Emanuel Schwarz

Emanuel Schwarz

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Emanuel Schwarz

Publications by authors named "Emanuel Schwarz"

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Common brain disorders are associated with heritable patterns of apparent aging of the brain.

Nat Neurosci 2019 10 24;22(10):1617-1623. Epub 2019 Sep 24.

NORMENT, Division of Mental Health and Addiction Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1038/s41593-019-0471-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823048PMC
October 2019

Neural correlates of individual differences in affective benefit of real-life urban green space exposure.

Nat Neurosci 2019 09 29;22(9):1389-1393. Epub 2019 Jul 29.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Baden-Wuerttemberg, Germany.

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http://dx.doi.org/10.1038/s41593-019-0451-yDOI Listing
September 2019

Computational Approaches for Identification of Pleiotropic Biomarker Profiles in Psychiatry.

Adv Exp Med Biol 2019 ;1134:111-128

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1007/978-3-030-12668-1_6DOI Listing
August 2019

RMTL: an R library for multi-task learning.

Bioinformatics 2019 May;35(10):1797-1798

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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https://academic.oup.com/bioinformatics/advance-article/doi/
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http://dx.doi.org/10.1093/bioinformatics/bty831DOI Listing
May 2019

Gimpute: an efficient genetic data imputation pipeline.

Bioinformatics 2019 Apr;35(8):1433-1435

Department of Psychiatry and Psychotherapy, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1093/bioinformatics/bty814DOI Listing
April 2019

Comparative Evaluation of Machine Learning Strategies for Analyzing Big Data in Psychiatry.

Int J Mol Sci 2018 Oct 29;19(11). Epub 2018 Oct 29.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Mannheim, Germany.

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http://dx.doi.org/10.3390/ijms19113387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274760PMC
October 2018

Male increase in brain gene expression variability is linked to genetic risk for schizophrenia.

Transl Psychiatry 2018 08 1;8(1):140. Epub 2018 Aug 1.

Medical Faculty Mannheim, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1038/s41398-018-0200-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070530PMC
August 2018

A gene-based review of RGS4 as a putative risk gene for psychiatric illness.

Authors:
Emanuel Schwarz

Am J Med Genet B Neuropsychiatr Genet 2018 03 24;177(2):267-273. Epub 2017 May 24.

Medical Faculty Mannheim, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1002/ajmg.b.32547DOI Listing
March 2018

Identification and Clinical Translation of Biomarker Signatures: Statistical Considerations.

Authors:
Emanuel Schwarz

Methods Mol Biol 2017 ;1546:103-114

Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1007/978-1-4939-6730-8_6DOI Listing
February 2018

Opportunities and Challenges of Multiplex Assays: A Machine Learning Perspective.

Methods Mol Biol 2017 ;1546:115-122

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J 5, Mannheim, 68159, Germany.

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http://dx.doi.org/10.1007/978-1-4939-6730-8_7DOI Listing
February 2018

A polygenic score for schizophrenia predicts glycemic control.

Transl Psychiatry 2017 12 18;7(12):1295. Epub 2017 Dec 18.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1038/s41398-017-0044-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802590PMC
December 2017

Association of anandamide with altered binocular depth inversion illusion in schizophrenia.

World J Biol Psychiatry 2017 09 11;18(6):483-488. Epub 2016 Nov 11.

a Department of Psychiatry and Psychotherapy , Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University , Mannheim , Germany.

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http://dx.doi.org/10.1080/15622975.2016.1246750DOI Listing
September 2017

The Utility of Multiplex Assays for Identification of Proteomic Signatures in Psychiatry.

Adv Exp Med Biol 2017 ;974:131-138

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1007/978-3-319-52479-5_8DOI Listing
September 2017

Multiplex Immunoassay Profiling of Serum in Psychiatric Disorders.

Adv Exp Med Biol 2017 ;974:149-156

Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Rua Monteiro Lobato 255 F/01, Cidade Universitária ZeferinoVaz, 13083-862, Campinas, Brazil.

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http://dx.doi.org/10.1007/978-3-319-52479-5_10DOI Listing
September 2017

Protein Interaction Networks Link Schizophrenia Risk Loci to Synaptic Function.

Schizophr Bull 2016 11 7;42(6):1334-1342. Epub 2016 Apr 7.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049524PMC
http://dx.doi.org/10.1093/schbul/sbw035DOI Listing
November 2016

The association of pineal gland volume and body mass in obese and normal weight individuals: a pilot study.

Psychiatr Danub 2016 Sep;28(3):220-224

Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany.

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September 2016

Pretreatment levels of the fatty acid handling proteins H-FABP and CD36 predict response to olanzapine in recent-onset schizophrenia patients.

Brain Behav Immun 2016 Feb 2;52:178-186. Epub 2015 Nov 2.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK; Department of Neuroscience, Erasmus Medical Centre, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2015.10.019DOI Listing
February 2016

Working memory genetics in schizophrenia and related disorders: An RDoC perspective.

Am J Med Genet B Neuropsychiatr Genet 2016 Jan 14;171B(1):121-31. Epub 2015 Sep 14.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://doi.wiley.com/10.1002/ajmg.b.32353
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http://dx.doi.org/10.1002/ajmg.b.32353DOI Listing
January 2016

Neural Correlates of the Cortisol Awakening Response in Humans.

Neuropsychopharmacology 2015 Aug 17;40(9):2278-85. Epub 2015 Mar 17.

Central Institute for Mental Health, University of Heidelberg/Medical Faculty Mannheim, J5, Mannheim, Germany.

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http://dx.doi.org/10.1038/npp.2015.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613622PMC
August 2015

IgG dynamics of dietary antigens point to cerebrospinal fluid barrier or flow dysfunction in first-episode schizophrenia.

Brain Behav Immun 2015 Feb 20;44:148-58. Epub 2014 Sep 20.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1016/j.bbi.2014.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275312PMC
February 2015

Investigation of molecular serum profiles associated with predisposition to antipsychotic-induced weight gain.

World J Biol Psychiatry 2015 Jan 3;16(1):22-30. Epub 2013 Sep 3.

Department of Chemical Engineering and Biotechnology, University of Cambridge , Cambridge , UK.

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http://dx.doi.org/10.3109/15622975.2013.817685DOI Listing
January 2015

Oleoylethanolamide and human neural responses to food stimuli in obesity.

JAMA Psychiatry 2014 Nov;71(11):1254-61

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1001/jamapsychiatry.2014.1215DOI Listing
November 2014

Identification of subgroups of schizophrenia patients with changes in either immune or growth factor and hormonal pathways.

Schizophr Bull 2014 Jul 9;40(4):787-95. Epub 2013 Aug 9.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK; Department of Neuroscience, Erasmus University Medical Centre, Rotterdam, the Netherlands

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http://dx.doi.org/10.1093/schbul/sbt105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059436PMC
July 2014

Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations.

Authors:
Jim van Os Bart P Rutten Inez Myin-Germeys Philippe Delespaul Wolfgang Viechtbauer Catherine van Zelst Richard Bruggeman Ulrich Reininghaus Craig Morgan Robin M Murray Marta Di Forti Philip McGuire Lucia R Valmaggia Matthew J Kempton Charlotte Gayer-Anderson Kathryn Hubbard Stephanie Beards Simona A Stilo Adanna Onyejiaka Francois Bourque Gemma Modinos Stefania Tognin Maria Calem Michael C O'Donovan Michael J Owen Peter Holmans Nigel Williams Nicholas Craddock Alexander Richards Isla Humphreys Andreas Meyer-Lindenberg F Markus Leweke Heike Tost Ceren Akdeniz Cathrin Rohleder J Malte Bumb Emanuel Schwarz Köksal Alptekin Alp Üçok Meram Can Saka E Cem Atbaşoğlu Sinan Gülöksüz Guvem Gumus-Akay Burçin Cihan Hasan Karadağ Haldan Soygür Eylem Şahin Cankurtaran Semra Ulusoy Berna Akdede Tolga Binbay Ahmet Ayer Handan Noyan Gülşah Karadayı Elçin Akturan Halis Ulaş Celso Arango Mara Parellada Miguel Bernardo Julio Sanjuán Julio Bobes Manuel Arrojo Jose Luis Santos Pedro Cuadrado José Juan Rodríguez Solano Angel Carracedo Enrique García Bernardo Laura Roldán Gonzalo López Bibiana Cabrera Sabrina Cruz Eva Ma Díaz Mesa María Pouso Estela Jiménez Teresa Sánchez Marta Rapado Emiliano González Covadonga Martínez Emilio Sánchez Ma Soledad Olmeda Lieuwe de Haan Eva Velthorst Mark van der Gaag Jean-Paul Selten Daniella van Dam Elsje van der Ven Floor van der Meer Elles Messchaert Tamar Kraan Nadine Burger Marion Leboyer Andrei Szoke Franck Schürhoff Pierre-Michel Llorca Stéphane Jamain Andrea Tortelli Flora Frijda Jeanne Vilain Anne-Marie Galliot Grégoire Baudin Aziz Ferchiou Jean-Romain Richard Ewa Bulzacka Thomas Charpeaud Anne-Marie Tronche Marc De Hert Ruud van Winkel Jeroen Decoster Catherine Derom Evert Thiery Nikos C Stefanis Gabriele Sachs Harald Aschauer Iris Lasser Bernadette Winklbaur Monika Schlögelhofer Anita Riecher-Rössler Stefan Borgwardt Anna Walter Fabienne Harrisberger Renata Smieskova Charlotte Rapp Sarah Ittig Fabienne Soguel-dit-Piquard Erich Studerus Joachim Klosterkötter Stephan Ruhrmann Julia Paruch Dominika Julkowski Desiree Hilboll Pak C Sham Stacey S Cherny Eric Y H Chen Desmond D Campbell Miaoxin Li Carlos María Romeo-Casabona Aitziber Emaldi Cirión Asier Urruela Mora Peter Jones James Kirkbride Mary Cannon Dan Rujescu Ilaria Tarricone Domenico Berardi Elena Bonora Marco Seri Thomas Marcacci Luigi Chiri Federico Chierzi Viviana Storbini Mauro Braca Maria Gabriella Minenna Ivonne Donegani Angelo Fioritti Daniele La Barbera Caterina Erika La Cascia Alice Mulè Lucia Sideli Rachele Sartorio Laura Ferraro Giada Tripoli Fabio Seminerio Anna Maria Marinaro Patrick McGorry Barnaby Nelson G Paul Amminger Christos Pantelis Paulo R Menezes Cristina M Del-Ben Silvia H Gallo Tenan Rosana Shuhama Mirella Ruggeri Sarah Tosato Antonio Lasalvia Chiara Bonetto Elisa Ira Merete Nordentoft Marie-Odile Krebs Neus Barrantes-Vidal Paula Cristóbal Thomas R Kwapil Elisa Brietzke Rodrigo A Bressan Ary Gadelha Nadja P Maric Sanja Andric Marina Mihaljevic Tijana Mirjanic

Schizophr Bull 2014 Jul 24;40(4):729-36. Epub 2014 May 24.

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http://dx.doi.org/10.1093/schbul/sbu069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059449PMC
July 2014

Proteomic profiling in schizophrenia: enabling stratification for more effective treatment.

Genome Med 2013 26;5(3):25. Epub 2013 Mar 26.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, UK ; Department of Neuroscience, Erasmus Medical Centre, NL-3000 CA Rotterdam, The Netherlands.

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http://genomemedicine.biomedcentral.com/articles/10.1186/gm4
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http://dx.doi.org/10.1186/gm429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706977PMC
June 2014

Cytokine alterations in first-episode schizophrenia patients before and after antipsychotic treatment.

Schizophr Res 2014 Apr 26;154(1-3):23-9. Epub 2014 Feb 26.

Department of Chemical Engineering and Biotechnology, Tennis Court Road, Cambridge CB21QT, University of Cambridge, UK; Department of Neuroscience, Erasmus Medical Centre, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2014.02.005DOI Listing
April 2014

Electroconvulsive therapy exerts mainly acute molecular changes in serum of major depressive disorder patients.

Eur Neuropsychopharmacol 2013 Oct 22;23(10):1199-207. Epub 2012 Nov 22.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2012.10.012DOI Listing
October 2013

Application of meta-analysis methods for identifying proteomic expression level differences.

Proteomics 2013 Jul 6;13(14):2072-6. Epub 2013 Jun 6.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/pmic.201300034DOI Listing
July 2013

Comparison of peripheral and central schizophrenia biomarker profiles.

PLoS One 2012 30;7(10):e46368. Epub 2012 Oct 30.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046368PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484150PMC
May 2013

Identification of a blood-based biological signature in subjects with psychiatric disorders prior to clinical manifestation.

World J Biol Psychiatry 2012 Dec 22;13(8):627-32. Epub 2011 Sep 22.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.3109/15622975.2011.599861DOI Listing
December 2012

Blood test for schizophrenia.

Eur Arch Psychiatry Clin Neurosci 2012 Nov 26;262 Suppl 2:S79-83. Epub 2012 Aug 26.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1007/s00406-012-0354-3DOI Listing
November 2012

Converging evidence of blood-based biomarkers for schizophrenia: an update.

Int Rev Neurobiol 2011 ;101:95-144

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/B978-0-12-387718-5.00005-5DOI Listing
August 2012

The application of multiplexed assay systems for molecular diagnostics.

Int Rev Neurobiol 2011 ;101:259-78

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/B978-0-12-387718-5.00010-9DOI Listing
August 2012

Algorithm development for diagnostic biomarker assays.

Int Rev Neurobiol 2011 ;101:279-98

Rules-Based Medicine, Inc., Austin, Texas, USA.

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http://dx.doi.org/10.1016/B978-0-12-387718-5.00011-0DOI Listing
August 2012

Challenges of introducing new biomarker products for neuropsychiatric disorders into the market.

Int Rev Neurobiol 2011 ;101:299-327

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/B97801238771850
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http://dx.doi.org/10.1016/B978-0-12-387718-5.00012-2DOI Listing
August 2012

Molecular validation of the acute phencyclidine rat model for schizophrenia: identification of translational changes in energy metabolism and neurotransmission.

J Proteome Res 2012 Jul 1;11(7):3704-14. Epub 2012 Jun 1.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 1QT, UK.

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http://dx.doi.org/10.1021/pr300197dDOI Listing
July 2012

Analysis of serum and plasma identifies differences in molecular coverage, measurement variability, and candidate biomarker selection.

Proteomics Clin Appl 2012 Jun;6(5-6):297-303

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/prca.201100061DOI Listing
June 2012

Translating potential biomarker candidates for schizophrenia and depression to animal models of psychiatric disorders.

Expert Rev Mol Diagn 2011 Sep;11(7):721-33

Institute of Biotechnology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1586/erm.11.61DOI Listing
September 2011

Altered levels of circulating insulin and other neuroendocrine hormones associated with the onset of schizophrenia.

Psychoneuroendocrinology 2011 Aug 20;36(7):1092-6. Epub 2011 Jan 20.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, UK.

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http://dx.doi.org/10.1016/j.psyneuen.2010.12.018DOI Listing
August 2011

Alterations of primary fatty acid amides in serum of patients with severe mental illness.

Front Biosci (Elite Ed) 2011 Jan 1;3:308-14. Epub 2011 Jan 1.

Institute of Biotechnology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.2741/e246DOI Listing
January 2011

Multidimensional protein fractionation of blood proteins coupled to data-independent nanoLC-MS/MS analysis.

J Proteomics 2010 Jan 5;73(3):689-95. Epub 2009 Nov 5.

Cambridge Centre for Neuropsychiatric Research, Institute of Biotechnology, Department of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, CB 2 1QT Cambridge, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S187439190900311
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http://dx.doi.org/10.1016/j.jprot.2009.10.013DOI Listing
January 2010

Clinical bioinformatics for complex disorders: a schizophrenia case study.

BMC Bioinformatics 2009 Oct 15;10 Suppl 12:S6. Epub 2009 Oct 15.

Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, UK.

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http://dx.doi.org/10.1186/1471-2105-10-S12-S6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762071PMC
October 2009

Real-time evaluation of experimental variation in large-scale LC-MS/MS-based quantitative proteomics of complex samples.

J Chromatogr B Analyt Technol Biomed Life Sci 2009 May 13;877(13):1299-305. Epub 2008 Nov 13.

Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QT, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S157002320800825
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http://dx.doi.org/10.1016/j.jchromb.2008.11.007DOI Listing
May 2009

High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides.

J Proteome Res 2008 Oct 9;7(10):4266-77. Epub 2008 Sep 9.

Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom.

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http://dx.doi.org/10.1021/pr800188yDOI Listing
October 2008

Biomarker discovery in psychiatric disorders.

Electrophoresis 2008 Jul;29(13):2884-90

Institute of Biotechnology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/elps.200700710DOI Listing
July 2008

Cerebrospinal fluid: identification of diagnostic markers for schizophrenia.

Expert Rev Mol Diagn 2008 Mar;8(2):209-16

Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QT, UK.

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http://dx.doi.org/10.1586/14737159.8.2.209DOI Listing
March 2008

Label-free LC-MS/MS quantitative proteomics for large-scale biomarker discovery in complex samples.

J Sep Sci 2007 Sep;30(14):2198-203

Institute of Biotechnology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/jssc.200700189DOI Listing
September 2007

Peptide correlation: a means to identify high quality quantitative information in large-scale proteomic studies.

J Sep Sci 2007 Sep;30(14):2190-7

Institute of Biotechnology, University of Cambridge, Cambridge, UK.

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http://doi.wiley.com/10.1002/jssc.200700190
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http://dx.doi.org/10.1002/jssc.200700190DOI Listing
September 2007

CSF biomarker discovery using label-free nano-LC-MS based proteomic profiling: technical aspects.

J Sep Sci 2007 Feb;30(2):214-25

Institute of Biotechnology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/jssc.200600350DOI Listing
February 2007