Elsa R Flores

Elsa R Flores

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Elsa R Flores

Elsa R Flores

Publications by authors named "Elsa R Flores"

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Beware of thy neighbor: Senescent cancer cells feast on adjacent cells to persist.

J Cell Biol 2019 Nov 18;218(11):3535-3536. Epub 2019 Oct 18.

Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

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http://dx.doi.org/10.1083/jcb.201910040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829664PMC
November 2019

Chromosome 19 miRNA cluster and CEBPB expression specifically mark and potentially drive triple negative breast cancers.

PLoS One 2018 18;13(10):e0206008. Epub 2018 Oct 18.

Sarcoma Department, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America and.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206008PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193703PMC
April 2019

miR-205 Regulates Basal Cell Identity and Stem Cell Regenerative Potential During Mammary Reconstitution.

Stem Cells 2018 12 31;36(12):1875-1889. Epub 2018 Oct 31.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/stem.2914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379077PMC
December 2018

HP1γ Promotes Lung Adenocarcinoma by Downregulating the Transcription-Repressive Regulators NCOR2 and ZBTB7A.

Cancer Res 2018 07 15;78(14):3834-3848. Epub 2018 May 15.

Department of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443096PMC
July 2018

MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes.

Mol Cell 2018 06 31;70(5):825-841.e6. Epub 2018 May 31.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.04.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528658PMC
June 2018

Another case for diet restriction: TAp73-expressing medulloblastomas are stunted by glutamine withdrawal.

Genes Dev 2017 09;31(17):1715-1716

Department of Molecular Oncology, Cancer Biology and Evolution Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.

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http://dx.doi.org/10.1101/gad.306837.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666670PMC
September 2017

Ccdc3: A New P63 Target Involved in Regulation Of Liver Lipid Metabolism.

Sci Rep 2017 08 21;7(1):9020. Epub 2017 Aug 21.

Department of Biochemistry & Molecular Biology and Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1038/s41598-017-09228-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566403PMC
August 2017

The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy.

Br J Cancer 2017 Jan 24;116(2):149-155. Epub 2016 Nov 24.

Department of Molecular Oncology, Cancer Biology and Evolution Program, Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

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http://dx.doi.org/10.1038/bjc.2016.384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243983PMC
January 2017

Commentary on "Apoptosis, p53, and Tumor Cell Sensitivity to Anticancer Agents".

Authors:
Elsa R Flores

Cancer Res 2016 12;76(23):6763-6764

Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2997DOI Listing
December 2016

Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73.

Cell Cycle 2016 ;15(2):164-71

a Department of Molecular and Cellular Oncology , The University of Texas M.D. Anderson Cancer Center , Houston , TX , USA.

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http://dx.doi.org/10.1080/15384101.2015.1121333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825839PMC
October 2016

MEK Is a Therapeutic and Chemopreventative Target in Squamous Cell Carcinoma.

J Invest Dermatol 2016 09 9;136(9):1920-1924. Epub 2016 Jun 9.

Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.05.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303342PMC
September 2016

Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation.

Aging Cell 2016 08 26;15(4):646-60. Epub 2016 Apr 26.

Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1111/acel.12476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933665PMC
August 2016

Unifying the p73 knockout phenotypes: TAp73 orchestrates multiciliogenesis.

Genes Dev 2016 06;30(11):1253-4

Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA Department of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA Graduate School of Biomedical Sciences, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1101/gad.283663.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911924PMC
June 2016

ΔNp63/DGCR8-Dependent MicroRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer.

Cancer Cell 2016 06;29(6):874-888

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908836PMC
June 2016

Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma.

Neuro Oncol 2015 Nov 19;17(11):1463-73. Epub 2015 Mar 19.

Department of Pediatrics Research, University of Texas MD Anderson Cancer Center, Houston, Texas (M.M.S., B.J., J.C.); Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (A.V., E.R.F.); Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas (M.B., J.C.); Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, Texas (J.Z., X.S.); Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, Texas (B.J., F.L.); Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, Texas (A.V., E.R.F., M.B., F.L., J.C.).

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http://dx.doi.org/10.1093/neuonc/nov041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648298PMC
November 2015

IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo.

Nature 2015 Jan 17;517(7536):626-30. Epub 2014 Nov 17.

1] Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [2] Department of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [3] Graduate School of Biomedical Sciences, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [4] Metastasis Research Center, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nature13910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312210PMC
January 2015

p53/p63/p73 in the epidermis in health and disease.

Cold Spring Harb Perspect Med 2014 Aug 1;4(8). Epub 2014 Aug 1.

Department of Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, Metastasis Research Center, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030.

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http://dx.doi.org/10.1101/cshperspect.a015248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109579PMC
August 2014

Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8.

Proc Natl Acad Sci U S A 2014 Feb 21;111(5):E572-81. Epub 2014 Jan 21.

Departments of Biochemistry and Molecular Biology, Immunology, and Dermatology and Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030.

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http://dx.doi.org/10.1073/pnas.1319743111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918754PMC
February 2014

Noxa couples lysosomal membrane permeabilization and apoptosis during oxidative stress.

Free Radic Biol Med 2013 Dec 14;65:26-37. Epub 2013 Jun 14.

Molecular Targets Program, James Graham Brown Cancer Center, Departments of Medicine, Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816129PMC
December 2013

p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior.

J Neurosci 2013 Jul;33(31):12569-85

Programs in Cell Biology, Developmental and Stem Cell Biology, and Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.1251-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728680PMC
July 2013

IκB kinase β (IKKβ) inhibits p63 isoform γ (TAp63γ) transcriptional activity.

J Biol Chem 2013 Jun 15;288(25):18184-93. Epub 2013 Apr 15.

Department of Biochemistry and Molecular Biology and Tulane Cancer Center, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.

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http://dx.doi.org/10.1074/jbc.M113.466540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689961PMC
June 2013

The family that eats together stays together: new p53 family transcriptional targets in autophagy.

Genes Dev 2013 May;27(9):971-4

Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://genesdev.cshlp.org/content/27/9/971.full.pdf
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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.219147.113
Publisher Site
http://dx.doi.org/10.1101/gad.219147.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656325PMC
May 2013

Role of p63 and the Notch pathway in cochlea development and sensorineural deafness.

Proc Natl Acad Sci U S A 2013 Apr 15;110(18):7300-5. Epub 2013 Apr 15.

Biochemistry Laboratory Istituto Dermopatico Dell'Immacolata, c/o Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, 00133 Rome, Italy.

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http://dx.doi.org/10.1073/pnas.1214498110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645580PMC
April 2013

p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis.

Nat Rev Cancer 2013 02;13(2):136-43

Department of Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nrc3446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181578PMC
February 2013

TAp63 is a master transcriptional regulator of lipid and glucose metabolism.

Cell Metab 2012 Oct;16(4):511-25

Department of Biochemistry and Molecular Biology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483083PMC
October 2012

ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.

J Clin Invest 2012 Sep 1;122(9):3170-83. Epub 2012 Aug 1.

Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1172/JCI63608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428095PMC
September 2012

The p53 family grows old.

Genes Dev 2012 Sep;26(18):1997-2000

Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1101/gad.202648.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444725PMC
September 2012

Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination.

Mol Cancer Res 2011 Dec 12;9(12):1780-90. Epub 2011 Oct 12.

Department of Laboratory Medicine and Pathology, 370 Heritage Medical Research Center, University of Alberta, Edmonton, Alberta T6G 2S2, Canada.

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http://dx.doi.org/10.1158/1541-7786.MCR-11-0157DOI Listing
December 2011

Stem cell proliferation in the skin: alpha-catenin takes over the hippo pathway.

Sci Signal 2011 Jul 26;4(183):pe34. Epub 2011 Jul 26.

Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1126/scisignal.2002311DOI Listing
July 2011

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs.

Nature 2010 Oct;467(7318):986-90

Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

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http://www.nature.com/articles/nature09459
Publisher Site
http://dx.doi.org/10.1038/nature09459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055799PMC
October 2010

ΔNp63 transcriptionally regulates brachyury, a gene with diverse roles in limb development, tumorigenesis and metastasis.

Cell Cycle 2010 Jun 15;9(12):2434-41. Epub 2010 Jun 15.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.4161/cc.9.12.12051DOI Listing
June 2010

p63 and p73 transcriptionally regulate genes involved in DNA repair.

PLoS Genet 2009 Oct 9;5(10):e1000680. Epub 2009 Oct 9.

Department of Molecular and Cellular Oncology, Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752189PMC
October 2009

TAp63: The fountain of youth.

Aging (Albany NY) 2009 Oct 21;1(10):866-9. Epub 2009 Oct 21.

Department of Molecular and Cellular Oncology, Graduate School of Biomedical Sciences, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815729PMC
http://dx.doi.org/10.18632/aging.100095DOI Listing
October 2009

Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf.

EMBO J 2009 Jul 4;28(13):1904-15. Epub 2009 Jun 4.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/emboj.2009.151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711186PMC
July 2009

TAp63 prevents premature aging by promoting adult stem cell maintenance.

Cell Stem Cell 2009 Jul;5(1):64-75

Department of Molecular and Cellular Oncology, Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.stem.2009.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418222PMC
July 2009

p73 suppresses polyploidy and aneuploidy in the absence of functional p53.

Mol Cell 2007 Aug;27(4):647-59

Department of Pathology, Health Science Center, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1016/j.molcel.2007.06.036DOI Listing
August 2007

The roles of p63 in cancer.

Authors:
Elsa R Flores

Cell Cycle 2007 Feb 3;6(3):300-4. Epub 2007 Feb 3.

Department of Molecular and Cellular Oncology, The University of Texas Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.4161/cc.6.3.3793DOI Listing
February 2007

Li-Fraumeni syndrome: a p53 family affair.

Cell Cycle 2005 Jul 4;4(7):865-7. Epub 2005 Jul 4.

Department of Molecular Genetics, M.D. Anderson Cancer Center, University of Texas Graduate School of Biomedical Sciences, Houston, Texas 77030, USA.

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http://dx.doi.org/10.4161/cc.4.7.1800DOI Listing
July 2005

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family.

Cancer Cell 2005 Apr;7(4):363-73

The University of Texas M.D. Anderson Cancer Center and The University of Texas Graduate School of Biomedical Sciences, Department of Molecular and Cellular Oncology, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S153561080500092
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http://dx.doi.org/10.1016/j.ccr.2005.02.019DOI Listing
April 2005

Multiple response elements and differential p53 binding control Perp expression during apoptosis.

Mol Cancer Res 2003 Dec;1(14):1048-57

Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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December 2003

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage.

Nature 2002 Apr;416(6880):560-4

Massachusetts Institute of Technology, Department of Biology and Center for Cancer Research, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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http://www.nature.com/articles/416560a
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http://dx.doi.org/10.1038/416560aDOI Listing
April 2002

Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function.

Proc Natl Acad Sci U S A 2002 Mar 26;99(5):2948-53. Epub 2002 Feb 26.

Department of Biology and Center for Cancer Research, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.052713099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122453PMC
March 2002