04.003DOI Listing
July 2017

IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections.

Sci Immunol 2017 Feb 3;2(8). Epub 2017 Feb 3.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1126/sciimmunol.aai8371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345941PMC
February 2017

Age-Dependent Effects of Haptoglobin Deletion in Neurobehavioral and Anatomical Outcomes Following Traumatic Brain Injury.

Front Mol Biosci 2016 19;3:34. Epub 2016 Jul 19.

Department of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of MedicineGainesville, FL, USA; Departments of Anesthesiology, Neurology, Psychiatry, Psychology, Pharmaceutics and Neuroscience, University of Florida College of MedicineGainesville, FL, USA.

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http://dx.doi.org/10.3389/fmolb.2016.00034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949397PMC
August 2016

Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage.

J Neuroinflammation 2016 Feb 1;13:26. Epub 2016 Feb 1.

Department of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, P.O. Box 100159, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1186/s12974-016-0490-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736638PMC
February 2016

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.

Blood 2016 Jan 16;127(4):473-86. Epub 2015 Dec 16.

Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany; Molecular Medicine Partnership Unit, Heidelberg University & European Molecular Biology Laboratory, Heidelberg, Germany;

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http://dx.doi.org/10.1182/blood-2015-08-663245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850229PMC
January 2016

Long Term Liver Engraftment of Functional Hepatocytes Obtained from Germline Cell-Derived Pluripotent Stem Cells.

PLoS One 2015 31;10(8):e0136762. Epub 2015 Aug 31.

Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136762PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556379PMC
June 2016

Crucial Role of FLVCR1a in the Maintenance of Intestinal Heme Homeostasis.

Antioxid Redox Signal 2015 Dec 20;23(18):1410-23. Epub 2015 Jul 20.

1 Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , Torino, Italy .

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http://dx.doi.org/10.1089/ars.2014.6216DOI Listing
December 2015

Increasing serum transferrin to reduce tissue iron overload due to ineffective erythropoiesis.

Haematologica 2015 May;100(5):565-6

Department of Molecular Biotechnology and Health Sciences, University of Torino, Italy

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http://dx.doi.org/10.3324/haematol.2015.124966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420202PMC
May 2015

Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development.

Front Physiol 2014 28;5:415. Epub 2014 Oct 28.

Division of Hematology, Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration Bethesda, MD, USA.

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http://dx.doi.org/10.3389/fphys.2014.00415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211382PMC
November 2014

Heme and erythropoieis: more than a structural role.

Haematologica 2014 Jun;99(6):973-83

Department of Molecular Biotechnology and Health Sciences and Molecular Biotechnology Center, University of Torino, Italy

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http://dx.doi.org/10.3324/haematol.2013.091991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040894PMC
June 2014

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes.

Front Pharmacol 2014 8;5:61. Epub 2014 Apr 8.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin Turin, Italy.

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http://dx.doi.org/10.3389/fphar.2014.00061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986552PMC
June 2014

Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1.

Biochim Biophys Acta 2014 24;1839(4):259-64. Epub 2014 Feb 24.

Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy; Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2014.02.010DOI Listing
June 2014

Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450.

Gastroenterology 2014 May 31;146(5):1325-38. Epub 2014 Jan 31.

Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.01.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000440PMC
May 2014

Acute-phase protein hemopexin is a negative regulator of Th17 response and experimental autoimmune encephalomyelitis development.

J Immunol 2013 Dec 23;191(11):5451-9. Epub 2013 Oct 23.

Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy;

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http://dx.doi.org/10.4049/jimmunol.1203076DOI Listing
December 2013

Renal cells from spermatogonial germline stem cells protect against kidney injury.

J Am Soc Nephrol 2014 Feb 17;25(2):316-28. Epub 2013 Oct 17.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, and.

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http://dx.doi.org/10.1681/ASN.2013040367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904562PMC
February 2014

Lack of Plasma Protein Hemopexin Results in Increased Duodenal Iron Uptake.

PLoS One 2013 27;8(6):e68146. Epub 2013 Jun 27.

Molecular Biotechnology Center, University of Torino, Torino, Italy ; Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068146PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694894PMC
October 2017

Therapeutic approaches to limit hemolysis-driven endothelial dysfunction: scavenging free heme to preserve vasculature homeostasis.

Oxid Med Cell Longev 2013 27;2013:396527. Epub 2013 May 27.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1155/2013/396527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678425PMC
August 2014

Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases.

Circulation 2013 Mar 27;127(12):1317-29. Epub 2013 Feb 27.

Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.130179DOI Listing
March 2013

Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.

Blood Cells Mol Dis 2013 Jan 24;50(1):25-30. Epub 2012 Aug 24.

Dept. of Genetics, Biology and Biochemistry, University of Torino, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2012.08.002DOI Listing
January 2013

Assessment of iron absorption in mice by ICP-MS measurements of (57)Fe levels.

Eur J Nutr 2012 Oct 19;51(7):783-9. Epub 2011 Oct 19.

Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Via Nizza 52, 10126, Turin, Italy.

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http://link.springer.com/content/pdf/10.1007/s00394-011-0256
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http://link.springer.com/10.1007/s00394-011-0256-6
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http://dx.doi.org/10.1007/s00394-011-0256-6DOI Listing
October 2012

Diamond Blackfan Anemia at the Crossroad between Ribosome Biogenesis and Heme Metabolism.

Adv Hematol 2010 5;2010:790632. Epub 2010 May 5.

Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1155/2010/790632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864449PMC
July 2011

Generation of functional hepatocytes from mouse germ line cell-derived pluripotent stem cells in vitro.

Stem Cells Dev 2010 Aug;19(8):1183-94

Department of Genetics, Biology and Biochemistry and Molecular Biotechnology Center, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1089/scd.2009.0496DOI Listing
August 2010

Heme scavenging and the other facets of hemopexin.

Antioxid Redox Signal 2010 Feb;12(2):305-20

Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1089/ars.2009.2787DOI Listing
February 2010

Heme-hemopexin complex attenuates neuronal cell death and stroke damage.

J Cereb Blood Flow Metab 2009 May 11;29(5):953-64. Epub 2009 Mar 11.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/jcbfm.2009.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015738PMC
May 2009

Lack of plasma protein hemopexin dampens mercury-induced autoimmune response in mice.

J Immunol 2008 Aug;181(3):1937-47

Department of Genetics, Biology and Biochemistry, and Molecular Biotechnology Center, University of Turin, Turin, Italy.

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http://dx.doi.org/10.4049/jimmunol.181.3.1937DOI Listing
August 2008

Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload.

Am J Pathol 2008 Jul 13;173(1):289-99. Epub 2008 Jun 13.

Molecular Biotechnology Center, Via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.2353/ajpath.2008.071130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438305PMC
July 2008

Lack of haptoglobin affects iron transport across duodenum by modulating ferroportin expression.

Gastroenterology 2007 Oct;133(4):1261-1271

Department of Genetics, Biology and Biochemistry, and Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1053/j.gastro.2007.07.004DOI Listing
October 2007

Hemoglobin and heme scavenging.

IUBMB Life 2005 Nov;57(11):749-59

National Institute for Infectious Diseases IRCCS 'Lazzaro Spallanzani', Roma, Italy.

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http://dx.doi.org/10.1080/15216540500380871DOI Listing
November 2005

Plasma protein haptoglobin modulates renal iron loading.

Am J Pathol 2005 Apr;166(4):973-83

Department of Genetics, Biology and Biochemistry, University of Turin, Via Santena 5bis, 10126 Turin, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602399PMC
http://dx.doi.org/10.1016/S0002-9440(10)62319-XDOI Listing
April 2005

Haptoglobin modifies the hemochromatosis phenotype in mice.

Blood 2005 Apr 21;105(8):3353-5. Epub 2004 Dec 21.

Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy. emanuela.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2004-07-28
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http://dx.doi.org/10.1182/blood-2004-07-2814DOI Listing
April 2005

Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis.

Blood 2002 Dec 25;100(12):4201-8. Epub 2002 Jul 25.

Department of Genetics, Biology and Biochemistry, University of Turin and the San Giovanni Battista Hospital, Turin, Italy.

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http://dx.doi.org/10.1182/blood-2002-04-1270DOI Listing
December 2002

Hemopexin: structure, function, and regulation.

DNA Cell Biol 2002 Apr;21(4):297-306

Department of Genetics, Biology and Biochemistry, University of Turin, 10126 Turin, Italy.

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http://dx.doi.org/10.1089/104454902753759717DOI Listing
April 2002