Publications by authors named "Emanuel F Petricoin"

100Publications

Perspectives on Triple-Negative Breast Cancer: Current Treatment Strategies, Unmet Needs, and Potential Targets for Future Therapies.

Cancers (Basel) 2020 Aug 24;12(9). Epub 2020 Aug 24.

Leroy T. Canoles Jr. Cancer Research Center, Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23501, USA.

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http://dx.doi.org/10.3390/cancers12092392DOI Listing
August 2020

Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers.

Cell Rep 2020 Jun;31(11):107764

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Charité Universitätsmedizin Berlin, Institute of Pathology, Laboratory of Molecular Tumor Pathology and Systems Biology, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393480PMC
June 2020

Phosphoproteomic Landscaping Identifies Non-canonical cKIT Signaling in Polycythemia Vera Erythroid Progenitors.

Front Oncol 2019 22;9:1245. Epub 2019 Nov 22.

Myeloproliferative Neoplasm Research Consortium, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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http://dx.doi.org/10.3389/fonc.2019.01245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883719PMC
November 2019

Phosphoprotein-based drug target activation mapping for precision oncology: a view to the future.

Expert Rev Proteomics 2018 11 12;15(11):851-853. Epub 2018 Oct 12.

a Center for Applied Proteomics and Molecular Medicine, School of Systems Biology , George Mason University , Manassas , Virginia , USA.

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https://www.tandfonline.com/doi/full/10.1080/14789450.2018.1
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http://dx.doi.org/10.1080/14789450.2018.1531709DOI Listing
November 2018

Evaluation of the HER/PI3K/AKT Family Signaling Network as a Predictive Biomarker of Pathologic Complete Response for Patients With Breast Cancer Treated With Neratinib in the I-SPY 2 TRIAL.

JCO Precis Oncol 2018 16;2. Epub 2018 Aug 16.

, , and , George Mason University, Manassas, VA; , , , , , , , and , University of California, San Francisco, San Francisco, CA; , , and , Netherlands Cancer Institute, Amsterdam, the Netherlands; , University of Pennsylvania, Philadelphia, PA; , University of Texas MD Anderson Cancer Center, Houston; , Berry Consultants, Austin, TX; , University of Minnesota, Minneapolis; and , Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1200/PO.18.00024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446527PMC
August 2018

Features of MRI stromal enhancement with neoadjuvant chemotherapy: a subgroup analysis of the ACRIN 6657/I-SPY TRIAL.

J Med Imaging (Bellingham) 2018 01 23;5(1):011014. Epub 2017 Dec 23.

University of California San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States.

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http://dx.doi.org/10.1117/1.JMI.5.1.011014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741993PMC
January 2018

Protein network construction using reverse phase protein array data.

Methods 2017 07 24;124:89-99. Epub 2017 Jun 24.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2017.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603262PMC
July 2017

The Warburg Effect and Mass Spectrometry-based Proteomic Analysis.

Cancer Genomics Proteomics 2017 Jul-Aug;14(4):211-218

Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, U.S.A.

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http://dx.doi.org/10.21873/cgp.20032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572299PMC
April 2018

Mass Spectrometry-Based Biomarker Discovery.

Methods Mol Biol 2017 ;1606:297-311

Center for Applied Proteomics and Molecular Medicine, George Mason University, 10920 George Mason Circle, MS1A9, Manassas, VA, 20110, USA.

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http://dx.doi.org/10.1007/978-1-4939-6990-6_19DOI Listing
February 2018

Reverse Phase Protein Microarrays.

Methods Mol Biol 2017 ;1606:149-169

Center for Applied Proteomics and Molecular Medicine, George Mason University, 10920 George Mason Circle, MS 1A9, Manassas, VA, 20110, USA.

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http://dx.doi.org/10.1007/978-1-4939-6990-6_11DOI Listing
February 2018

Innovations in Clinical Trial Design in the Era of Molecular Profiling.

Methods Mol Biol 2017 ;1606:19-36

Center for Applied Proteomics and Molecular Medicine, Institute for Advanced Biomedical Research, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, USA.

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http://dx.doi.org/10.1007/978-1-4939-6990-6_2DOI Listing
February 2018

Preclinical rationale for TGF-β inhibition as a therapeutic target for the treatment of myelofibrosis.

Exp Hematol 2016 Dec 31;44(12):1138-1155.e4. Epub 2016 Aug 31.

Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Biomedical and Neuromotorial Sciences, Alma Mater University, Bologna, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778911PMC
December 2016

D3D augmented reality imaging system: proof of concept in mammography.

Med Devices (Auckl) 2016 9;9:277-83. Epub 2016 Aug 9.

Department of Radiology, Fort Benning, Columbus, GA, USA.

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http://dx.doi.org/10.2147/MDER.S110756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984822PMC
August 2016

The Obama Administration's Cancer Moonshot: A Call for Proteomics.

Clin Cancer Res 2016 Sep 19;22(18):4556-8. Epub 2016 May 19.

The Inova-George Mason University Center for Clinical Proteomics, Manassas, Virginia. Center for Applied Proteomics and Molecular Medicine, School of Systems Biology, George Mason University, Manassas, Virginia.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0688DOI Listing
September 2016

Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin.

Cancer Prev Res (Phila) 2016 Mar 22;9(3):215-24. Epub 2016 Jan 22.

The University of Arizona Cancer Center, Tucson, Arizona. Department of Medicine, The University of Arizona, Tucson, Arizona. Department of Cellular and Molecular Medicine, The University of Arizona, Tucson, Arizona.

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http://dx.doi.org/10.1158/1940-6207.CAPR-15-0419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777684PMC
March 2016

Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.

Cancer Cell 2016 Jan 24;29(1):75-89. Epub 2015 Dec 24.

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816652PMC
January 2016

Multifactorial analysis of conditional reprogramming of human keratinocytes.

PLoS One 2015 25;10(2):e0116755. Epub 2015 Feb 25.

Department of Pathology, Georgetown University, Washington, DC, 20007, United States of America; Department of Oncology, Georgetown University, Washington, DC, 20007, United States of America; Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20007, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116755PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340869PMC
January 2016

Multiplex proteomic analysis of cells in fine needle aspiration samples: how soon can we expect to individualize therapy by comparing pre- and posttreatment biopsies?

Clin Chem 2014 Sep 9;60(9):1143-5. Epub 2014 Apr 9.

Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA.

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http://www.clinchem.org/cgi/doi/10.1373/clinchem.2014.222828
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http://dx.doi.org/10.1373/clinchem.2014.222828DOI Listing
September 2014

Stratification of clear cell renal cell carcinoma by signaling pathway analysis.

Expert Rev Proteomics 2014 Apr 27;11(2):237-49. Epub 2014 Feb 27.

Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori , Milan , Italy.

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http://dx.doi.org/10.1586/14789450.2014.893193DOI Listing
April 2014

Preparation and use of reverse protein microarrays.

Curr Protoc Protein Sci 2014 Feb 3;75:27.7.1-27.7.29. Epub 2014 Feb 3.

Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia.

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http://doi.wiley.com/10.1002/0471140864.ps2707s75
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http://dx.doi.org/10.1002/0471140864.ps2707s75DOI Listing
February 2014

Glioblastoma cell enrichment is critical for analysis of phosphorylated drug targets and proteomic-genomic correlations.

Cancer Res 2014 Feb 17;74(3):818-28. Epub 2013 Dec 17.

Authors' Affiliations: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia; Departments of Neurosurgery, Henry Ford Hospital, Detroit; and Pathology, Henry Ford Hospital, Detroit, Michigan.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-2172DOI Listing
February 2014

Cancer metabolism and mass spectrometry-based proteomics.

Cancer Lett 2015 Jan 18;356(2 Pt A):176-83. Epub 2013 Nov 18.

Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA 20110, USA.

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http://dx.doi.org/10.1016/j.canlet.2013.11.003DOI Listing
January 2015

Combining markers with and without the limit of detection.

Stat Med 2014 Apr 17;33(8):1307-20. Epub 2013 Oct 17.

Department of Statistics, George Mason University, Fairfax, VA 22030, U.S.A.

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http://dx.doi.org/10.1002/sim.6027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084760PMC
April 2014

Reverse phase protein microarrays and their utility in drug development.

Methods Mol Biol 2013 ;986:187-214

Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA.

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http://dx.doi.org/10.1007/978-1-62703-311-4_13DOI Listing
August 2013

The role of proteomics in prostate cancer research: biomarker discovery and validation.

Clin Biochem 2013 Apr 22;46(6):524-38. Epub 2012 Dec 22.

George Mason University, Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA.

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http://dx.doi.org/10.1016/j.clinbiochem.2012.12.012DOI Listing
April 2013

Preclinical magnetic resonance imaging and systems biology in cancer research: current applications and challenges.

Am J Pathol 2013 Feb 4;182(2):312-8. Epub 2012 Dec 4.

Lombardi Comprehensive Cancer Center and Department of Oncology, Georgetown University Medical Center, Washington, District of Columbia 20057, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00029440120081
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http://dx.doi.org/10.1016/j.ajpath.2012.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969503PMC
February 2013

Cancer metabolism: what we can learn from proteomic analysis by mass spectrometry.

Cancer Genomics Proteomics 2012 Nov;9(6):373-81

Center for Applied Proteomics and Molecular Medicine, George Mason University, 10900 University Blvd, MS 1A9, Manassas, VA 20110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547437PMC
November 2012

MS analysis reveals O-methylation of L-lactate dehydrogenase from pancreatic ductal adenocarcinoma cells.

Electrophoresis 2012 Jul;33(12):1850-4

Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA 20110, USA.

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http://dx.doi.org/10.1002/elps.201200017DOI Listing
July 2012

The spectra count label-free quantitation in cancer proteomics.

Cancer Genomics Proteomics 2012 May-Jun;9(3):135-42

Center for Applied Proteomics and Molecular Medicine, George Mason University, 10900 University Blvd, MS 1A9, Manassas, VA 20110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761408PMC
November 2012

Protein pathway activation mapping reveals molecular networks associated with antiestrogen resistance in breast cancer cell lines.

Int J Cancer 2012 Nov 20;131(9):1998-2007. Epub 2012 Mar 20.

Department of Pathology, Josephine Nefkens Institute, Erasmus MC-University Medical Center Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/ijc.27489DOI Listing
November 2012

Regulatory approval pathways for molecular diagnostic technology.

Methods Mol Biol 2012 ;823:409-20

Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA.

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http://dx.doi.org/10.1007/978-1-60327-216-2_27DOI Listing
April 2012

Mass spectrometry-based biomarker discovery.

Methods Mol Biol 2012 ;823:251-64

Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA.

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http://dx.doi.org/10.1007/978-1-60327-216-2_16DOI Listing
April 2012

Reverse-phase protein microarrays.

Methods Mol Biol 2012 ;823:215-35

Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA.

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http://dx.doi.org/10.1007/978-1-60327-216-2_14DOI Listing
April 2012