Publications by authors named "Emanuela Marcenaro"

76Publications

Female Malignancies and Immunotherapy: What's New?

Cancers (Basel) 2020 Oct 10;12(10). Epub 2020 Oct 10.

Department of Experimental Medicine (DI.ME.S.) and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, 16132 Genoa, Italy.

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http://dx.doi.org/10.3390/cancers12102909DOI Listing
October 2020

Natural killer cell impairment in ovarian clear cell carcinoma.

J Leukoc Biol 2020 Aug 13. Epub 2020 Aug 13.

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1002/JLB.5MA0720-295RDOI Listing
August 2020

Comprehensive Phenotyping of Human PB NK Cells by Flow Cytometry.

Cytometry A 2020 Sep 21;97(9):891-899. Epub 2020 Mar 21.

Department of Experimental Medicine, University of Genoa, Genoa, Italy.

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http://dx.doi.org/10.1002/cyto.a.24001DOI Listing
September 2020

Harnessing NK Cells for Cancer Treatment.

Front Immunol 2019 6;10:2836. Epub 2019 Dec 6.

Department of Experimental Medicine, University of Genoa, Genova, Italy.

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http://dx.doi.org/10.3389/fimmu.2019.02836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908847PMC
December 2019

Downregulation of HLA Class I Renders Inflammatory Neutrophils More Susceptible to NK Cell-Induced Apoptosis.

Front Immunol 2019 15;10:2444. Epub 2019 Oct 15.

TIMM Laboratory, Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.3389/fimmu.2019.02444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803460PMC
October 2019

PD/1-PD-Ls Checkpoint: Insight on the Potential Role of NK Cells.

Front Immunol 2019 4;10:1242. Epub 2019 Jun 4.

Department of Experimental Medicine, University of Genoa, Genoa, Italy.

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http://dx.doi.org/10.3389/fimmu.2019.01242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557993PMC
June 2019

NK cells to cure cancer.

Semin Immunol 2019 02 10;41:101272. Epub 2019 May 10.

Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy; Department of Medical Biotechnologies and Translational Medicine (BioMeTra), University of Milan, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10445323183008
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http://dx.doi.org/10.1016/j.smim.2019.03.004DOI Listing
February 2019

Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer.

Int J Mol Sci 2019 Feb 19;20(4). Epub 2019 Feb 19.

Department of Experimental Medicine (DIMES) and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, 16132 Genoa, Italy.

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http://dx.doi.org/10.3390/ijms20040890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412350PMC
February 2019

PD-1 is expressed by and regulates human group 3 innate lymphoid cells in human decidua.

Mucosal Immunol 2019 05 12;12(3):624-631. Epub 2019 Feb 12.

Department of Experimental Medicine (DIMES) and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy.

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http://dx.doi.org/10.1038/s41385-019-0141-9DOI Listing
May 2019

Targeting NKG2A to elucidate natural killer cell ontogenesis and to develop novel immune-therapeutic strategies in cancer therapy.

J Leukoc Biol 2019 06 15;105(6):1243-1251. Epub 2019 Jan 15.

Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.

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http://doi.wiley.com/10.1002/JLB.MR0718-300R
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http://dx.doi.org/10.1002/JLB.MR0718-300RDOI Listing
June 2019

Editorial: NK Cell Subsets in Health and Disease: New Developments.

Front Immunol 2017 18;8:1363. Epub 2017 Oct 18.

Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.

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http://dx.doi.org/10.3389/fimmu.2017.01363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651263PMC
October 2017

Corrigendum: Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56 NKG2A Cells, and Yet Display Increased Degranulation and Higher Perforin Content.

Front Immunol 2017 10;8:1244. Epub 2017 Oct 10.

Laboratory of Host Defenses, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01
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http://dx.doi.org/10.3389/fimmu.2017.01244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641412PMC
October 2017

Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56 NKG2A Cells, and Yet Display Increased Degranulation and Higher Perforin Content.

Front Immunol 2017 17;8:798. Epub 2017 Jul 17.

Laboratory of Host Defenses, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00
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http://dx.doi.org/10.3389/fimmu.2017.00798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511964PMC
July 2017

Regulatory Functions of Natural Killer Cells in Multiple Sclerosis.

Front Immunol 2016 19;7:606. Epub 2016 Dec 19.

Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy; IRCCS San Martino-IST, Genova, Italy.

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http://dx.doi.org/10.3389/fimmu.2016.00606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5165263PMC
December 2016

Markers and function of human NK cells in normal and pathological conditions.

Cytometry B Clin Cytom 2017 03 12;92(2):100-114. Epub 2017 Feb 12.

Department of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

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http://dx.doi.org/10.1002/cyto.b.21508DOI Listing
March 2017

Human NK Cell Subsets Redistribution in Pathological Conditions: A Role for CCR7 Receptor.

Front Immunol 2016 7;7:414. Epub 2016 Oct 7.

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy; CEBR, Università degli Studi di Genova, Genova, Italy.

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http://dx.doi.org/10.3389/fimmu.2016.00414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053980PMC
October 2016

Features of Memory-Like and PD-1(+) Human NK Cell Subsets.

Front Immunol 2016 14;7:351. Epub 2016 Sep 14.

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy; CEBR, Università degli Studi di Genova, Genova, Italy.

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http://journal.frontiersin.org/Article/10.3389/fimmu.2016.00
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021715PMC
http://dx.doi.org/10.3389/fimmu.2016.00351DOI Listing
September 2016

Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization.

J Allergy Clin Immunol 2017 01 27;139(1):335-346.e3. Epub 2016 May 27.

Department of Experimental Medicine, University of Genoa, Genoa, Italy; Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy.

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http://dx.doi.org/10.1016/j.jaci.2016.04.025DOI Listing
January 2017

Dysregulation of regulatory CD56(bright) NK cells/T cells interactions in multiple sclerosis.

J Autoimmun 2016 08 4;72:8-18. Epub 2016 May 4.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Largo Daneo 3, 16132 Genova, Italy; Centre of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV, 9, 1612 Genova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2016.04.003DOI Listing
August 2016

Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1β, IFN-β, and IL-15 Pathways.

J Immunol 2015 Sep 14;195(6):2818-28. Epub 2015 Aug 14.

Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center, I-20089 Rozzano, Milan, Italy; Department of Medical Biotechnologies and Translational Medicine, University of Milan, I-20089 Rozzano, Milan, Italy; and

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http://dx.doi.org/10.4049/jimmunol.1500325DOI Listing
September 2015

B7-H6-mediated downregulation of NKp30 in NK cells contributes to ovarian carcinoma immune escape.

Oncoimmunology 2015 Apr 22;4(4):e1001224. Epub 2015 Jan 22.

Dipartimento di Medicina Sperimentale and Centro di Eccellenza per le Ricerche Biomediche; Università degli Studi di Genova ; Genova, Italy ; Service d'Immunologie; Assistance Publique-Hôpitaux de Marseille; Hôpital de la Conception ; Marseille, France.

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http://dx.doi.org/10.1080/2162402X.2014.1001224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485754PMC
April 2015

Uptake of CCR7 by KIR2DS4⁺ NK cells is induced upon recognition of certain HLA-C alleles.

J Immunol Res 2015 16;2015:754373. Epub 2015 Apr 16.

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Sezione di Istologia, Via G.B. Marsano 10, 16132 Genova, Italy ; Centro di Eccellenza per le Ricerche Biomediche, Università degli Studi di Genova, Viale Benedetto XV 9, 16132 Genova, Italy.

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http://dx.doi.org/10.1155/2015/754373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415677PMC
January 2016

NK Cell Subset Redistribution during the Course of Viral Infections.

Front Immunol 2014 14;5:390. Epub 2014 Aug 14.

Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center , Milan , Italy ; Dipartimento di Medicina Sperimentale, Centro di Eccellenza per le Ricerche Biomediche, Università degli Studi di Genova , Genova , Italy ; Department of Medical Biotechnologies and Translational Medicine, University of Milan , Milan , Italy.

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http://dx.doi.org/10.3389/fimmu.2014.00390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132273PMC
September 2014

TLR/NCR/KIR: Which One to Use and When?

Front Immunol 2014 19;5:105. Epub 2014 Mar 19.

Dipartimento di Medicina Sperimentale, Centro di Eccellenza per le Ricerche Biomediche, Università degli Studi di Genova , Genova , Italy.

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http://dx.doi.org/10.3389/fimmu.2014.00105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958761PMC
June 2014

Human NK cell response to pathogens.

Semin Immunol 2014 Apr 28;26(2):152-60. Epub 2014 Feb 28.

DI.ME.S. Dipartimento di Medicina Sperimentale and Centro di Eccellenza per la Ricerca Biomedica, Università di Genova, Genova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2014.02.001DOI Listing
April 2014

Primitive neuroectodermal tumor in an ovarian cystic teratoma: natural killer and neuroblastoma cell analysis.

Case Rep Oncol 2014 Jan 24;7(1):70-8. Epub 2014 Jan 24.

Dipartimento di Medicina Molecolare e Traslazionale, Università degli Studi di Brescia, Genoa, Italy.

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http://dx.doi.org/10.1159/000357802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934805PMC
January 2014

KIR2DS1-dependent acquisition of CCR7 and migratory properties by human NK cells interacting with allogeneic HLA-C2+ DCs or T-cell blasts.

Blood 2013 Apr 28;121(17):3396-401. Epub 2013 Feb 28.

Dipartimento di Medicina Sperimentale and Centro di Eccellenza per le Ricerche Biomediche, Università degli Studi di Genova, Genoa, Italy.

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http://dx.doi.org/10.1182/blood-2012-09-458752DOI Listing
April 2013

NK/DC crosstalk in anti-viral response.

Adv Exp Med Biol 2012 ;946:295-308

Dipartimento di Medicina Sperimentale, Centro di Eccellenza per le Richerche Biomediche, Università degli Studi di Genova, 16132 Genova, Italy.

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http://dx.doi.org/10.1007/978-1-4614-0106-3_17DOI Listing
January 2012

NK cells and their receptors during viral infections.

Immunotherapy 2011 Sep;3(9):1075-86

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Via LB Alberti 2, 16132, Italy.

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http://dx.doi.org/10.2217/imt.11.99DOI Listing
September 2011

Role of alloreactive KIR2DS1(+) NK cells in haploidentical hematopoietic stem cell transplantation.

J Leukoc Biol 2011 Oct 26;90(4):661-7. Epub 2011 Jul 26.

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy.

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http://dx.doi.org/10.1189/jlb.0311137DOI Listing
October 2011

Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection.

AIDS 2010 Jan;24(1):27-34

Laboratory Clinical and Experimental Immunology, IRCCS, Istituto Clinico Humanitas, Rozzano, Milano, Italy.

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http://dx.doi.org/10.1097/QAD.0b013e3283328d1fDOI Listing
January 2010

Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction.

Blood 2009 Nov 11;114(19):4108-16. Epub 2009 Sep 11.

Dipartimento di Medicina Sperimentale and Centro di Eccellenza per le Ricerche Biomediche, Università degli Studi di Genova, Genova, Italy.

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http://dx.doi.org/10.1182/blood-2009-05-222265DOI Listing
November 2009

The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia.

Blood 2009 Oct 26;114(18):3822-30. Epub 2009 Aug 26.

Laboratory of Clinical and Experimental Immunology, Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Clinico Humanitas, Rozzano, Milano, Italy.

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http://dx.doi.org/10.1182/blood-2009-06-226332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773483PMC
October 2009

The NK/DC complot.

Adv Exp Med Biol 2009 ;633:7-16

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Via L.B. Alberti 2, 16132, Italy.

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http://dx.doi.org/10.1007/978-0-387-79311-5_2DOI Listing
May 2009

Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals.

PLoS Pathog 2008 Jul 11;4(7):e1000101. Epub 2008 Jul 11.

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1000101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438610PMC
July 2008

Human NK cells directly recognize Mycobacterium bovis via TLR2 and acquire the ability to kill monocyte-derived DC.

Int Immunol 2008 Sep 1;20(9):1155-67. Epub 2008 Jul 1.

Dipartimento di Medicina Sperimentale, Università di Genova, Genova, Italy.

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https://academic.oup.com/intimm/article-lookup/doi/10.1093/i
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http://dx.doi.org/10.1093/intimm/dxn073DOI Listing
September 2008

Human natural killer cells exposed to IL-2, IL-12, IL-18, or IL-4 differently modulate priming of naive T cells by monocyte-derived dendritic cells.

Blood 2008 Sep 25;112(5):1776-83. Epub 2008 Jun 25.

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Italy.

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http://dx.doi.org/10.1182/blood-2008-02-135871DOI Listing
September 2008

In the thick of the fray: NK cells in inflamed tissues.

Adv Exp Med Biol 2007 ;598:12-9

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Via L.B. Alberti 2, 16132 Italy.

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http://dx.doi.org/10.1007/978-0-387-71767-8_2DOI Listing
October 2007

It's only innate immunity but I like it.

Adv Exp Med Biol 2007 ;590:89-101

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Via L.B. Alberti 2, 16132 Italy.

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http://dx.doi.org/10.1007/978-0-387-34814-8_6DOI Listing
February 2007

NK-DC interaction: on the usefulness of auto-aggression.

Autoimmun Rev 2005 Nov;4(8):520-5

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Via L.B. Alberti 2, 16132, Italy.

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http://dx.doi.org/10.1016/j.autrev.2005.04.015DOI Listing
November 2005

Early liaisons between cells of the innate immune system in inflamed peripheral tissues.

Trends Immunol 2005 Dec 28;26(12):668-75. Epub 2005 Sep 28.

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Via L.B. Alberti 2, 16132 Italy.

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http://dx.doi.org/10.1016/j.it.2005.09.008DOI Listing
December 2005

Identification of NKG2A and NKp80 as specific natural killer cell markers in rhesus and pigtailed monkeys.

Blood 2005 Sep 17;106(5):1718-25. Epub 2005 May 17.

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bldg 10, Rm 6A08A, MSC 1576, Bethesda, MD 20814, USA.

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http://dx.doi.org/10.1182/blood-2004-12-4762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895226PMC
September 2005

IL-12 or IL-4 prime human NK cells to mediate functionally divergent interactions with dendritic cells or tumors.

J Immunol 2005 Apr;174(7):3992-8

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy.

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http://dx.doi.org/10.4049/jimmunol.174.7.3992DOI Listing
April 2005

Pathogen-induced private conversations between natural killer and dendritic cells.

Trends Microbiol 2005 Mar;13(3):128-36

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Via L.B. Alberti 2, 16132 Genoa, Italy.

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http://dx.doi.org/10.1016/j.tim.2005.01.006DOI Listing
March 2005

Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals.

Proc Natl Acad Sci U S A 2005 Feb 7;102(8):2886-91. Epub 2005 Feb 7.

Laboratory of Immunoregulation and Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0409872102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549494PMC
February 2005

NK cells: innate immunity against hematological malignancies?

Trends Immunol 2004 Jun;25(6):328-33

Laboratoire Immunologie des Tumeurs, Centre de Lutte Contre le Cancer de Marseille, 232 boulevard Sainte Marguerite, 13009 Marseille, France.

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http://dx.doi.org/10.1016/j.it.2004.04.005DOI Listing
June 2004

Natural killer cell-triggering receptors in patients with acute leukaemia.

Leuk Lymphoma 2003 Oct;44(10):1683-9

Institut Paoli-Calmettes, Faculté de Médecine de Marseille & Université de la Méditerranée, Marseille, France.

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http://dx.doi.org/10.1080/1042819031000104006DOI Listing
October 2003

Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates.

Proc Natl Acad Sci U S A 2003 Dec 25;100(25):15011-6. Epub 2003 Nov 25.

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.2336091100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC299884PMC
December 2003

Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia.

Blood 2002 May;99(10):3661-7

Unité d'Immunologie des Tumeurs Département d'Hématologie, Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France.

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http://dx.doi.org/10.1182/blood.v99.10.3661DOI Listing
May 2002